KEGG   ENZYME: 2.1.1.302
Entry
EC 2.1.1.302                Enzyme                                 
Name
3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase;
AziB2
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-hydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 3-methoxy-5-methyl-1-naphthoate [RN:R10962]
Reaction(KEGG)
R10962
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-hydroxy-5-methyl-1-naphthoate [CPD:C20805]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-5-methyl-1-naphthoate [CPD:C20980]
Comment
The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.
History
EC 2.1.1.302 created 2014
Orthology
K21377  3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase
Genes
DCSISN74_02020
PSILPMA3_00655
ACTBRHM62_11910
MESMEJ066_14925
RSULN2599_30620
BICLMTR13_32305
SKTIGS68_31330
SMUCJL100_030960
SROEJL101_033185
PARHI5S86_11245
SCLFBB341_25940
SALUDC74_715 DC74_7945
SALLSAZ_04130 SAZ_41020
SGVB1H19_37285
SKACP970_07475
SFYGFH48_00330
SRIMCP984_04385
SVDCP969_01705
STUBMMF93_32410
SSPNLXH13_29645
STUDSTRTU_000072
MPHMLP_09820
MIKFOE78_04350
MICGGJV80_17680
SACGFDZ84_22140 FDZ84_37520
AROONQK81_30355
APRECNX65_24625
STPStrop_0204
SAQSare_0232
MICHFJK98_18645
MCABHXZ27_19965
MSAGGCM10017556_00720
MENOJiend_35270
AFSAFR_08625
ACTRAsp14428_27890
PFLAPflav_078160
PSUUPsuf_040820
PRYPrubr_68450
DAURDaura_15970
NHYJQS43_13200
CCAZCOUCH_30980
CVLJ8C06_05040
 » show all
Reference
1  [PMID:20485749]
  Authors
Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W
  Title
Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B.
  Journal
Mol Biosyst 6:1071-81 (2010)
DOI:10.1039/b926358f
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.302
IUBMB Enzyme Nomenclature: 2.1.1.302
ExPASy - ENZYME nomenclature database: 2.1.1.302
BRENDA, the Enzyme Database: 2.1.1.302

DBGET integrated database retrieval system