| Entry |
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| Name |
6-hydroxytryprostatin B O-methyltransferase;
ftmD (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A [RN: R10588]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
6-hydroxytryprostatin B [CPD: C20513]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
tryprostatin A [CPD: C20607]
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| Comment |
Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
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| History |
EC 2.1.1.293 created 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K18280 | 6-hydroxytryprostatin B O-methyltransferase |
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| Genes |
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| Reference |
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| Authors |
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H |
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| Title |
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.293 |
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