Entry
Name
tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase;
TYW3 (gene name);
tRNA-yW synthesizing enzyme-3
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNAPhe 7-[(3S)-(3-amino-3-carboxypropyl)-4-demethylwyosine-N4]-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 7-[(3S)-(3-amino-3-carboxypropyl)]-4-demethylwyosine37 in tRNAPhe = S-adenosyl-L-homocysteine + 7-[(3S)-(3-amino-3-carboxypropyl)]wyosine37 in tRNAPhe [RN:
R10498 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
7-[(3S)-(3-amino-3-carboxypropyl)]-4-demethylwyosine37 in tRNAPhe
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
7-[(3S)-(3-amino-3-carboxypropyl)]wyosine37 in tRNAPhe
Comment
The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs. These modifications are important for translational reading-frame maintenance. The enzyme is found in all eukaryotes and in some archaea, but not in bacteria. The eukaryotic enzyme is involved in the biosynthesis of wybutosine.
History
EC 2.1.1.282 created 2013, modified 2014
Orthology
K15450 tRNA wybutosine-synthesizing protein 3
Genes
ZCA : 113923670 113938588(TYW3)
LRUF : 124502053 124515428
ODA : 120856986(TYW3) 120861094
PKL : 118709459 118723374(TYW3)
AJM : 119038739 119040010(TYW3)
MUO : 115472899 115473082(TYW3)
MSAM : 119898427 119902609(tyw3)
PTAO : 133474055 133489327
RSAN : 119394031 119394035
CSAT : 104707612 104716760 104737313
CSIN : 114259058 114305213
PSOM : 113287932 113304991
TAES : 123044687 123052552 123188437
PVIR : 120661497 120689501
SMO : SELMODRAFT_415589 SELMODRAFT_418563
CGR : 2887001(GVI51_D06325)
NCS : NCAS_0A05860(NCAS0A05860)
NDI : NDAI_0D02870(NDAI0D02870)
TPF : TPHA_0K01950(TPHA0K01950)
TBL : TBLA_0B09900(TBLA0B09900)
TDL : TDEL_0E05640(TDEL0E05640)
KAF : KAFR_0F03080(KAFR0F03080)
LBG : 92206042(LODBEIA_P08460)
CAL : CAALFM_CR03160WA(CaO19.2408)
CTEN : 18246902(PSN45_004878)
YLI : 2911049(YALI2_D00463g)
NTE : NEUTE1DRAFT125395(NEUTE1DRAFT_125395)
TATV : 25776152(TrAtP1_012842)
TASP : 36618098(TrAFT101_009908)
MAW : 19250404(J3458_019679)
PLJ : 28888139(PLICBS_003349)
BFU : BCIN_09g06380(Bctyw3)
PTRR : 6343596(PtrM4_111320)
SPAR : SPRG_10645 SPRG_17507
TCR : 508777.170 511483.30
LMAT : 92517465(LSCM1_07587)
PHO : PH1069(PH1069) PH1887(PH1887)
PYA : PYCH_05320 PYCH_12820
PYC : TQ32_05610 TQ32_07300
TBA : TERMP_01586 TERMP_02053
TGY : X802_04430 X802_04740
THV : ADU37_CDS05050 ADU37_CDS18580
TCH : CHITON_0027 CHITON_0747
TPEP : A0127_03105 A0127_05595
TPIE : A7C91_04455 A7C91_05290
TGG : A3K92_08895 A3K92_09115
TCE : A3L02_01300 A3L02_07640
TBS : A3L01_00020 A3L01_08550
THH : CDI07_00070 CDI07_08550
TSL : A3L11_02010 A3L11_03740
TTD : A3L14_01290 A3L14_11135
TPRF : A3L09_00910 A3L09_10535
TRL : A3L10_08045 A3L10_09750
TPAF : A3L08_01630 A3L08_03175
THY : A3L12_03020 A3L12_04375
TIC : FH039_00090 FH039_01980
TCQ : TIRI35C_0210(taw3) TIRI35C_2038(taw3)
THEM : FPV09_07290 FPV09_09370
THEI : K1720_01545 K1720_05865
PPAC : PAP_00500 PAP_05245
MJK : N2V74_00520 N2V74_05335
PFM : Pyrfu_1306 Pyrfu_1978
PDL : Pyrde_0564 Pyrde_1225
PABI : PABY_03210 PABY_10700
PARE : PYJP_04760 PYJP_15210
FFO : FFONT_0669 FFONT_0964
» show all
Taxonomy
Reference
Authors
Noma A, Kirino Y, Ikeuchi Y, Suzuki T
Title
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.282