KEGG   ENZYME: 2.1.1.281Help
Entry
EC 2.1.1.281                Enzyme                                 

Name
phenylpyruvate C3-methyltransferase;
phenylpyruvate Cbeta-methyltransferase;
phenylpyruvate methyltransferase;
mppJ (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate [RN:R10431]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-phenylpyruvate
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(3S)-2-oxo-3-phenylbutanoate [CPD:C20646]
Comment
The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
History
EC 2.1.1.281 created 2013
Orthology
K21457  phenylpyruvate C(3)-methyltransferase
Genes
SLC: SL103_33905
STRM: M444_37930
STRO: STRMOE7_21420
KAB: B7C62_33390
KPHY: AOZ06_30990
AHM: TL08_16330
ACTA: C1701_01075
Taxonomy
Reference
1  [PMID:19731276]
  Authors
Huang YT, Lyu SY, Chuang PH, Hsu NS, Li YS, Chan HC, Huang CJ, Liu YC, Wu CJ, Yang WB, Li TL
  Title
In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin.
  Journal
Chembiochem 10:2480-7 (2009)
DOI:10.1002/cbic.200900351
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.281
IUBMB Enzyme Nomenclature: 2.1.1.281
ExPASy - ENZYME nomenclature database: 2.1.1.281
BRENDA, the Enzyme Database: 2.1.1.281

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