KEGG   ENZYME: 2.1.1.286Help
Entry
EC 2.1.1.286                Enzyme                                 

Name
25S rRNA (adenine2142-N1)-methyltransferase;
BMT2 (gene name);
25S rRNA m1A2142 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:25S rRNA (adenine2142-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine2142 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA [RN:R10497]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine2142 in 25S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N1-methyladenine2142 in 25S rRNA
Comment
In the yeast Saccharomyces cerevisiae this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin.
History
EC 2.1.1.286 created 2013
Orthology
K18849  25S rRNA (adenine2142-N1)-methyltransferase
Genes
HSA: 154743(BMT2)
PTR: 735339(BMT2)
PPS: 100975067(BMT2)
GGO: 101147012(BMT2)
PON: 100172852(BMT2)
NLE: 100589355(BMT2)
MCC: 704714(BMT2)
MCF: 102145897(BMT2)
CSAB: 103226755(BMT2)
RRO: 104671186(BMT2)
RBB: 108537052(BMT2)
CJC: 100408784(BMT2)
SBQ: 101043157
MMU: 101148(Bmt2)
MCAL: 110296318(Bmt2)
MPAH: 110316980(Bmt2)
RNO: 500034(Bmt2)
MUN: 110564905(Bmt2)
CGE: 100765096(Bmt2)
NGI: 103751162(Bmt2)
HGL: 101702632(Bmt2)
CCAN: 109687528(Bmt2)
OCU: 100357732(BMT2)
TUP: 102484590(BMT2)
CFA: 475290(BMT2)
VVP: 112929905(BMT2)
AML: 100464475(BMT2)
UMR: 103659075(BMT2)
UAH: 113263037(BMT2)
ORO: 101370081
ELK: 111151958
FCA: 101084094(BMT2)
PTG: 102967712(BMT2)
PPAD: 109248409(BMT2)
AJU: 106970628(BMT2)
BTA: 538658(BMT2)
BOM: 102272702(BMT2)
BIU: 109557895(BMT2)
BBUB: 102409366(BMT2)
CHX: 102177403(BMT2)
OAS: 101111794(BMT2)
SSC: 100621338(BMT2)
CFR: 102509756(BMT2)
CDK: 105085412(BMT2)
BACU: 102998050(BMT2)
LVE: 103079373(BMT2)
OOR: 101284399
DLE: 111179384(BMT2)
PCAD: 102984636(BMT2)
ECB: 100070896(BMT2)
EPZ: 103566124(BMT2)
EAI: 106836798(BMT2)
MYB: 102246204(BMT2)
MYD: 102751318(BMT2) 102756455
MNA: 107530705
HAI: 109377631(BMT2)
DRO: 112300509(BMT2)
PALE: 102892508(BMT2)
RAY: 107507073
MJV: 108394822(BMT2)
LAV: 100653542(BMT2)
TMU: 101347522
MDO: 100011270(BMT2)
SHR: 100913878(BMT2)
PCW: 110207037(BMT2)
OAA: 100080228(BMT2)
GGA: 417776(BMT2)
MGP: 100547198(BMT2)
CJO: 107309285(BMT2)
NMEL: 110392641(BMT2)
APLA: 101803947(BMT2)
ACYG: 106042065
TGU: 100231884(BMT2)
LSR: 110478554(BMT2)
SCAN: 103813456(BMT2)
GFR: 102039196(BMT2)
FAB: 101813144(BMT2)
PHI: 102102668(BMT2)
PMAJ: 107204703(BMT2)
CCAE: 111937051(BMT2)
CCW: 104698301(BMT2)
ETL: 114056076(BMT2)
FPG: 101910774(BMT2)
FCH: 102059753(BMT2)
CLV: 102092099(BMT2)
EGZ: 104123126
NNI: 104013593
ACUN: 113487517(BMT2)
PADL: 103920014
AAM: 106488914(BMT2)
ASN: 102387890(BMT2)
AMJ: 102563226(BMT2)
PSS: 102446594(BMT2)
CMY: 102932920(BMT2)
CPIC: 101938967(BMT2)
ACS: 100558407(bmt2)
PVT: 110088244(BMT2)
PBI: 103060377(BMT2)
PMUR: 107293992(BMT2)
TSR: 106538684
PMUA: 114604918(BMT2)
GJA: 107114026(BMT2)
XLA: 447453(bmt2.L)
XTR: 496879(bmt2)
NPR: 108791018(BMT2)
DRE: 558558(bmt2)
CCAR: 109050691(bmt2)
IPU: 108268699(bmt2)
PHYP: 113546538(bmt2)
AMEX: 103041481(bmt2)
EEE: 113586440(bmt2)
TRU: 101070129(bmt2)
LCO: 104921021(bmt2)
NCC: 104945160
MZE: 101474164(bmt2)
ONL: 100711560(bmt2)
OLA: 101173386(bmt2)
XMA: 102221147(bmt2)
XCO: 114157198(bmt2)
PRET: 103465928(bmt2)
CVG: 107104096
NFU: 107388404(csgr13h7orf60)
KMR: 108246986(bmt2)
ALIM: 106517283
AOCE: 111579530(bmt2)
CSEM: 103379960(bmt2)
POV: 109624381(bmt2)
LCF: 108883056(bmt2)
SDU: 111229648(bmt2)
SLAL: 111650417(bmt2)
HCQ: 109529838(bmt2)
BPEC: 110164303(bmt2)
SASA: 106561513(bmt2) 106573247
OTW: 112251198(bmt2) 112252625
SALP: 111952679 111962683(bmt2)
ELS: 105018084(bmt2)
SFM: 108920926(bmt2)
PKI: 111843128(bmt2)
LCM: 102351832(BMT2)
CMK: 103179342(bmt2)
RTP: 109935222(bmt2) 109935224
CIN: 778832
DME: Dmel_CG3570(Samtor)
DER: 6548566
DSI: Dsimw501_GD11882(Dsim_GD11882)
DSR: 110191433
DPE: 6600959
DMN: 108159113
DWI: 6640300
DAZ: 108615549
DNV: 108653671
DHE: 111595316
MDE: 101893866
LCQ: 111679548
AAG: 5574041
AME: 727303
BIM: 100749676
BTER: 100644156
OBB: 114871001
SOC: 105204235
MPHA: 105827768
AEC: 105144745
ACEP: 105621461
PBAR: 105426083
VEM: 105560772
HST: 105183694
DQU: 106751712
CFO: 105254588
LHU: 105674462
PGC: 109859106
OBO: 105288193
PCF: 106786373
NVI: 100117446
CSOL: 105366831
MDL: 103576434
TCA: 661538
DPA: 109544236
ATD: 109600166
NVL: 108559559
BMOR: 101743089
BMAN: 114243655
PMAC: 106715415
PRAP: 110992418
HAW: 110376803
TNL: 113499335
PXY: 105390581
API: 100163068
DNX: 107163149
RMD: 113551702
BTAB: 109031085
CLEC: 106674108
ZNE: 110829733
FCD: 110851736
PVM: 113821324
PTEP: 107439174
PCAN: 112572569
CRG: 105322368
MYI: 110456728
OBI: 106879784
LAK: 106162450
DGT: 114521683
HMG: 105847070
AQU: 100632104
SCE: YBR141C(BMT2)
ERC: Ecym_5325
NCS: NCAS_0I02310(NCAS0I02310)
NDI: NDAI_0A06890(NDAI0A06890)
TPF: TPHA_0M00760(TPHA0M00760)
TBL: TBLA_0E03410(TBLA0E03410)
TDL: TDEL_0D05000(TDEL0D05000)
KAF: KAFR_0G01450(KAFR0G01450)
PIC: PICST_52942(YBZ1)
CAL: CAALFM_C205080CA(CaO19.3539)
SLB: AWJ20_3775(BMT2)
NCR: NCU06227
NTE: NEUTE1DRAFT81366(NEUTE1DRAFT_81366)
MGR: MGG_10184
SSCK: SPSK_02656
CMT: CCM_05840
BFU: BCIN_03g07450(Bcbmt2)
MBE: MBM_07039
ANI: AN8855.2
ANG: ANI_1_320154(An17g02230)
ABE: ARB_00878
TVE: TRV_07919
PTE: PTT_16424
CNE: CNF03010
CNB: CNBF1700
ABP: AGABI1DRAFT118273(AGABI1DRAFT_118273)
ABV: AGABI2DRAFT199801(AGABI2DRAFT_199801)
MRT: MRET_1387
SMIN: v1.2.001061.t1(symbB.v1.2.001061.t1) v1.2.020840.t1(symbB.v1.2.020840.t1) v1.2.027271.t1(symbB.v1.2.027271.t1)
SPAR: SPRG_03893
TCR: 510513.30
 » show all
Taxonomy
Reference
1  [PMID:23558746]
  Authors
Sharma S, Watzinger P, Kotter P, Entian KD
  Title
Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.
  Journal
Nucleic Acids Res 41:5428-43 (2013)
DOI:10.1093/nar/gkt195
  Sequence
[sce:YBR141C]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.286
IUBMB Enzyme Nomenclature: 2.1.1.286
ExPASy - ENZYME nomenclature database: 2.1.1.286
BRENDA, the Enzyme Database: 2.1.1.286

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