KEGG   ENZYME: 2.1.1.267
Entry
EC 2.1.1.267                Enzyme                                 
Name
flavonoid 3',5'-methyltransferase;
AOMT;
CrOMT2
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:flavonoid 3'-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + a 3'-hydroxyflavonoid = S-adenosyl-L-homocysteine + a 3'-methoxyflavonoid;
(2) S-adenosyl-L-methionine + a 5'-hydroxy-3'-methoxyflavonoid = S-adenosyl-L-homocysteine + a 3',5'-dimethoxyflavonoid
Reaction(KEGG)
(other) R06815 R06816
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3'-hydroxyflavonoid [CPD:C02790];
5'-hydroxy-3'-methoxyflavonoid
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3'-methoxyflavonoid;
3',5'-dimethoxyflavonoid
Comment
Isolated from Vitis vinifera (grape) [2]. Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside. The enzyme from Catharanthus roseus was most active with myricetin [1].
History
EC 2.1.1.267 created 2013, modified 2014
Pathway
ec00944  Flavone and flavonol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13272  flavonoid O-methyltransferase
Genes
TCC: 18609023
GRA: 105785009
GHI: 107933317
GAB: 108458342
HSYR: 120117959 120138721 120179562 120197908
DZI: 111282216 111288157 111317993
EGR: 104415685 104415688 104415689 104417751
RARG: 115738850
FVE: 101297250 101302900 101307171
AANS: 126795993 126795995
RCN: 112181235 112201013
PPER: 109947186 18793505
PMUM: 103322058 103331367
PAVI: 110756049 110769740
PDUL: 117616544 117619928
MDM: 103403159 103452136
MSYL: 126595165 126611729
PXB: 103929948 103961472 103965012
PCOX: 137731728 137732533 137736493 137748436
ZJU: 107428351
CSAV: 115712602 115712603 115712971 115712973
JRE: 109003166
CILL: 122309323
CAVE: 132192083
AGLU: 133864727
QSU: 112011645 112011654 112017664 112017707 136065185 136066073
QLO: 115982101 115982433
VVI: 100233134(FAOMT) 100245452 100250567 100250579
VRI: 117911684 117922688 117923246
SLY: 101255734(AnthOMT)
SPEN: 107031250
SOT: 102599242(AOMT3)
SSTN: 125851865
LBB: 132617324
SIND: 105156703 105168404 105168406 105168407
OEU: 111391869 111393471 111393476
EGT: 105950082 105952615 105952640 105958570 105958578 105958584 105970959
SSPL: 121793763 121798458 121802564 121802888 121809514
SMIL: 130995613 130995615
SHIS: 125198982 125200483 125204768 125211759 125211845 125217009
APAN: 127241181 127241183 127244939
HPUM: 140871705 140871825
PHUA: 140982457
PEBU: 140808260 140808261 140817306 140830010 140840494
CSIN: 114275659 114293531 114305583 114312686 114317032
RVL: 131311302 131311303 131311304
AEW: 130771302 130771738
DLT: 127796891
ATRI: 130809233 130809234
SLAF: 141586205 141623483 141637806
NNU: 104593275
MING: 122079574
TSS: 122647755 122652785 122652787 122663698
CJF: 131038561
 » show all
Reference
1  [PMID:12482447]
  Authors
Cacace S, Schroder G, Wehinger E, Strack D, Schmidt J, Schroder J
  Title
A flavonol O-methyltransferase from Catharanthus roseus performing two sequential methylations.
  Journal
Phytochemistry 62:127-37 (2003)
DOI:10.1016/S0031-9422(02)00483-1
  Sequence
[ag:AAM97497]
Reference
2  [PMID:19525322]
  Authors
Hugueney P, Provenzano S, Verries C, Ferrandino A, Meudec E, Batelli G, Merdinoglu D, Cheynier V, Schubert A, Ageorges A
  Title
A novel cation-dependent O-methyltransferase involved in anthocyanin methylation in grapevine.
  Journal
Plant Physiol 150:2057-70 (2009)
DOI:10.1104/pp.109.140376
  Sequence
[vvi:100233134]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.267
IUBMB Enzyme Nomenclature: 2.1.1.267
ExPASy - ENZYME nomenclature database: 2.1.1.267
BRENDA, the Enzyme Database: 2.1.1.267

  All links  
Protein sequence (18)   
   UniProt (12)   
   SWISS-PROT (4)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (9)   
   InterPro (9)   
All databases (31)   

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