KEGG   ENZYME: 2.1.1.335Help
Entry
EC 2.1.1.335                Enzyme                                 

Name
4-amino-anhydrotetracycline N4-methyltransferase;
oxyT (gene name);
ctcO (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(4S,4aS,12aS)-4-amino-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide Nalpha-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline = S-adenosyl-L-homocysteine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline [RN:R11520];
(2) S-adenosyl-L-methionine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline = S-adenosyl-L-homocysteine + anhydrotetracycline [RN:R11521]
Reaction(KEGG)
R11520 R11521;
(other) R09191
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4-amino-4-de(dimethylamino)anhydrotetracycline [CPD:C06654];
4-methylamino-4-de(dimethylamino)anhydrotetracycline [CPD:C21436]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4-methylamino-4-de(dimethylamino)anhydrotetracycline [CPD:C21436];
anhydrotetracycline [CPD:C02811]
Comment
The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics.
History
EC 2.1.1.335 created 2016
Pathway
ec00253  Tetracycline biosynthesis
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K14255  4-amino-anhydrotetracycline N4-methyltransferase
Genes
KAU: B6264_18530
Taxonomy
Reference
1  [PMID:18422316]
  Authors
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J.
  Title
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.
  Journal
J Am Chem Soc 130:6068-9 (2008)
DOI:10.1021/ja800951e
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.335
IUBMB Enzyme Nomenclature: 2.1.1.335
ExPASy - ENZYME nomenclature database: 2.1.1.335
BRENDA, the Enzyme Database: 2.1.1.335

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