KEGG   ENZYME: 2.1.1.248Help
Entry
EC 2.1.1.248                Enzyme                                 

Name
methylamine---corrinoid protein Co-methyltransferase;
mtmB (gene name);
monomethylamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + NH3 [RN:R10014]
Reaction(KEGG)
R10014;
(other) R09998
Show
Substrate
methylamine [CPD:C00218];
[Co(I) methylamine-specific corrinoid protein]
Product
[methyl-Co(III) methylamine-specific corrinoid protein];
NH3 [CPD:C00014]
Comment
The enzyme, which catalyses the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
History
EC 2.1.1.248 created 2012
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K16176  methylamine---corrinoid protein Co-methyltransferase
Genes
SDF: ACG33_12615
DEO: CAY53_02475
DML: Dmul_02380(mtmB)
CTHD: CDO33_18585
DAE: Dtox_0025
AAR: Acear_1719
SRI: SELR_27700(mtmB)
CPOR: BED41_14915
MAC: MA_0144(mtmB1) MA_2972(mtmB2)
MBA: Mbar_A0843 Mbar_A0846
MMA: MM_1436(mtmB) MM_1437(mtmB) MM_3335(mtmB) MM_3336(mtmB)
MTHE: MSTHC_1357
MTHR: MSTHT_1926
MMH: Mmah_1399
MEAR: Mpt1_c05730(mtmB11) Mpt1_c05760(mtmB13)
TPE: Tpen_1211
 » show all
Taxonomy
Reference
1  [PMID:9195968]
  Authors
Burke SA, Krzycki JA
  Title
Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.
  Journal
J Biol Chem 272:16570-7 (1997)
DOI:10.1074/jbc.272.26.16570
  Sequence
Reference
2  [PMID:9642198]
  Authors
Burke SA, Lo SL, Krzycki JA
  Title
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
  Journal
J Bacteriol 180:3432-40 (1998)
  Sequence
Reference
3  [PMID:15450490]
  Authors
Krzycki JA
  Title
Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
  Journal
Curr Opin Chem Biol 8:484-91 (2004)
DOI:10.1016/j.cbpa.2004.08.012
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.248
IUBMB Enzyme Nomenclature: 2.1.1.248
ExPASy - ENZYME nomenclature database: 2.1.1.248
BRENDA, the Enzyme Database: 2.1.1.248

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