KEGG ENZYME: 2.1.1.322

ENZYME: 2.1.1.322

Entry

EC 2.1.1.322                Enzyme

Name

type IV protein arginine methyltransferase;
RMT2 (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)

Reaction(IUBMB)

S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine [RN:R11221]

Reaction(KEGG)

R11221

Substrate

S-adenosyl-L-methionine [CPD:C00019];
[protein]-L-arginine [CPD:C00613]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
[protein]-N5-methyl-L-arginine [CPD:C21190]

Comment

This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.321, type III protein arginine methyltransferase.

History

EC 2.1.1.322 created 2015

Orthology

K18477

type IV protein arginine methyltransferase

Genes

SMM:	Smp_024380

OVI:	T265_13792

EGL:

EGR_07793

ATH:

AT5G65860

ALY:

9301058

CRB:

17875279

CSAT:

104727248 104744337 104762774

EUS:	EUTSA_v10005718mg

BRP:

103874022

BNA:	106346625 106348175

BOE:

106328863

RSZ:	108857199 108861753

THJ:

104807092

CPAP:

110818793

CIT:

102617746

CIC:	CICLE_v10001599mg

PVY:

116129072

MINC:

123229941

TCC:

18592010

GRA:

105769321

GHI:	107905628 107958173

GAB:

108450487

DZI:

111312562

EGR:

104447825

GMX:	100527621 100796916

GSJ:	114408758 114414759

PVU:	PHAVU_009G070400g

VRA:

106761118

VAR:

108331651

VUN:

114162111

CCAJ:

109796001

APRC:

113865451

MTR:

25489940

CAM:

101504178

PSAT:

127088047

LJA:	Lj1g3v1720140.1(Lj1g3v1720140.1) Lj1g3v1720140.2(Lj1g3v1720140.2)

ADU:

107461180

AIP:

107606376

AHF:	112706449 112762445

LANG:

109343866

FVE:

101307454

RCN:

112174110

PPER:

18791164

PMUM:

103320401

PAVI:

110744880

PDUL:

117619808

MDM:

103441063

PXB:

103945293

ZJU:	107420557 107433653

MNT:

21393556

CSV:

101206863

CMO:

103487848

BHJ:

120075618

MCHA:

111004738

CMAX:

111495906

CMOS:

111454147

CPEP:

111798359

RCU:

8288515

HBR:

110671978

MESC:

110605917

POP:

18104803

PEU:

105128808

PALZ:

118036618

JRE:

108981343

CILL:

122319101

QSU:	111991221 112020323 112023925

QLO:

115971948

TWL:

120008925

VVI:

100259168

VRI:

117907434

SLY:

101264002

SPEN:

107016038

SOT:

102604578

SSTN:

125856643

CANN:

107867217

NTA:	107765586 107792104

NSY:

104249239

NTO:

104107915

NAU:

109215478

INI:

109153010

ITR:

116026771

SIND:

105155586

OEU:

111389319

EGT:

105971363

SSPL:

121763244

APAN:

127257120

HAN:

110885808

ECAD:

122579428

LSV:

111901692

CCAV:

112514525

DCR:

108192844

CSIN:

114291796

BVG:

104902325

SOE:

110786191

CQI:	110695543 110724407

NNU:

104611655

MING:

122085180

TSS:

122657333

PSOM:

113289222 113293666

OSA:

4334192

DOSA:

Os03t0761200-01(Os03g0761200)

OBR:

102707569

OGL:

127768413

BDI:

100840055

ATS:

109743493

TDC:	119303236 119311910

TAES:

123105111 123113403 123122921

TUA:

125510744

LPER:

127292729

SBI:

8062466

ZMA:

100286312

SITA:

101761593

SVS:

117838788

PVIR:

120690018

PHAI:

112873600

PDA:	103700807 120104061

EGU:

105058565

MUS:

103997354

ZOF:	121969841 122028008

DCT:

110099348

PEQ:

110023864

AOF:

109834172

NCOL:

116260042

ATR:

18431821

SMO:	SELMODRAFT_118824 SELMODRAFT_131773

PPP:

112294549

CRE:	CHLRE_01g050050v5

VCN:	VOLCADRAFT_69095

MNG:	MNEG_11764

CSL:	COCSUDRAFT_32480

CVR:	CHLNCDRAFT_144236

APRO:

F751_6706

OLU:	OSTLU_86989

OTA:	OT_ostta04g02060

BPG:	Bathy01g01620

MIS:	MICPUN_56989

MPP:	MICPUCDRAFT_25272

SCE:	YDR465C(RMT2)

SEUB:

DI49_0631

SPAO:

SPAR_D06450

AGO:	AGOS_ADR161W

ERC:

Ecym_2800

KLA:	KLLA0_E03631g

KMX:	KLMA_20552(RMT2)

LTH:	KLTH0G05170g

VPO:	Kpol_1004p62

ZRO:	ZYRO0C06820g

CGR:	CAGL0K06457g

NCS:	NCAS_0A08140(NCAS0A08140)

NDI:	NDAI_0H01030(NDAI0H01030)

TPF:	TPHA_0D02720(TPHA0D02720)

TBL:	TBLA_0J00700(TBLA0J00700)

TGB:	HG536_0A06120

TDL:	TDEL_0A04560(TDEL0A04560)

KAF:	KAFR_0A06740(KAFR0A06740)

KNG:	KNAG_0C06050(KNAG0C06050)

ZMK:	HG535_0D05550

PPA:	PAS_chr1-4_0106

DHA:	DEHA2E19228g

PIC:	PICST_66076(RMT2)

PGU:	PGUG_03413

SPAA:

SPAPADRAFT_61117

LEL:	LELG_03736

CAL:	CAALFM_C500680WA(RMT2)

CTP:	CTRG_05285

COT:	CORT_0E05920

CDU:	CD36_50680

CTEN:

CANTEDRAFT_114589

YLI:	YALI0C14718g

CLU:	CLUG_04928

CLUS:

A9F13_03g03025

CAUR:

CJI97_001153

SLB:	AWJ20_2397(RMT2)

PKZ:	C5L36_0B07540

BNN:	FOA43_003317

BBRX:

BRETT_004162

OPA:	HPODL_00552

SLUD:

SCDLUD_004911

NCR:

NCU08111

NTE:	NEUTE1DRAFT125124(NEUTE1DRAFT_125124)

SMP:	SMAC_08035

PAN:	PODANSg09947

TTT:	THITE_2114023

MTM:	MYCTH_2295764

CTHR:

CTHT_0057220

MGR:

MGG_09290

PPEI:

PpBr36_07629

TMN:	UCRPA7_1231

SSCK:

SPSK_10638

FGR:	FGSG_00501

FPU:	FPSE_04406

FVR:	FVEG_00958

FOX:	FOXG_00555

NHE:	NECHADRAFT_31691

TRE:	TRIREDRAFT_53796

TRR:	M419DRAFT_67962

MAW:

MAC_02976

MAJ:

MAA_04208

CMT:

CCM_06279

PLJ:	VFPFJ_05055

VAL:	VDBG_04543

VDA:	VDAG_04088

CFJ:	CFIO01_13485

CLUP:

CLUP02_05715

CHIG:

CH63R_00762

SAPO:

SAPIO_CDS3344

ELA:	UCREL1_5435

PFY:	PFICI_01109

SSL:	SS1G_01272

BFU:	BCIN_11g05680(Bcrmt2)

MBE:

MBM_09897

PSCO:

LY89DRAFT_502650

GLZ:	GLAREA_02283

ANI:

AN6072.2

AFM:	AFUA_2G09080

ACT:	ACLA_080890

NFI:	NFIA_084610

AOR:	AO090011000791

ANG:	ANI_1_1792104(An12g04740)

AFV:	AFLA_008183

ALUC:

AKAW2_60866A(RMT2)

ACHE:

ACHE_50460A(RMT2)

APUU:

APUU_11164A(RMT2)

PCS:	Pc16g10470

PDP:	PDIP_19700

TMF:	PMAA_029060

TRG:	TRUGW13939_06032

CIM:	CIMG_01019

CPW:	CPC735_053400

URE:	UREG_00965

PBL:	PAAG_01039

PBN:	PADG_03791

ABE:

ARB_05048

TVE:

TRV_01451

AJE:	HCAG_03681

BGH:	BDBG_05448

PNO:	SNOG_02787 SNOG_15549

PTE:	PTT_09392 PTT_15349

BZE:	COCCADRAFT_112323 COCCADRAFT_96483

BSC:	COCSADRAFT_105599

BOR:	COCMIDRAFT_21364 COCMIDRAFT_81956

AALT:

CC77DRAFT_1016203 CC77DRAFT_374429

ZTR:	MYCGRDRAFT_100619

PFJ:	MYCFIDRAFT_38502

FFU:	CLAFUR5_08805

BCOM:

BAUCODRAFT_71929

NPA:	UCRNP2_8449

TML:	GSTUM_00004878001

SPO:	SPAC26A3.17c

CNE:

CNA04170

CNB:

CNBA4000

CNG:	CNAG_00434

CGI:	CGB_A4280C

TMS:	TREMEDRAFT_73009

TASA:

A1Q1_00168

TVS:	TRAVEDRAFT_112907

DSQ:	DICSQDRAFT_99226

PCO:	PHACADRAFT_123415

SHS:	STEHIDRAFT_143419 STEHIDRAFT_163146 STEHIDRAFT_92135

HIR:	HETIRDRAFT_389401

FME:	FOMMEDRAFT_133950

GTR:	GLOTRDRAFT_38096

LBC:	LACBIDRAFT_256162

CCI:	CC1G_14139

ABP:	AGABI1DRAFT71703(AGABI1DRAFT_71703)

ABV:	AGABI2DRAFT204671(AGABI2DRAFT_204671)

PCUB:

JR316_0002347

MPR:	MPER_11317

MRR:	Moror_6340

E1B28_000552

SCM:	SCHCO_02634853(SCHCODRAFT_02634853)

CPUT:

CONPUDRAFT_121194

SLA:	SERLADRAFT_361134

WSE:	WALSEDRAFT_60904

WIC:	J056_001249

UMA:	UMAG_11334

PFP:	PFL1_04152

MGL:

MGL_2081

MRT:

MRET_1613

MSYM:

MSY001_1151

PGR:	PGTG_08661

MLR:	MELLADRAFT_46233 MELLADRAFT_74296

MBR:	MONBRDRAFT_33022

SRE:	PTSG_00809

SMIN:

v1.2.008584.t1(symbB.v1.2.008584.t1)

PTI:	PHATR_46736

FCY:	FRACYDRAFT_238326

EHX:	EMIHUDRAFT_246103 EMIHUDRAFT_68769

MRI:	Mal4_55900

» show all

Reference

1 [PMID:9873020]

Authors

Niewmierzycka A, Clarke S

Title

S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase.

Journal

J Biol Chem 274:814-24 (1999)
DOI:10.1074/jbc.274.2.814

Sequence

[sce:YDR465C]

Reference

2 [PMID:11856739]

Authors

Chern MK, Chang KN, Liu LF, Tam TC, Liu YC, Liang YL, Tam MF

Title

Yeast ribosomal protein L12 is a substrate of protein-arginine methyltransferase 2.

Journal

J Biol Chem 277:15345-53 (2002)
DOI:10.1074/jbc.M111379200

Sequence

[sce:YDR465C]

Reference

3 [PMID:17448464]

Authors

Olsson I, Berrez JM, Leipus A, Ostlund C, Mutvei A

Title

The arginine methyltransferase Rmt2 is enriched in the nucleus and co-purifies with the nuclear porins Nup49, Nup57 and Nup100.

Journal

Exp Cell Res 313:1778-89 (2007)
DOI:10.1016/j.yexcr.2007.03.007

Sequence

[sce:YDR465C]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.322

IUBMB Enzyme Nomenclature:

2.1.1.322

ExPASy - ENZYME nomenclature database:

2.1.1.322

BRENDA, the Enzyme Database:

2.1.1.322

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (3659)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (319)   
   KEGG MGENES (1883)   
   RefGene (1456)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (9)   
   RefSeq(nuc) (6)   
   GenBank (2)   
   EMBL (1)   
All databases (3679)   

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