KEGG   ENZYME: 2.1.1.261
Entry
EC 2.1.1.261                Enzyme                                 
Name
4-dimethylallyltryptophan N-methyltransferase;
fgaMT (gene name);
easF (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 4-prenyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-prenyl-L-abrine [RN:R10166]
Reaction(KEGG)
R10166
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4-prenyl-L-tryptophan [CPD:C04290]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4-prenyl-L-abrine [CPD:C20410]
Comment
The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.
History
EC 2.1.1.261 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18884  4-dimethylallyltryptophan N-methyltransferase
Genes
HRJ124279223
FPOAFPOAC1_004563
FVNFVRRES_05060
FMUJ7337_008472
MAWMAC_06987
MAJMAA_06738
AMUSLMH87_011355
PLJVFPFJ_09684
PTKZJDV02_003061(EGT1_1)
GLZGLAREA_05928
AFMAFUA_2G18060
ABEARB_04647
TVETRV_01861
 » show all
Reference
1  [PMID:18678866]
  Authors
Rigbers O, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.
  Journal
J Biol Chem 283:26859-68 (2008)
DOI:10.1074/jbc.M804979200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.261
IUBMB Enzyme Nomenclature: 2.1.1.261
ExPASy - ENZYME nomenclature database: 2.1.1.261
BRENDA, the Enzyme Database: 2.1.1.261

DBGET integrated database retrieval system