KEGG   ENZYME: 2.1.1.268
Entry
EC 2.1.1.268                Enzyme                                 

Name
tRNAThr (cytosine32-N3)-methyltransferase;
ABP140;
Trm140p
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;
(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine32 in tRNAThr;
cytosine32 in tRNASer
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N3-methylcytosine32 in tRNAThr;
N3-methylcytosine32 in tRNASer
Comment
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer.
History
EC 2.1.1.268 created 2013
Orthology
K17053  tRNAThr (cytosine32-N3)-methyltransferase
Genes
BMY: Bm1_03075
LOA: LOAG_04036
QSU: 112002654 112011384
SCE: YOR239W(ABP140)
AGO: AGOS_ACR130W
KLA: KLLA0_F11385g
KMX: KLMA_20196(ABP140)
CGR: CAGL0J03780g
NDI: NDAI_0E01210(NDAI0E01210)
TPF: TPHA_0D01190(TPHA0D01190)
TBL: TBLA_0B03890(TBLA0B03890) TBLA_0C01800(TBLA0C01800)
TDL: TDEL_0A06110(TDEL0A06110)
KAF: KAFR_0A03810(KAFR0A03810)
PPA: PAS_chr4_0460
DHA: DEHA2C02354g
PIC: PICST_71233
PGU: PGUG_05867
SPAA: SPAPADRAFT_57933
LEL: LELG_01644
CAL: CAALFM_C102190WA(ABP140)
CTP: CTRG_04624
COT: CORT_0B07420
CDU: CD36_02040
CTEN: CANTEDRAFT_115070
YLI: YALI0E24717g
CLU: CLUG_01724
CLUS: A9F13_13g01683
CAUR: CJI97_000960
SLB: AWJ20_210(ABP140)
PKZ: C5L36_0D03210
NCR: NCU04647
NTE: NEUTE1DRAFT77456(NEUTE1DRAFT_77456)
SMP: SMAC_08355
PAN: PODANSg8101
TTT: THITE_2037550
MTM: MYCTH_2300670
CTHR: CTHT_0066740
MGR: MGG_13398
TMN: UCRPA7_5288
SSCK: SPSK_09213
FGR: FGSG_07428
FPU: FPSE_09391
FVR: FVEG_07829
FOX: FOXG_01463
NHE: NECHADRAFT_71663
TRE: TRIREDRAFT_81906
TRR: M419DRAFT_115572
MAW: MAC_02427
MAJ: MAA_06813
CMT: CCM_03905
PLJ: VFPFJ_07749
VAL: VDBG_04185
VDA: VDAG_01410
CFJ: CFIO01_10425
SAPO: SAPIO_CDS9678
ELA: UCREL1_3165
PFY: PFICI_07895
SSL: SS1G_11246
BFU: BCIN_07g00620
MBE: MBM_07827
PSCO: LY89DRAFT_708347
GLZ: GLAREA_06442
ANI: AN2190.2
AFM: AFUA_6G07150
ACT: ACLA_088950
NFI: NFIA_052800
AOR: AO090012000934
ANG: ANI_1_1326124(An14g03270)
AFV: AFLA_021790
PCS: Pc18g05620
PDP: PDIP_70930
TMF: PMAA_058130
CIM: CIMG_07993
CPW: CPC735_020350
PBL: PAAG_06356
PBN: PADG_01254
URE: UREG_02276
ABE: ARB_01396
TVE: TRV_02216
AJE: HCAG_07819
BGH: BDBG_07368
PNO: SNOG_03585
PTE: PTT_08189
BZE: COCCADRAFT_82581
BSC: COCSADRAFT_38965
BOR: COCMIDRAFT_104084
AALT: CC77DRAFT_1026276
ZTR: MYCGRDRAFT_86865
PFJ: MYCFIDRAFT_15074
BCOM: BAUCODRAFT_79996
NPA: UCRNP2_3934
TML: GSTUM_00010681001
SPO: SPBC21C3.07c
CNE: CNJ02050
CNB: CNBJ1410
CGI: CGB_I2700C
TMS: TREMEDRAFT_42575
TASA: A1Q1_02073
TVS: TRAVEDRAFT_71770
DSQ: DICSQDRAFT_101215
PCO: PHACADRAFT_178695
SHS: STEHIDRAFT_131476
HIR: HETIRDRAFT_478113
PSQ: PUNSTDRAFT_115533
ADL: AURDEDRAFT_113297
FME: FOMMEDRAFT_149999
GTR: GLOTRDRAFT_74684
LBC: LACBIDRAFT_229586
MPR: MPER_02127
MRR: Moror_15712
CCI: CC1G_00792
SCM: SCHCODRAFT_54150
ABP: AGABI1DRAFT69948(AGABI1DRAFT_69948)
ABV: AGABI2DRAFT205628(AGABI2DRAFT_205628)
CPUT: CONPUDRAFT_169634
SLA: SERLADRAFT_350627
WSE: WALSEDRAFT_40920
WIC: J056_001028
UMA: UMAG_04193
PFP: PFL1_06064
MGL: MGL_3396
MRT: MRET_1860
MSYM: MSY001_1598
PGR: PGTG_00520
MLR: MELLADRAFT_48489
PFD: PFDG_01285
PFH: PFHG_03746
PYO: PY17X_1463600
PKN: PKH_146540
PVX: PVX_101295
 » show all
Reference
1  [PMID:21518805]
  Authors
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T
  Title
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
  Journal
RNA 17:1111-9 (2011)
DOI:10.1261/rna.2653411
  Sequence
[sce:YOR239W]
Reference
2  [PMID:21518804]
  Authors
D'Silva S, Haider SJ, Phizicky EM
  Title
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.
  Journal
RNA 17:1100-10 (2011)
DOI:10.1261/rna.2652611
  Sequence
[sce:YOR239W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.268
IUBMB Enzyme Nomenclature: 2.1.1.268
ExPASy - ENZYME nomenclature database: 2.1.1.268
BRENDA, the Enzyme Database: 2.1.1.268

  All links  
Gene (224)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (132)   
   KEGG MGENES (40)   
   RefGene (51)   
Protein sequence (10)   
   UniProt (7)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (7)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (2)   
Protein domain (3)   
   InterPro (3)   
All databases (244)   

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