KEGG   ENZYME: 2.1.1.325
Entry
EC 2.1.1.325                Enzyme                                 
Name
juvenile hormone-III synthase;
farnesoic acid methyltransferase;
juvenile hormone acid methyltransferase;
JHAMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(2E,6E)-farnesoate O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + (2E,6E)-farnesoate = S-adenosyl-L-homocysteine + methyl (2E,6E)-farnesoate [RN:R08147];
(2) S-adenosyl-L-methionine + juvenile hormone III acid = S-adenosyl-L-homocysteine + juvenile hormone III [RN:R08151]
Reaction(KEGG)
R08147 R08151
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(2E,6E)-farnesoate [CPD:C16502];
juvenile hormone III acid [CPD:C16504]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methyl (2E,6E)-farnesoate [CPD:C16503];
juvenile hormone III [CPD:C09694]
Comment
The enzyme, found in insects, is involved in the synthesis of juvenile hormone III, a sesquiterpenoid that regulates several processes including embryonic development, metamorphosis, and reproduction, in many insect species.
History
EC 2.1.1.325 created 2016
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K10718  juvenile hormone-III synthase
K22546  juvenile hormone-III synthase
Genes
BFO118403346 118404249 118405827 118409862 118413724 118415847 118422267 118424899 118430371 118431045
BBEL109461876 109463814 109464997 109471513 109472219 109473276 109475220 109475223 109477849 109478059 109479879 109485996
SPU105440269 105446656
APLC110973357 110973358 110975845 110989548
SKO102800802 102803287 102805153 102805273
DMEDmel_CG17330(jhamt)
DER6547578
DSE6613700
DSIDsimw501_GD29004(Dsim_GD29004)
DYADyak_GE13105
DAN6507586
DSR110181192
DPODpse_GA14462
DPE6589341
DMN108161394
DWI6643814
DGR6570211
DMODmoj_GI17257
DAZ108611017
DNV115563239
DHE111594183
DVI6627699
CCAT101449918
BOD106627512
MDE101888075 101890701 101890875 101891045 101893410 101893577 101893913 101894087 101894256 101894420 101894582 101894744
SCAC106081652 106087705 106089772 106091417 106091418 106091419 106092534 106092535 106092536 106092537 106092538 106092539 106092540 106092541 106092542 106094097
LCQ111683712
AGAAgaP_AGAP005256
ACOZ120949713
AARA120893690
AAG5567710
AALB109408242 115266576
CQUCpipJ_CPIJ009212 CpipJ_CPIJ010255
CPII120414046 120419319
CNS116339195 116344810
AME724216
ACER108002008
ALAB122719902
BIM100748241
BBIF117212320
BVK117238099
BVAN117164830
BTER100649865
BPYO122567209
CCAL108623758
OBB114877883
MGEN117226489
NMEA116432585
CGIG122396827
SOC105193367 105193898 105193899 105193929 105199041 105200209 105205338 105206645 113002660
MPHA105828179 105833532 105837575
AEC105151374 105152121 105152127 105153307 105153364
ACEP105621469 105621672 105625157 105626619 105627590 105627658
PBAR105422775 105422776 105422778 105425356 105429868 105433151 105434285
VEM105558293 105561194 105562234 105562248 105564253 105567816 105567817 105567818 105567820 105567821
HST105181393 105181715 105182982 105184533 105189347 105191672 112588406 112589220 112589239 112590297
DQU106743026 106744811 106749293
CFO105248281 105248540 105248541 105251055 105251599 105255785 112638413 112639560 112639561 112639562 112639563
FEX115232724 115233248 115233249 115236573 115243141 115245379
LHU105667283 105668024 105668035 105668037 105670117 105670118 105671800 105674928 105675116 105677695 105678373
PGC109852184 109852198 109854027 109858394
OBO105285433 105287635
PCF106792460
PFUC122522486
VPS122634682
NVI100117819 100120870
CSOL105364772
TPRE106654322
MDL103579048
CGLO123273309
FAS105262657 105264930 105264933 105270246 105270259 105272880 105272935 105272936
DAM107040171 107040183 107040192 107041842 107048436 114841320
AGIF122853948
CCIN107268125
TCA100141982(Mt1) 100142187(Mt2) 662961(Tcjhamt)
DPA109537726
SOY115874597
ATD109604639 109607963
CSET123309771 123310042 123310117 123310474 123311158 123311254 123311257 123312244
AGB108906149
LDC111502064 111502586 111502587 111506333 111506436 111507224 111509625 111509626 111509627 111509629 111512300 111512549 111513768 111516397 111516398 111516426 111516427
NVL108559401 108560797 108565344 108565345 108565347 108565349 108565351 108565352
APLN108736655 112904348 112904877
PPYR116159431 116160142 116161043 116161044 116161045 116161428 116161499 116161715 116162178 116162183 116162303 116164366 116164693 116164812 116166824 116168523 116169042 116169778 116172599 116172617 116173043 116173365 116173367 116174292 116174442 116174651 116174953 116175217 116176319 116177014 116177063 116177404 116177405 116177780 116177823 116179008 116179645 116179687 116180447 116181280 116181305 116181610 116181611 116182940
OTU111413176 111415244 111415253 111415254 111415261 111415726 111415740 111415741 111417467 111419251 111419253 111419254 111419255 111419256 111419258 111419259 111419260 111422332 111422521 111424067 111424192 111424193 111424222 111424237 111424238 111424239
BMOR101738236 101742377 101742799 101743036 101745245 101745533 692445(Jhamt)
BMAN114243420 114245881 114246206 114246207 114246208 114246210 114253317
MSEX115440433 115440440 115440441 115440444 115440446 115440467 115444117 115450562 115453161 115453662 115453664 119190500 119193482
DPLKGM_214058
BANY112044720
PMAC106714896
PPOT106106522
PXU106127862
PRAP110992253 110992262 110992273 110992275 110992276 110992278 110992279
ZCE119834441 119834642
HAW110370758 110370759
TNL113497459 113497729
OFU114365517
PXY105388451
API100160278 100166857(Jhamt) 100569254 100572117
AGS114124070 114127477 114127483 114129169
RMD113552195 113553367 113554226 113554250 113558508
BTAB109033068 109033069 109033378 109034261 109044195
DCI103523376
CLEC106669599 106672662
HHAL106677535 106682685 106685542 106690143 106691703 106691704 106692954
NLU111043495
PHUPhum_PHUM350920
FOC113202626
ZNE110830587
CSEC111862089
FCD110850800 110855402 110855472 110855473 110859094 110860133 110860510 110861942 110863480
DPXDAPPUDRAFT_300180
DMK116918952
PVM113819003
PJA122256220
HAME121874208
PCLA123766013
PTRU123498947
HAZT108665431
EAF111703382 111711802
ISCIscW_ISCW000153 IscW_ISCW000579 IscW_ISCW000581 IscW_ISCW002306 IscW_ISCW002935 IscW_ISCW003340 IscW_ISCW004808 IscW_ISCW005290 IscW_ISCW005302 IscW_ISCW005399 IscW_ISCW005831 IscW_ISCW006025 IscW_ISCW006197 IscW_ISCW006201 IscW_ISCW006304 IscW_ISCW006899 IscW_ISCW006924 IscW_ISCW007368 IscW_ISCW007369 IscW_ISCW008032 IscW_ISCW008748 IscW_ISCW010473 IscW_ISCW011169 IscW_ISCW012621 IscW_ISCW013074 IscW_ISCW013675 IscW_ISCW014084 IscW_ISCW017567 IscW_ISCW018807 IscW_ISCW018808 IscW_ISCW019053 IscW_ISCW019728 IscW_ISCW021492 IscW_ISCW023837
DSV119435037 119435434 119435977 119440113 119440163 119440457 119441134 119442330 119443867 119445465 119445466 119449641 119452815 119452840 119452958 119452959 119454388 119455211 119455212 119455610 119456320 119457001 119457023 119457095 119461732 119462130 119462389 119462462 119462467 119463662 119463706 119463707 119463708 119463713 119463793 119463822 119463825 119463828 119463844 119464830 119464831 119464894 119464895 119464964 119464985 119465356
RSAN119373644 119377094 119377193 119377311 119378528 119378546 119381263 119381827 119381829 119382484 119385775 119385778 119385833 119386516 119387218 119391939 119392800 119393171 119393954 119394591 119394593 119394805 119394806 119396312 119397895 119398535 119398536 119398537 119398538 119398540 119398822 119398823 119398825 119398826 119398827 119399176 119399195 119399196 119399197 119399440 119399558 119400298 119400302 119400355 119400649 119400677 119400745 119400746 119400776 119400994 119401435 119401436 119401437 119401834 119402505 119402655 119402656 119403202 119403228 119403302 119403303 119403304 119403609 119404668 119405334
RMP119159580 119163125 119164228 119164360 119164361 119164566 119165199 119165725 119165758 119165803 119166729 119167765 119171606 119174122 119174151 119174540 119177721 119178505 119178628 119179033 119179035 119179118 119179345 119179748 119179783 119180005 119180128 119182403 119183813 119183814 119185270 119185616 119187490
VDE111244745 111253332
VJA111266430 111270802
TUT107364690 107365451 107368442
DFR124492175
CSCU111613501 111613503 111614263 111620237 111620246 111625423 111629721 111629724 111629733 111629754 111631670 111631671 111633888 111633900 111635987 111639267 111639268
PTEP107436431 107441988
SDM118186142 118190510 118192089
PMAX117340718
LAK106153710
ATHAT3G44840 AT3G44860(FAMT) AT3G44870
ALY9313440
CRB17887228
CSAT104710958 104780338 104790740
EUSEUTSA_v10002598mg
BRP103837883
BNA106368677 106413711
BOE106310155
APUUAPUU_40477A
LHALHA_0531
LADLNCTC12735_00117
 » show all
Reference
1  [PMID:14530389]
  Authors
Shinoda T, Itoyama K
  Title
Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis.
  Journal
Proc Natl Acad Sci U S A 100:11986-91 (2003)
DOI:10.1073/pnas.2134232100
  Sequence
[bmor:692445]
Reference
2  [PMID:21195763]
  Authors
Defelipe LA, Dolghih E, Roitberg AE, Nouzova M, Mayoral JG, Noriega FG, Turjanski AG
  Title
Juvenile hormone synthesis: "esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase.
  Journal
Insect Biochem Mol Biol 41:228-35 (2011)
DOI:10.1016/j.ibmb.2010.12.008
  Sequence
[aag:5567710]
Reference
3  [PMID:24657668]
  Authors
Van Ekert E, Heylen K, Rouge P, Powell CA, Shatters RG Jr, Smagghe G, Borovsky D
  Title
Aedes aegypti juvenile hormone acid methyl transferase, the ultimate enzyme in the biosynthetic pathway of juvenile hormone III, exhibits substrate control.
  Journal
J Insect Physiol 64:62-73 (2014)
DOI:10.1016/j.jinsphys.2014.03.001
  Sequence
[aag:5567710]
Reference
4  [PMID:25893162]
  Authors
Van Ekert E, Shatters RG Jr, Rouge P, Powell CA, Smagghe G, Borovsky D
  Title
Cloning and expressing a highly functional and substrate specific farnesoic acid  o-methyltransferase from the Asian citrus psyllid (Diaphorina citri Kuwayama).
  Journal
FEBS Open Bio 5:264-75 (2015)
DOI:10.1016/j.fob.2015.03.012
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.325
IUBMB Enzyme Nomenclature: 2.1.1.325
ExPASy - ENZYME nomenclature database: 2.1.1.325
BRENDA, the Enzyme Database: 2.1.1.325

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