KEGG   ENZYME: 2.1.1.307
Entry
EC 2.1.1.307                Enzyme                                 

Name
8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase;
ElmMIII
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:8-demethyl-8-(2,3-di-O-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10958]
Reaction(KEGG)
R10958
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20976]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20977]
Comment
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
History
EC 2.1.1.307 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19569  8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
Genes
SCW: TU94_23010
SLE: sle_21920(sle_21920)
FRI: FraEuI1c_5710
SEN: SACE_0650(cloP)
Reference
1  [PMID:11376004]
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.307
IUBMB Enzyme Nomenclature: 2.1.1.307
ExPASy - ENZYME nomenclature database: 2.1.1.307
BRENDA, the Enzyme Database: 2.1.1.307

DBGET integrated database retrieval system