KEGG   ENZYME: 2.1.1.258Help
Entry
EC 2.1.1.258                Enzyme                                 

Name
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase;
acsE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate [RN:R02289]
Reaction(KEGG)
R02289;
(other) R10243
Show
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrofolate [CPD:C00101]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrofolate [CPD:C00440]
Comment
Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin) and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.
History
EC 2.1.1.258 created 2012
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15023  5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase
Genes
DAK: DaAHT2_1991
DSF: UWK_01140
DOL: Dole_3182
DML: Dmul_30880(metH) Dmul_32250
DAL: Dalk_0683
DAT: HRM2_16640(metH3)
DTO: TOL2_C05310 TOL2_C11790(metH)
DAO: Desac_1969
DTI: Desti_0229
SFU: Sfum_2563
DBR: Deba_0238
CLJ: CLJU_c37560(meTr)
CSQ: CSCA_4550
CACE: CACET_c10310(acsE)
AMT: Amet_2027
RUM: CK1_12640
ROB: CK5_28650
BPRO: PMF13cell1_04280(acsE_4)
PDC: CDIF630_00843(acsE)
DSY: DSY1647
DHD: Dhaf_2792
DAE: Dtox_1276
PTH: PTH_1004(MetH)
DAU: Daud_0876
ELM: ELI_3604
AWO: Awo_c10730(acsE)
CTHM: CFE_1661
TKI: TKV_c19830(acsE)
CHY: CHY_1227(acsE)
MTA: Moth_1197
ADG: Adeg_0341
TPZ: Tph_c15130(acsE)
TOC: Toce_0812
MANA: MAMMFC1_00471(acsE_1)
STED: SPTER_13730(acsE_3)
KST: KSMBR1_1319(acsE)
PBU: L21SP3_00049(acsE)
CTHI: THC_1765
 » show all
Taxonomy
Reference
1  [PMID:7928975]
  Authors
Roberts DL, Zhao S, Doukov T, Ragsdale SW
  Title
The reductive acetyl coenzyme A pathway: sequence and heterologous expression of  active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum.
  Journal
J Bacteriol 176:6127-30 (1994)
DOI:10.1128/JB.176.19.6127-6130.1994
  Sequence
[mta:Moth_1197]
Reference
2  [PMID:10997901]
  Authors
Doukov T, Seravalli J, Stezowski JJ, Ragsdale SW
  Title
Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
  Journal
Structure 8:817-30 (2000)
DOI:10.1016/S0969-2126(00)00172-6
  Sequence
[mta:Moth_1197]
Reference
3  [PMID:17172470]
  Authors
Doukov TI, Hemmi H, Drennan CL, Ragsdale SW
  Title
Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in  activation of methyl transfer by methyltransferases.
  Journal
J Biol Chem 282:6609-18 (2007)
DOI:10.1074/jbc.M609828200
  Sequence
[mta:Moth_1197]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.258
IUBMB Enzyme Nomenclature: 2.1.1.258
ExPASy - ENZYME nomenclature database: 2.1.1.258
BRENDA, the Enzyme Database: 2.1.1.258

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