KEGG   ENZYME: 2.1.1.330Help
Entry
EC 2.1.1.330                Enzyme                                 

Name
5'-demethylyatein 5'-O-methyltransferase;
OMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(-)-5'-demethylyatein 5'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (-)-5'-demethylyatein = S-adenosyl-L-homocysteine + (-)-yatein [RN:R11545]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(-)-5'-demethylyatein [CPD:C21184]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(-)-yatein [CPD:C10557]
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
EC 2.1.1.330 created 2016
Pathway
ec00998  Biosynthesis of various secondary metabolites - part 2
ec01110  Biosynthesis of secondary metabolites
Orthology
K21204  5'-demethylyatein 5'-O-methyltransferase
Reference
1  [PMID:26359402]
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.330
IUBMB Enzyme Nomenclature: 2.1.1.330
ExPASy - ENZYME nomenclature database: 2.1.1.330
BRENDA, the Enzyme Database: 2.1.1.330

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