KEGG   ENZYME: 2.1.1.268
Entry
EC 2.1.1.268                Enzyme                                 
Name
tRNAThr (cytosine32-N3)-methyltransferase;
ABP140;
Trm140p
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;
(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine32 in tRNAThr;
cytosine32 in tRNASer
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N3-methylcytosine32 in tRNAThr;
N3-methylcytosine32 in tRNASer
Comment
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer.
History
EC 2.1.1.268 created 2013
Orthology
K17053  tRNAThr (cytosine32-N3)-methyltransferase
Genes
BMY: BM_BM6765(Bma-metl-2)
LOA: LOAG_04036
SCE: YOR239W(ABP140)
AGO: AGOS_ACR130W
KLA: KLLA0_F11385g
KMX: KLMA_20196(ABP140)
NDI: NDAI_0E01210(NDAI0E01210)
TPF: TPHA_0D01190(TPHA0D01190)
TBL: TBLA_0B03890(TBLA0B03890) TBLA_0C01800(TBLA0C01800)
TGB: HG536_0A07660
TDL: TDEL_0A06110(TDEL0A06110)
KAF: KAFR_0A03810(KAFR0A03810)
KNG: KNAG_0A02950(KNAG0A02950)
ZMK: HG535_0A06020
SLUD: SCDLUD_002146
DHA: DEHA2C02354g
PIC: PICST_71233
PGU: PGUG_05867
SPAA: SPAPADRAFT_57933
LEL: PVL30_001616
LBG: 92207966(LODBEIA_P27700)
CAL: CAALFM_C102190WA(ABP140)
CTP: CTRG_04624
COT: CORT_0B07420
CDU: CD36_02040
CTEN: 18247707(PSN45_000293)
CLU: CLUG_01724
CLUS: A9F13_13g01683
CAUR: CJI96_0003157
ASAU: 88171538(PUMCH_000469)
PPA: PAS_chr4_0460
PKZ: C5L36_0D03210
BNN: FOA43_002296
BBRX: BRETT_005075
OPA: HPODL_03430
YLI: 2912660(YALI2_E01262g)
SLB: AWJ20_210(ABP140)
NCR: NCU04647
NTE: NEUTE1DRAFT77456(NEUTE1DRAFT_77456)
SMP: 10804811(SMAC4_08355)
PAN: PODANSg8101
PBEL: QC761_203160
PPSD: QC762_203160
PPSP: QC763_203160
PPSA: QC764_203160
TTT: THITE_2037550
MTM: MYCTH_2300670
CTHR: CTHT_0066740
RTHE: 98126918(VTJ83DRAFT_5650)
MGR: MGG_13398
PPEI: PpBr36_02386
PGRI: PgNI_02393
TMN: UCRPA7_5288
SSCK: SPSK_09213
FGR: FGSG_07428
FPU: FPSE_09391
FPOA: FPOAC1_011222
FVN: FVRRES_12253
FVR: FVEG_07829
FOX: FOXG_01463
NHE: NECHADRAFT_71663
FFC: NCS54_01124800
FKR: NCS57_01115500
FMU: J7337_003120
TRE: TRIREDRAFT_81906
TRR: M419DRAFT_115572
TATV: 25780621(TrAtP1_011046)
TASP: 36612956(TrAFT101_009042)
MAW: 19246738(J3458_012816)
MAJ: MAA_06813
MBRN: 26241166(ABP140)
PCHM: VFPPC_09810
CMT: CCM_03905
AMUS: LMH87_004567
PLJ: 28889872(PLICBS_008716)
PTKZ: JDV02_005354
VAL: VDBG_04185
VDA: VDAG_01410
CFJ: CFIO01_10425
CLUP: CLUP02_08288
CHIG: CH63R_04398
CDET: 87941453(CDEST_04950)
SAPO: SAPIO_CDS9678
ELA: UCREL1_3165
PFY: PFICI_07895
SSL: SS1G_11246
BFU: BCIN_07g00620
MBE: MBM_07827
PSCO: LY89DRAFT_708347
GLZ: GLAREA_06442
ANI: ANIA_02190
AFM: AFUA_6G07150
ACT: ACLA_088950
NFI: NFIA_052800
AOR: AO090012000934
ANG: An14g03270
AFV: AFLA_002657
ALUC: AKAW2_41012A
ACHE: ACHE_11343S
APUU: APUU_20495A
PCS: N7525_000451
PDP: PDIP_70930
POU: POX_b02507
TMF: EYB26_007876
TRG: TRUGW13939_00799
CIM: CIMG_07993
CPW: 9690621(D8B26_004301)
URE: UREG_02276
ABE: ARB_01396
TVE: TRV_02216
PBL: PAAG_06356
PBN: PADG_01254
AJE: HCAG_07819
BGH: BDBG_07368
PNO: SNOG_03585
PTE: PTT_08189
PTRR: 6340998(PtrM4_063580)
BZE: COCCADRAFT_82581
BSC: COCSADRAFT_38965
BOR: COCMIDRAFT_104084
AALT: CC77DRAFT_1026276
ADAC: 96088346(ACET3X_008024)
ARAB: EKO05_0008413
ZTR: MYCGRDRAFT_86865
PFJ: MYCFIDRAFT_15074
FFU: CLAFUR5_12454
CBET: CB0940_11341
BCOM: BAUCODRAFT_79996
NPA: UCRNP2_3934
TML: GSTUM_00010681001
SPO: 2540321(trm140)
SOM: SOMG_00578(trm140)
CNE: CNJ02050
CNB: CNBJ1410
CNG: CNAG_04777
CGI: CGB_I2700C
CDEU: CNBG_5617
CDEC: 89992062(IAS62_005292)
CTEG: 91992411(I308_105556)
CBAS: 91983486(I312_103441)
CDEP: 91088750(L203_104540)
KMG: 30161587(I203_107027)
KNE: 92182698(IAR55_005440)
KDJ: 28965329(I303_102230)
KBI: 30207960(I302_100186)
KPIN: 30175218(I206_102058)
KSH: 87953651(IL334_001520)
KER: 91104356(V865_005555)
TMS: TREMEDRAFT_42575
TASA: A1Q1_02073
CCAC: CcaHIS019_0106090(ABP140)
TVS: TRAVEDRAFT_71770
DSQ: DICSQDRAFT_101215
PCO: PHACADRAFT_178695
SHS: STEHIDRAFT_131476
HIR: HETIRDRAFT_478113
PSQ: PUNSTDRAFT_115533
ADL: AURDEDRAFT_113297
FME: FOMMEDRAFT_149999
GTR: GLOTRDRAFT_74684
RSX: RhiXN_04998
LBC: LACBIDRAFT_229586
CCI: CC1G_00792
ABP: AGABI1DRAFT69948(AGABI1DRAFT_69948)
ABV: AGABI2DRAFT205628(AGABI2DRAFT_205628)
PCUB: JR316_0007893
MPR: MPER_02127
MRR: Moror_15712
MORE: E1B28_007789 E1B28_007805
CPUT: CONPUDRAFT_169634
SLA: SERLADRAFT_350627
WSE: WALSEDRAFT_40920
WIC: J056_001028
UMA: UMAG_04193
PFP: PFL1_06064
SGRA: EX895_001644
MGL: MGL_3396
MRT: MRET_1860
MSYM: MSY001_1598
PGR: PGTG_00520
PTRC: PtA15_1A434
PSTR: Pst134EA_000662
MLR: MELLADRAFT_48489
RIE: OCT59_017553
PFD: PFDG_01285
PFH: PFHG_03746
PYO: PY17X_1463600
PKN: PKNH_1467800
PVX: PVX_101295
 » show all
Reference
1  [PMID:21518805]
  Authors
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T
  Title
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
  Journal
RNA 17:1111-9 (2011)
DOI:10.1261/rna.2653411
  Sequence
[sce:YOR239W]
Reference
2  [PMID:21518804]
  Authors
D'Silva S, Haider SJ, Phizicky EM
  Title
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.
  Journal
RNA 17:1100-10 (2011)
DOI:10.1261/rna.2652611
  Sequence
[sce:YOR239W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.268
IUBMB Enzyme Nomenclature: 2.1.1.268
ExPASy - ENZYME nomenclature database: 2.1.1.268
BRENDA, the Enzyme Database: 2.1.1.268

  All links  
Gene (94)   
   MGENES (43)   
   RefGene (51)   
Protein sequence (19)   
   UniProt (11)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (64)   
   RefSeq(nuc) (14)   
   GenBank (25)   
   EMBL (25)   
Protein domain (3)   
   InterPro (3)   
All databases (180)   

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