Entry Name carminomycin 4-O-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:carminomycin 4-O-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin [RN:
R06693 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
carminomycin [CPD:
C12432 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
daunorubicin [CPD:
C01907 ]
Comment The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. In vitro the enzyme from Streptomyces sp. C5 also catalyses the 4-O-methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy-13-deoxycarminomycin [3].
History EC 2.1.1.292 created 2013
Pathway ec01057 Biosynthesis of type II polyketide products
ec01110 Biosynthesis of secondary metabolites
Orthology K15954 carminomycin 4-O-methyltransferase
Genes Taxonomy Reference Authors Connors NC, Strohl WR
Title Partial purification and properties of carminomycin 4-O-methyltransferase from Streptomyces sp. strain C5.
Journal Sequence Reference Authors Jansson A, Koskiniemi H, Mantsala P, Niemi J, Schneider G
Title Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products.
Journal Sequence Reference Authors Dickens ML, Priestley ND, Strohl WR
Title In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.292
