KEGG   ENZYME: 2.1.1.296Help
Entry
EC 2.1.1.296                Enzyme                                 

Name
methyltransferase cap2;
MTR2;
cap2-MTase;
mRNA (nucleoside-2'-O)-methyltransferase (ambiguous)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-ribonucleotide-[mRNA] 2'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA] [RN:R10812]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] [CPD:C04802]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA] [CPD:C20862]
Comment
The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream purine ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency [2].
History
EC 2.1.1.296 created 2014
Orthology
K14590  cap2 methyltransferase
K18776  cap2 methyltransferase
Genes
HSA: 55783(CMTR2)
PTR: 745202(CMTR2)
PPS: 100985401(CMTR2)
GGO: 101137210(CMTR2)
PON: 100172540(CMTR2)
NLE: 100579817(CMTR2)
MCC: 711529(CMTR2)
MCF: 102120594(CMTR2)
CSAB: 103233165(CMTR2)
RRO: 104677811(CMTR2)
RBB: 108527451(CMTR2)
CJC: 100412690(CMTR2)
SBQ: 101045320(CMTR2)
MMU: 234728(Cmtr2)
MCAL: 110300394(Cmtr2)
MPAH: 110337588(Cmtr2)
RNO: 292016(Cmtr2)
MUN: 110542580 110546039(Cmtr2)
CGE: 100754099(Cmtr2)
NGI: 103735630(Cmtr2)
HGL: 101696697(Cmtr2)
OCU: 100346528(CMTR2)
TUP: 102482679(CMTR2)
CFA: 489718(CMTR2)
VVP: 112929495(CMTR2)
AML: 100482851(CMTR2)
UMR: 103673582(CMTR2)
UAH: 113252464(CMTR2)
ORO: 101385736(CMTR2)
FCA: 101081592(CMTR2)
PTG: 102969106(CMTR2)
BTA: 781914(CMTR2)
BOM: 102269376(CMTR2)
BIU: 109572848(CMTR2)
BBUB: 102413700(CMTR2)
PHD: 102332669(CMTR2)
CHX: 102182998(CMTR2)
OAS: 101106100(CMTR2)
SSC: 100625187(CMTR2)
CFR: 102518757(CMTR2)
CDK: 105104273(CMTR2)
BACU: 103017175(CMTR2)
LVE: 103086480(CMTR2)
OOR: 101277993(CMTR2)
DLE: 111179544(CMTR2)
PCAD: 102992875(CMTR2)
ECB: 100068485(CMTR2)
EPZ: 103551750(CMTR2)
EAI: 106830912(CMTR2)
MYB: 102252269(CMTR2)
MYD: 102758049(CMTR2)
MNA: 107524398(CMTR2)
HAI: 109388964(CMTR2)
RSS: 109461376(CMTR2)
DRO: 112300833(CMTR2)
PALE: 102893817(CMTR2)
RAY: 107520520(CMTR2)
LAV: 100671400(CMTR2)
TMU: 101340596
MDO: 100024780(CMTR2)
SHR: 100914522(CMTR2)
PCW: 110192470(CMTR2)
OAA: 100074514(CMTR2)
GGA: 427537(CMTR2)
MGP: 100550810(CMTR2)
CJO: 107319188(CMTR2)
NMEL: 110404401(CMTR2)
APLA: 101802442(CMTR2)
ACYG: 106033270(CMTR2)
TGU: 100230404(CMTR2)
LSR: 110476247(CMTR2)
SCAN: 103816673(CMTR2)
GFR: 102044295(CMTR2)
FAB: 101817347(CMTR2)
PHI: 102112750(CMTR2)
PMAJ: 107210044(CMTR2)
CCAE: 111934531(CMTR2)
CCW: 104687521(CMTR2)
ETL: 114063438(CMTR2)
FPG: 101913175(CMTR2)
FCH: 102045864(CMTR2)
CLV: 102092901(CMTR2)
EGZ: 104130241(CMTR2)
NNI: 104017447(CMTR2)
ACUN: 113484389(CMTR2)
PADL: 103922258(CMTR2)
AAM: 106489389(CMTR2)
ASN: 102379025(CMTR2)
AMJ: 102567886(CMTR2)
PSS: 102462904(CMTR2)
CMY: 102941834(CMTR2)
CPIC: 101933286(CMTR2)
ACS: 100566866(cmtr2)
PVT: 110091268(CMTR2)
PBI: 103049103(CMTR2)
PMUR: 107298304(CMTR2)
GJA: 107109618(CMTR2)
XLA: 108714154(cmtr2.L)
XTR: 100496665(cmtr2)
NPR: 108802960(CMTR2)
DRE: 406742(cmtr2)
SRX: 107749817
SANH: 107691918
SGH: 107588175
CCAR: 109093042
IPU: 108270675(cmtr2)
PHYP: 113523947(cmtr2)
AMEX: 103026585(cmtr2)
EEE: 113586074(cmtr2)
TRU: 101076967(cmtr2)
LCO: 104927813(cmtr2)
NCC: 104965821(cmtr2)
MZE: 101481599(cmtr2)
OLA: 101158006(cmtr2)
XMA: 102226934(cmtr2)
XCO: 114143795(cmtr2)
PRET: 103462552(cmtr2)
NFU: 107381339(cmtr2)
KMR: 108251077(cmtr2)
AOCE: 111573313(cmtr2)
CSEM: 103378880(cmtr2)
POV: 109636722(cmtr2)
SDU: 111219044(cmtr2)
HCQ: 109526031(cmtr2)
BPEC: 110175448(cmtr2)
MALB: 109966039(cmtr2)
SASA: 106562241(cmtr2)
OTW: 112263738(cmtr2)
SALP: 111969410
ELS: 105016137(cmtr2)
SFM: 108926348(cmtr2)
PKI: 111851836(cmtr2)
LCM: 102351997(CMTR2)
CMK: 103172567(cmtr2)
CIN: 100183192
SPU: 579852
APLC: 110981401
SKO: 102810133
DME: Dmel_CG5032(aft)
DER: 6546823
DPE: 6593041
DSI: Dsimw501_GD11317(Dsim_GD11317)
DWI: 6643365
DAZ: 108616474
DNV: 108654171
DHE: 111605360
MDE: 101891303
LCQ: 111684792
AAG: 5568314
BIM: 100743301
BTER: 105667128
AEC: 105150713
ACEP: 105619279
PBAR: 105433397
VEM: 105570574
CFO: 112637055
LHU: 105673251
PGC: 109852588
OBO: 105280253
PCF: 106793804
MDL: 103571661
TCA: 658920
DPA: 109542469
NVL: 108559500
BMOR: 101737449
PMAC: 106708107
PRAP: 110991846
HAW: 110374672
TNL: 113493669
PXY: 105391860
BTAB: 109036652
CLEC: 106662807
ZNE: 110838990
CEL: CELE_Y40D12A.1(Y40D12A.1)
CBR: CBG15196
BMY: Bm1_32855
PCAN: 112575293
CRG: 105322668
MYI: 110451340
OBI: 106867681
LAK: 106171494
EPA: 110239898
PDAM: 113669963
SPIS: 111324537
HMG: 101238854
AQU: 105313501
CRE: CHLREDRAFT_111541(SSA18)
VCN: VOLCADRAFT_62343(ssa18)
TAN: TA05485
TPV: TP03_0172
BBO: BBOV_I003250(19.m02092)
CPV: cgd7_2570
 » show all
Taxonomy
Reference
1  [PMID:16516986]
  Authors
Arhin GK, Ullu E, Tschudi C
  Title
2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39.
  Journal
Mol Biochem Parasitol 147:137-9 (2006)
DOI:10.1016/j.molbiopara.2006.01.011
  Sequence
Reference
2  [PMID:21310715]
  Authors
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
  Title
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
  Journal
Nucleic Acids Res 39:4756-68 (2011)
DOI:10.1093/nar/gkr038
  Sequence
[hsa:55783]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.296
IUBMB Enzyme Nomenclature: 2.1.1.296
ExPASy - ENZYME nomenclature database: 2.1.1.296
BRENDA, the Enzyme Database: 2.1.1.296

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