KEGG   ENZYME: 2.1.1.329
Entry
EC 2.1.1.329                Enzyme                                 
Name
demethylphylloquinol methyltransferase;
menG (gene name);
2-phytyl-1,4-naphthoquinol methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinol C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + demethylphylloquinol = S-adenosyl-L-homocysteine + phylloquinol [RN:R04994]
Reaction(KEGG)
R04994
Substrate
S-adenosyl-L-methionine [CPD:C00019];
demethylphylloquinol [CPD:C21084]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
phylloquinol [CPD:C03313]
Comment
The enzyme, found in plants and cyanobacteria, catalyses the final step in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is specific for the quinol form of the substrate, and does not act on the quinone form [3].
History
EC 2.1.1.329 created 2016
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23095  demethylphylloquinol methyltransferase
Genes
ATHAT1G23360(MENG)
ALY9329343
CRB17899545
CSAT104741051 104756704 104776464
EUSEUTSA_v10008293mg
BRP103835666
BNA106411915 125577144
BOE106309873
RSZ108818956 108820890
THJ104822157
CPAP110813133
CIT102628556
CICCICLE_v10032509mg
PVY116108078 116135475
MINC123214645
TCC18609512
GRA105785795
GHI107917047 107921369
GAB108466502
HSYR120134153 120145045
DZI111282120 111287271
EGR104414166
GMX100789470 100789973
GSJ114380496 114409703
PVUPHAVU_002G064000g
VRA106776995
VAR108335286
VUN114173432
VUM124846184
CCAJ109801011
APRC113869602
MTR11409460
TPRA123906871
CAM101512362
PSAT127119279
VVO131650706
LJALj2g3v1415220.1(Lj2g3v1415220.1)
ADU107488778 107488807
AIP107643333
AHF112749985 112801120 112801152
LANG109333461
PCIN129310359 129310868 129311291
FVE101294364 101304776
RCN112197869
PPER18791522
PMUM103321798
PAVI110748068
PDUL117612274
MDM103403043 103452001
MSYL126607968
ZJU107428577 125420330
MNT21410343
CSAV115712800
CSV101208642
CMO103487713
BHJ120075676
MCHA111004744
CMAX111496525
CMOS111454302 111462490
CPEP111798157 111805142
RCU8273511
JCU105644633
HBR110631646 110673679
MESC110628266 110629107
POP7473219
PEU105132353
PALZ118037864
JRE109020896
CILL122313616
CAVE132178582
QSU112010981 112023562 112032331
QLO115982511 115982514
TWL120007078
VVI100246556 100256830
VRI117908152 117908250
SLY101263675
SPEN107005385
SOT102585507
SSTN125862708
SDUL129871344
CANN107863754
LBB132636106
NTA107824549 107827350
NSY104211136
NTO104101649
NAU109226748
INI109157980
ITR115998674
SIND105156625 105168283 105168658
OEU111403390
EGT105974760
SSPL121753652 121759440 121768441 121772259
SMIL131025306
APAN127260867 127261743
HAN110895055
ECAD122609095
LSV111902019
CCAV112524684
DCR108225269
CSIN114313633
RVL131310220
AEW130771267 130792338
BVG104908393
SOE110785625
CQI110694202 110709155
ATRI130820445
MOF131145064
NNU104593146
MING122076580 122079414
TSS122655970 122670900
PSOM113274264 113279492
OSA9270356
DOSAOs04t0507800-01(Os04g0507800)
OBR102704055
OGL127770111
BDI100831799 100836089
ATS109735764
TDC119355693 119358004 119368011
TAES123045984 123053859 123189733 123189751
TUA125529072 125537429 125538988
LPER127335522
LRD124677522
SBI8075905
ZMA100384459
SITA101763323
SVS117863501
PVIR120642531 120681463
PHAI112900296
PDA103703803 120107556
EGU105035064
MUS103978194
ZOF122010220 122017803
DCT110110820
PEQ110028315
AOF109828899
MSIN131237856
NCOL116248965
ATR105420369 105420370
SMOSELMODRAFT_141944 SELMODRAFT_96041
PPP112282043
CRECHLRE_02g084300v5
VCNVOLCADRAFT_75878
MNGMNEG_1473
CSLCOCSUDRAFT_11335
CVRCHLNCDRAFT_48897
APROF751_2917
OLUOSTLU_12765
OTAOT_ostta07g04500
BPGBathy17g02190
MISMICPUN_56113
MPPMICPUCDRAFT_6421(JGI:MicpuC2_6421)
SYNsll1653(gerCb)
SYZMYO_12590(gerCb)
SYYSYNGTS_0257(menG)
SYTSYNGTI_0257(menG)
SYSSYNPCCN_0257(menG)
SYQSYNPCCP_0257(menG)
SYJD082_05490(menG)
SYOC7I86_01340
SYCsyc0450_d(ubiE)
SYUM744_11170
SYFSynpcc7942_1099
SYDSyncc9605_0809
SYESyncc9902_1570
SYGsync_0700(ubiE)
SYRSynRCC307_0581(ubiE)
SYXSynWH7803_1772(ubiE)
CYACYA_2236(ubiE)
CYBCYB_0364(ubiE)
SYNESyn6312_1947
SYNPSyn7502_00638
SYNKKR100_12025
SYNRKR49_13190
SYNDKR52_12890
SYHSyncc8109_1901
SYNWSynWH8103_01905(MENG)
SYNCCB0101_13770(ubiE)
SYNYBM449_03640
DSLDacsa_2146
SYWSYNW1674
CGCCyagr_1377
CYICBM981_1477(ubiE)
PMAPro_0427(ubiE_menG)
PMMPMM0431
PMTPMT_0275 PMT_0276
PMNPMN2A_1762
PMIPMT9312_0430
PMBA9601_04861(ubiE)
PMCP9515_04931(ubiE)
PMFP9303_20621(ubiE)
PMGP9301_04551(ubiE)
PMHP9215_05101(ubiE)
PMJP9211_04271(ubiE)
PMENATL1_04841(ubiE)
PRCEW14_0473
PRMEW15_0514
WNAKA717_29640(ubiE)
CMPCha6605_5136
CYNCyan7425_2785
CEPCri9333_3867
TVNNIES2134_103300
SLWBRW62_11985
AMRAM1_3823(ubiE)
ACAMHRE53_15880(ubiE)
TELtll2373
THNNK55_08730(menG)
THECFFX45_06660(ubiE)
TSZOOK60_11470(ubiE)
LENLEP3755_33110
LETO77CONTIG1_02831(ubiE_3)
LBOLBWT_24850
KOVK9N68_18360(ubiE)
LSCKIK02_00470(ubiE)
LSKJ5X98_01315(ubiE)
HHGXM38_011590
PSEUPse7367_1658
PSERABRG53_2868(ubiE)
PGXOA858_19455(ubiE)
THEUHPC62_16825(ubiE)
TOGHNI00_00150(ubiE)
TSINOXH18_19465(ubiE)
GLPGlo7428_1593
CHONNIES4102_28550
GDUP0S91_18060(ubiE)
GENGM3709_1554
GEEGM3708_3178
CANCyan10605_0543
CSNCyast_2552
CYLAA637_02565(menG)
SYPSYNPCC7002_A1100(menG)
SYVAWQ23_05660
SYLAWQ21_05650
LEPLepto7376_4061
MARMAE_37840(ubiE)
MPKVL20_5484
MIQB5D77_02000
MVZmyaer102_12660(ubiE)
HAOPCC7418_0313
ENNFRE64_10265(ubiE)
CYUUCYN_00120
CYTcce_2570(ubiE)
CWACwatDRAFT_4679
CYPPCC8801_2496
CYHCyan8802_3610
CYCPCC7424_0747
CYJCyan7822_5318
TERTery_3972
ARPNIES39_K03190
PAGHNIES204_15890
PPSUNO713_03669(menG)
PRUNPCC7821_01850(menG)
OXYHCG48_04760(ubiE)
MVAGD0A34_25885(ubiE)
LFSHFV01_01615(ubiE)
OACOscil6304_0831
ONIOsc7112_5572
PHORJWS08_21540(ubiE)
PYHNEA10_10385(ubiE)
MICMic7113_0668
GEIGEI7407_0380
GVIgll0127(menG)
GLJGKIL_3721(ubiE)
GMLISF26_07390(ubiE)
ANAalr5252
NPUNpun_R4434
NOSNos7107_2553
NOPNos7524_3345
NONNOS3756_08110(ubiE)
NFLCOO91_03075
NOECLI64_12695
NSHGXM_03248
NEDHUN01_23220(ubiE)
AVAAva_1422
NAZAazo_4318
ANBANA_C12287
ACYAnacy_5065
AWAAA650_24965
ANNEH233_26810
CSGCylst_6194
RSINB6N60_03154
HBQQI031_13370(ubiE)
CALOCal7507_4755
CALTCal6303_3738
CALHIJ00_11885
CALNNIES2098_70430(ubiE)
CALSNIES3974_25770(ubiE)
RIVRiv7116_5407
FISFIS3754_46880
NSPBMF81_01745(ubiE)
NSPHBDGGKGIB_02443(menG_2)
DOUBMF77_00341(menG_1)
DFSHGD76_16465(ubiE)
DHTNG743_10885(ubiE)
CCURIAR63_05630(ubiE)
CRKL3I90_06125(ubiE)
AFLOHEQ12_03675(ubiE)
TOQHCG51_17670(ubiE)
NCNBZZ01_18990
CTHEChro_1764
PLPPle7327_3669
SCSSta7437_4306
STANSTA3757_37130
GCYLQF76_00950(ubiE)
 » show all
Reference
1  [PMID:11772039]
  Authors
Sakuragi Y, Zybailov B, Shen G, Jones AD, Chitnis PR, van der Est A, Bittl R, Zech S, Stehlik D, Golbeck JH, Bryant DA
  Title
Insertional inactivation of the menG gene, encoding 2-phytyl-1,4-naphthoquinone methyltransferase of Synechocystis sp. PCC 6803, results in the incorporation of  2-phytyl-1,4-naphthoquinone into the A(1) site and alteration of the equilibrium  constant between A(1) and F(X) in photosystem I.
  Journal
Biochemistry 41:394-405 (2002)
DOI:10.1021/bi011297w
  Sequence
[syn:sll1653]
Reference
2  [PMID:17082184]
  Authors
Lohmann A, Schottler MA, Brehelin C, Kessler F, Bock R, Cahoon EB, Dormann P
  Title
Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.
  Journal
J Biol Chem 281:40461-72 (2006)
DOI:10.1074/jbc.M609412200
  Sequence
[ath:AT1G23360]
Reference
3  [PMID:26023160]
  Authors
Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ
  Title
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.
  Journal
Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103
  Sequence
[ath:AT1G23360] [syn:sll1653]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.329
IUBMB Enzyme Nomenclature: 2.1.1.329
ExPASy - ENZYME nomenclature database: 2.1.1.329
BRENDA, the Enzyme Database: 2.1.1.329

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