| Entry |
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| Name |
cobalt-precorrin-4 methyltransferase;
CbiF;
S-adenosyl-L-methionine:cobalt-precorrin-4 11-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:cobalt-precorrin-4 C11-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + cobalt-precorrin-4 = S-adenosyl-L-homocysteine + cobalt-precorrin-5A [RN: R05810]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
cobalt-precorrin-4 [CPD: C11540]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
cobalt-precorrin-5A [CPD: C16242]
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| Comment |
This enzyme, which participates in the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, catalyses the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. See EC 2.1.1.133, precorrin-4 C11-methyltransferase, for the equivalent enzyme that participates in the aerobic cobalamin biosynthesis pathway.
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| History |
EC 2.1.1.271 created 2013
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| Pathway |
| ec00860 | Porphyrin and chlorophyll metabolism |
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| Orthology |
| K05936 | precorrin-4/cobalt-precorrin-4 C11-methyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Raux E, Schubert HL, Woodcock SC, Wilson KS, Warren MJ |
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| Title |
Cobalamin (vitamin B12) biosynthesis--cloning, expression and crystallisation of the Bacillus megaterium S-adenosyl-L-methionine-dependent cobalt-precorrin-4 transmethylase CbiF. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ |
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| Title |
The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase. |
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| Journal |
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| Reference |
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| Authors |
Kajiwara Y, Santander PJ, Roessner CA, Perez LM, Scott AI |
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| Title |
Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B12: definition of the roles of the CbiF and CbiG enzymes. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.271 |
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