KEGG ENZYME: 2.1.1.325

ENZYME: 2.1.1.325

Entry

EC 2.1.1.325                Enzyme

Name

juvenile hormone-III synthase;
farnesoic acid methyltransferase;
juvenile hormone acid methyltransferase;
JHAMT

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(2E,6E)-farnesoate O-methyltransferase

Reaction(IUBMB)

(1) S-adenosyl-L-methionine + (2E,6E)-farnesoate = S-adenosyl-L-homocysteine + methyl (2E,6E)-farnesoate [RN:R08147];
(2) S-adenosyl-L-methionine + juvenile hormone III acid = S-adenosyl-L-homocysteine + juvenile hormone III [RN:R08151]

Reaction(KEGG)

R08147 R08151

Substrate

S-adenosyl-L-methionine [CPD:C00019];
(2E,6E)-farnesoate [CPD:C16502];
juvenile hormone III acid [CPD:C16504]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
methyl (2E,6E)-farnesoate [CPD:C16503];
juvenile hormone III [CPD:C09694]

Comment

The enzyme, found in insects, is involved in the synthesis of juvenile hormone III, a sesquiterpenoid that regulates several processes including embryonic development, metamorphosis, and reproduction, in many insect species.

History

EC 2.1.1.325 created 2016

Pathway

ec00981

Insect hormone biosynthesis

ec01100

Metabolic pathways

Orthology

K10718

juvenile hormone-III synthase

K22546

juvenile hormone-III synthase

Genes

BFO:	118403346 118404249 118405827 118409862 118413724 118415847 118422267 118424899 118430371 118431045

BBEL:

109461876 109463814 109464997 109471513 109472219 109473276 109475220 109475223 109478059 109479879

APLC:

110973357 110973358

PFLL:

139114094 139114096 139114097

DME:	Dmel_CG17330(jhamt)

DER:

6547578

DSE:

6613700

DSI:	Dsimw501_GD29004(Dsim_GD29004)

DYA:	Dyak_GE13105

DAN:

6507586

DSR:

110181192

DPO:

4817490

DPE:

6589341

DMN:

108161394

DWI:

6643814

DGR:

6570211

DMO:	Dmoj_GI17257

DAZ:

108611017

DNV:

115563239

DHE:

111594183

DVI:	6627699(jhamt)

CCAT:

101449918

BOD:	106627512(jhamt)

BDR:	105227167 105228715 125779003 125779004

RZE:	108367705 108367706 108373159 108373160

AOQ:	129247957 129248183

ALUD:

128863497 128863733

TDA:

119690000

MDE:	101888075 101890875 101891045 101893410 101894087 101894256 101894420 101894582 101894744 131806466 131806468

SCAC:

106087697 106087705 106089772 106091417 106091418 106091419 106092534 106092535 106092536 106092538 106092539 106092541 106092542 131993985

LCQ:

111683712

LSQ:

119607319

CVJ:	135951149(jhamt)

GFS:	119633456 119633585

ECOE:

129952533 129952534

CLON:

129615502

HIS:

119660561

AGA:

1274971

ACOZ:

120949713

AARA:

120893690

AMER:

121592635

ASTE:

118512011

AMAP:

126562760

AFUN:

125768555

AMOU:

128301103

AMRS:

128714608

ANIL:

128727266

AALI:

118465745

ADAR:

125957538

ACOS:

131266987

AAG:

5567710

AALB:

109408242 115266576

ASUA:

134209549

CQU:	CpipJ_CPIJ009212 CpipJ_CPIJ010255

CPII:

120414046 120419319

CBRI:

134836971

CNS:	116339195 116344810

BCOO:

119066154 119069742 119070575 119073096 119074417 119075461 119075556 119077703 119077704 119077705 119078432 119078433 119078943 119079959 119082399 119084670 119085690

LLL:	129789109 129790055 129794561 129794562 129794564 129794565 129794566 129794568 129794819 129794820 129795078 129795080 129795208 129795209 129795210 129795238 129795311 129795312 129795314 129795315 129795318 129795364 129796221 129796379

PPAP:

129800950 129800951 129800959 129801953 129801954 129802203 129804159 129804160 129804161 129806051

AME:

724216

ACER:

108002008

ALAB:

122719902

ADR:

102676067

BIM:

100748241

BBIF:

117212320

BVK:

117238099

BVAN:

117164830

BHUN:

126867853

BTER:

100649865

BAFF:

126914420

BPYO:

122567209

BPAS:

132910067

FVI:

122533496

CCAL:

108623758

OBB:

114877883

OLG:

117601262

MGEN:

117226489

NMEA:

116432585

CGIG:

122396827

SOC:	105193367 105199041 105200209 105205338 105206645 120358771 120358774 120358775

MPHA:

105828179 105833532 105837575 118646735

AEC:	105151374 105152121 105152127 105153307 105153364

ACEP:

105621469 105621672 105625157 105626619 105627590 105627658

ACOC:

108690936

MZT:	108720279(jhamt)

CCOA:

108775587 108777669 108777721

TCZ:	108760258 108763547 108764262 108770526 108770593 108770609 108770610 108770771

TSEP:

108751728 108751729 108751773 108752536 108752939 108753445

PBAR:

105422775 105422776 105422778 105425356 105429868 105433151 105434285

VEM:	105558293 105561194 105562234 105562248 105564253 105567816 105567817 105567818 105567820 105567821

COBS:

139105633 139108641(Jhamt)

TLN:	139808817 139813686(Jhamt) 139814075 139814401 139816032 139823372

TAME:

143903752(Jhamt) 143905500

HST:	105181393 105181715 105182982 105184533 105189347 105191672 112588406 112589220 112589239 112590297

DQU:	106743026 106744811 106749293

CFO:	105248281 105248540 105248541 105251055 105251599 105255785 112638413 112639560 112639561 112639562 112639563

FEX:	115232724 115233248 115233249 115236573 115243141 115245379

PMEC:

138932510 138938521 138939295 138940799 138941218 138942390(Jhamt) 138944921 138944922 138944923 138944924 138944926

LHU:	105667283 105668024 105668035 105668037 105670117 105671800 105674928 105675116 105677695 105678373 136997928 136997929 137001909

PGC:	109852184 109852198 109854027 109858394

OBO:	105285433 105287635

PCF:

106792460

PFUC:

122522486

VPS:

122634682

VCRB:

124430253

VVE:

124954919

NVI:	100117819 100120870

CSOL:

105364772

TPRE:

106654322

LHT:

122503848

LBD:	127278430 127278575 127281566 127281567

MDL:

103579048

CGLO:

123273309

CTYP:

141529287(Jhamt)

FAS:	105262657 105264930 105264933 105270246 105270259 105272880 105272935 105272936

DAM:	107040171 107040183 107040192 107041842 107048436 114841320

AGIF:

122853948

CINS:

118073887

VCAN:

122405702

CCIN:

107268125

DSM:	124407460 124407783 124407784 124407785

NPT:	124215096 124215099 124215549 124215550 124215551

NFB:	124177189 124178718 124178719 124178950 124178951 124178952 124178953

NLO:	107222130 107222133 107226002 107226009 124293514 124293614 124293615 124293616 124293617 124293618 124293619 124293620 124293622

NVG:	124299668 124300578 124300579 124300960 124300961 124300962 124300963 124300964 124300966 124301038 124301040

AROA:

105684546 105689603 125499864 125499865

TCA:	100141982(Mt1) 100142187(Mt2) 662961(Tcjhamt)

TMOL:

138133051 138133052 138133053 138133094 138133102 138133103 138138330

DPA:

109537726

ESIM:

136408393(jhamt)

EFOR:

136343197(jhamt)

SOY:

115874597

RFG:	143204502(jhamt)

AGRG:

126739303

ATD:

109604639

CSET:

123309771 123310042 123310117 123310474 123311158 123311254 123311257 123312244

HAXR:

123676120 123677399 123679098 123684010 123684184 123684308

AGB:

108906149

LDC:	111502064 111506333 111507224 111509625 111509627 111512549

DVV:

114329939

NVL:	108559401 108560797 108565344 108565345 108565347 108565349 108565351 108565352

DCOR:

135792312

APLN:

108736655 112904348 112904877

PPYR:

116168523 116169778

OTU:

111417467

BMOR:

101738236 101742377 101742799 101743036 101745245 692445(Jhamt)

BMAN:

114243420 114245881 114246206 114246207 114246208 114246210 114253317

MSEX:

115440433 115440440 115440441 115440444 115440446 115440467 115444117 115450562 115453161 115453662 115453664 119190500 119193482

DPL:	KGM_214058

BANY:

112044720

MJU:

123869621

NIQ:

126771343

VCD:

124532142

MCIX:

123655603 123655660 123655783 123655784 123655926 123655927 123655928 123655937 123655953

PMAC:

106714896

PPOT:

106106522

PXU:

106127862

BPHI:

137932751(jhamt)

PRAP:

110992253 110992262 110992273 110992275 110992276 110992278 110992279

PBX:	123717107 123717108 123717109 123717111 123717113 123717115 123717498 123717525

PNAP:

125055329 125055330 125055331 125055333 125055334 125055335 125055336 125055337 125055338 125055340 125055647

ZCE:	119834441 119834642

CCRC:

123693756 123694050 123694080

LSIN:

126965398

AAGE:

121727046 121727341 121728998 121731966 121738412

HZE:	124630080 124630122

TNL:	113497459 113497729

SLIU:

111348094 111348095 111348096 111348097 111348433 111348434 111348544 111348620

OFU:

114365517

ONU:

135072611

ATRA:

106132343

GMW:

113512451

ECLR:

140749747(jhamt)

PXY:

105388451

PGW:	126368352 126368353 126372799

LGLY:

125224788 125224816 125224817 125224818 125226426 125230628

CSTB:

134742170 134743806 134755339

CFUM:

141427077 141432083

CFEL:

113366644 113368174

CCRN:

123292216 123295332 123296117 123298311

API:	100160278 100166857(Jhamt) 100569254

AGS:	114124070 114127483 114129169 126549821

RMD:	113552195 113553367 113554226 113554250 113558508

ACOO:

126846207

DVT:	126895645 126895646 126895647

BTAB:

109033068 109033069 109033378 109034261 109044195

DCI:

103523376

CLEC:

106669599 106672662

HHAL:

106677535 106682685 106685542(jhamt) 106690143 106691703 106691704 106692954

NLU:

111043495

LDA:	142326082(jhamt)

HVI:	124356647 124358885 124359377 124366423 124374939

MQU:	128984921 128988817 129002648

PHU:	Phum_PHUM350920

FOC:

113202626

TPAL:

117648235

ZNE:

110830587

CSEC:

111862089

PAME:

138694872 138694874 138694875 138694876 138694877 138694878 138694879 138694880 138694881 138694882 138694883 138694884 138694885 138695168 138695169

BROR:

134541844

IEL:

124157665

HAMR:

139698908(jhamt)

FCD:	110850800 110855402 110855472 110855473 110859094 110860133 110860510 110861942 110863480

DPX:	DAPPUDRAFT_300180

DMK:

116918952

DPZ:

124344050

AFRA:

136036483

PVM:	113819003(jhamt)

PJA:

122256220

PCHN:

125035439

PMOO:

119583897

HAME:

121874208

PCLA:

123766013(jhamt)

CQD:	128687087(jhamt)

PTRU:

123498947

ESN:

127003709

MNZ:

135213418

MRJ:

136825966

PORN:

139751090(jhamt)

HAZT:

108665431

OOT:	143029013(jhamt)

EAF:	111703382 111711802

TCF:

131887674

PPOI:

119093466

DALB:

135905471 139050750 139050844

RSAN:

119387218 119396312 125756190

VDE:	111244745 111253332

VJA:	111266430 111270802

CSCU:

111635987

CVS:

136976335

PTEP:

107436431 107441988

ABRU:

129983704

UDV:	129217179 129217353 129224020 129233489

SDM:	118190510 118192089

LPOL:

106464289 106470843 106474262

ATH:	AT3G44840 AT3G44860(FAMT) AT3G44870

ALY:

9313440

CRB:

17887228

CSAT:

104710958 104780338 104790740

EUS:	EUTSA_v10002598mg

BRP:

103837883

BNA:	106368677 106413711

BOE:

106310155

» show all

Reference

1 [PMID:14530389]

Authors

Shinoda T, Itoyama K

Title

Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis.

Journal

Proc Natl Acad Sci U S A 100:11986-91 (2003)
DOI:10.1073/pnas.2134232100

Sequence

[bmor:692445]

Reference

2 [PMID:21195763]

Authors

Defelipe LA, Dolghih E, Roitberg AE, Nouzova M, Mayoral JG, Noriega FG, Turjanski AG

Title

Juvenile hormone synthesis: "esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase.

Journal

Insect Biochem Mol Biol 41:228-35 (2011)
DOI:10.1016/j.ibmb.2010.12.008

Sequence

[aag:5567710]

Reference

3 [PMID:24657668]

Authors

Van Ekert E, Heylen K, Rouge P, Powell CA, Shatters RG Jr, Smagghe G, Borovsky D

Title

Aedes aegypti juvenile hormone acid methyl transferase, the ultimate enzyme in the biosynthetic pathway of juvenile hormone III, exhibits substrate control.

Journal

J Insect Physiol 64:62-73 (2014)
DOI:10.1016/j.jinsphys.2014.03.001

Sequence

[aag:5567710]

Reference

4 [PMID:25893162]

Authors

Van Ekert E, Shatters RG Jr, Rouge P, Powell CA, Smagghe G, Borovsky D

Title

Cloning and expressing a highly functional and substrate specific farnesoic acid o-methyltransferase from the Asian citrus psyllid (Diaphorina citri Kuwayama).

Journal

FEBS Open Bio 5:264-75 (2015)
DOI:10.1016/j.fob.2015.03.012

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.325

IUBMB Enzyme Nomenclature:

2.1.1.325

ExPASy - ENZYME nomenclature database:

2.1.1.325

BRENDA, the Enzyme Database:

2.1.1.325

All links

Gene (82)   
   RefGene (82)   
Protein sequence (49)   
   UniProt (45)   
   SWISS-PROT (3)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
All databases (134)   

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