KEGG   ENZYME: 2.1.1.267Help
Entry
EC 2.1.1.267                Enzyme                                 

Name
flavonoid 3',5'-methyltransferase;
AOMT;
CrOMT2
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:flavonoid 3'-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + a 3'-hydroxyflavonoid = S-adenosyl-L-homocysteine + a 3'-methoxyflavonoid;
(2) S-adenosyl-L-methionine + a 5'-hydroxy-3'-methoxyflavonoid = S-adenosyl-L-homocysteine + a 3',5'-dimethoxyflavonoid
Reaction(KEGG)
(other) R06815 R06816
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3'-hydroxyflavonoid [CPD:C02790];
5'-hydroxy-3'-methoxyflavonoid
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3'-methoxyflavonoid;
3',5'-dimethoxyflavonoid
Comment
Isolated from Vitis vinifera (grape) [2]. Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside. The enzyme from Catharanthus roseus was most active with myricetin [1].
History
EC 2.1.1.267 created 2013, modified 2014
Pathway
ec00944  Flavone and flavonol biosynthesis
Orthology
K13272  flavonoid O-methyltransferase
Genes
VVI: 100233134(FAOMT) 100245452 100250567 100250579
Taxonomy
Reference
1  [PMID:12482447]
  Authors
Cacace S, Schroder G, Wehinger E, Strack D, Schmidt J, Schroder J.
  Title
A flavonol O-methyltransferase from Catharanthus roseus performing two sequential methylations.
  Journal
Phytochemistry 62:127-37 (2003)
DOI:10.1016/S0031-9422(02)00483-1
  Sequence
Reference
2  [PMID:19525322]
  Authors
Hugueney P, Provenzano S, Verries C, Ferrandino A, Meudec E, Batelli G, Merdinoglu D, Cheynier V, Schubert A, Ageorges A
  Title
A novel cation-dependent O-methyltransferase involved in anthocyanin methylation  in grapevine.
  Journal
Plant Physiol 150:2057-70 (2009)
DOI:10.1104/pp.109.140376
  Sequence
[vvi:100233134]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.267
IUBMB Enzyme Nomenclature: 2.1.1.267
ExPASy - ENZYME nomenclature database: 2.1.1.267
BRENDA, the Enzyme Database: 2.1.1.267

DBGET integrated database retrieval system