KEGG   ENZYME: 2.1.1.293Help
Entry
EC 2.1.1.293                Enzyme                                 

Name
6-hydroxytryprostatin B O-methyltransferase;
ftmD (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A [RN:R10588]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-hydroxytryprostatin B [CPD:C20513]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
tryprostatin A [CPD:C20607]
Comment
Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
History
EC 2.1.1.293 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K18280  6-hydroxytryprostatin B O-methyltransferase
Genes
NHE: NECHADRAFT_63896
AFM: AFUA_8G00200
AOR: AO090010000047
ANG: ANI_1_2036014(An01g15010)
AFV: AFLA_116210
NFI: NFIA_093710
ABE: ARB_02574 ARB_07989
TVE: TRV_04616 TRV_05502
PTE: PTT_20107
Taxonomy
Reference
1  [PMID:23649274]
  Authors
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
  Title
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
  Journal
Biosci Biotechnol Biochem 77:1061-7 (2013)
DOI:10.1271/bbb.130026
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.293
IUBMB Enzyme Nomenclature: 2.1.1.293
ExPASy - ENZYME nomenclature database: 2.1.1.293
BRENDA, the Enzyme Database: 2.1.1.293

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