KEGG   ENZYME: 2.1.1.317
Entry
EC 2.1.1.317                Enzyme                                 
Name
sphingolipid C9-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(4E,8E)-sphinga-4,8-dienine ceramide C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide = S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide [RN:R11193]
Reaction(KEGG)
R11193
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(4E,8E)-sphinga-4,8-dienine ceramide [CPD:C21022]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide [CPD:C21165]
Comment
The enzyme, characterized from the fungi Komagataella pastoris and Fusarium graminearum, acts only on ceramides and has no activity with free sphingoid bases or glucosylceramides.
History
EC 2.1.1.317 created 2015
Orthology
K20238  sphingolipid C9-methyltransferase
Genes
NVE5510658
EPA110236733
ATEN116295686
ADF107340147
AMIL114962239
PDAM113665883
SPIS111341672
DGT114521708
XEN124434262
HMG100198707
HSY130628742
AGOAGOS_AFR735W
ERCEcym_1018
KLAKLLA0_C00715g
KMXKLMA_10030
LTHKLTH0F00682g
PPAPAS_chr4_0465
DHADEHA2E13552g
PICPICST_81203
PGUPGUG_03326
SPAASPAPADRAFT_61519
CALCAALFM_C109680WA(MTS1)
CTPCTRG_03390
COTCORT_0A03910
CDUCD36_09120
CTENCANTEDRAFT_115288
YLIYALI0C21494g
CLUCLUG_01276
CLUSA9F13_06g00770
CAURCJI96_0000755
SLBAWJ20_1451
PKZC5L36_0C10030
BNNFOA43_003443
BBRXBRETT_004294
OPAHPODL_02936
NCRNCU07859
NTENEUTE1DRAFT62280(NEUTE1DRAFT_62280)
SMPSMAC_02133
PANPODANSg5532
TTTTHITE_2120192
MTMMYCTH_2303482
CTHRCTHT_0071450
MGRMGG_14886
PPEIPpBr36_06551
PGRIPgNI_00636
TMNUCRPA7_1693 UCRPA7_8532
SSCKSPSK_03213
FGRFGSG_03951 FGSG_05593
FPUFPSE_02369 FPSE_05323 FPSE_06183
FPOAFPOAC1_006374(MT1) FPOAC1_008017(MT2)
FVNFVRRES_06983 FVRRES_08578
FVRFVEG_06896 FVEG_10123
FOXFOXG_09295 FOXG_11716
NHENECHADRAFT_47156 NECHADRAFT_61548
FFCNCS54_00767400 NCS54_01031300
FMUJ7337_009553(MT2) J7337_011388(MT1)
TRETRIREDRAFT_80509
TRRM419DRAFT_102296
MAWMAC_02943 MAC_09633
MAJMAA_03402 MAA_07734
PCHMVFPPC_04272 VFPPC_05313
CMTCCM_02837
AMUSLMH87_007125
PLJVFPFJ_01351 VFPFJ_10457
PTKZJDV02_007330(MT2) JDV02_008170(MT1)
VALVDBG_05490
VDAVDAG_05956
CFJCFIO01_07812 CFIO01_10282
CLUPCLUP02_18162
CHIGCH63R_13624
SAPOSAPIO_CDS9162
ELAUCREL1_4508
PFYPFICI_11474 PFICI_11535
SSLSS1G_05986
BFUBCIN_05g00940
MBEMBM_07835
PSCOLY89DRAFT_691551
ANIAN5688.2 AN7375.2
AFMAFUA_7G04190
ACTACLA_005890
NFINFIA_025160
AORAO090005000104 AO090103000119
ANGAn02g04530 An13g00740
AFVAFLA_002883 AFLA_013401
ALUCAKAW2_20134S(MT2) AKAW2_21236A(MT1)
ACHEACHE_40205S(MT2) ACHE_50093S(MT1)
APUUAPUU_20119S(MT1) APUU_21650S APUU_30850S APUU_41066S(MT2)
PCSN7525_005297 N7525_006935
PDPPDIP_82450
POUPOX_c04296
TMFEYB26_005550
TRGTRUGW13939_00984 TRUGW13939_09612
CIMCIMG_07553
CPWCPC735_043780
UREUREG_07726
PBNPADG_08618
ABEARB_02437
TVETRV_06510
AJEHCAG_06377
BGHBDBG_08008
PNOSNOG_03511
PTEPTT_17218
BZECOCCADRAFT_90884
BSCCOCSADRAFT_38748
BORCOCMIDRAFT_37490
AALTCC77DRAFT_861258
ARABEKO05_0008279
ZTRMYCGRDRAFT_100674
PFJMYCFIDRAFT_78053
FFUCLAFUR5_04970
CBETCB0940_11336
BCOMBAUCODRAFT_79835
NPAUCRNP2_3944
TMLGSTUM_00009583001
CNECNC07040
CNBCNBC0150
CNGCNAG_01475
CGICGB_C0170C
TMSTREMEDRAFT_69739
TASAA1Q1_07509
CCACCcaHIS019_0201220(CcaverHIS019_0201220)
TVSTRAVEDRAFT_64761
DSQDICSQDRAFT_183486
PCOPHACADRAFT_147483
SHSSTEHIDRAFT_61773
HIRHETIRDRAFT_67724
PSQPUNSTDRAFT_145949
ADLAURDEDRAFT_117380
FMEFOMMEDRAFT_146710
GTRGLOTRDRAFT_81225
RSXRhiXN_06096
LBCLACBIDRAFT_295662
CCICC1G_02451
ABPAGABI1DRAFT115213(AGABI1DRAFT_115213)
ABVAGABI2DRAFT195342(AGABI2DRAFT_195342)
PCUBJR316_0011474
MRRMoror_3037
MOREE1B28_005900
SCMSCHCO_02641924(SCHCODRAFT_02641924)
CPUTCONPUDRAFT_131566 CONPUDRAFT_57179
SLASERLADRAFT_471119(cfs5)
WSEWALSEDRAFT_33053
WICJ056_000732
UMAUMAG_01070
PFPPFL1_06855
SGRAEX895_006118
MGLMGL_1826
MRTMRET_1986
MSYMMSY001_0947
PGRPGTG_13395
PTRCPtA15_18A159
PSTRPst134EA_026816 Pst134EA_031675
MLRMELLADRAFT_53990
SMINv1.2.029480.t1(symbB.v1.2.029480.t1)
EHXEMIHUDRAFT_365614 EMIHUDRAFT_468817
GTTGUITHDRAFT_97996
SURSTAUR_2907
AGEAA314_05679
AVMJQX13_43000
CFUSCYFUS_005416
LLUAKJ09_05784 AKJ09_07416 AKJ09_08951
TPXTurpa_0943
 » show all
Reference
1  [PMID:16339149]
  Authors
Ternes P, Sperling P, Albrecht S, Franke S, Cregg JM, Warnecke D, Heinz E
  Title
Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling.
  Journal
J Biol Chem 281:5582-92 (2006)
DOI:10.1074/jbc.M512864200
  Sequence
Reference
2  [PMID:19028992]
  Authors
Ramamoorthy V, Cahoon EB, Thokala M, Kaur J, Li J, Shah DM
  Title
Sphingolipid C-9 methyltransferases are important for growth and virulence but not for sensitivity to antifungal plant defensins in Fusarium graminearum.
  Journal
Eukaryot Cell 8:217-29 (2009)
DOI:10.1128/EC.00255-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.317
IUBMB Enzyme Nomenclature: 2.1.1.317
ExPASy - ENZYME nomenclature database: 2.1.1.317
BRENDA, the Enzyme Database: 2.1.1.317

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