KEGG   ENZYME: 2.1.1.328
Entry
EC 2.1.1.328                Enzyme                                 
Name
N-demethylindolmycin N-methyltransferase;
ind7 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:N-demethylindolmycin N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + N-demethylindolmycin = S-adenosyl-L-homocysteine + indolmycin [RN:R11534]
Reaction(KEGG)
R11534
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N-demethylindolmycin [CPD:C21443]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
indolmycin [CPD:C21444]
Comment
The enzyme, characterized from the bacterium Streptomyces griseus, catalyses the ultimate reaction in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2).
History
EC 2.1.1.328 created 2016
Orthology
K21282  N-demethylindolmycin N-methyltransferase
Genes
PLZ: S4054249_18855
Reference
1  [PMID:25730866]
  Authors
Du YL, Alkhalaf LM, Ryan KS
  Title
In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
  Journal
Proc Natl Acad Sci U S A 112:2717-22 (2015)
DOI:10.1073/pnas.1419964112
  Sequence
[ag:AJT38688]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.328
IUBMB Enzyme Nomenclature: 2.1.1.328
ExPASy - ENZYME nomenclature database: 2.1.1.328
BRENDA, the Enzyme Database: 2.1.1.328

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (8)   
   GenBank (4)   
   EMBL (4)   
Protein domain (2)   
   InterPro (2)   
All databases (21)   

Download RDF
DBGET integrated database retrieval system