KEGG   ENZYME: 2.1.1.281
Entry
EC 2.1.1.281                Enzyme                                 
Name
phenylpyruvate C3-methyltransferase;
phenylpyruvate Cbeta-methyltransferase;
phenylpyruvate methyltransferase;
mppJ (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate [RN:R10431]
Reaction(KEGG)
R10431
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-phenylpyruvate
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(3S)-2-oxo-3-phenylbutanoate [CPD:C20646]
Comment
The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
History
EC 2.1.1.281 created 2013
Orthology
K21457  phenylpyruvate C(3)-methyltransferase
Genes
SLCSL103_33905
STRMM444_37930
STROSTRMOE7_21420
STIRDDW44_31410
SGALCP966_11175
SVRCP971_02355
SFUGCNQ36_06340
SPLACP981_01755
SFEUIM697_42470
SMOBJ7W19_03325
SPRACP972_04285
SDDD9753_27310
KABB7C62_33390
AABA4R43_02245
KPHYAOZ06_30990
AHMTL08_16330
ACTAC1701_01075
MCRAID554_06665
AIHAiant_51620
VERHUT12_06295
 » show all
Reference
1  [PMID:19731276]
  Authors
Huang YT, Lyu SY, Chuang PH, Hsu NS, Li YS, Chan HC, Huang CJ, Liu YC, Wu CJ, Yang WB, Li TL
  Title
In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin.
  Journal
Chembiochem 10:2480-7 (2009)
DOI:10.1002/cbic.200900351
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.281
IUBMB Enzyme Nomenclature: 2.1.1.281
ExPASy - ENZYME nomenclature database: 2.1.1.281
BRENDA, the Enzyme Database: 2.1.1.281

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