KEGG   ENZYME: 2.1.1.240
Entry
EC 2.1.1.240                Enzyme                                 
Name
trans-resveratrol di-O-methyltransferase;
ROMT;
resveratrol O-methyltransferase;
pterostilbene synthase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction) [RN:R09872];
(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene [RN:R09870];
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene [RN:R09871]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
trans-resveratrol [CPD:C03582];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD:C20154]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
pterostilbene [CPD:C10287];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD:C20154]
Comment
The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.
History
EC 2.1.1.240 created 2012
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K16040  trans-resveratrol di-O-methyltransferase
Genes
PVY116115212 116115213
HSYR120156172 120156178 120156181 120174583
PDUL117613692 117625003 117625109
CSAV115698786 115721959 115722957
MESC122721528 122721537 122721543 122721619
CAVE132181317
QLO115957891
VVI100233030(OMT2.1) 100243765 100247173 100247273 100248917 100250627 100254011 100255808 100257423 100259140 100260877 100263651 100854823 132254760
ITR116010914 116011107 116021924
EGT105965021
APAN127240307
ECAD122607106 122607775 122607905
CSIN114286906 114317229
RVL131323191 131323192
AEW130791859
ATRI130806885 130808131 130813363
MOF131148217 131148770 131148782
MING122067618
TSS122638722 122640140 122641039 122641041 122641086 122643291 122643292 122643293 122650255
ZOF122003828 122039783 122049223
MSIN131225686 131245280 131245283 131245293 131245294 131245295 131245297 131245298 131246904 131246908
NCOL116245693 116252660 116266629
 » show all
Reference
1  [PMID:18799660]
  Authors
Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P
  Title
A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine.
  Journal
Plant Physiol 148:1630-9 (2008)
DOI:10.1104/pp.108.126003
  Sequence
[vvi:100233030]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.240
IUBMB Enzyme Nomenclature: 2.1.1.240
ExPASy - ENZYME nomenclature database: 2.1.1.240
BRENDA, the Enzyme Database: 2.1.1.240

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