KEGG ENZYME: 2.1.1.325

ENZYME: 2.1.1.325

Entry

EC 2.1.1.325                Enzyme

Name

juvenile hormone-III synthase;
farnesoic acid methyltransferase;
juvenile hormone acid methyltransferase;
JHAMT

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(2E,6E)-farnesoate O-methyltransferase

Reaction(IUBMB)

(1) S-adenosyl-L-methionine + (2E,6E)-farnesoate = S-adenosyl-L-homocysteine + methyl (2E,6E)-farnesoate [RN:R08147];
(2) S-adenosyl-L-methionine + juvenile hormone III acid = S-adenosyl-L-homocysteine + juvenile hormone III [RN:R08151]

Reaction(KEGG)

R08147 R08151

Substrate

S-adenosyl-L-methionine [CPD:C00019];
(2E,6E)-farnesoate [CPD:C16502];
juvenile hormone III acid [CPD:C16504]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
methyl (2E,6E)-farnesoate [CPD:C16503];
juvenile hormone III [CPD:C09694]

Comment

The enzyme, found in insects, is involved in the synthesis of juvenile hormone III, a sesquiterpenoid that regulates several processes including embryonic development, metamorphosis, and reproduction, in many insect species.

History

EC 2.1.1.325 created 2016

Pathway

ec00981

Insect hormone biosynthesis

Orthology

K10718

juvenile hormone-III synthase

K22546

juvenile hormone-III synthase

Genes

BFO:	118403346 118404249 118405827 118409862 118413724 118415847 118422267 118424899 118430371 118431045

BBEL:

109461876 109463814 109464997 109471513 109472219 109473276 109475220 109475223 109477849 109478059 109479879 109485996

SPU:	105440269 105446656

APLC:

110973357 110973358 110975845 110989548

SKO:	102800802 102803287 102805153 102805273

DME:	Dmel_CG17330(jhamt)

DER:

6547578

DSE:

6613700

DSI:	Dsimw501_GD29004(Dsim_GD29004)

DYA:	Dyak_GE13105

DAN:

6507586

DSR:

110181192

DPO:

4817490

DPE:

6589341

DMN:

108161394

DWI:

6643814

DGR:

6570211

DMO:	Dmoj_GI17257

DAZ:

108611017

DNV:

115563239

DHE:

111594183

DVI:

6627699

CCAT:

101449918

BOD:

106627512

RZE:	108367705 108367706 108373159 108373160

TDA:

119690000

MDE:	101888075 101890875 101891045 101893410 101894087 101894256 101894420 101894582 101894744 131806466 131806468

SCAC:

106081652 106087705 106089772 106091417 106091418 106091419 106092534 106092535 106092536 106092537 106092538 106092539 106092540 106092541 106092542 106094097

LCQ:

111683712

LSQ:

119607319

ECOE:

129952533 129952534

HIS:

119660561

AGA:	AgaP_AGAP005256

ACOZ:

120949713

AARA:

120893690

AMER:

121592635

ASTE:

118512011

AFUN:

125768555

AALI:

118465745

AAG:

5567710

AALB:

109408242 115266576

CQU:	CpipJ_CPIJ009212 CpipJ_CPIJ010255

CPII:

120414046 120419319

CNS:	116339195 116344810

BCOO:

119066154 119069742 119070575 119073096 119074417 119075461 119075556 119077703 119077704 119077705 119078432 119078433 119078943 119079959 119082399 119084670 119085690

AME:

724216

ACER:

108002008

ALAB:

122719902

ADR:

102676067

BIM:

100748241

BBIF:

117212320

BVK:

117238099

BVAN:

117164830

BTER:

100649865

BAFF:

126914420

BPYO:

122567209

FVI:

122533496

CCAL:

108623758

OBB:

114877883

MGEN:

117226489

NMEA:

116432585

CGIG:

122396827

SOC:	105193367 105199041 105200209 105205338 105206645 120358771 120358774 120358775

MPHA:

105828179 105833532 105837575

AEC:	105151374 105152121 105152127 105153307 105153364

ACEP:

105621469 105621672 105625157 105626619 105627590 105627658

PBAR:

105422775 105422776 105422778 105425356 105429868 105433151 105434285

VEM:	105558293 105561194 105562234 105562248 105564253 105567816 105567817 105567818 105567820 105567821

HST:	105181393 105181715 105182982 105184533 105189347 105191672 112588406 112589220 112589239 112590297

DQU:	106743026 106744811 106749293

CFO:	105248281 105248540 105248541 105251055 105251599 105255785 112638413 112639560 112639561 112639562 112639563

FEX:	115232724 115233248 115233249 115236573 115243141 115245379

LHU:	105667283 105668024 105668035 105668037 105670117 105670118 105671800 105674928 105675116 105677695 105678373

PGC:	109852184 109852198 109854027 109858394

OBO:	105285433 105287635

PCF:

106792460

PFUC:

122522486

VPS:

122634682

VCRB:

124430253

NVI:	100117819 100120870

CSOL:

105364772

TPRE:

106654322

LHT:

122503848

LBD:	127278430 127278575 127281566 127281567

MDL:

103579048

CGLO:

123273309

FAS:	105262657 105264930 105264933 105270246 105270259 105272880 105272935 105272936

DAM:	107040171 107040183 107040192 107041842 107048436 114841320

AGIF:

122853948

VCAN:

122405702

CCIN:

107268125

DSM:	124407460 124407783 124407784 124407785

NPT:	124215096 124215099 124215549 124215550 124215551

NFB:	124177189 124178718 124178719 124178950 124178951 124178952 124178953

NLO:	107222130 107222133 107226002 107226009 124293514 124293614 124293615 124293616 124293617 124293618 124293619 124293620 124293622

NVG:	124299668 124300578 124300579 124300960 124300961 124300962 124300963 124300964 124300966 124301038 124301040

TCA:	100141982(Mt1) 100142187(Mt2) 662961(Tcjhamt)

DPA:

109537726

SOY:

115874597

AGRG:

126739303

ATD:

109604639

CSET:

123309771 123310042 123310117 123310474 123311158 123311254 123311257 123312244

AGB:

108906149

LDC:	111502064 111502586 111502587 111506333 111506436 111507224 111509625 111509626 111509627 111509629 111512300 111512549 111513768 111516397 111516398 111516426 111516427

NVL:	108559401 108560797 108565344 108565345 108565347 108565349 108565351 108565352

APLN:

108736655 112904348 112904877

PPYR:

116159431 116160142 116161043 116161044 116161045 116161428 116161499 116161715 116162178 116162183 116162303 116164366 116164693 116164812 116166824 116168523 116169042 116169778 116172599 116172617 116173043 116173365 116173367 116174292 116174442 116174651 116174953 116175217 116176319 116177014 116177063 116177404 116177405 116177780 116177823 116179008 116179645 116179687 116180447 116181280 116181305 116181610 116181611 116182940

OTU:	111413176 111415244 111415253 111415254 111415261 111415726 111415740 111415741 111417467 111419251 111419253 111419254 111419255 111419256 111419258 111419259 111419260 111422332 111422521 111424067 111424192 111424193 111424222 111424237 111424238 111424239

BMOR:

101738236 101742377 101742799 101743036 101745245 101745533 692445(Jhamt)

BMAN:

114243420 114245881 114246206 114246207 114246208 114246210 114253317

MSEX:

115440433 115440440 115440441 115440444 115440446 115440467 115444117 115450562 115453161 115453662 115453664 119190500 119193482

DPL:	KGM_214058

BANY:

112044720

MJU:

123869621

NIQ:

126771343

VCD:

124532142

MCIX:

123655603 123655660 123655783 123655784 123655926 123655927 123655928 123655937 123655953

PMAC:

106714896

PPOT:

106106522

PXU:

106127862

PRAP:

110992253 110992262 110992273 110992275 110992276 110992278 110992279

PBX:	123717107 123717108 123717109 123717111 123717113 123717115 123717498 123717525

PNAP:

125055329 125055330 125055331 125055333 125055334 125055335 125055336 125055337 125055338 125055340 125055647

ZCE:	119834441 119834642

CCRC:

123693756 123694050 123694080

LSIN:

126965398

HAW:	110370758 110370759

HZE:	124630080 124630122

TNL:	113497459 113497729

SLIU:

111348094 111348095 111348096 111348097 111348433 111348434 111348544 111348620

OFU:

114365517

PXY:

105388451

PGW:	126368352 126368353 126372799

CFEL:

113366644 113368174

CCRN:

123292216 123295332 123296117 123298311

API:	100160278 100166857(Jhamt) 100569254 100572117

AGS:	114124070 114127477 114127483 114129169

RMD:	113552195 113553367 113554226 113554250 113558508

ACOO:

126846207

BTAB:

109033068 109033069 109033378 109034261 109044195

DCI:

103523376

CLEC:

106669599 106672662

HHAL:

106677535 106682685 106685542 106690143 106691703 106691704 106692954

NLU:

111043495

HVI:	124356647 124358885 124359377 124366423 124374939

PHU:	Phum_PHUM350920

FOC:

113202626

TPAL:

117648235

ZNE:

110830587

CSEC:

111862089

IEL:

124157665

FCD:	110850800 110855402 110855472 110855473 110859094 110860133 110860510 110861942 110863480

DPX:	DAPPUDRAFT_300180

DMK:

116918952

DPZ:

124344050

PVM:

113819003

PJA:

122256220

PCHN:

125035439

PMOO:

119583897

HAME:

121874208

PCLA:

123766013

CQD:

128687087

PTRU:

123498947

ESN:

127003709

HAZT:

108665431

EAF:	111703382 111711802

PPOI:

119093466

DSV:

119435037 119435434 119435977 119440113 119440163 119441134 119442330 119443867 119445466 119449641 119452815 119452840 119452958 119452959 119454388 119455211 119455212 119455610 119456320 119457023 119457095 119461732 119462130 119462389 119462462 119462467 119463662 119463706 119463708 119463713 119463822 119463825 119463828 119463844 119464830 119464831 119464894 119464895 119464964 119464985 119465356

RSAN:

119373644 119377094 119377193 119377311 119378528 119378546 119381263 119381827 119381829 119382484 119385775 119385778 119385833 119386516 119387218 119391939 119392800 119393171 119393954 119394591 119394593 119394805 119396312 119398536 119398537 119398538 119398540 119398822 119398826 119399195 119399196 119399440 119399558 119400298 119400302 119400355 119400649 119400677 119400745 119400746 119400776 119400994 119401435 119401436 119401437 119401834 119402505 119402655 119402656 119403202 119403228 119403302 119403304 119403609 119404668 119405334 125756190

RMP:

119159580 119163125 119164228 119164360 119164361 119164566 119165199 119165725 119165758 119165803 119166729 119167765 119171606 119174122 119174151 119174540 119177721 119178505 119178628 119179033 119179035 119179118 119179345 119179748 119179783 119180005 119180128 119182403 119183813 119183814 119185270 119185616 119187490

VDE:	111244745 111253332

VJA:	111266430 111270802

TUT:	107364690 107365451 107368442

DPTE:

113788597

DFR:

124492175

CSCU:

111613501 111613503 111614263 111620237 111620246 111625423 111629721 111629724 111629733 111629754 111631670 111631671 111633888 111633900 111635987 111639267 111639268

PTEP:

107436431 107441988

UDV:	129217179 129217353 129223421 129224020 129233489

SDM:	118186142 118190510 118192089

LPOL:

106464289 106470843 106474262

PMAX:

117340718

LAK:

106153710

ATH:	AT3G44840 AT3G44860(FAMT) AT3G44870

ALY:

9313440

CRB:

17887228

CSAT:

104710958 104780338 104790740

EUS:	EUTSA_v10002598mg

BRP:

103837883

BNA:	106368677 106413711

BOE:

106310155

LHA:

LHA_0531

LADL:

NCTC12735_00117

» show all

Reference

1 [PMID:14530389]

Authors

Shinoda T, Itoyama K

Title

Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis.

Journal

Proc Natl Acad Sci U S A 100:11986-91 (2003)
DOI:10.1073/pnas.2134232100

Sequence

[bmor:692445]

Reference

2 [PMID:21195763]

Authors

Defelipe LA, Dolghih E, Roitberg AE, Nouzova M, Mayoral JG, Noriega FG, Turjanski AG

Title

Juvenile hormone synthesis: "esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase.

Journal

Insect Biochem Mol Biol 41:228-35 (2011)
DOI:10.1016/j.ibmb.2010.12.008

Sequence

[aag:5567710]

Reference

3 [PMID:24657668]

Authors

Van Ekert E, Heylen K, Rouge P, Powell CA, Shatters RG Jr, Smagghe G, Borovsky D

Title

Aedes aegypti juvenile hormone acid methyl transferase, the ultimate enzyme in the biosynthetic pathway of juvenile hormone III, exhibits substrate control.

Journal

J Insect Physiol 64:62-73 (2014)
DOI:10.1016/j.jinsphys.2014.03.001

Sequence

[aag:5567710]

Reference

4 [PMID:25893162]

Authors

Van Ekert E, Shatters RG Jr, Rouge P, Powell CA, Smagghe G, Borovsky D

Title

Cloning and expressing a highly functional and substrate specific farnesoic acid o-methyltransferase from the Asian citrus psyllid (Diaphorina citri Kuwayama).

Journal

FEBS Open Bio 5:264-75 (2015)
DOI:10.1016/j.fob.2015.03.012

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.325

IUBMB Enzyme Nomenclature:

2.1.1.325

ExPASy - ENZYME nomenclature database:

2.1.1.325

BRENDA, the Enzyme Database:

2.1.1.325

DBGET integrated database retrieval system