KEGG   ENZYME: 2.1.1.288Help
Entry
EC 2.1.1.288                Enzyme                                 

Name
aklanonic acid methyltransferase;
DauC;
AAMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:aklanonate O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate [RN:R06680]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
aklanonate [CPD:C12421]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methyl aklanonate [CPD:C12422]
Comment
The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
History
EC 2.1.1.288 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K15942  O-methyltransferase / aklanonic acid methyltransferase
Genes
MAU: Micau_3998
MIL: ML5_4423
Taxonomy
Reference
1  [PMID:7836284]
  Authors
Dickens ML, Ye J, Strohl WR.
  Title
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
  Journal
J Bacteriol 177:536-43 (1995)
DOI:10.1128/JB.177.3.536-543.1995
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.288
IUBMB Enzyme Nomenclature: 2.1.1.288
ExPASy - ENZYME nomenclature database: 2.1.1.288
BRENDA, the Enzyme Database: 2.1.1.288

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