KEGG   ENZYME: 2.1.1.299
Entry
EC 2.1.1.299                Enzyme                                 
Name
protein N-terminal monomethyltransferase;
NRMT2 (gene name);
METTL11B (gene name);
N-terminal monomethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N-terminal-(A,P,S)PK-[protein]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Comment
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.
History
EC 2.1.1.299 created 2014
Orthology
K19579  protein N-terminal monomethyltransferase
Genes
HSA149281(NTMT2)
PTR469577(METTL11B)
PPS100987718(METTL11B)
GGO101152939(METTL11B)
PON100444887 112132363
NLE100586787(METTL11B)
HMH116472304(NTMT2)
MCC705503(METTL11B)
MCF102119511(NTMT2)
MTHB126950485
MNI105493046(METTL11B)
CSAB103230610(METTL11B)
CATY105600153(METTL11B)
PANU101013648(METTL11B)
TGE112611070(METTL11B)
MLEU105539608(METTL11B)
RRO104669430(METTL11B)
RBB108527263(METTL11B)
TFN117075584(METTL11B)
PTEH111539265(METTL11B)
CANG105526325(METTL11B)
CJC100411855(NTMT2)
SBQ101045661(METTL11B)
CIMI108308350(METTL11B)
CSYR103253493(METTL11B)
MMUR105870800(METTL11B)
LCAT123634675(NTMT2)
PCOQ105821121(METTL11B)
OGA100955421(METTL11B)
MMU240879(Ntmt2)
MCAL110303799(Mettl11b)
MPAH110322511(Mettl11b)
RNO289167(Mettl11b)
MCOC116070827(Mettl11b)
ANU117716493(Mettl11b)
MUN110549919(Ntmt2)
CGE100752444(Mettl11b)
MAUA101825921(Mettl11b)
PROB127223239(Ntmt2)
PLEU114689952(Mettl11b)
MORG121454932(Mettl11b)
MFOT126511339
AAMP119827031(Ntmt2)
NGI103727098(Mettl11b)
HGL101718425(Mettl11b) 101722032
CPOC100718393
CCAN109691209(Mettl11b)
DORD105985142(Mettl11b)
DSP122103707(Ntmt2)
PLOP125359531(Ntmt2)
NCAR124961130
MMMA107147391(Ntmt2)
OCU100346292(NTMT2)
OPI101522919(METTL11B)
TUP102475213(METTL11B)
GVR103604863(METTL11B)
CFA490351(METTL11B)
CLUD112648647(NTMT2)
VVP112923452(METTL11B)
VLG121501613(NTMT2)
NPO129508618(NTMT2)
AML100466656(METTL11B)
UMR103667791(METTL11B)
UAH113262619(METTL11B)
UAR123792646(NTMT2)
ELK111150612
LLV125085727
MPUF101678072(METTL11B)
MNP132026040(NTMT2)
MLK131815049(NTMT2)
NVS122918118(NTMT2)
ORO101386407(METTL11B)
EJU114223976(METTL11B)
ZCA113932593(METTL11B)
MLX118014492(METTL11B)
NSU110574225(NTMT2)
LWW102730266(METTL11B)
FCA101084764(NTMT2)
PYU121014970(METTL11B)
PCOO112863215(METTL11B)
PBG122476045(NTMT2)
LRUF124510103
PTG102967658(METTL11B)
PPAD109252208(METTL11B)
PUC125925132
AJU106966229(NTMT2)
HHV120234157(METTL11B)
BTA521303(NTMT2)
BOM102274395(METTL11B)
BIU109570672(METTL11B)
BBUB102415209(NTMT2)
BBIS104986239(METTL11B)
CHX102172563(METTL11B)
OAS101103252(NTMT2)
BTAX128061802(NTMT2)
ODA120880263(METTL11B)
CCAD122452495(NTMT2)
MBEZ129551577(NTMT2)
SSC100157210(METTL11B)
CFR102523187(METTL11B)
CBAI105068083(METTL11B)
CDK105092751(METTL11B)
VPC102530912(METTL11B)
BACU103016571(METTL11B)
LVE103073590(METTL11B)
OOR101289399(NTMT2)
DLE111167368(METTL11B)
PCAD102995569(NTMT2)
PSIU116756222(METTL11B)
NASI112398068(METTL11B)
ECB100059169(METTL11B)
EPZ103550805(METTL11B)
EAI106833811(NTMT2)
MYB102255085(METTL11B)
MYD102754821(METTL11B)
MMYO118672660(METTL11B)
MLF102426834(METTL11B)
MNA107543739(METTL11B)
PKL118721548(METTL11B)
EFUS103289949(NTMT2)
HAI109385450(METTL11B)
DRO112321237(METTL11B)
SHON118979242(METTL11B)
AJM119065396(METTL11B)
PDIC114512146(METTL11B)
PHAS123818483(NTMT2)
MMF118637911(METTL11B)
RFQ117014930(METTL11B)
PPAM129081938(NTMT2)
PALE102885906(METTL11B)
PGIG120617742(METTL11B)
PVP105299808(METTL11B)
RAY107512770(METTL11B)
TOD119240078(NTMT2)
SARA101542862(METTL11B)
LAV100661734(METTL11B)
TMU101361457
ETF101653475(NTMT2)
DNM101438615(METTL11B)
MDO100019985(METTL11B)
GAS123245891(NTMT2)
SHR100922386(METTL11B)
AFZ127562919
PCW110196979(METTL11B)
OAA120637992(METTL11B)
GGA429066(METTL11B)
PCOC116230484(METTL11B)
MGP104909323(METTL11B)
CJO107317298(METTL11B)
TPAI128072297(NTMT2)
LMUT125692928(NTMT2)
NMEL110402352(METTL11B)
APLA101799335(METTL11B)
ACYG106041617(NTMT2)
CATA118243546(NTMT2)
AFUL116492169(METTL11B)
TGU100223826(METTL11B)
LSR110478926(METTL11B)
SCAN103823381(METTL11B)
PMOA120512248(METTL11B)
OTC121344286(METTL11B)
PRUF121359787(METTL11B)
GFR102040508(METTL11B)
FAB101821734(METTL11B)
OMA130256257(NTMT2)
PHI102112950(METTL11B)
PMAJ107208356(METTL11B)
CCAE111932492(METTL11B)
CCW104695457(METTL11B)
CBRC103612522(METTL11B)
ETL114063562(METTL11B)
ZAB102064024(METTL11B)
ACHL103804535(METTL11B)
SVG106852314(METTL11B)
MMEA130577414(NTMT2)
HRT120756453(NTMT2)
FPG101921234(METTL11B)
FCH102057343(METTL11B)
CLV102084074(METTL11B)
EGZ104132065(METTL11B)
NNI104010396(METTL11B)
PCRI104030079(METTL11B)
PLET104625108(METTL11B)
EHS104504164(METTL11B)
PCAO104045531(METTL11B)
ACUN113483115(METTL11B)
TALA104356912(NTMT2)
PADL103914011(METTL11B)
AFOR103893992(METTL11B)
ACHC115348986(METTL11B)
HALD104317251(METTL11B)
HLE104840536(METTL11B)
AGEN126042344
GCL127019313
CCRI104163326(METTL11B)
CSTI104557138(METTL11B)
CMAC104481188(METTL11B)
MUI104536041(METTL11B)
BREG104636914(METTL11B)
FGA104083643(METTL11B)
GSTE104262654(METTL11B)
LDI104346658(METTL11B)
MNB103775228(METTL11B)
OHA104333716(METTL11B)
NNT104400233(METTL11B)
SHAB115611948(METTL11B)
DPUB104301544(METTL11B)
PGUU104470659(METTL11B)
ACAR104521613(METTL11B)
CPEA104390554(METTL11B)
AVIT104274284(METTL11B)
CVF104293326(METTL11B)
RTD128913376(NTMT2)
CUCA104058358(METTL11B)
TEO104374520(METTL11B)
BRHI104491161(METTL11B)
AAM106493883(METTL11B)
AROW112975093 112976430(METTL11B)
NPD112951176(METTL11B)
TGT104569975(METTL11B)
DNE112997409(METTL11B)
SCAM104142684(METTL11B)
ASN102370453(METTL11B)
AMJ102575018(METTL11B)
CPOO109307617(METTL11B)
GGN109305389(METTL11B)
PSS102446567(METTL11B)
CMY102935596(NTMT2)
CCAY125641300(NTMT2)
DCC119860376(NTMT2)
CPIC101944603(NTMT2)
TST117882047(METTL11B)
CABI116839891(METTL11B)
MRV120370099(METTL11B)
ACS100555292(mettl11b)
ASAO132774332(NTMT2)
PVT110090583(METTL11B)
SUND121929046(NTMT2)
PBI103057111(METTL11B)
PMUA114598326(METTL11B)
PRAF128415317(NTMT2)
ZVI118089068(METTL11B)
HCG128323339(NTMT2)
GJA107106117(METTL11B)
STOW125433149(NTMT2)
EMC129331296(NTMT2)
XLA108713669(mettl11b.L) 108715745(mettl11b.S)
XTR100485318(mettl11b)
NPR108793700(METTL11B)
RTEM120945511(METTL11B)
BBUF120979532(METTL11B)
BGAR122944092(NTMT2)
MUO115472822(METTL11B)
GSH117368351(METTL11B)
DRE568419(ntmt2)
SRX107726432 107732414
SANH107696087 107698316 107698334
SGH107553430 107580753 107599113(mettl11b)
CCAR109051906 109063849
CAUA113062953 113081988 113120854
CGIB127938256 127984392
PTET122325148(ntmt2)
LROH127182582(ntmt2)
OMC131526566(ntmt2)
PPRM120493776(mettl11b)
RKG130103277(ntmt2)
MAMB125278213(ntmt2)
CIDE127502509
MASI127410053 127416146
TROS130566152(ntmt2)
TDW130434744(ntmt2)
MANU129430054(ntmt2)
IPU108257661(ntmt2)
IFU128601118(ntmt2)
PHYP113546860(mettl11b)
SMEO124377288(ntmt2)
TFD113653671(ntmt2)
TVC132842441(ntmt2)
AMEX103038020(mettl11b)
CMAO118816143(mettl11b)
EEE113581064(mettl11b)
CHAR105910875(ntmt2)
TRU101074892(mettl11b)
TFS130528460(ntmt2)
TNGGSTEN00010049G001
LCO104936067(mettl11b)
NCC104952141(mettl11b)
TBEN117495804(mettl11b)
CGOB115007533(mettl11b)
PGEO117445150(mettl11b)
GACU117560473(mettl11b)
ELY117270691
EFO125896329(ntmt2)
PLEP121941409(ntmt2)
SLUC116054900(mettl11b)
ECRA117949923(mettl11b)
ESP116684597(mettl11b)
PFLV114561967(mettl11b)
GAT120823532(mettl11b)
PPUG119217268(mettl11b)
AFB129095130(ntmt2)
CLUM117730021(mettl11b)
MSAM119900215(mettl11b)
SCHU122877955(ntmt2)
CUD121512671(mettl11b)
ALAT119029170(mettl11b)
MZE101485145(mettl11b)
ONL100712557(mettl11b)
OAU116320841(mettl11b)
OLA101166618(mettl11b)
OML112150173(mettl11b)
XMA102226777(mettl11b)
XCO114141417(mettl11b)
XHE116725810(mettl11b)
PRET103463194(mettl11b)
PFOR103149968(mettl11b)
PLAI106952854(mettl11b)
PMEI106924167(mettl11b)
GAF122838110(ntmt2)
CVG107095467(mettl11b)
CTUL119780675(mettl11b)
GMU124873789(ntmt2)
NFU107374283(mettl11b)
KMR108247575(mettl11b)
ALIM106537053(mettl11b)
NWH119430468(ntmt2)
AOCE111583804(mettl11b)
MCEP125008945(ntmt2)
CSEM103399314(mettl11b)
POV109643291(mettl11b)
SSEN122781307(ntmt2)
HHIP117760477(mettl11b)
HSP118120855(ntmt2)
LCF108883491(ntmt2)
SDU111227492(mettl11b)
SLAL111671603(mettl11b)
XGL120791225(mettl11b)
HCQ109523463(mettl11b)
SBIA133504044(ntmt2)
PEE133406017(ntmt2)
PTAO133480678(ntmt2)
BPEC110174554(mettl11b)
MALB109965197(mettl11b)
BSPL114854760(ntmt2)
SJO128362068(ntmt2)
SASA106560537(mettl11b)
STRU115158758(mettl11b)
OTW112251384(ntmt2)
OMY110524770(mettl11b)
OGO123997997(ntmt2)
ONE115108686(mettl11b)
OKI109902874(mettl11b)
OKE118379856(ntmt2)
SALP111975411(mettl11b)
SNH120042743(mettl11b)
CCLU121534065(ntmt2)
ELS105011974(mettl11b)
SFM108935366(mettl11b)
PKI111840065(mettl11b)
AANG118225198(mettl11b)
LOC102686624(mettl11b)
PSPA121327257 121330592(mettl11b)
ARUT117406079 117416568
PSEX120514926(mettl11b)
LCM102347657(METTL11B)
CMK103179979(ntmt2)
RTP109927142(mettl11b)
CPLA122554448(ntmt2)
HOC132818717(ntmt2)
LERI129701118(ntmt2)
PMRN116944811
LRJ133341176 133341631
 » show all
Reference
1  [PMID:24090352]
  Authors
Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE
  Title
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.
  Journal
Biochem J 456:453-62 (2013)
DOI:10.1042/BJ20131163
  Sequence
[hsa:149281]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.299
IUBMB Enzyme Nomenclature: 2.1.1.299
ExPASy - ENZYME nomenclature database: 2.1.1.299
BRENDA, the Enzyme Database: 2.1.1.299

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