KEGG   ENZYME: 2.1.1.304
Entry
EC 2.1.1.304                Enzyme                                 
Name
L-tyrosine C3-methyltransferase;
SfmM2;
SacF
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:L-tyrosine C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + L-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine [RN:R10964]
Reaction(KEGG)
R10964
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-tyrosine [CPD:C00082]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methyl-L-tyrosine [CPD:C20800]
Comment
The enzyme from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
History
EC 2.1.1.304 created 2014
Orthology
K21460  L-tyrosine C(3)-methyltransferase
Genes
LPOP: I6N93_03605
POI: BOP93_17430
NBR: O3I_021170
NOZ: DMB37_35935
NWL: NWFMUON74_37020
SANL: KZO11_29645
SBH: SBI_00214
SRW: TUE45_pSRc_0392(crtF)
SPAV: Spa2297_02655
SGS: AVL59_15490
SNW: BBN63_30130
SDX: C4B68_39100
STUB: MMF93_31555
STPB: QR97_21860
AMYY: YIM_25125(tcmN2)
SSYI: EKG83_27610
KPHY: AOZ06_21630
ALO: CRK56714
MCRA: ID554_15035
AEY: CDG81_20600
TER: Tery_3121
PAGH: NIES204_43770
 » show all
Reference
1  [PMID:22187429]
  Authors
Tang MC, Fu CY, Tang GL
  Title
Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.
  Journal
J Biol Chem 287:5112-21 (2012)
DOI:10.1074/jbc.M111.306316
  Sequence
[ag:ABI22137]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.304
IUBMB Enzyme Nomenclature: 2.1.1.304
ExPASy - ENZYME nomenclature database: 2.1.1.304
BRENDA, the Enzyme Database: 2.1.1.304

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (23)   
   KEGG MGENES (12)   
Protein sequence (18)   
   UniProt (17)   
   SWISS-PROT (1)   
DNA sequence (42)   
   GenBank (22)   
   EMBL (20)   
Protein domain (5)   
   InterPro (5)   
All databases (108)   

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