KEGG   ENZYME: 2.1.1.317Help
Entry
EC 2.1.1.317                Enzyme                                 

Name
sphingolipid C9-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(4E,8E)-sphinga-4,8-dienine ceramide C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide = S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide [RN:R11193]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(4E,8E)-sphinga-4,8-dienine ceramide [CPD:C21022]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide [CPD:C21165]
Comment
The enzyme, characterized from the fungi Komagataella pastoris and Fusarium graminearum, acts only on ceramides and has no activity with free sphingoid bases or glucosylceramides.
History
EC 2.1.1.317 created 2015
Orthology
K20238  sphingolipid C9-methyltransferase
Genes
NVE: NEMVE_v1g168568
EPA: 110236733
ADF: 107340147
AMIL: 114962239
PDAM: 113665883
SPIS: 111341672
DGT: 114521708
HMG: 100198707
QSU: 112002712 112011444
AGO: AGOS_AFR735W
ERC: Ecym_1018
CAL: CAALFM_C109680WA(MTS1)
NCR: NCU07859
NTE: NEUTE1DRAFT62280(NEUTE1DRAFT_62280)
MGR: MGG_14886
SSCK: SPSK_03213
CMT: CCM_02837
MBE: MBM_07835
ANG: ANI_1_642024(An02g04530) ANI_1_98114(An13g00740)
ABE: ARB_02437
TVE: TRV_06510
PTE: PTT_17218
CNE: CNC07040
CNB: CNBC0150
ABP: AGABI1DRAFT115213(AGABI1DRAFT_115213)
ABV: AGABI2DRAFT195342(AGABI2DRAFT_195342)
SLA: SERLADRAFT_471119(cfs5)
MGL: MGL_1826
MRT: MRET_1986
SMIN: v1.2.029480.t1(symbB.v1.2.029480.t1)
 » show all
Taxonomy
Reference
1  [PMID:16339149]
  Authors
Ternes P, Sperling P, Albrecht S, Franke S, Cregg JM, Warnecke D, Heinz E
  Title
Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling.
  Journal
J Biol Chem 281:5582-92 (2006)
DOI:10.1074/jbc.M512864200
  Sequence
Reference
2  [PMID:19028992]
  Authors
Ramamoorthy V, Cahoon EB, Thokala M, Kaur J, Li J, Shah DM
  Title
Sphingolipid C-9 methyltransferases are important for growth and virulence but not for sensitivity to antifungal plant defensins in Fusarium graminearum.
  Journal
Eukaryot Cell 8:217-29 (2009)
DOI:10.1128/EC.00255-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.317
IUBMB Enzyme Nomenclature: 2.1.1.317
ExPASy - ENZYME nomenclature database: 2.1.1.317
BRENDA, the Enzyme Database: 2.1.1.317

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