KEGG   ENZYME: 2.1.1.306Help
Entry
EC 2.1.1.306                Enzyme                                 

Name
8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase;
ElmMII
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10957]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20975]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20976]
Comment
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
History
EC 2.1.1.306 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K19568  8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
Reference
1  [PMID:11376004]
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA.
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.306
IUBMB Enzyme Nomenclature: 2.1.1.306
ExPASy - ENZYME nomenclature database: 2.1.1.306
BRENDA, the Enzyme Database: 2.1.1.306

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