KEGG   ENZYME: 2.1.1.329
Entry
EC 2.1.1.329                Enzyme                                 

Name
demethylphylloquinol methyltransferase;
menG (gene name);
2-phytyl-1,4-naphthoquinol methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinol C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + demethylphylloquinol = S-adenosyl-L-homocysteine + phylloquinol [RN:R04994]
Reaction(KEGG)
R04994
Substrate
S-adenosyl-L-methionine [CPD:C00019];
demethylphylloquinol [CPD:C21084]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
phylloquinol [CPD:C03313]
Comment
The enzyme, found in plants and cyanobacteria, catalyses the final step in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is specific for the quinol form of the substrate, and does not act on the quinone form [3].
History
EC 2.1.1.329 created 2016
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23095  demethylphylloquinol methyltransferase
Genes
ATH: AT1G23360(MENG)
ALY: 9329343
CRB: 17899545
CSAT: 104741051 104756704 104776464
EUS: EUTSA_v10008293mg
BRP: 103835666
BNA: 106411915 106434207
BOE: 106309873
RSZ: 108818956 108820890
THJ: 104822157
CPAP: 110813133
CIT: 102628556
MINC: 123214645
TCC: 18609512
GRA: 105785795
GAB: 108466502
EGR: 104414166
VRA: 106776995
VAR: 108335286
VUN: 114173432
CCAJ: 109801011
APRC: 113869602
CAM: 101512362
LJA: Lj2g3v1415220.1(Lj2g3v1415220.1)
AIP: 107643333
LANG: 109333461
RCN: 112197869
PPER: 18791522
PMUM: 103321798
PAVI: 110748068
PDUL: 117612274
MNT: 21410343
CSV: 101208642
CMO: 103487713
BHJ: 120075676
MCHA: 111004744
CMAX: 111496525
RCU: 8273511
JCU: 105644633
POP: 7473219
PEU: 105132353
PALZ: 118037864
JRE: 109020896
TWL: 120007078
SLY: 101263675
SPEN: 107005385
SOT: 102585507
CANN: 107863754
NSY: 104211136
NTO: 104101649
NAU: 109226748
INI: 109157980
ITR: 115998674
OEU: 111403390
EGT: 105974760
HAN: 110895055
ECAD: 122609095
LSV: 111902019
CCAV: 112524684
DCR: 108225269
CSIN: 114313633
BVG: 104908393
SOE: 110785625
NNU: 104593146
NCOL: 116248965
OSA: 9270356
DOSA: Os04t0507800-01(Os04g0507800)
OBR: 102704055
ATS: 109735764
SBI: 8075905
ZMA: 100384459
SITA: 101763323
PHAI: 112900296
EGU: 105035064
MUS: 103978194
DCT: 110110820
PEQ: 110028315
AOF: 109828899
PPP: 112282043
MNG: MNEG_1473
APRO: F751_2917
MAQ: Maqu_2224
MHC: MARHY1004
DML: Dmul_37550(ubiE3)
SYN: sll1653(gerCb)
SYZ: MYO_12590(gerCb)
SYY: SYNGTS_0257(menG)
SYT: SYNGTI_0257(menG)
SYS: SYNPCCN_0257(menG)
SYQ: SYNPCCP_0257(menG)
SYJ: D082_05490(menG)
SYC: syc0450_d(ubiE)
SYG: sync_0700(ubiE)
SYR: SynRCC307_0581(ubiE)
SYX: SynWH7803_1772(ubiE)
SYP: SYNPCC7002_A1100(menG)
CYA: CYA_2236(ubiE)
CYB: CYB_0364(ubiE)
SYNR: KR49_13190
SYND: KR52_12890
SYNW: SynWH8103_01905(MENG)
SYNC: CB0101_13770(ubiE)
SYW: SYNW1674
CYI: CBM981_1477(ubiE)
PMA: Pro_0427(ubiE_menG)
PMM: PMM0431
PMB: A9601_04861(ubiE)
PMC: P9515_04931(ubiE)
PMF: P9303_20621(ubiE)
PMG: P9301_04551(ubiE)
PMH: P9215_05101(ubiE)
PMJ: P9211_04271(ubiE)
PME: NATL1_04841(ubiE)
PRC: EW14_0473
PRM: EW15_0514
AMR: AM1_3823(ubiE)
TEL: tll2373(ubiE)
THN: NK55_08730(menG)
THEC: FFX45_06660(ubiE)
LET: O77CONTIG1_02831(ubiE_3)
KOV: K9N68_18360(ubiE)
LSC: KIK02_00470(ubiE)
PSER: ABRG53_2868(ubiE)
THEU: HPC62_16825(ubiE)
MAR: MAE_37840(ubiE)
MPK: VL20_5484
MVZ: myaer102_12660(ubiE)
CYL: AA637_02565(menG)
ENN: FRE64_10265(ubiE)
CYT: cce_2570(ubiE)
TER: Tery_3972
OXY: HCG48_04760(ubiE)
LFS: HFV01_01615(ubiE)
PHOR: JWS08_21540(ubiE)
GVI: gll0127(menG)
GLJ: GKIL_3721(ubiE)
ANA: alr5252
NON: NOS3756_08110(ubiE)
NSH: GXM_03248
NED: HUN01_23220(ubiE)
AVA: Ava_1422
NAZ: Aazo_4318
CALH: IJ00_11885
NSP: BMF81_01745(ubiE)
DOU: BMF77_00341(menG_1)
DFS: HGD76_16465(ubiE)
CCUR: IAR63_05630(ubiE)
AFLO: HEQ12_03675(ubiE)
TOQ: HCG51_17670(ubiE)
CTHE: Chro_1764
ABAC: LuPra_00745(ubiE_3)
MPL: Mpal_1129
ABI: Aboo_0957
 » show all
Reference
1  [PMID:11772039]
  Authors
Sakuragi Y, Zybailov B, Shen G, Jones AD, Chitnis PR, van der Est A, Bittl R, Zech S, Stehlik D, Golbeck JH, Bryant DA
  Title
Insertional inactivation of the menG gene, encoding 2-phytyl-1,4-naphthoquinone methyltransferase of Synechocystis sp. PCC 6803, results in the incorporation of  2-phytyl-1,4-naphthoquinone into the A(1) site and alteration of the equilibrium  constant between A(1) and F(X) in photosystem I.
  Journal
Biochemistry 41:394-405 (2002)
DOI:10.1021/bi011297w
  Sequence
[syn:sll1653]
Reference
2  [PMID:17082184]
  Authors
Lohmann A, Schottler MA, Brehelin C, Kessler F, Bock R, Cahoon EB, Dormann P
  Title
Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.
  Journal
J Biol Chem 281:40461-72 (2006)
DOI:10.1074/jbc.M609412200
  Sequence
[ath:AT1G23360]
Reference
3  [PMID:26023160]
  Authors
Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ
  Title
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.
  Journal
Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103
  Sequence
[ath:AT1G23360] [syn:sll1653]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.329
IUBMB Enzyme Nomenclature: 2.1.1.329
ExPASy - ENZYME nomenclature database: 2.1.1.329
BRENDA, the Enzyme Database: 2.1.1.329

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