KEGG   ENZYME: 2.1.1.284
Entry
EC 2.1.1.284                Enzyme                                 

Name
8-demethylnovobiocic acid C8-methyltransferase;
NovO
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid [RN:R10454]
Reaction(KEGG)
R10454
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethylnovobiocic acid [CPD:C20629]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
novobiocic acid [CPD:C12474]
Comment
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.
History
EC 2.1.1.284 created 2013
Pathway
ec00401  Novobiocin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12705  8-demethylnovobiocic acid C8-methyltransferase
Reference
1  [PMID:16274243]
  Authors
Pacholec M, Tao J, Walsh CT
  Title
CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis.
  Journal
Biochemistry 44:14969-76 (2005)
DOI:10.1021/bi051599o
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.284
IUBMB Enzyme Nomenclature: 2.1.1.284
ExPASy - ENZYME nomenclature database: 2.1.1.284
BRENDA, the Enzyme Database: 2.1.1.284

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