KEGG   ENZYME: 2.1.1.282
Entry
EC 2.1.1.282                Enzyme                                 
Name
tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase;
TYW3 (gene name);
tRNA-yW synthesizing enzyme-3
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNAPhe 7-[(3S)-(3-amino-3-carboxypropyl)-4-demethylwyosine-N4]-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 7-[(3S)-(3-amino-3-carboxypropyl)]-4-demethylwyosine37 in tRNAPhe = S-adenosyl-L-homocysteine + 7-[(3S)-(3-amino-3-carboxypropyl)]wyosine37 in tRNAPhe [RN:R10498]
Reaction(KEGG)
R10498
Substrate
S-adenosyl-L-methionine [CPD:C00019];
7-[(3S)-(3-amino-3-carboxypropyl)]-4-demethylwyosine37 in tRNAPhe
Product
S-adenosyl-L-homocysteine [CPD:C00021];
7-[(3S)-(3-amino-3-carboxypropyl)]wyosine37 in tRNAPhe
Comment
The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs. These modifications are important for translational reading-frame maintenance. The enzyme is found in all eukaryotes and in some archaea, but not in bacteria. The eukaryotic enzyme is involved in the biosynthesis of wybutosine.
History
EC 2.1.1.282 created 2013, modified 2014
Orthology
K15450  tRNA wybutosine-synthesizing protein 3
Genes
HSA127253(TYW3)
PTR745288(TYW3)
PPS100989797(TYW3)
GGO101137627(TYW3)
PON100173692(TYW3)
NLE100598652(TYW3)
MCC704515(TYW3)
MCF102131944(TYW3)
CSAB103224601(TYW3)
CATY105595853(TYW3)
PANU101002287(TYW3)
TGE112628652(TYW3)
RRO104676320(TYW3)
RBB108527891(TYW3)
TFN117092108(TYW3)
PTEH111540825(TYW3)
CJC100385836(TYW3)
SBQ101035404(TYW3)
CSYR103251438(TYW3)
MMUR105883960(TYW3)
OGA100960649(TYW3)
MMU209584(Tyw3)
MCAL110291357(Tyw3)
MPAH110320994(Tyw3)
RNO499731(Tyw3)
MCOC116093970(Tyw3)
MUN110539939(Tyw3)
CGE100769973(Tyw3)
PLEU114702498(Tyw3)
NGI103750545(Tyw3)
HGL101713190(Tyw3)
CPOC100716313(Tyw3)
CCAN109699393(Tyw3)
DORD105986180(Tyw3)
DSP122106576(Tyw3)
OCU100348497(TYW3)
OPI101516867(TYW3)
TUP102468826(TYW3)
CFA479986(TYW3)
VVP112934599(TYW3)
VLG121487265(TYW3)
AML100479651(TYW3)
UMR103663004(TYW3)
UAH113254524(TYW3)
UAR123795308(TYW3)
ELK111143210
LLV125097944
MPUF101679577(TYW3)
ORO101368372(TYW3)
EJU114208508(TYW3)
ZCA113923670 113938588(TYW3)
MLX118019265(TYW3)
FCA101086328(TYW3)
PYU121027323(TYW3)
PBG122480645(TYW3)
PTG102963178(TYW3)
PPAD109266672(TYW3)
AJU106971816(TYW3)
HHV120223898(TYW3)
BTA519731(TYW3)
BOM102287033(TYW3)
BIU109556159(TYW3)
BBUB102401760(TYW3)
CHX102169351(TYW3)
OAS101107062(TYW3)
ODA120856986(TYW3) 120861094
CCAD122436814(TYW3)
SSC733652(TYW3)
CFR102518413(TYW3)
CBAI105075531(TYW3)
CDK105096647(TYW3)
VPC102527022(TYW3)
BACU103013167(TYW3)
LVE103076037(TYW3)
OOR101286224(TYW3)
DLE111178415(TYW3)
PCAD102980136(TYW3)
PSIU116744414(TYW3)
ECB100053370(TYW3)
EPZ103554141(TYW3)
EAI106824900(TYW3)
MYB102251617(TYW3)
MYD102759915(TYW3)
MMYO118676419(TYW3)
MLF102426049(TYW3)
MNA107540126(TYW3)
PKL118709459 118723374(TYW3)
HAI109383503(TYW3)
DRO112309119(TYW3)
SHON118984389(TYW3)
AJM119038739 119040010(TYW3)
PDIC114497453(TYW3)
PHAS123816454(TYW3)
MMF118626858(TYW3)
RFQ117027454(TYW3)
PALE102892456(TYW3)
PGIG120583236(TYW3)
PVP105295866(TYW3)
RAY107511009(TYW3)
MJV108399174(TYW3)
TOD119235304(TYW3)
SARA101545727(TYW3)
LAV100661348(TYW3)
TMU101356763
DNM101438459(TYW3)
MDO100011614(TYW3)
GAS123244124(TYW3)
PCW110195705(TYW3)
OAA100074370(TYW3)
GGA424720(TYW3)
PCOC116235969(TYW3)
MGP104912408(TYW3)
CJO107317803(TYW3)
NMEL110402782(TYW3)
APLA101794609(TYW3)
ACYG106043617(TYW3)
AFUL116492068(TYW3)
TGU101233321(TYW3)
LSR110477123(TYW3)
SCAN103815087(TYW3)
PMOA120499672(TYW3)
OTC121332657(TYW3)
PRUF121354667(TYW3)
GFR102036499(TYW3)
FAB101818854(TYW3)
PHI102112648(TYW3)
PMAJ107208284(TYW3)
CCAE111944641(TYW3)
CCW104695482(TYW3)
ETL114065501(TYW3)
ZAB102066689(TYW3)
FPG101919625(TYW3)
FCH102055133(TYW3)
CLV102093600(TYW3)
EGZ104123855(TYW3)
NNI104009309(TYW3)
ACUN113483171(TYW3)
TALA104369529(TYW3)
PADL103914061(TYW3)
ACHC115348883(TYW3)
AAM106486523(TYW3)
AROW112970294(TYW3)
NPD112950002(TYW3)
DNE112982277(TYW3)
ASN102384683(TYW3)
AMJ102576139(TYW3)
CPOO109307599(TYW3)
GGN109305402(TYW3)
PSS102448111(TYW3)
CMY102944527(TYW3)
CPIC101948228(TYW3)
TST117882038(TYW3)
CABI116825848(TYW3)
MRV120370557(TYW3)
ACS100566113(tyw3)
PVT110079525(TYW3)
SUND121928797(TYW3)
PBI103062825(TYW3)
PMUR107285065(TYW3)
TSR106544735(TYW3)
PGUT117677101(TYW3)
VKO123028709(TYW3)
PMUA114598850(TYW3)
ZVI118089506(TYW3)
GJA107113038(TYW3)
XLA447714(tyw3.L)
XTR549182(tyw3)
NPR108804942(TYW3)
RTEM120946016(TYW3)
BBUF120979693(TYW3)
BGAR122943040(TYW3)
DRE436884(tyw3)
SRX107716943(tyw3)
SANH107700527(tyw3)
SGH107588882(tyw3)
CCAR109099260(tyw3)
CAUA113094216(tyw3)
IPU108280477(tyw3)
PHYP113546448(tyw3)
SMEO124402954(tyw3)
AMEX103027647(tyw3)
EEE113590877(tyw3)
TRU101073335(tyw3)
TNGGSTEN00005081G001
LCO104933486(tyw3)
CGOB115023143(tyw3)
ELY117272312(tyw3)
PLEP121948082(tyw3)
SLUC116057107(tyw3)
ECRA117954148(tyw3)
PFLV114565528(tyw3)
GAT120816397(tyw3)
PPUG119209258(tyw3)
MSAM119898427 119902609(tyw3)
CUD121520319(tyw3)
MZE101471765(tyw3)
ONL100698917(tyw3)
OAU116319228(tyw3)
OLA101155543(tyw3)
OML112144445(tyw3)
XMA102235951(tyw3)
XCO114146486(tyw3)
PRET103479205(tyw3)
PFOR103131536(tyw3)
PLAI106940075(tyw3)
PMEI106907498(tyw3)
GAF122840791(tyw3)
CVG107103306(tyw3)
CTUL119792226(tyw3)
GMU124869771(tyw3)
NFU107384217(tyw3)
KMR108238583(tyw3)
ALIM106514949(tyw3)
NWH119414486(tyw3)
AOCE111578491(tyw3)
CSEM103396634(tyw3)
POV109640978(tyw3)
SSEN122778197(tyw3)
HHIP117777811(tyw3)
LCF108885344(tyw3)
SDU111233903(tyw3)
SLAL111648354(tyw3)
XGL120799088(tyw3)
HCQ109521294(tyw3)
BPEC110155734(tyw3)
MALB109971397(tyw3)
SASA106569012(tyw3)
OTW112261096(tyw3)
OMY110530196(tyw3)
ONE115114826(tyw3)
SALP111957069(tyw3)
ELS105007087(tyw3)
SFM108935030(tyw3)
PKI111846068(tyw3)
AANG118229138(tyw3)
LOC102695863(tyw3)
PSPA121326811(tyw3)
ARUT117417409(tyw3)
LCM102351252(TYW3)
CMK103174739(tyw3)
RTP109912090(tyw3)
BFO118420715
BBEL109462005
CIN100176625
SCLV120345708
SPU100890851
APLC110975831
SKO102807046
CLEC106669262
HHAL106677096
PHUPhum_PHUM400440
ZNE110831496
CSEC111863331
FCD110863575
DMK116936638
EAF111710228
ISCIscW_ISCW024657
DSV119455968
RSAN119394031 119394035 119394867
RMP119172748
DPTE113793488
DFR124492081
CSCU111618509
PTEP107457098
HROHELRODRAFT_73542
LGILOTGIDRAFT_157605
PCAN112566990
BGT106063801
GAE121379028
HRF124129493 124139130
HRJ124277939
CRG105323656
MYI110446662
PMAX117334545
MMER123562730
OBI106875964
OSN115212077
LAK106161327
NVE5515265
EPA110246328
ATEN116305341
ADF107339419
AMIL114961629
PDAM113669096
SPIS111329648
HMG105843790
TADTRIADDRAFT_53200
AQU100634955 100637146
ATHAT4G04670
ALY9310876
CRB17883143
CSAT104707612 104716760 104737313
EUSEUTSA_v10028391mg
BRP103858670
BNA106381444 106438749
BOE106328180 106336056
RSZ108846796 108846797
THJ104813121
CPAP110808043
CIT102630801
CICCICLE_v10018338mg
PVY116111778 116123770
MINC123218181
TCC18597148
GRA105768444
GHI107905930 107958270
GAB108453767
DZI111280313
EGR104445708
GMX100816336
GSJ114420168
PVUPHAVU_003G078700g
VRA106769298
VAR108323147
VUN114177956
CCAJ109807775
APRC113847341
MTRMTR_4g132120
CAM101500265
LJALj4g3v0153680.1(Lj4g3v0153680.1)
ADU107466736
AIP107637231
AHF112705737 112722926
LANG109361729
FVE101292484
RCN112167203
PPER18780475
PMUM103324538
PAVI110763082
PDUL117625806
MDM103446720
PXB103948175
ZJU107420278
MNT21391259
CSV101218510
CMO103484609
BHJ120073297
MCHA111012371
CMAX111496687
CMOS111433898
CPEP111781253
RCU8284198
JCU105649334
HBR110632238 110655657
MESC110603645
POP7458525
PEU105134796
PALZ118059077
JRE108988715
QSU111999497 112004326 112005928 112027744
QLO115988554
TWL119988875
VVI100257307
VRI117923703
SLY101263515
SPEN107020397
SOT102599033
CANN107871430
NTA107811207 107819037
NSY104240885
NTO104101502
NAU109215369 109216036
INI109188343
ITR116010552
SIND105175344
OEU111395202
EGT105968869
SSPL121745275
HAN110939634 110939636
ECAD122593908
LSV111890917
CCAV112526701
DCR108199623
CSIN114259058 114305213
BVG104900995
SOE110777318
CQI110687370 110731332
NNU104612804
MING122059580
TSS122642653
PSOM113287932 113304991
NCOL116267911
OSA4343372
OBR102702769
BDI100836909
ATS109737597 109751969
TDC119354324 119363489
TAES123044687 123052552 123188437
SBI110432829
ZMA103633227
SITA101786401
SVS117844659
PVIR120661497 120689501
PHAI112881811
PDA103717625
EGU105051262
MUS103989848
DCT110092071
PEQ110020203
AOF109848458
ATR18445684
SMOSELMODRAFT_415589 SELMODRAFT_418563
PPP112286221
VCNVOLCADRAFT_118079
SCEYGL050W(TYW3)
AGOAGOS_AGL045W
ERCEcym_7281
LTHKLTH0D03762g
VPOKpol_1026p26
ZROZYRO0G22286g
CGRCAGL0D06336g
NCSNCAS_0A05860(NCAS0A05860)
NDINDAI_0D02870(NDAI0D02870)
TPFTPHA_0K01950(TPHA0K01950)
TBLTBLA_0B09900(TBLA0B09900)
TDLTDEL_0E05640(TDEL0E05640)
KAFKAFR_0F03080(KAFR0F03080)
ZMKHG535_0E05820
PPAPAS_chr1-4_0655
DHADEHA2A12078g
PICPICST_56695
PGUPGUG_01915
SPAASPAPADRAFT_134561
LELLELG_00241
CALCAALFM_CR03160WA(CaO19.2408)
CTPCTRG_00784
COTCORT_0A02440
CDUCD36_28300
CTENCANTEDRAFT_113328
YLIYALI0D22220g
CLUCLUG_04414
CLUSA9F13_04g00946
CAURCJI97_003378
SLBAWJ20_2119(TYW3)
PKZC5L36_0B10760
NCRNCU02014
NTENEUTE1DRAFT125395(NEUTE1DRAFT_125395)
SMPSMAC_05458
PANPODANSg4459
MTMMYCTH_2132486
CTHRCTHT_0012240
MGRMGG_03665
SSCKSPSK_06370
FGRFGSG_08527
FPUFPSE_10179
FVRFVEG_15001
FOXFOXG_03331
NHENECHADRAFT_36482
TRETRIREDRAFT_4862
TRRM419DRAFT_83489
MAWMAC_06093
MAJMAA_09058
CMTCCM_00960
PLJVFPFJ_06015
VALVDBG_06460
VDAVDAG_05000
CFJCFIO01_10554
SAPOSAPIO_CDS10058
ELAUCREL1_6239
PFYPFICI_02923
SSLSS1G_14209
BFUBCIN_09g06380(Bctyw3)
MBEMBM_06462
PSCOLY89DRAFT_550357
GLZGLAREA_01913
ANIAN8696.2
AFMAFUA_6G02350
ACTACLA_098120
NFINFIA_048610
AORAO090120000120
ANGANI_1_2156104(An12g08400)
APUUAPUU_10432S
TMFPMAA_018510
TRGTRUGW13939_04159
CIMCIMG_05859
CPWCPC735_024770
UREUREG_04488
PBLPAAG_06189
PBNPADG_07932
ABEARB_01988
TVETRV_05810
AJEHCAG_03176
BGHBDBG_06940
PNOSNOG_07687
PTEPTT_12676
BZECOCCADRAFT_353
BSCCOCSADRAFT_207921
BORCOCMIDRAFT_82118
AALTCC77DRAFT_926633
ZTRMYCGRDRAFT_42049
PFJMYCFIDRAFT_127154
BCOMBAUCODRAFT_564046
NPAUCRNP2_2340
TMLGSTUM_00012179001
SPOSPAC25B8.15c
PGRPGTG_18064
MLRMELLADRAFT_38436
MBRMONBRDRAFT_5697
SREPTSG_02179
TANTA11725
TPVTP02_0179
TOTTOT_020000163
BEQBEWA_018950
BBOBBOV_II007240(18.m06602)
BMICBMR1_01G03510
BBIGBBBOND_0102990
TGOTGME49_234490
SMINv1.2.032250.t1(symbB.v1.2.032250.t1)
PTIPHATR_33584
FCYFRACYDRAFT_251007
TPSTHAPSDRAFT_23751
AAFAURANDRAFT_26173
PIFPITG_03780
PSOJPHYSODRAFT_309454
SPARSPRG_10645 SPRG_17507
EHXEMIHUDRAFT_449657
GTTGUITHDRAFT_152659
TBRTb11.01.4510
TBGTbgDal_XI14130
TCR508777.170 511483.30
LMALMJF_09_0660
LIFLINJ_09_0710
LDOLDBPK_090710
LMILMXM_09_0660
LBZLBRM_09_0740
LPANLPMP_090670
HSRHSBAA_36930
BCOPJD108_14390
PLONPla110_43950
EDAGWR55_18135
MJAMJ_1510
MFEMefer_0050
MVUMetvu_1314
MFSMFS40622_0519
MIFMetin_1382
MJHJH146_0363
MESGMLAUSG7_1217(taw)
MESAMLASG1_0560(taw)
MIGMetig_0584
MMPMMP0310
MMQMmarC5_1364
MMXMmarC6_0641
MMZMmarC7_1312
MMDGYY_01590
MMAKMMKA1_03170
MMAOMMOS7_03440
MMADMMJJ_07480
MAEMaeo_1057
MVNMevan_1321
MVOMvol_1232
MOKMetok_1326
METFCFE53_03335
MKAMK0048
AFUAF_2059
AFGAFULGI_00023270
APOArcpr_0077
AVEArcve_1106
FPLFerp_0738
GACGACE_0352
GAHGAH_01146
PFUPF1098 PF2034
PFIPFC_04715 PFC_08395
PHOPH1069(PH1069) PH1887(PH1887)
PABPAB0615 PAB2159
PYNPNA2_0502 PNA2_1503
PYAPYCH_05320 PYCH_12820
PYSPy04_0023 Py04_0777
PYCTQ32_05610 TQ32_07300
TKOTK0175 TK1907
TONTON_1531 TON_1881
TGATGAM_0098 TGAM_0155
TSITSIB_0547 TSIB_1747
TBATERMP_01586 TERMP_02053
THEGQS_05865 GQS_07755
THATAM4_1220 TAM4_1341
THMCL1_0808 CL1_1182
TLTOCC_04325 OCC_13026
THSTES1_1580 TES1_2000
TNUBD01_1197 BD01_1299
TEUTEU_00825 TEU_01365
TGYX802_04430 X802_04740
THVADU37_CDS05050 ADU37_CDS18580
TCHCHITON_0027 CHITON_0747
TPEPA0127_03105 A0127_05595
TPIEA7C91_04455 A7C91_05290
TGGA3K92_08895 A3K92_09115
TCEA3L02_01300 A3L02_07640
TBSA3L01_00020 A3L01_08550
THHCDI07_00070 CDI07_08550
TSLA3L11_02010 A3L11_03740
TTDA3L14_01290 A3L14_11135
TPRFA3L09_00910 A3L09_10535
TRLA3L10_08045 A3L10_09750
TPAFA3L08_01630 A3L08_03175
THYA3L12_03020 A3L12_04375
TICFH039_00090 FH039_01980
TCQTIRI35C_0210(taw3) TIRI35C_2038(taw3)
THEMFPV09_07290 FPV09_09370
PPACPAP_00500 PAP_05245
MELUMTLP_02780
ABIAboo_1247
ACFAciM339_1319
APEAPE_0816
ACJACAM_0574
SMRSmar_0446
SHCShell_0359
IHOIgni_1000 Igni_1050
IISEYM_01005 EYM_01900
DKADKAM_0848
DFDDesfe_0979
DMUDesmu_0898
TAGTagg_0723
IAGIgag_0026
THGTCELL_0709
HBUHbut_0026 Hbut_1144
PFMPyrfu_1306 Pyrfu_1978
PDLPyrde_0564 Pyrde_1225
STOSTK_14890
SOHD1869_08365
SSOSSO0622
SOLSsol_1686
SSOASULA_1714
SSOLSULB_1715
SSOFSULC_1713
SCASSACC_03550
SAISaci_1603
SACNSacN8_07780
SACRSacRon12I_07790
SACSSUSAZ_07590
SISLS215_1618
SIAM1425_1510
SIMM1627_1625
SIDM164_1507
SIYYG5714_1514
SINYN1551_1322
SIILD85_1717
SIHSiH_1477
SICSiL_1388
SULABFU36_02910
SULEGFS03_08615
SULOGFS33_00390
SULLEWF20_09535
MSEMsed_1973
MHKDFR87_08640
MPRUDFR88_08310
MTENGWK48_03685
MJNMjAS7_0273
AHOAhos_1120
AMANB6F84_09685
ABRIDFR85_09310
ASULDFR86_08370
AAMBD1866_00480
ACIHHS5_25160
SACDHS1genome_0119
SAZOD1868_05405
CSTYKN1_26870
STEPIC006_1344
SAHSHS7_06900
PAIPAE2913
PISPisl_0308
PCLPcal_0351
PASPars_0991
PYRP186_1609
POGPogu_1329
TNETneu_1813
PYWPYWP30_01946
CMACmaq_0720
TTNTTX_0700
TUZTUZN_0351
VDIVdis_1927
VMOVMUT_0339
TPETpen_0125
THBN186_01545
TCBTCARB_1393
THFMA03_00850
THELIG193_06920
CLGCalag_0488
FFOFFONT_0669 FFONT_0964
KCRKcr_0381
NEQNEQ325
AGWQT03_C0001G1193
 » show all
Reference
1  [PMID:16642040]
  Authors
Noma A, Kirino Y, Ikeuchi Y, Suzuki T
  Title
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.
  Journal
EMBO J 25:2142-54 (2006)
DOI:10.1038/sj.emboj.7601105
  Sequence
[sce:YGL050W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.282
IUBMB Enzyme Nomenclature: 2.1.1.282
ExPASy - ENZYME nomenclature database: 2.1.1.282
BRENDA, the Enzyme Database: 2.1.1.282

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