| Entry |
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| Name |
tRNAThr (cytosine32-N3)-methyltransferase;
ABP140;
Trm140p
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase
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| Reaction(IUBMB) |
(1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;
(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
cytosine32 in tRNAThr;
cytosine32 in tRNASer
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N3-methylcytosine32 in tRNAThr;
N3-methylcytosine32 in tRNASer
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| Comment |
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer.
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| History |
EC 2.1.1.268 created 2013
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| Orthology |
| K17053 | tRNAThr (cytosine32-N3)-methyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T |
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| Title |
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
D'Silva S, Haider SJ, Phizicky EM |
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| Title |
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.268 |
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