KEGG ENZYME: 2.1.1.244

ENZYME: 2.1.1.244

Entry

EC 2.1.1.244                Enzyme

Name

protein N-terminal methyltransferase;
NMT1 (gene name);
METTL11A (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] methyltransferase

Reaction(IUBMB)

(1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] (overall reaction);
(1a) S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein];
(1b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein];
(1c) S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein];
(2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] (overall reaction);
(2a) S-adenosyl-L-methionine + N-terminal-PPK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein];
(2b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]

Substrate

S-adenosyl-L-methionine [CPD:C00019];
N-terminal-(A,S)PK-[protein];
N-terminal-N-methyl-N-(A,S)PK-[protein];
N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein];
N-terminal-PPK-[protein];
N-terminal-N-methyl-N-PPK-[protein]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein];
N-terminal-N-methyl-N-(A,S)PK-[protein];
N-terminal-N,N-dimethyl-N-(A,S)PK-[protein];
N-terminal-N,N-dimethyl-N-PPK-[protein];
N-terminal-N-methyl-N-PPK-[protein]

Comment

This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. When the terminal amino acid is L-proline, the enzyme catalyses two successive methylations of its alpha-amino group. When the first amino acid is either L-alanine or L-serine, the enzyme catalyses three successive methylations.
The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids [1,2].

History

EC 2.1.1.244 created 2012

Orthology

K16219

protein N-terminal methyltransferase

Genes

HSA:	28989(NTMT1)

PTR:	464790(NTMT1)

PPS:	100987374(NTMT1)

GGO:	101142309(NTMT1)

PON:	100431666(NTMT1)

PPYG:

129043908(NTMT1)

NLE:	100603188(NTMT1)

HMH:	116475753(NTMT1)

SSYN:

129478795(NTMT1)

MCC:	716763(NTMT1)

MCF:	102126169(NTMT1)

MTHB:

126937078

MNI:	105464017(NTMT1)

CSAB:

103239762(NTMT1)

CATY:

105576193(NTMT1)

PANU:

101016876(NTMT1)

TGE:	112608013(NTMT1)

MLEU:

105532856(NTMT1)

RRO:	104660538(NTMT1)

RBB:	108512842(NTMT1)

TFN:	117073093(NTMT1)

PTEH:

111545855(NTMT1)

CANG:

105504026(NTMT1)

CJC:	100415418(NTMT1)

SBQ:	101030485(NTMT1)

CIMI:

108283019(NTMT1)

ANAN:

105721125(NTMT1)

CSYR:

103255564(NTMT1)

MMUR:

105875284(NTMT1)

LCAT:

123646362(NTMT1)

PCOQ:

105806661(NTMT1)

OGA:	100965959(NTMT1)

MMU:	66617(Ntmt1)

MCAL:

110285120(Ntmt1)

MPAH:

110317629(Ntmt1)

RNO:	362103(Ntmt1)

MCOC:

116089955(Ntmt1)

ANU:	117703385(Ntmt1)

ASYL:

127685191(Ntmt1)

MUN:	110556800(Ntmt1)

CGE:	100771449(Ntmt1)

MAUA:

101830294(Ntmt1)

PROB:

127222736(Ntmt1)

PLEU:

114703767(Ntmt1)

MORG:

121462762(Ntmt1)

MFOT:

126509292

AAMP:

119819102(Ntmt1)

NGI:	103727878(Ntmt1)

HGL:	101704679(Ntmt1)

CPOC:

100713196(Ntmt1)

CCAN:

109696680(Ntmt1)

DORD:

105989281(Ntmt1)

DSP:	122109066(Ntmt1)

DMER:

138822210(Ntmt1)

PLOP:

125350304(Ntmt1)

NCAR:

124964188

MMMA:

107152008(Ntmt1)

ITI:	101976880(Ntmt1)

OCU:

100339797

OPI:	101520368(NTMT1)

TUP:	102484497(NTMT1)

GVR:	103599076(NTMT1)

CFA:	491300(NTMT1)

CLUD:

112677315(NTMT1)

VVP:	112927973(NTMT1)

VLG:	121473416(NTMT1)

NPO:	129513995(NTMT1)

AML:	100464977(NTMT1)

UMR:	103670267(NTMT1)

UAH:	113266511(NTMT1)

UAR:	123775679(NTMT1)

ELK:

111145787

LLV:

125083448

MPUF:

101693672(NTMT1)

MNP:	132024341(NTMT1)

MLK:	131812408(NTMT1)

NVS:	122917175(NTMT1)

ORO:	101376956(NTMT1)

EJU:	114198836(NTMT1)

ZCA:	113934460(NTMT1)

MLX:	118017596(NTMT1)

NSU:	110581477(NTMT1)

LWW:	102738248(NTMT1)

FCA:	101085326(NTMT1)

PYU:	121035100(NTMT1)

PCOO:

112848955(NTMT1)

PBG:	122474772(NTMT1)

PVIV:

125150406(NTMT1)

LRUF:

124505045

LGF:	123593455(NTMT1)

AJU:

106989375

PTG:	102970588(NTMT1)

PPAD:

109250038

PUC:

125922478

PLEZ:

122204846(NTMT1)

HHV:	120230095(NTMT1)

BTA:	617042(NTMT1)

BOM:	102266812(NTMT1)

BIU:	109566536(NTMT1)

BBUB:

102408786(NTMT1)

BBIS:

105000798(NTMT1)

CHX:	102172454(NTMT1)

OAS:	101115521(NTMT1)

BTAX:

128055342(NTMT1)

CSUM:

138086230(NTMT1)

ODA:	120852080(NTMT1)

CCAD:

122442258(NTMT1)

MREE:

136163711(NTMT1)

OVR:	110125682(NTMT1)

MBEZ:

129539323(NTMT1)

SSC:	100153919(NTMT1)

CFR:	102516861(NTMT1)

CBAI:

105081125(NTMT1)

CDK:	105092546(NTMT1)

VPC:	102534411(NTMT1)

BACU:

103004017(NTMT1)

BMUS:

118897294(NTMT1)

LVE:	103077988(NTMT1)

OOR:	101286272(NTMT1)

LALB:

132523284(NTMT1)

GMF:	115843004(NTMT1)

DDP:	132426489(NTMT1)

DLE:	111177133(NTMT1)

PCAD:

102991813(NTMT1)

PSIU:

116755773(NTMT1)

PPHC:

136124567(NTMT1)

NASI:

112411462(NTMT1)

ECB:	100066820(NTMT1)

EPZ:	103551894(NTMT1)

EAI:	106845408(NTMT1)

MYB:	102242208(NTMT1) 106724132

MYD:	102765040(NTMT1)

MMYO:

118666974(NTMT1)

MLF:	102432912(NTMT1)

MDT:	132212468(NTMT1)

MYUM:

139020700(NTMT1)

PKL:	118706658(NTMT1)

EFUS:

103296027(NTMT1)

MNA:	107524656(NTMT1)

DRO:	112306347 112306440

SHON:

118980211(NTMT1)

AJM:	119049754(NTMT1)

PDIC:

114501981(NTMT1)

PHAS:

123823477(NTMT1)

MMF:	118629791(NTMT1)

PPAM:

129079580(NTMT1)

HAI:	109380490(NTMT1)

RFQ:	117031947(NTMT1)

PALE:

102893601(NTMT1)

PGIG:

120601613(NTMT1)

PVP:	105294789(NTMT1)

RAY:	107504534(NTMT1)

MJV:	108394783(NTMT1)

TOD:	119230945(NTMT1) 119250917

SARA:

101556639(NTMT1)

SFUM:

130017463(NTMT1)

SETR:

126009580(NTMT1)

LAV:	100653829(NTMT1)

TMU:

101360319

ETF:	101663347(NTMT1)

DNM:	101428116(NTMT1)

MDO:	100012728(NTMT1)

GAS:	123237232(NTMT1)

SHR:	100927559(NTMT1)

AFZ:

127550887

PCW:	110198906(NTMT1)

TVP:	118842916(NTMT1)

PBRV:

138147128(NTMT1)

MLAO:

141505269(NTMT1)

OAA:	114811139(NTMT1)

TACU:

119926614(NTMT1)

GGA:	425539(NTMT1)

PCOC:

116234239(NTMT1)

MGP:	100549024(NTMT1) 100549986

CJO:	107321904(NTMT1)

TPAI:

128073726(NTMT1)

LMUT:

125702689(NTMT1)

NMEL:

110406913(NTMT1)

APLA:

101791577(NTMT1)

ACYG:

106047278(NTMT1)

CATA:

118252148(NTMT1)

AFUL:

116496874(NTMT1)

TGU:	100222445(NTMT1)

LSR:	110482273(NTMT1)

SCAN:

103819009(NTMT1)

PMOA:

120507443(NTMT1)

OTC:	121337100(NTMT1)

PRUF:

121357642(NTMT1)

ATRC:

139603259(NTMT1)

GFR:	102033433 102043790

FAB:	101813844(NTMT1)

OMA:	130260049(NTMT1)

PHI:	102112016(NTMT1)

PMAJ:

107212070(NTMT1)

CCAE:

111943674(NTMT1)

CCW:	104688292(NTMT1)

CBRC:

103623163(NTMT1)

ACOE:

138119663(NTMT1)

ETL:	114054512(NTMT1)

ZAB:	102075366(NTMT1)

ZLE:	135454987(NTMT1)

ACHL:

103806441(NTMT1)

SVG:	106851395(NTMT1)

MMEA:

130578518(NTMT1)

HRT:	120761714(NTMT1)

SATI:

136369717(NTMT1)

CCIC:

134051621(NTMT1)

FPG:	101914918(NTMT1)

FCH:	102054150(NTMT1)

CCRI:

104161944(NTMT1)

NNT:	104412110(NTMT1)

SHAB:

115617059(NTMT1)

ACUN:

113486555(NTMT1)

TALA:

104368855(NTMT1)

ACHC:

115335369(NTMT1)

HALD:

104320482(NTMT1)

HLE:	104833916(NTMT1)

AGEN:

126052173

HHAR:

128154497(NTMT1)

GCL:

127023654

CSTI:

104552374(NTMT1)

LDI:	104342024(NTMT1)

MNB:	103773244(NTMT1)

DPUB:

104296388(NTMT1)

PPUS:

135190201(NTMT1)

AVIT:

104279248(NTMT1)

BRHI:

104502036(NTMT1)

EGZ:	104129807(NTMT1)

NNI:	104023158(NTMT1)

PCRI:

104036715(NTMT1)

PCAO:

104043104(NTMT1)

PADL:

103915294(NTMT1)

AFOR:

103905298(NTMT1)

FGA:	104073626(NTMT1)

GSTE:

104257413(NTMT1)

CBOY:

140661195(NTMT1)

CLV:	102084809(NTMT1)

CNIC:

135996460(NTMT1)

MUI:	104537192(NTMT1)

PGUU:

104462471(NTMT1)

PLET:

104619268(NTMT1)

EHS:	104505347(NTMT1)

CMAC:

104485108(NTMT1)

CUCA:

104066797(NTMT1)

TEO:	104384390(NTMT1)

BREG:

104631646(NTMT1)

OHA:	104329280(NTMT1)

ACAR:

104519955(NTMT1)

CPEA:

104389847(NTMT1)

CVF:	104289110(NTMT1)

RTD:	128917525(NTMT1)

CRID:

134523800(NTMT1)

AAM:	106486486 106491507

AROW:

112964270(NTMT1)

NPD:	112955871(NTMT1)

TGT:	104564543(NTMT1)

DNE:	112984147(NTMT1)

SCAM:

104150662(NTMT1)

ASN:	102385028(NTMT1)

AMJ:	102572961(NTMT1)

CPOO:

109313931(NTMT1)

GGN:	109292950(NTMT1)

PSS:	102449305(NTMT1)

CMY:	102947090(NTMT1)

CCAY:

125623364(NTMT1)

DCC:	119844018(NTMT1)

CPIC:

101942466(NTMT1)

TST:	117889364(NTMT1)

CABI:

116835155(NTMT1)

MRV:	120386693(NTMT1)

ASAO:

132763744(NTMT1)

PVT:	110079706(NTMT1)

SUND:

121936037(NTMT1)

PBI:	103065843(NTMT1)

PMUR:

107293513(NTMT1)

CTIG:

120308696(NTMT1)

PGUT:

117676570(NTMT1)

PCAE:

139325642(NTMT1)

APRI:

131186014(NTMT1)

PTEX:

113443853(NTMT1)

NSS:	113426138(NTMT1)

VKO:	123035227(NTMT1)

PMUA:

114589175(NTMT1)

PRAF:

128406293(NTMT1)

ZVI:	118084313(NTMT1)

HCG:	128338863(NTMT1)

STOW:

125441949(NTMT1)

EMC:	129342141(NTMT1)

XLA:	734671(ntmt1.S) 735155(ntmt1.L)

XTR:	100145456(ntmt1) 116407067

NPR:	108792684(NTMT1)

RTEM:

120914156(NTMT1)

ACAT:

141108488(NTMT1)

BBUF:

120977615(NTMT1)

BGAR:

122919493(NTMT1)

DTC:	141046564(NTMT1)

MUO:	115473150(NTMT1)

GSH:	117367893(NTMT1)

DRE:	405834(ntmt1)

SRX:	107723349 107740971

SANH:

107691051 107693833

SGH:	107587381 107597156

CCAR:

109079202 109080699

CAUA:

113049362 113075420

CGIB:

127957667 128006905

PTET:

122345756(ntmt1)

LROH:

127165876(ntmt1)

GRF:	141335605(ntmt1)

OMC:	131540334(ntmt1)

PPRM:

120469733(ntmt1)

RKG:	130101601(ntmt1)

MAMB:

125267108(ntmt1)

CIDE:

127512565

CERY:

137034262(ntmt1)

MASI:

127421721 127440177

TROS:

130567660(ntmt1)

TDW:	130418957(ntmt1)

MANU:

129440276(ntmt1)

PDAB:

135748692(ntmt1)

IPU:	100528268(ntmt1)

IFU:	128603389(ntmt1)

PHYP:

113531082(ntmt1)

SMEO:

124378918(ntmt1)

TFD:	113655168(ntmt1)

TVC:	132841037(ntmt1)

CGAR:

128511846(ntmt1)

NGRA:

132875963(ntmt1)

TRN:	134303434(ntmt1)

AMEX:

103027538(ntmt1)

CMAO:

118802404(ntmt1)

EEE:	113570259(ntmt1)

CHAR:

105911121(ntmt1)

SPIL:

134100796(ntmt1)

TRU:	101071402(ntmt1)

TFS:	130517016(ntmt1)

TNG:	GSTEN00013850G001

LCO:	104926251(ntmt1)

TBEN:

117478842(ntmt1)

CGOB:

115016686(ntmt1)

EMAC:

134868318(ntmt1)

ELY:	117269361(ntmt1)

EFO:	125906178(ntmt1)

PLEP:

121959866 121965519

SLUC:

116041412(ntmt1)

ECRA:

117959239(ntmt1)

ESP:	116704066(ntmt1)

PFLV:

114571402(ntmt1)

GAT:	120832034(ntmt1)

PPUG:

119226648(ntmt1)

AFB:	129102561(ntmt1)

CLUM:

117740941(ntmt1)

PSWI:

130205182(ntmt1)

CANA:

137784271(ntmt1)

CVE:	137868773(ntmt1)

MSAM:

119914408(ntmt1)

SCHU:

122865166(ntmt1)

CUD:	121525402(ntmt1)

SPUL:

138605180(ntmt1)

LMIX:

132992089(ntmt1)

ALAT:

119030452(ntmt1)

ASTR:

137608515(ntmt1)

MZE:	101485931(ntmt1)

ONL:	100691602(ntmt1)

OAU:	116334147(ntmt1)

OLA:	101168668(ntmt1)

OML:	112144193(ntmt1)

CSAI:

133454514(ntmt1)

XMA:	102223153(ntmt1)

XCO:	114149425(ntmt1)

XHE:	116724242(ntmt1)

PRET:

103474089(ntmt1)

PFOR:

103153942(ntmt1)

PLAI:

106956734(ntmt1)

PMEI:

106924603(ntmt1)

GAF:	122819365(ntmt1)

PPRL:

129354269 129355035

CVG:	107098858(ntmt1)

CTUL:

119773642(ntmt1)

GMU:	124872841(ntmt1)

NFU:	107375044(ntmt1)

KMR:	108250999(ntmt1)

ALIM:

106533019(ntmt1)

NWH:	119424766(ntmt1)

AOCE:

111567041(ntmt1)

EJA:	138210096(ntmt1)

BFRE:

138634804(ntmt1)

MCEP:

124997080(ntmt1)

CSEM:

103389150(ntmt1)

POV:	109646211(ntmt1)

SSEN:

122758275(ntmt1)

SSOE:

131446544(ntmt1)

HHIP:

117771438(ntmt1)

HSP:	118125644(ntmt1)

PPLT:

128424798(ntmt1)

SMAU:

118285067(ntmt1)

LCF:

108877709

SDU:	111221176(ntmt1)

SLAL:

111648140(ntmt1) 111671270

XGL:	120806742(ntmt1)

HCQ:	109529156(ntmt1)

SSCV:

125979849(ntmt1)

SBIA:

133490925(ntmt1)

PEE:	133414170(ntmt1)

PTAO:

133490214(ntmt1)

BPEC:

110161386(ntmt1)

ENY:	140367214(ntmt1)

MALB:

109960777(ntmt1)

BSPL:

114867327(ntmt1)

SJO:	128380091(ntmt1)

SSCO:

133995506(ntmt1)

GMH:	115542127(ntmt1)

SASA:

106570305(ntmt1)

STRU:

115160017(ntmt1)

OTW:	112220042(ntmt1)

OMY:	110523232(ntmt1)

OGO:	123989433(ntmt1)

ONE:	115118831(ntmt1)

OKI:	109868052(ntmt1)

OKE:	118387303(ntmt1)

OMM:	135518305(ntmt1)

OCLA:

139408369

SALP:

112080633(ntmt1)

SNH:	120025762(ntmt1)

CCLU:

121582037(ntmt1)

ELS:	105021779(ntmt1)

OEP:	134033627(ntmt1)

SFM:	108922683(ntmt1)

PKI:	111836264(ntmt1)

AANG:

118212350(ntmt1)

AROT:

135239511(ntmt1)

CCOG:

133142374(ntmt1)

LOC:	102697458(ntmt1)

PSPA:

121309641(ntmt1)

ARUT:

117421904 117964696

PSEX:

120536077(ntmt1)

LCM:	102358139(NTMT1)

CMK:	103184690(ntmt1)

RTP:	109926002(ntmt1)

CPLA:

122546545(ntmt1)

HOC:	132825735(ntmt1)

LERI:

129712082(ntmt1)

HAKA:

140731077(ntmt1)

PMRN:

116955397(NTMT1)

LRJ:	133360065(NTMT1)

BFO:

118420717

BBEL:

109462008

CIN:

100185139

SCLV:

120345406

SPU:

579562

LPIC:

129277780

AJJ:

139963857

APLC:

110976444

ARUN:

117303217

AAMU:

139948179

AFIL:

140136895

AJC:

117121056

SKO:

100371905

PFLL:

139118877

DME:	Dmel_CG1675(Ntmt)

DER:

6541388

DSE:

6608421

DSI:	Dsimw501_GD10692(Dsim_GD10692)

DYA:	Dyak_GE19310

DAN:

6494723

DSR:

110189448

DPO:

4803875

DPE:

6590206

DMN:	108159563 117191495

DWI:

6640666

DGR:

6560742

DMO:	Dmoj_GI18834

DAZ:

108615198

DNV:

108652957

DHE:

111599988

DVI:	6627190(Ntmt)

CCAT:

101455484

BOD:

106618748

BDR:

105228442

RZE:	108365163 108368310

AOQ:

129244612

ALUD:

128868072

TDA:	119677719 119680033 119680034

MDE:	101889727 131804082

SCAC:

106080937

LCQ:

111691221

LSQ:

119603928

CVJ:	135962196(Ntmt)

GFS:

119641230

ECOE:

129941097

CLON:

129614118

HIS:

119653694

AGA:

3291081

ACOZ:

120956763

AARA:

120903712

AMER:

121599559 121602436

ASTE:

118504891

AMAP:

126558794

AFUN:

125768308

AMOU:

128297805

AMRS:

128707520

AALI:

118465967

ACOS:

131259458

AAG:

5566860

AALB:

109426481

ASUA:

134226630

CQU:	CpipJ_CPIJ013727

CPII:

120421870

CBRI:

134838186

CNS:

116345038

BCOO:

119066903

LLL:

129796222

PPAP:

129802336

AME:

550780

ACER:

107996017

ALAB:

122714524

ADR:

102678594

AFLR:

100864922

BIM:

100741318

BBIF:

117211938

BVK:

117239086

BVAN:

117166000

BHUN:

126875098

BTER:

100651146

BAFF:

126926004

BPYO:

122577123

BPAS:

132915092

FVI:

122530085

CCAL:

108623917

OBB:

114876331

OLG:

117604282

MGEN:

117226977

NMEA:

116429313

SOC:

105199772

MPHA:

105835643

AEC:

105154167

ACEP:

105622691

ACOC:

108693634

MZT:	108729485(Ntmt)

CCOA:

108777269

PBAR:

105424877

VEM:

105562637

COBS:

139108326(Ntmt)

TLN:	139816172(Ntmt)

HST:

105190277

DQU:

106741807

CFO:

105250764

FEX:

115236148

PMEC:

138936160(Ntmt)

LHU:	105679798(Ntmt)

PGC:

109858708

OBO:

105275263

PCF:

106783798

PFUC:

122520074

VPS:

122631815

VCRB:

124426977

VVE:

124952265

NVI:

100121605

CSOL:

105368955

TPRE:

106655528

LHT:

122500138

LBD:

127280625

MDL:

103571657

CGLO:

123272716

FAS:

105264434

DAM:

107038044

AGIF:

122847709

CINS:

118070619

VCAN:

122411065

CCIN:

107273798

DSM:

124405828

NPT:	124212012(Ntmt)

NFB:

124175720

NLO:

107226169

NVG:

124297972

AROA:

105689840

TCA:

659517

TMOL:

138131867(Ntmt)

DPA:

109538561

ESIM:

136418075(Ntmt)

EFOR:

136346751(Ntmt)

SOY:

115880693

AGRG:

126743923

ATD:

109599751

CSET:

123312042

HAXR:

123678331

AGB:

108909452

LDC:

111514726

DVV:

114326524

NVL:

108568005

APLN:

108741306

PPYR:

116172007

OTU:

111424776

BMOR:

101743128 101746959

BMAN:

114250958 114252517

MSEX:

115440975 115456136

DPL:	KGM_206479 KGM_214199

BANY:

112047352 112058589

MJU:	123866504 123872596

NIQ:	126773715 126780895

VCD:

124531031

MCIX:

123656515 123669420

PMAC:

106707246 106710766

PPOT:

106099726 106108535

PXU:	106115867 106127508

BPHI:

137922005 137933416

PRAP:

110998672 111003422

PBX:	123709271 123711926

PNAP:

125048940 125056392

ZCE:	119830069 119830648

CCRC:

123696057 123706083

LSIN:

126972864 126977420

AAGE:

121733026

HAW:	110374792 110375455

HZE:	124637716 124645727

TNL:	113498876 113501555

SLIU:

111352431 111365041

OFU:	114360689 114365582

ONU:	135075107 135088331

ATRA:

106143067 132902408

GMW:	113513943 116413134

PXY:	105387308 105393311

PGW:

126366806

LGLY:

125230046

CSTB:

134740606 134746092

CFUM:

141426587 141436941

CFEL:

113373228

CCRN:

123305414

API:	100167499(Mettl11a)

DNX:

107163768

AGS:

114120182

RMD:

113553816

ACOO:

126833737

DVT:

126906899

BTAB:

109035782

DCI:	103510947 103510950

CLEC:

106672588

HHAL:

106680261(Ntmt)

NLU:

111062436

HVI:

124364096

MQU:	129001244 129001306

PHU:	Phum_PHUM136020

FOC:

113217366

TPAL:

117639822

ZNE:

110833881

CSEC:

111866236

PAME:

138711187(Ntmt)

SGRE:

126272045

BROR:

134537427

IEL:

124168930

HAMR:

139700073(Ntmt)

FCD:

110846999

DPX:	DAPPUDRAFT_299834

DMK:

116918882

DPZ:

124352589

AFRA:

136040369

PVM:

113824921

PJA:

122250675

PCHN:

125041411

PMOO:

119592104

HAME:

121873856

PCLA:

123745830(Ntmt)

CQD:

128685724

PTRU:

123505787

ESN:	126980721 127004759

MNZ:

135205282

MRJ:

136845185

PORN:

139756129

HAZT:

108673290

LSM:	121126447(Ntmt)

TCF:

131888149

PPOI:

119095482 119095528

DSV:

119437650

RSAN:

119391997

RMP:

119160745

GOE:

100897199

TUT:

107362614

DPTE:

113794962 113799039

DFR:

124490779

CSCU:

111612778

CVS:	136975992(Ntmt)

PTEP:

107453515

ABRU:

129969523

UDV:

129227743

SDM:

118203967

LPOL:

106459990

PMEO:

129602815

CEL:	CELE_Y74C9A.3(homt-1)

CBR:	CBG_03917 CBG_17371

CRQ:	GCK72_000817 GCK72_023766

NAI:	NECAME_17552

BMY:	BM_BM7124(Bma-homt-1)

LOA:	LOAG_05539

HRO:	HELRODRAFT_185381

LGI:	LOTGIDRAFT_225615

PVUL:

126808560

PCAN:

112575072

LSAX:

138948807

BGT:

106076885

GAE:

121383219

HRF:

124145626

HRJ:

124267414

HASI:

137272187

HCRA:

139459926

CRG:

105321221

CANU:

128191699

CVN:

111126383

OED:

125678915

MYI:

110451703

PMAX:

117320271

AIRR:

138321208

MCAF:

127729476

MMER:

123557417 123557419

RPHI:

132716268 132739983 132739984

DPOL:

127876918

MAEA:

128228506

OBI:

106875627

OSN:	115215036 115232084

LJP:

135480572

LAK:	106155767 106155768

SHX:	MS3_00010049(NTMT1_2)

EGL:	EGR_06518 EGR_10765

LLON:

135501208

NVE:	116615065 5504078

EPA:

110254177

ATEN:

116306455

ADF:

107354651

AMIL:

114970507 122952989

MCAZ:

138049545

MFOO:

137985591

PDAM:

113676901

SPIS:

111330215

DGT:

114518165

XEN:

124452741

HMG:

101236709

HSY:

130614128

RES:

135680791

TAD:	TRIADDRAFT_18419 TRIADDRAFT_49985

AQU:

100636448

ATH:

AT5G44450

ALY:

9301441

CRB:

17876613

CSAT:

104724999 104760456 104771613

EUS:	EUTSA_v10000956mg

BRP:	103827900 103839174

BNA:	106434267 106437298 111211944 125609875

BOE:	106303677 106315768

RSZ:	108833511 108853298

THJ:

104812070

CPAP:

110821864

CIT:

102626144

CIC:	CICLE_v10016195mg

PVY:	116105280 116130693

MINC:

123219397

TCC:

18595119

GRA:

105777102

GHI:	107925241 107930389

GAB:

108487132

HSYR:

120156067 120170636 120205833

DZI:

111275399

EGR:

104441224

RARG:

115756021

GMX:	100777982 100809415

GSJ:	114412620 114422926 114424762

PVU:

137811779

VRA:

106752829

VAR:

108321030

VUN:

114176259

VUM:

124840373

CCAJ:

109814486

APRC:

113858961

MTR:

25493345

TPRA:

123916345

CAM:

101504939

PSAT:

127101244

VVO:

131603101

LJA:

130711521

ADU:

107481711

AIP:

107631571

AHF:	112734533 112792329

LANG:

109350827 109358046

PCIN:

129302388

QSA:	O6P43_013882

FVE:

101297996

AANS:

126786447

RCN:

112165406

PPER:

18779269

PMUM:

103325303

PAVI:

110764958

PDUL:

117623780

MDM:	103446084 103454462

MSYL:

126584706 126620722

PXB:

103945075

PCOX:

137730019

ZJU:

107418025

MNT:

21397877

CSAV:

115722215

CSV:

101208679

CMO:

103484292

BHJ:

120072685

MCHA:

111015851

CMAX:

111477809 111497490

CMOS:

111433034 111433513

CPEP:

111782110 111804120

RCU:

8287902

MEAN:

126673459

JCU:

105636784

HBR:

110633462

MESC:

110600139

POP:

7485157

PEU:

105136763

PALZ:

118040806

PNZ:

133702717

JRE:

108985678

CILL:

122276437

CAVE:

132172735

AGLU:

133868675

QSU:

112035016

QLO:

115991716

TWL:

119987864

VVI:

104880540

VRI:

117923962

SLY:

101263650

SPEN:

107011688

SOT:

102580009

SSTN:

125848861

SDUL:

129887405

CANN:

107857634

LBB:

132631660

NTA:	107792842 107806004

NSY:

104236734

NTO:

104118695

NAU:

109234230

INI:

109153045

ITR:

116026654

SIND:

105175818

OEU:

111370461

EGT:

105948798

SSPL:

121769412 121772606

SMIL:

130998770 130998771 130999288 131026369

SHIS:

125203392

APAN:

127247049

PEBU:

140819923

HAN:

110894132

ECAD:

122596104

LSV:

111882930

CCAV:

112517308

DCR:

108201251

CSIN:

114265081 114293497

RVL:

131312399

AEW:

130787113

DLT:

127807825

BVG:

104903184

SOE:

110785214

CQI:	110682702 110713143

ATRI:

130806316

SLAF:

141600364

MOF:

131159887

NNU:

104587869

MING:

122058935

TSS:

122649454

PSOM:

113280837 113289974

OSA:	4334312(NTM1)

DOSA:

Os03g0780900

OBR:

102721148

OGL:

127766229

BDI:

100831888

ATS:

109753013

TDC:	119303378 119312036

TAES:

123105256 123113514 123123045

TUA:

125510799

LPER:

127292578

LRD:

124680472

SBI:

8083934

ZMA:

100193831

MFLO:

136477663 136478001 136537899 136537928

SITA:

101781056

SVS:

117836178

PVIR:

120649558 120689879

PHAI:

112874589

PAUA:

133913453 133915318

TANG:

140758986

PDA:

103709829

EGU:

105033081

MUS:

103989578

ZOF:	122002468 122006716

DCT:

110103417

PEQ:

110027876

AOF:

109833088

MSIN:

131220859

ACAK:

137953244

NCOL:

116267669

ATR:

18443027

CJF:

131070743

SMO:	SELMODRAFT_140975 SELMODRAFT_143000

PPP:

112274777

CRE:	CHLRE_06g274400v5

VCN:	VOLCADRAFT_55463

MNG:

MNEG_9034

CSL:	COCSUDRAFT_30891

CVR:	CHLNCDRAFT_27478

APRO:

F751_6105

OLU:	OSTLU_35539

OTA:	OT_ostta07g02870

BPG:	Bathy04g02480

MIS:	MICPUN_78394

MPP:	MICPUCDRAFT_16294

GSL:	Gasu_12730

SCE:	YBR261C(TAE1)

SEUB:

DI49_1286

SPAO:

SPAR_B03580

AGO:	AGOS_AFR615W

ERC:

Ecym_2334

KLA:	KLLA0_F02101g

KMX:	KLMA_50089(TAE1)

LTH:	KLTH0H11110g

VPO:	Kpol_1035p14

ZRO:	ZYRO0B09086g

CGR:	2888971(GVI51_I09097)

NCS:	NCAS_0B07330(NCAS0B07330)

NDI:	NDAI_0B04650(NDAI0B04650)

TPF:	TPHA_0O01360(TPHA0O01360)

TBL:	TBLA_0F03410(TBLA0F03410)

TGB:	HG536_0F02230

TDL:	TDEL_0D02090(TDEL0D02090)

KAF:	KAFR_0C04340(KAFR0C04340)

KNG:	KNAG_0C01870(KNAG0C01870)

ZMK:	HG535_0C04740

SLUD:

SCDLUD_003537

DHA:	DEHA2A05786g

PIC:	PICST_83711

PGU:	PGUG_03498

SPAA:

SPAPADRAFT_57602

LEL:	PVL30_005061

LBG:	92211076(LODBEIA_P58800)

CAL:	CAALFM_C700490CA(CaO19.7069)

CTP:	CTRG_04906

COT:	CORT_0H01490

CDU:	CD36_70150

CTEN:

18250682(PSN45_004783)

CLU:	CLUG_00409

CLUS:

A9F13_08g02156

CAUR:

CJI96_0001113

ASAU:

88173213(PUMCH_002148)

PPA:	PAS_chr1-4_0630

PKZ:	C5L36_0A09870

BBRX:

BRETT_001663

OPA:	HPODL_04244

YLI:	2905995(YALI2_A00012g)

SLB:	AWJ20_2262(TAE1)

NCR:

NCU01114

NTE:	NEUTE1DRAFT76613(NEUTE1DRAFT_76613)

SMP:	10807096(SMAC4_03189)

PAN:	PODANSg8577

PBEL:

QC761_207470

PPSD:

QC762_207470

PPSP:

QC763_207470

PPSA:

QC764_207470

MTM:	MYCTH_2301513

CTHR:

CTHT_0027750

RTHE:

98122724(VTJ83DRAFT_1873)

MGR:

MGG_05014

PPEI:

PpBr36_03391

PGRI:

PgNI_01292 PgNI_09057

TMN:	UCRPA7_3848

SSCK:

SPSK_06537

FGR:	FGSG_02421

FPU:	FPSE_01986

FPOA:

FPOAC1_002533

FVN:	FVRRES_02828

FVR:	FVEG_09328

FOX:	FOXG_10679 FOXG_10680

NHE:	NECHADRAFT_94674

FFC:	NCS54_00859600

FKR:	NCS57_00903100

FMU:	J7337_005087

TRE:	TRIREDRAFT_57277

TRR:	M419DRAFT_127279

TATV:

25782119(TrAtP1_004520)

TASP:

36607241(TrAFT101_012013)

MAW:	19252324(J3458_005880)

MAJ:

MAA_03167

MBRN:

26241329(tae1)

PCHM:

VFPPC_08339

CMT:	CCM_05270 CCM_07162

AMUS:

LMH87_001648 LMH87_011176

PLJ:	28883919(PLICBS_005214)

PTKZ:

JDV02_002187 JDV02_005804

VDA:	VDAG_03286

CFJ:	CFIO01_04320

CLUP:

CLUP02_04154

CHIG:

CH63R_03097

CDET:

87937923(CDEST_01420)

SAPO:

SAPIO_CDS5778

ELA:	UCREL1_8891

PFY:	PFICI_15068

SSL:	SS1G_00643

BFU:	BCIN_03g02980(Bctae1)

MBE:

MBM_08281

PSCO:

LY89DRAFT_612328

GLZ:	GLAREA_00900

AFM:	AFUA_5G01020

ACT:	ACLA_004190

NFI:	NFIA_041150

AOR:	AO090102000220 AO090103000204

ANG:	An15g06850

AFV:	AFLA_011669 AFLA_013318

ALUC:

AKAW2_60099A(TAE1)

ACHE:

ACHE_20787A(TAE1_1) ACHE_30335A(TAE1_2)

APUU:

APUU_50598S(TAE1)

PCS:	N7525_006902

PDP:	PDIP_82140

POU:	POX_d06017

TMF:	EYB26_007990

TRG:	TRUGW13939_01681

CIM:	CIMG_08869

CPW:	9696150(TAE1)

ABE:

ARB_05928

TVE:

TRV_00128

PBL:	PAAG_03220

PBN:	PADG_03098

AJE:	HCAG_06206

BGH:	BDBG_00509

PNO:	SNOG_00087

BZE:	COCCADRAFT_104393

BSC:	COCSADRAFT_310759

BOR:	COCMIDRAFT_102464

AALT:

CC77DRAFT_1015638

ADAC:

96085368(ACET3X_005046)

ARAB:

EKO05_0004336

ZTR:	MYCGRDRAFT_98635

PFJ:	MYCFIDRAFT_210088

FFU:	CLAFUR5_01255

CBET:

CB0940_01248

BCOM:

BAUCODRAFT_73639

NPA:	UCRNP2_325

TML:	GSTUM_00007109001

SPO:	2542340(tae1)

SOM:	SOMG_03317(tae1)

CNE:

CNM02350

CNB:

CNBM2190

CNG:	CNAG_06235

CGI:	CGB_M3410W

CDEU:

CNBG_4935

CDEC:

89992532(IAS62_005763)

CTEG:

91992878(I308_106023)

CBAS:

91986139(I312_106095)

CDEP:

91088606(L203_104396)

KMG:	30168347(I203_106828)

KNE:	92178584(IAR55_001325)

KDJ:	28965145(I303_101437)

KBI:	30207735(I302_104628)

KPIN:

30176215(I206_100031)

KSH:	87953488(IL334_001357)

KER:	91106621(V865_007820)

TMS:	TREMEDRAFT_70692

TASA:

A1Q1_02264

CCAC:

CcaHIS019_0209170(CcaverHIS019_0209170)

TVS:	TRAVEDRAFT_40860

DSQ:	DICSQDRAFT_49323

SHS:	STEHIDRAFT_74641

HIR:	HETIRDRAFT_471078

PSQ:	PUNSTDRAFT_135996

ADL:	AURDEDRAFT_133778

FME:	FOMMEDRAFT_124738

GTR:	GLOTRDRAFT_72005

RSX:	RhiXN_02085

LBC:	LACBIDRAFT_182129

CCI:	CC1G_04197

ABP:	AGABI1DRAFT35058(AGABI1DRAFT_35058)

ABV:	AGABI2DRAFT148576(AGABI2DRAFT_148576)

PCUB:

JR316_0003826

MRR:	Moror_8017

E1B28_008868

SCM:	SCHCO_02484794(SCHCODRAFT_02484794)

SLA:	SERLADRAFT_474692

WSE:	WALSEDRAFT_19040

UMA:	UMAG_01818

PFP:	PFL1_01620

SGRA:

EX895_003898

MGL:

MGL_0691

MRT:

MRET_0134

MSYM:

MSY001_2070

PTRC:

PtA15_7A402

PSTR:

Pst134EA_013322 Pst134EA_013354

MLR:	MELLADRAFT_32182

RIE:	OCT59_004243

MBR:	MONBRDRAFT_21077

SRE:	PTSG_09959

DDI:	DDB_G0269658

DPP:	DICPUDRAFT_151386

DFA:

DFA_02725

EHI:	EHI_036850(283.t00004)

EDI:	EDI_174580

EIV:	EIN_026250

ACAN:

ACA1_323160

CPV:

cgd6_1210

CHO:	Chro.60155

TGO:	TGME49_201720

BBES:

BESB_013700

TET:	TTHERM_000309909 TTHERM_00279880

PTM:	GSPATT00005538001 GSPATT00030451001

PTI:	PHATRDRAFT_9115

FCY:	FRACYDRAFT_208503

TPS:	THAPSDRAFT_33511

PIF:	PITG_18863

PSOJ:

PHYSODRAFT_562742

SPAR:

SPRG_13692 SPRG_17107

TBR:	Tb927.6.2270 Tb927.6.2330

TBG:	TbgDal_VI2050 TbgDal_VI2090

TCR:	503835.30 509049.20

LMA:	LMJF_30_0810

LIF:	LINJ_30_0880

LDO:	LDBPK_300880

LMI:	LMXM_29_0810

LMAT:

92513750(LSCM1_03705)

LBZ:	LBRM_30_0940

LPAN:

LPMP_300880

LOI:	92357977(LSCM4_02006)

LEIS:

94178149(GH5_02643)

LENR:

94170239(CUR178_02991)

LEIN:

94187056(JIQ42_03376)

PHET:

94288982(JKF63_02881)

NGR:	NAEGRDRAFT_3529

TVA:	4732954(TVAGG3_0224810) 4750261(TVAGG3_0449160) 4760502(TVAGG3_0193630) 4767904(TVAGG3_0406420) 5464848(TVAGG3_0290400)

GLA:	GL50803_0012215

SSAO:

94302362(SS50377_28339)

EHX:	EMIHUDRAFT_100287 EMIHUDRAFT_124527

GTT:	GUITHDRAFT_110071

» show all

Reference

1 [PMID:20481588]

Authors

Webb KJ, Lipson RS, Al-Hadid Q, Whitelegge JP, Clarke SG

Title

Identification of protein N-terminal methyltransferases in yeast and humans.

Journal

Biochemistry 49:5225-35 (2010)
DOI:10.1021/bi100428x

Sequence

[hsa:28989] [sce:YBR261C]

Reference

2 [PMID:20668449]

Authors

Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG

Title

NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

Journal

Nature 466:1125-8 (2010)
DOI:10.1038/nature09343

Sequence

[hsa:28989] [mmu:66617]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.244

IUBMB Enzyme Nomenclature:

2.1.1.244

ExPASy - ENZYME nomenclature database:

2.1.1.244

BRENDA, the Enzyme Database:

2.1.1.244

All links

Gene (2866)   
   MGENES (391)   
   RefGene (2475)   
Protein sequence (4481)   
   UniProt (4360)   
   SWISS-PROT (18)   
   RefSeq(pep) (46)   
   PDBSTR (57)   
DNA sequence (105)   
   RefSeq(nuc) (57)   
   GenBank (25)   
   EMBL (23)   
3D Structure (19)   
   PDB (19)   
Protein domain (2)   
   InterPro (2)   
All databases (7473)   

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