KEGG   ENZYME: 2.1.1.28
Entry
EC 2.1.1.28                 Enzyme                                 
Name
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033]
Reaction(KEGG)
R04033;
(other) R02533
Substrate
S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711]
Comment
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
History
EC 2.1.1.28 created 1972
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00553  phenylethanolamine N-methyltransferase
Genes
HSA5409(PNMT)
PTR454634(PNMT)
PPS100978896(PNMT)
GGO101140487(PNMT)
PON100450669(PNMT)
NLE100603046(PNMT)
HMH116474143(PNMT)
MCC697444(PNMT)
MCF102144850(PNMT)
MTHB126938523
MNI105472245(PNMT)
CSAB103243536(PNMT)
CATY105579551(PNMT)
PANU101008479(PNMT)
TGE112609871(PNMT)
MLEU105553094(PNMT)
RRO104674852(PNMT)
RBB108527783(PNMT)
TFN117067090(PNMT)
PTEH111537273(PNMT)
CANG105503122(PNMT)
CJC100405480(PNMT)
SBQ101032723(PNMT)
CIMI108281624(PNMT)
CSYR103275270(PNMT)
MMUR105872103(PNMT)
LCAT123620835(PNMT)
PCOQ105824370(PNMT)
OGA100954802(PNMT)
MMU18948(Pnmt)
MCAL110306272(Pnmt)
MPAH110332744(Pnmt)
RNO24661(Pnmt)
MCOC116078086(Pnmt)
ANU117709922(Pnmt)
MUN110562946(Pnmt)
CGE100768410(Pnmt)
MAUA101842703(Pnmt)
PROB127221416(Pnmt)
PLEU114706966(Pnmt)
MORG121442328 121456155
MFOT126510548
AAMP119811412(Pnmt)
NGI103743823(Pnmt)
HGL101706187(Pnmt)
CPOC100727379(Pnmt)
CCAN109694115(Pnmt)
DORD106002191(Pnmt)
DSP122100311(Pnmt)
PLOP125365357(Pnmt)
NCAR124980951
MMMA107160002(Pnmt)
OCU100355890
OPI101529625(PNMT)
TUP102501155(PNMT)
GVR103605212(PNMT)
CFA491023(PNMT)
CLUD112655419(PNMT)
VVP112918118(PNMT)
VLG121473337(PNMT)
NPO129511313(PNMT)
AML100480535(PNMT)
UMR103662175(PNMT)
UAH113265179(PNMT)
UAR123779538(PNMT)
ELK111151828
LLV125086857
MPUF101694546(PNMT)
MNP132003511(PNMT)
MLK131815693(PNMT)
NVS122907627(PNMT)
ORO101365469(PNMT)
EJU114198479(PNMT)
ZCA113907960(PNMT)
MLX118025065(PNMT)
NSU110593247(PNMT)
LWW102734219(PNMT)
FCA101101350(PNMT)
PYU121044912(PNMT)
PBG122485477(PNMT)
LRUF124513489
PTG102961408(PNMT)
PPAD109247421(PNMT)
PUC125926478
AJU106980500
HHV120229107(PNMT)
BTA281413(PNMT)
BOM102267416(PNMT)
BIU109574122(PNMT)
BBUB102410415(PNMT)
BBIS104990534(PNMT)
CHX102175988(PNMT)
OAS101103826(PNMT)
BTAX128064540(PNMT)
ODA120867218(PNMT)
MBEZ129544353(PNMT)
SSC100144479(PNMT)
CFR102520076(PNMT)
CBAI105073263(PNMT)
CDK105099042(PNMT)
VPC102539133(PNMT)
BACU103001658(PNMT)
LVE103074918(PNMT)
OOR101283122(PNMT)
DLE111166487(PNMT)
PCAD102991209(PNMT)
PSIU116745885(PNMT)
NASI112399915(PNMT)
ECB100033859(PNMT)
EPZ103550153(PNMT)
EAI106826394(PNMT)
MYB102249392(PNMT)
MYD102758984(PNMT)
MMYO118672411(PNMT)
MLF102427470(PNMT)
MNA107528967(PNMT)
PKL118702176(PNMT)
EFUS103297141(PNMT)
HAI109380659(PNMT)
DRO112316421(PNMT)
SHON118978084(PNMT)
AJM119045744(PNMT)
PDIC114503842(PNMT)
PHAS123817477(PNMT)
MMF118634656(PNMT)
RFQ117012975(PNMT)
PPAM129087053(PNMT)
PALE102883108 102885798
PGIG120611193(PNMT)
PVP105307496(PNMT)
RAY107520713(PNMT)
MJV108390001(PNMT)
TOD119231999(PNMT)
SARA101540554(PNMT)
LAV100655935(PNMT)
TMU101355696
ETF101640186(PNMT)
DNM101414088(PNMT)
MDO100017260(PNMT)
GAS123245478(PNMT)
SHR100928301(PNMT)
AFZ127560215
PCW110215827(PNMT)
OAA100079586(PNMT)
GGA100858738(PNMT)
PCOC116233706(PNMT)
MGP104914599(PNMT) 104916482
CJO107325268(PNMT)
TPAI128089054(PNMT)
NMEL110388710(PNMT)
APLA113840035(PNMT)
CATA118261284(PNMT)
AFUL116498579(PNMT)
TGU100228437(PNMT)
LSR110471932(PNMT)
PMOA120496644(PNMT)
OTC121347647(PNMT)
PRUF121354027
GFR102031976(PNMT)
OMA130264176(PNMT)
PHI102110801(PNMT)
CCAE111944131
CCW120411314(PNMT)
ETL114071804(PNMT)
SVG106858600(PNMT)
HRT120763816(PNMT)
NNI104017695(PNMT)
TALA116962923(PNMT)
ACHC115344854(PNMT)
HLE104842900(PNMT)
AGEN126038632
SHAB115617688(PNMT)
RTD128919300(PNMT)
CUCA104067976(PNMT)
AROW112969536(PNMT)
NPD112960207(PNMT)
DNE112978741(PNMT)
ASN102370069(PNMT)
AMJ102558831(PNMT)
CPOO109320279(PNMT)
CMY102946470(PNMT)
CCAY125626760(PNMT)
DCC119849060(PNMT)
CPIC101947293(PNMT)
TST117869275(PNMT)
CABI116831383(PNMT)
MRV120392099(PNMT)
ACS100565710(pnmt)
ASAO132778281(PNMT)
PVT110082064(PNMT)
SUND121934184(PNMT)
PBI103057808(PNMT)
PMUR107303015(PNMT)
CTIG120315092(PNMT)
TSR106538850(PNMT)
PGUT117664671(PNMT)
APRI131197796(PNMT)
PTEX113447382(PNMT)
NSS113420010(PNMT)
VKO123031789(PNMT)
PMUA114582804(PNMT)
PRAF128400681(PNMT)
ZVI118095231(PNMT)
HCG128330746(PNMT)
GJA107114737(PNMT)
STOW125445179(PNMT)
EMC129340553(PNMT)
XLA108700775(pnmt.L) 108702360(pnmt.S)
XTR100492236(pnmt)
NPR108792760(PNMT)
RTEM120918714(PNMT)
BBUF121005290(PNMT)
BGAR122942578(PNMT)
MUO115459237 115481886(PNMT)
GSH117347095(PNMT)
DRE100332609
SRX107716495(pnmt)
SANH107676565
SGH107571312
CCAR109092887
CAUA113097040(pnmt)
CGIB127968979
PTET122355392 122355418
LROH127173937
OMC131551149
PPRM120488708
RKG130087361
MAMB125251887
CIDE127523965
MASI127427224
TROS130568790 130569553
TDW130438768
MANU129420695
IPU108273631
PHYP113535195(pnmt)
SMEO124400866
TFD113662506
TVC132857913
AMEX103022410
CMAO118808907
EEE113576882(pnmt)
CHAR105896459
TRU101068284(pnmt)
TFS130527702
LCO104922126 104933416
NCC104943468(pnmt) 104960380
TBEN117473456
CGOB115024816(pnmt)
PGEO117464483
GACU117543104
ELY117247628
EFO125880726
PLEP121959377
SLUC116048219 116050010 116050892 116055161 116055163 116061328 116061329
ECRA117936956 117958272
ESP116671185 116684757 116702995
PFLV114547626(pnmt) 114568862 114569203 114569205 114569206 114570235 114570242
GAT120819704
PPUG119213098
AFB129091703
CLUM117748978
MSAM119916634
SCHU122867745 122867746
CUD121528851
ALAT119010219
MZE101478707(pnmt)
ONL100704948(pnmt)
OAU116327519
OLA101172030(pnmt)
OML112154569
XMA102217979(pnmt)
XCO114151774(pnmt)
XHE116726809(pnmt)
PRET103481424(pnmt)
PFOR103142266(pnmt)
PLAI106949709(pnmt)
PMEI106920906(pnmt)
GAF122822990
PPRL129368118
CVG107089993(pnmt)
CTUL119774906
GMU124874672
NFU107387578(pnmt)
KMR108247644
ALIM106516992(pnmt)
NWH119423675
AOCE111566735(pnmt)
MCEP125022515
CSEM103381482(pnmt)
POV109626801(pnmt)
SSEN122759235
HHIP117753434
HSP118100870
LCF108901731
SDU111220132(pnmt)
SLAL111657100(pnmt)
XGL120794598
HCQ109513412(pnmt)
SSCV125991200
SBIA133495800
PEE133418069
PTAO133469429
BPEC110154403(pnmt)
MALB109962872(pnmt)
BSPL114845670
SJO128381642
SASA106579371(pnmt)
STRU115161153(pnmt)
OTW112223306
OMY110491677
OGO124047743
ONE115106201(pnmt)
OKI109865886(pnmt)
OKE118369033
SALP111977642(pnmt)
SNH120045776
CCLU121582224
ELS105006836(pnmt)
SFM108919132(pnmt)
PKI111856096(pnmt)
AANG118221305
LOC102687297(pnmt)
PSPA121324706
ARUT117435192
PSEX120522527
LCM102365914(PNMT)
CMK103183857
RTP109930472(pnmt)
CPLA122539657
HOC132830960
LERI129710061
BFO118404812 118408157 118411785 118425090 118427144 118428020
BBEL109485686 109485819
DMK116915613 116920610 116924061
PTRU123513674
HAZT108680444
LSM121121405
TCF131880982
PPOI119090506
MYI110456502 110459317 110459319
BLEPAL038_03540
 » show all
Reference
1  [PMID:13863458]
  Authors
AXELROD J.
  Title
Purification and properties of phenylethanolamine-N-methyl transferase.
  Journal
J Biol Chem 237:1657-60 (1962)
Reference
2  [PMID:5412063]
  Authors
Connett RJ, Kirshner N.
  Title
Purification and properties of bovine phenylethanolamine N-methyltransferase.
  Journal
J Biol Chem 245:329-34 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.28
IUBMB Enzyme Nomenclature: 2.1.1.28
ExPASy - ENZYME nomenclature database: 2.1.1.28
BRENDA, the Enzyme Database: 2.1.1.28
CAS: 9037-68-7

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