KEGG   ENZYME: 2.1.1.268
Entry
EC 2.1.1.268                Enzyme                                 
Name
tRNAThr (cytosine32-N3)-methyltransferase;
ABP140;
Trm140p
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;
(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine32 in tRNAThr;
cytosine32 in tRNASer
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N3-methylcytosine32 in tRNAThr;
N3-methylcytosine32 in tRNASer
Comment
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer.
History
EC 2.1.1.268 created 2013
Orthology
K17053  tRNAThr (cytosine32-N3)-methyltransferase
Genes
BMYBM_BM6765(Bma-metl-2)
LOALOAG_04036
SCEYOR239W(ABP140)
AGOAGOS_ACR130W
KLAKLLA0_F11385g
KMXKLMA_20196(ABP140)
CGRCAGL0J03780g
NDINDAI_0E01210(NDAI0E01210)
TPFTPHA_0D01190(TPHA0D01190)
TBLTBLA_0B03890(TBLA0B03890) TBLA_0C01800(TBLA0C01800)
TGBHG536_0A07660
TDLTDEL_0A06110(TDEL0A06110)
KAFKAFR_0A03810(KAFR0A03810)
KNGKNAG_0A02950(KNAG0A02950)
ZMKHG535_0A06020
PPAPAS_chr4_0460
DHADEHA2C02354g
PICPICST_71233
PGUPGUG_05867
SPAASPAPADRAFT_57933
LELPVL30_001616
CALCAALFM_C102190WA(ABP140)
CTPCTRG_04624
COTCORT_0B07420
CDUCD36_02040
CTENCANTEDRAFT_115070
YLIYALI0E24717g
CLUCLUG_01724
CLUSA9F13_13g01683
CAURCJI96_0003157
SLBAWJ20_210(ABP140)
PKZC5L36_0D03210
BNNFOA43_002296
BBRXBRETT_005075
OPAHPODL_03430
SLUDSCDLUD_002146
NCRNCU04647
NTENEUTE1DRAFT77456(NEUTE1DRAFT_77456)
SMPSMAC_08355
PANPODANSg8101
TTTTHITE_2037550
MTMMYCTH_2300670
CTHRCTHT_0066740
MGRMGG_13398
PPEIPpBr36_02386
PGRIPgNI_02393
TMNUCRPA7_5288
SSCKSPSK_09213
FGRFGSG_07428
FPUFPSE_09391
FPOAFPOAC1_011222
FVNFVRRES_12253
FVRFVEG_07829
FOXFOXG_01463
NHENECHADRAFT_71663
FFCNCS54_01124800
FMUJ7337_003120
TRETRIREDRAFT_81906
TRRM419DRAFT_115572
MAWMAC_02427
MAJMAA_06813
PCHMVFPPC_09810
CMTCCM_03905
AMUSLMH87_004567
PLJVFPFJ_07749
PTKZJDV02_005354
VALVDBG_04185
VDAVDAG_01410
CFJCFIO01_10425
CLUPCLUP02_08288
CHIGCH63R_04398
SAPOSAPIO_CDS9678
ELAUCREL1_3165
PFYPFICI_07895
SSLSS1G_11246
BFUBCIN_07g00620
MBEMBM_07827
PSCOLY89DRAFT_708347
GLZGLAREA_06442
ANIAN2190.2
AFMAFUA_6G07150
ACTACLA_088950
NFINFIA_052800
AORAO090012000934
ANGAn14g03270
AFVAFLA_002657
ALUCAKAW2_41012A
ACHEACHE_11343S
APUUAPUU_20495A
PCSN7525_000451
PDPPDIP_70930
POUPOX_b02507
TMFEYB26_007876
TRGTRUGW13939_00799
CIMCIMG_07993
CPWCPC735_020350
UREUREG_02276
PBLPAAG_06356
PBNPADG_01254
ABEARB_01396
TVETRV_02216
AJEHCAG_07819
BGHBDBG_07368
PNOSNOG_03585
PTEPTT_08189
BZECOCCADRAFT_82581
BSCCOCSADRAFT_38965
BORCOCMIDRAFT_104084
AALTCC77DRAFT_1026276
ARABEKO05_0008413
ZTRMYCGRDRAFT_86865
PFJMYCFIDRAFT_15074
FFUCLAFUR5_12454
CBETCB0940_11341
BCOMBAUCODRAFT_79996
NPAUCRNP2_3934
TMLGSTUM_00010681001
SPOSPBC21C3.07c
SOMSOMG_00578(trm140)
CNECNJ02050
CNBCNBJ1410
CNGCNAG_04777
CGICGB_I2700C
TMSTREMEDRAFT_42575
TASAA1Q1_02073
CCACCcaHIS019_0106090(ABP140)
TVSTRAVEDRAFT_71770
DSQDICSQDRAFT_101215
PCOPHACADRAFT_178695
SHSSTEHIDRAFT_131476
HIRHETIRDRAFT_478113
PSQPUNSTDRAFT_115533
ADLAURDEDRAFT_113297
FMEFOMMEDRAFT_149999
GTRGLOTRDRAFT_74684
RSXRhiXN_04998
LBCLACBIDRAFT_229586
CCICC1G_00792
ABPAGABI1DRAFT69948(AGABI1DRAFT_69948)
ABVAGABI2DRAFT205628(AGABI2DRAFT_205628)
PCUBJR316_0007893
MPRMPER_02127
MRRMoror_15712
MOREE1B28_007789 E1B28_007805
CPUTCONPUDRAFT_169634
SLASERLADRAFT_350627
WSEWALSEDRAFT_40920
WICJ056_001028
UMAUMAG_04193
PFPPFL1_06064
SGRAEX895_001644
MGLMGL_3396
MRTMRET_1860
MSYMMSY001_1598
PGRPGTG_00520
PTRCPtA15_1A434
PSTRPst134EA_000662
MLRMELLADRAFT_48489
PFDPFDG_01285
PFHPFHG_03746
PYOPY17X_1463600
PKNPKNH_1467800
PVXPVX_101295
 » show all
Reference
1  [PMID:21518805]
  Authors
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T
  Title
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
  Journal
RNA 17:1111-9 (2011)
DOI:10.1261/rna.2653411
  Sequence
[sce:YOR239W]
Reference
2  [PMID:21518804]
  Authors
D'Silva S, Haider SJ, Phizicky EM
  Title
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.
  Journal
RNA 17:1100-10 (2011)
DOI:10.1261/rna.2652611
  Sequence
[sce:YOR239W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.268
IUBMB Enzyme Nomenclature: 2.1.1.268
ExPASy - ENZYME nomenclature database: 2.1.1.268
BRENDA, the Enzyme Database: 2.1.1.268

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