[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase;
methyltransferase 2 (ambiguous);
mtbA (gene name);
[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase
Transferring one-carbon groups;
methylated monomethylamine-specific corrinoid protein:CoM methyltransferase
a [methyl-Co(III) methylamine-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methylamine-specific corrinoid protein] [RN:
[methyl-Co(III) methylamine-specific corrinoid protein];
[Co(I) methylamine-specific corrinoid protein]
Contains zinc . The enzyme, which is involved in methanogenesis from mono-, di-, and trimethylamine, catalyses the transfer of a methyl group bound to the cobalt cofactor of several corrinoid proteins (mono-, di-, and trimethylamine-specific corrinoid proteins, cf. EC
, methylamine---corrinoid protein Co-methyltransferase, EC
, dimethylamine---corrinoid protein Co-methyltransferase, and EC
, trimethylamine---corrinoid protein Co-methyltransferase) to CoM, forming the substrate for EC
, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis.
EC 188.8.131.52 created 2012
ec01120 Microbial metabolism in diverse environments
K14082 [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase
METM: MSMTP_0576 MSMTP_3048 MSMTP_3126
MZI: HWN40_00845 HWN40_00915 HWN40_05355
MHZ: Metho_0007 Metho_0037 Metho_0355 » show all
Burke SA, Krzycki JA
Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine.
LeClerc GM, Grahame DA
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression.
Ferguson DJ Jr, Krzycki JA
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.
Burke SA, Lo SL, Krzycki JA
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
Ferguson DJ Jr, Gorlatova N, Grahame DA, Krzycki JA
Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.
ExPASy - ENZYME nomenclature database: 184.108.40.206