Entry
Name
cobalt-factor III methyltransferase;
CbiH60 (gene name);
S-adenosyl-L-methionine:cobalt-factor III 17-methyltransferase (ring contracting)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:cobalt-factor III C17-methyltransferase (ring contracting)
Reaction(IUBMB)
S-adenosyl-L-methionine + cobalt-factor III + reduced acceptor = S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor [RN:
R11580 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
cobalt-factor III [CPD:
C17401 ];
reduced acceptor [CPD:
C00030 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
cobalt-precorrin-4;
acceptor [CPD:
C00028 ]
Comment
Isolated from the bacterium Bacillus megaterium. The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin. See EC
2.1.1.131 , precorrin-3B C17-methyltransferase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.272 created 2013
Pathway
Orthology
K05934 precorrin-3B C17-methyltransferase / cobalt-factor III methyltransferase
K13541 cobalt-precorrin 5A hydrolase / cobalt-factor III methyltransferase / precorrin-3B C17-methyltransferase
K21479 cobalt-factor III methyltransferase
Genes
SETC : CFSAN001921_06650(cbiH)
SEEN : SE451236_16345(cbiH)
SENH : CFSAN002069_21685(cbiH)
SEEH : SEEH1578_19415(cbiH)
SENJ : CFSAN001992_01300(cbiH)
SEEC : CFSAN002050_17095(cbiH)
SEEB : SEEB0189_009330(cbiH)
SENC : SEET0819_17280(cbiH)
KIE : NCTC12125_04868(cbiH)
BUF : D8682_20860 D8682_24240
BFT : MNO13_05080 MNO13_08220
METY : MRY16398_18710(cbiH)
PAEB : NCGM1900_3408(cobJ)
PAEU : BN889_03244(cobJ_2)
PPRC : PFLCHA0_c06670(cobJ)
PMUD : NCTC8068_00609(cobJ)
PFW : PF1751_v1c05690(cobJ)
PPUU : PputUW4_00541(cobJ)
PTRT : HU722_0003940(cobJ)
PTW : TUM18999_08410(cobJ)
PTAE : NCTC10697_03992(cobJ)
GAI : IMCC3135_08945(cobJ)
BMV : BMASAVP1_A1605(cbiG_cobJ)
BML : BMA10229_A0267(cbiG_cobJ)
BMN : BMA10247_0893(cbiG_cobJ)
BPM : BURPS1710b_2110(cobJ)
BPL : BURPS1106A_1964(cbiG_cobJ)
PLG : NCTC10937_00833(cobJ)
LMIR : NCTC12852_01764(cbiH)
MPT : Mpe_B0447(cobJ) Mpe_B0482(cobJ)
AZA : AZKH_4165(cbiH_cobJ)
PHYL : HB779_02255(cobJ) HB779_17730
SMEL : SM2011_c03190(cobJ)
SFD : USDA257_c53940(cobJ)
SAME : SAMCFNEI73_Ch3350(cobJ)
AGR : AGROH133_09252(cobJ)
AVF : RvVAR031_22330(cobJ)
RET : RHE_CH02486(cobE) RHE_PE00452(cobJ)
REC : RHECIAT_PA0000375(cobJ)
REL : REMIM1_PD00475(cobJ)
REP : IE4803_PA00411(cobJ)
REI : IE4771_PC00424(cobJ)
RLE : RL2826(cobE) pRL110628(cobJ)
RTR : RTCIAT899_PC07005(cobJ)
RHL : LPU83_pLPU83d0184(cobJ)
RGA : RGR602_PC01213(cobJ)
RPHA : AMC79_PB00384(cobJ)
RRHO : PR018_08405 PR018_17450
RTU : PR017_08575 PR017_17340
NEN : NCHU2750_36480(cobJ)
SZO : K8M09_09605 K8M09_16555
SOJ : K6301_08560 K6301_14330
BMEL : DK63_715(cobJ) DK63_728
BMI : BMEA_A1336(cobJ) BMEA_A1348
BMZ : BM28_A1300(cbiG) BM28_A1314
BMG : BM590_A1291 BM590_A1305
BMW : BMNI_I1250 BMNI_I1264
BMEE : DK62_126 DK62_139(cobJ)
BMB : BruAb1_1290 BruAb1_1302
BMC : BAbS19_I12200 BAbS19_I12340
BAA : BAA13334_I01900 BAA13334_I01925
BABO : DK55_1284(cobJ) DK55_1297
BABR : DO74_594 DO74_606(cobJ)
BABT : DK49_1041(cobJ) DK49_1053
BABB : DK48_823 DK48_836(cobJ)
BABU : DK53_1268(cobJ) DK53_1280
BABS : DK51_180 DK51_192(cobJ)
BABC : DO78_1189(cobJ) DO78_1201
BSI : BS1330_I1285 BS1330_I1297
BSF : BSS2_I1256 BSS2_I1268
BSUI : BSSP1_I0392(cobE) BSSP1_I0404(cobJ)
BSUP : BSPT1_I0399(cobE) BSPT1_I0411(cobJ)
BSUV : BSPT2_I0394(cobE) BSPT2_I0406(cobJ)
BSUC : BSSP2_I1315(cobJ) BSSP2_I1327(cobE)
BMT : BSUIS_A1339(cobJ) BSUIS_A1351(cobE)
BSZ : DK67_1009(cobJ) DK67_997
BSV : BSVBI22_A1285 BSVBI22_A1297
BSW : IY71_06380 IY71_06440
BSG : IY72_06120 IY72_06180
BCS : BCAN_A1312(cobJ) BCAN_A1324(cobE)
BSK : BCA52141_I3106 BCA52141_I3126
BOL : BCOUA_I1289 BCOUA_I1301
BCAR : DK60_1328(cobJ) DK60_1340
BCAS : DA85_06185 DA85_06245
BMR : BMI_I1302(cobJ) BMI_I1314
BPP : BPI_I1341(cobJ) BPI_I1353
BPV : DK65_79 DK65_91(cobJ)
BVL : BF3285c1_2100(cobJ) BF3285c1_2114
BRU : BFS01_06230 BFS01_06300
BRJ : BKD03_15630 BKD03_15690
BIO : BR141012304_11396 BR141012304_11408(cobJ)
BPSN : NIK97_04230(cobJ) NIK97_04290
BSEP : HAP48_0032375(cobJ)
BCAN : BcanWSM471_15560(cobJ)
MAQU : Maq22A_c09445(cobJ)
MMES : MMSR116_15290(cobJ)
MTUN : MTUNDRAET4_2077(cobJ)
FIL : BN1229_v1_3172(cobJ)
FIY : BN1229_v1_2750(cobJ)
DEA : FPZ08_00575 FPZ08_01585
DNP : N8A98_03005 N8A98_04715
RLI : RLO149_c006210(cobJ)
PHP : PhaeoP97_00780(cobJ)
PPIC : PhaeoP14_00735(cobJ)
SINL : DSM14862_03169(cobJ)
SPSE : SULPSESMR1_02792(cobJ)
RMM : ROSMUCSMR3_03055(cobJ)
AHT : ANTHELSMS3_02549(cobJ)
LVS : LOKVESSMR4R_00337(cobJ)
GEH : HYN69_05165(cobJ) HYN69_19255(cobJ) HYN69_20065(cobJ)
AALK : LGT41_0000210(cobJ)
PPOR : JCM14722_14140(cobJ)
BON : A361_03605 A361_15150 A361_27950
LGY : T479_11790 T479_13910
LFU : HR49_01340 HR49_09305 HR49_12990
LYS : LBYS11_10450 LBYS11_13880(cobJ)
LYB : C3943_14025(cobJ) C3943_17560
LPAK : GDS87_11410 GDS87_14760(cobJ)
LMAC : I6G82_05915(cobJ) I6G82_20220
LMOC : LMOSLCC5850_1188(cbiH)
LMW : LMOSLCC2755_1191(cbiH)
LMX : LMOSLCC2372_1195(cbiH)
LMZ : LMOSLCC2482_1239(cbiH)
LMON : LMOSLCC2376_1150(cbiH)
LMOS : LMOSLCC7179_1166(cbiH)
LMOO : LMOSLCC2378_1204(cbiH)
LMOY : LMOSLCC2479_1196(cbiH)
LMOT : LMOSLCC2540_1178(cbiH)
LMOA : LMOATCC19117_1198(cbiH)
BBE : BBR47_12450(cbiH60) BBR47_22700
BFM : BP422_01465 BP422_06560
BCHS : JNE38_06610(cobJ) JNE38_27705
PPQ : PPSQR21_047960(cobJ)
PCHI : PC41400_25735(cobJ)
SSIL : SOLI23_06220 SOLI23_06310
SOB : CSE16_00750(cobJ) CSE16_00840 CSE16_07470
SPOR : SporoP33_04320 SporoP33_07735
VIJ : JNUCC6_02600(cobJ) JNUCC6_15715
SMEN : SAMEA4412692_0361(cbiH)
LRU : HMPREF0538_20901(cobJ)
AUR : HMPREF9243_1734(cobJ)
CTYK : CTK_C09500(cbiH_cobJ)
CCOH : SAMEA4530647_0622(cbiH)
CGEL : psyc5s11_37870(cbiH)
BPRO : PMF13cell1_04264(cbiH)
CSCI : HDCHBGLK_00120(cbiH)
ACEL : acsn021_39670(cbiH)
ACHT : bsdcttw_22320(cbiH)
PDF : CD630DERM_34240(cbiH)
EAC : EAL2_808p01060(cbiH)
PHX : KGNDJEFE_00486(cbiH)
TJR : TherJR_1565 TherJR_2116
CBAR : PATL70BA_0224(cbiH)
SAY : TPY_1366(cbiGH-cobJ)
AMIC : Ami3637_15820(cobJ)
ABUT : Ami103574_09195(cobJ)
ETM : CE91St48_21110(cbiH)
PIV : NCTC13079_00693(cbiH)
SPOA : EQM13_01820(cobJ) EQM13_15080
VRM : 44547418_01211(cbiH)
VDN : NCTC11831_00752(cbiH)
MANA : MAMMFC1_04002(cbiH)
PFAC : PFJ30894_01757(cbiH)
SLE : sle_52760(sle_52760)
SALF : SMD44_02005(cbiGH-cobJ)
SGOB : test1122_02380(cobJ)
PAK : HMPREF0675_3455(cobJ)
CGRN : 4412665_00756(cbiH)
PAUS : NCTC13651_00950(cbiH)
PPC : HMPREF9154_0396(cobJ)
RAIN : Rai3103_03660(cobJ)
SYG : sync_0391(cbiG_cobJ)
SYR : SynRCC307_2160(cbiG)
SYX : SynWH7803_0388(cbiG)
CYA : CYA_1591(cbiG_cobJ-1) CYA_1847(cbiG_cobJ-2)
SYH : Syncc8109_0335(cobJ)
SYNW : SynWH8103_02442(cobJ)
PMM : PMM1525(cbiG_cobJ_fusion)
TVN : NIES2134_112480(cobJ)
LET : O77CONTIG1_00345(cbiH)
MVZ : myaer102_16530(cobJ_2)
PAGH : NIES204_04470(cobJ)
PPSU : NO713_00083(cbiH60)
NSPH : BDGGKGIB_01190(cobJ)
DOU : BMF77_04143(cobIJ_1)
DFO : Dform_01778(cbiGH-cobJ)
FPOL : ERS445057_01282(cbiH)
PCAG : NCTC12856_00426(cbiH)
MRU : mru_0890(cbiH1) mru_2210(cbiH)
MCHK : MchiMG62_06360(cobJ)
HAL : VNG_1555G(cobH) VNG_1557G(cbiH)
HSL : OE_3214F(cbiH1) OE_3216F(cbiH2)
HHB : Hhub_2896(cbiH1) Hhub_2897(cbiH2)
HAGS : JT689_07665 JT689_07670(cobJ)
HABO : JRZ79_06080 JRZ79_06085(cobJ)
HNO : LT974_11260 LT974_11265(cobJ)
HANR : LJ422_06325 LJ422_06330(cobJ)
HALH : HTSR_1844(cbiH) HTSR_1845(cbiH2)
HHSR : HSR6_1913(cbiH) HSR6_1914(cbiH2)
HAAD : MW046_12735 MW046_12740(cobJ)
HALX : M0R89_15160(cobJ) M0R89_15165
SAIM : K0C01_09810 K0C01_09815(cobJ)
HARA : AArcS_1191(cobJ) AArcS_1192(cobJ2)
HMA : rrnAC3005(cobH) rrnAC3008(cbiH)
HHI : HAH_0263(cobJ1) HAH_0264(cobJ2)
HHN : HISP_01400 HISP_01405
HTA : BVU17_01300 BVU17_01305
HALJ : G9465_01500(cobJ) G9465_01505
HSIN : KDQ40_12330(cobJ) KDQ40_12335
NPH : NP_1114A(cbiH2) NP_1116A(cbiH1)
NMO : Nmlp_3782(cbiH2) Nmlp_3783(cbiH1)
NHO : HWV23_09005(cobJ) HWV23_09010
NSAL : HWV07_12725(cobJ) HWV07_12730
HALZ : E5139_12465(cobJ) E5139_12470
HALL : LC1Hm_1194(cobJ) LC1Hm_1195(cobJ2)
HAZP : GBQ70_12475(cobJ) GBQ70_12480
HALI : BV210_15265 BV210_15270
HDO : MUK72_18260(cobJ) MUK72_18265
HWA : HQ_3033A(cbiH2) HQ_3034A(cbiH1)
HWC : Hqrw_3551(cbiH2) Hqrw_3552(cbiH1)
HVO : HVO_B0057(cbiH2) HVO_B0058(cbiH1)
HME : HFX_5061(cobJ) HFX_5062(cobJ)
HGI : ABY42_15745 ABY42_15750
HALE : G3A49_06895 G3A49_06900(cobJ)
HLS : KU306_03925 KU306_03930(cobJ)
HLN : SVXHx_3414(cbih) SVXHx_3415(cbih2)
HBO : Hbor_03460 Hbor_03470
HRA : EI982_05810(cobJ) EI982_05815
HLM : DV707_02900(cobJ) DV707_02905
HAE : halTADL_3155 halTADL_3156
HMP : K6T50_18745 K6T50_18750(cobJ)
HRE : K6T36_17890 K6T36_17895(cobJ)
HACB : Hbl1158_00230 Hbl1158_00235(cobJ)
HDF : AArcSl_3201(cbiH) AArcSl_3202(cbiH2)
HSAL : JMJ58_03965 JMJ58_03970(cobJ)
HAKZ : J0X25_12025(cobJ) J0X25_12030
HXA : Halxa_2935 Halxa_2936
NPE : Natpe_2698 Natpe_2699
NVR : FEJ81_12465(cobJ) FEJ81_12470
NPL : FGF80_12110(cobJ) FGF80_12115
NAY : HYG81_15655(cobJ) HYG81_15660
HALY : HYG82_01055 HYG82_01060(cobJ)
HJT : DVR14_03465(cobJ) DVR14_03470
HLO : J0X27_16680 J0X27_16685(cobJ)
NOU : Natoc_4258 Natoc_4259
HLR : HALLA_10080 HALLA_10085
HLC : CHINAEXTREME18605 CHINAEXTREME18610
NAJ : B1756_11715 B1756_11720
NAG : AArcMg_1622 AArcMg_1623
NAN : AArc1_2018 AArc1_2019
NBG : DV706_02620 DV706_02625(cobJ)
NAS : GCU68_10920(cobJ) GCU68_10925
HDA : BB347_03445 BB347_03450
TVO : TVG0973788(TVG0973788)
» show all
Taxonomy
Reference
Authors
Moore SJ, Biedendieck R, Lawrence AD, Deery E, Howard MJ, Rigby SE, Warren MJ
Title
Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.272