KEGG   ENZYME: 2.1.1.315
Entry
EC 2.1.1.315                Enzyme                                 
Name
27-O-demethylrifamycin SV methyltransferase;
AdoMet:27-O-demethylrifamycin SV methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:27-O-demethylrifamycin-SV 27-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 27-O-demethylrifamycin SV = S-adenosyl-L-homocysteine + rifamycin SV [RN:R06998]
Reaction(KEGG)
R06998
Substrate
S-adenosyl-L-methionine [CPD:C00019];
27-O-demethylrifamycin SV [CPD:C14727]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
rifamycin SV [CPD:C12044]
Comment
The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the antitubercular drug rifamycin B.
History
EC 2.1.1.315 created 2015
Pathway
ec01051  Biosynthesis of ansamycins
ec01110  Biosynthesis of secondary metabolites
Orthology
K15467  27-O-demethylrifamycin SV methyltransferase
Genes
ETBN7L95_28790
SGRFSGFS_005370 SGFS_005510
SOVQZH56_34125
SFIYF0344_35090
SFPQUY26_37950
ACTQOG417_43005
AMDAMED_0650
AMNRAM_03320
AMMAMES_0648
AMZB737_0649
SAQSare_1271
 » show all
Reference
1  [PMID:12623077]
  Authors
Xu J, Mahmud T, Floss HG
  Title
Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.
  Journal
Arch Biochem Biophys 411:277-88 (2003)
DOI:10.1016/S0003-9861(03)00004-3
  Sequence
[amn:RAM_03320]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.315
IUBMB Enzyme Nomenclature: 2.1.1.315
ExPASy - ENZYME nomenclature database: 2.1.1.315
BRENDA, the Enzyme Database: 2.1.1.315

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