Entry
Name
25S rRNA (adenine645-N1)-methyltransferase;
25S rRNA m1A645 methyltransferase;
Rrp8
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:25S rRNA (adenine645-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine645 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine645 in 25S rRNA [RN:
R10497 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
adenine645 in 25S rRNA
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
N1-methyladenine645 in 25S rRNA
Comment
The enzyme is found in eukaryotes. The adenine position refers to rRNA in the yeast Saccharomyces cerevisiae, in which the enzyme is important for ribosome biogenesis.
History
EC 2.1.1.287 created 2013
Orthology
K14850 ribosomal RNA-processing protein 8
Genes
MAUA : 101822816(Rrp8) 121139915
DMER : 138815879 138836483(Rrp8)
GMF : 115839512 132593311(RRP8)
XLA : 108708784(rrp8.L) 108710099(rrp8.S)
SRX : 107736631 107752393 107758622(rrp8)
SGH : 107577195 107582664 107592790
CCAR : 109067115 109076615(rrp8)
MASI : 127422456 127429557
SASA : 106581208 106612810
STRU : 115163394 115206318
OMY : 110503900 110507740(rrp8)
ONE : 115136773(rrp8) 115141806
OCLA : 139382773 139386242
CCLU : 121557549 121567937
SCLV : 120328199 120330252
DSI : Dsimw501_GD11435(Dsim_GD11435)
MPHA : 105839560 105839948
AFRA : 136042053 136042955
MAEA : 128227259 128227519
MCAZ : 138015006 138015007
CSAT : 104719715 104724414 104732767
HSYR : 120125410 120137859
TPRA : 123883637 123883656 123889784 123891338
CMAX : 111487746 111489378
CMOS : 111431375 111444708
CPEP : 111808226 111810982
SSPL : 121778313 121781061
PEBU : 140823489 140840508
PSOM : 113342001 113344064 113345545
TAES : 123127580 123144685
MFLO : 136463008 136471363
PVIR : 120656284 120707145
PAUA : 133919207 133921850
ZOF : 122008071 122015788 122019509 122021763 122023264
SMO : SELMODRAFT_107406 SELMODRAFT_111018 SELMODRAFT_419191
CGR : 2890210(GVI51_K09845)
NCS : NCAS_0B04110(NCAS0B04110)
NDI : NDAI_0A03530(NDAI0A03530)
TPF : TPHA_0A02020(TPHA0A02020)
TBL : TBLA_0B01850(TBLA0B01850)
TDL : TDEL_0A01470(TDEL0A01470)
KAF : KAFR_0A02530(KAFR0A02530)
KNG : KNAG_0H02890(KNAG0H02890)
LBG : 92208939(LODBEIA_P37430)
CAL : CAALFM_C208480WA(RRP8)
ASAU : 88173659(PUMCH_002595)
YLI : 2909035(YALI2_F00349g)
NTE : NEUTE1DRAFT80362(NEUTE1DRAFT_80362)
SMP : 10806141(SMAC4_01697)
RTHE : 98125970(VTJ83DRAFT_4798)
TATV : 25783972(TrAtP1_001741)
TASP : 36610604(TrAFT101_000831)
PLJ : 28883081(PLICBS_000912)
CDET : 87941655(CDEST_05152)
BFU : BCIN_07g01620(Bcrrp8)
PTRR : 6349567(PtrM4_071440)
ADAC : 96080908(ACET3X_000586)
CDEC : 89987214(IAS62_000438)
CTEG : 91987269(I308_100411)
CBAS : 91980491(I312_100443)
CDEP : 91088158(L203_103948)
KMG : 30163136(I203_102128)
KNE : 92180010(IAR55_002752)
KDJ : 28969007(I303_105245)
KBI : 30210355(I302_106779)
KPIN : 30170687(I206_104779)
KSH : 87956819(IL334_004688)
KER : 91101810(V865_003006)
CCAC : CcaHIS019_0606290(RRP8)
ABP : AGABI1DRAFT113380(AGABI1DRAFT_113380)
ABV : AGABI2DRAFT191974(AGABI2DRAFT_191974)
PTRC : PtA15_1A919 PtA15_7A247
EHI : EHI_006010(76.t00012) EHI_065720(83.t00014)
EDI : EDI_198800 EDI_199180
PLAG : 39741772(PADL01_0924200)
PBRS : 92370122(MKS88_002034)
TET : TTHERM_000085239 TTHERM_00085250
TCR : 507949.140 511423.60
LMAT : 92516330(LSCM1_06388)
LOI : 92361980(LSCM4_06121)
LEIS : 94181303(GH5_05956)
LENR : 94173007(CUR178_05818)
LEIN : 94189289(JIQ42_05667)
PHET : 94291946(JKF63_05916)
TVA : 4759443(TVAGG3_0216300)
SSAO : 94294672(SS50377_20649)
EHX : EMIHUDRAFT_43478 EMIHUDRAFT_43605
» show all
Taxonomy
Reference
Authors
Peifer C, Sharma S, Watzinger P, Lamberth S, Kotter P, Entian KD
Title
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.287