Entry |
|
Name |
tRNA (guanosine18-2'-O)-methyltransferase;
tRNA (Gm18) 2'-O-methyltransferase;
tRNA (Gm18) methyltransferase;
TrmH;
SpoU
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-adenosyl-L-methionine:tRNA (guanosine18-2'-O)-methyltransferase
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Reaction(IUBMB) |
S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA [RN: R02917]
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Reaction(KEGG) |
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Substrate |
S-adenosyl-L-methionine [CPD: C00019];
guanosine18 in tRNA
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Product |
S-adenosyl-L-homocysteine [CPD: C00021];
2'-O-methylguanosine18 in tRNA
|
Comment |
The enzyme catalyses the methylation of guanosine18 in tRNA.
|
History |
EC 2.1.1.34 created 1972, modified 2005, modified 2011
|
Orthology |
K00556 | tRNA (guanosine-2'-O-)-methyltransferase |
K15333 | tRNA guanosine-2'-O-methyltransferase |
|
Genes |
NGI: | 103726261 103745131(Tarbp1) |
CCAN: | 109678050 109692626(Tarbp1) |
PLOP: | 125345179 125367325(Tarbp1) |
TUP: | 102478704(TARBP1) 106734619 |
HHV: | 120241828(TARBP1) 120242866 |
ODA: | 120860506 120865430(TARBP1) |
CCAE: | 111922607 111926865(TARBP1) |
ETL: | 114064880(TARBP1) 114072297 |
PMUR: | 107288315(TARBP1) 107295944 |
CVG: | 107102085 107103012(tarbp1) |
NFU: | 107395681 107397186(tarbp1) |
SASA: | 106593393 106613610(tarbp1) 106613671 |
STRU: | 115152794 115193532 |
OMY: | 110511718(tarbp1) 110516660 |
OKI: | 109878985 109878993(tarbp1) |
APLC: | 110978164 110978165 |
DME: | Dmel_CG18596(CG18596) |
DSI: | Dsimw501_GD20941(Dsim_GD20941) |
DYA: | Dyak_GE10262 Dyak_GE10291 |
DWI: | 111518768 111518769 111518788 111518789 111518790 111519827 124462069 26529330 26530271 6649446 |
DMO: | Dmoj_GI10153 Dmoj_GI18469 Dmoj_GI22376 |
DNV: | 108653571 108659607 108659941 |
DHE: | 111593340 111594125 111603621 |
AGA: | 1276532 133390945 4576628 |
ACOZ: | 120950997 120952898 |
AARA: | 120894999 120897525 |
AMER: | 121593259 121594100 121602352 |
AALB: | 109422737 109425704 |
MPHA: | 105836856 105839091 |
PBAR: | 105423114 105426612 105426682 |
MDL: | 103569443 103569466 103573053 |
CGLO: | 123259258 123259467 |
BMAN: | 114243456 114243498 |
CSCU: | 111625152 111625154 |
CEL: | CELE_T14B4.1(T14B4.1) |
NAI: | NECAME_05764 NECAME_05765 |
CSAT: | 104718575 104723330 104731804 |
PSOM: | 113321550 113330031 |
TDC: | 119292266 119293061 119304334 119344358 |
TAES: | 123093975 123099174 123106138 |
DCT: | 110102511 110105855 110107437 |
SMO: | SELMODRAFT_77385 SELMODRAFT_95047 |
VCN: | VOLCADRAFT_35411 VOLCADRAFT_65891 |
CGR: | 2888520(GVI51_H10307) |
NCS: | NCAS_0B06090(NCAS0B06090) |
NDI: | NDAI_0B03380(NDAI0B03380) |
TPF: | TPHA_0C03590(TPHA0C03590) |
TDL: | TDEL_0G02550(TDEL0G02550) |
KAF: | KAFR_0A06820(KAFR0A06820) |
KNG: | KNAG_0A05550(KNAG0A05550) |
LBG: | 92210372(LODBEIA_P51760) |
CAL: | CAALFM_C403830WA(CaO19.5038) |
CTEN: | 18249818(PSN45_004742) |
YLI: | 2910720(YALI2_D00898g) |
DDI: | DDB_G0271370 DDB_G0285499 |
DPP: | DICPUDRAFT_153035 DICPUDRAFT_156844 |
ACAN: | ACA1_098860 ACA1_098870 |
PLAG: | 39744232(PADL01_1429400) |
FCY: | FRACYDRAFT_142076 FRACYDRAFT_181295 |
PIF: | PITG_16516 PITG_16517 PITG_16519 PITG_16521 PITG_16522 PITG_16523 PITG_16524 PITG_16525 PITG_17222 PITG_17224 PITG_17225 PITG_17226 PITG_17228 PITG_23106 |
LMAT: | 92512027(LSCM1_01917) |
LOI: | 92358689(LSCM4_02733) |
LEIS: | 94178508(GH5_03013) 94178731(GH5_03242) |
LENR: | 94169666(CUR178_02398) |
LEIN: | 94186156(JIQ42_02437) |
PHET: | 94288729(JKF63_02628) |
EHX: | EMIHUDRAFT_354326 EMIHUDRAFT_357133 |
ECOO: | ECRM13514_4660(spoU) |
ECOH: | ECRM13516_4440(spoU) |
ECW: | EcE24377A_4154(trmH) |
EDJ: | ECDH1ME8569_3536(trmH) |
ECOI: | ECOPMV1_03985(trmH) |
REE: | electrica_00094(trmH) |
RTG: | NCTC13098_00111(trmH) |
CLAP: | NCTC11466_04577(trmH) |
KIE: | NCTC12125_03912(trmH) |
AHN: | NCTC12129_04928(spoU) |
METY: | MRY16398_01030(trmH) |
PSHI: | SAMEA2665130_2922(trmH) |
YPG: | YpAngola_A0042(trmH) |
YPI: | YpsIP31758_0038(trmH) |
SMW: | SMWW4_v1c47880(trmH) |
SFJ: | SAMEA4384070_4788(trmH) |
SOF: | NCTC11214_01649(trmH) |
SSAR: | SSARUM_004735(trmH) |
PAQU: | DMB82_0020145(trmH) |
PARL: | PEC302110_40320(trmH) |
DIC: | Dpoa569_000038(trmH) |
PLF: | PANA5342_0111(trmH1) |
TPTY: | NCTC11468_03858(trmH) |
PHEI: | NCTC12003_00320(trmH) |
PRJ: | NCTC6933_00353(trmH) |
LRI: | NCTC12151_00056(trmH) |
VCY: | IX92_05790 IX92_15505 |
VNP: | KW548_01485(trmH) KW548_07770 KW548_11710 |
VIB: | VspSTUT11_28110(trmH) |
VIS: | VspSTUT16_29510(trmH) |
MSHE: | MAALD49_27140(trmH) |
SCAA: | TUM17387_35920(trmH) |
CPS: | CPS_0784 CPS_4975(spoU) |
COM: | CMT41_03685 CMT41_17980 |
COZ: | A3Q34_07905 A3Q34_10960 |
COLW: | A3Q33_02015 A3Q33_07625 |
COLA: | DBO93_05520 DBO93_18050 |
COV: | EKO29_13260 EKO29_19605(trmH) |
CBER: | B5D82_04145 B5D82_08820 |
TPSY: | RGQ13_01415(trmH) RGQ13_18610 |
TNN: | RI845_10125 RI845_17615(trmH) |
TFT: | RI844_11880(trmH) RI844_17580 |
SALH: | HMF8227_02900(trmH) |
MICC: | AUP74_02852(trmH_1) |
MCEL: | LPW13_01215(trmH) LPW13_12435 |
MPAF: | R5R33_08880 R5R33_13140(trmH) |
MBRG: | PVT68_00805 PVT68_15920(trmH) |
THIC: | TspCOW1_18360(trmH) |
ALCA: | ASALC70_02741(trmH_1) ASALC70_03665(trmH_2) |
AEL: | NCTC12917_00033(trmH) |
SFLA: | SPHFLASMR4Y_03219(trmH) |
PPOR: | JCM14722_28050(trmH) |
SDYN: | Mal52_48480(trmH_1) |
BAFH: | BafHLJ01_0054(spoU) |
SCOR: | J3U87_02000 J3U87_30415 |
ACOU: | A5CBH24_13690(trmH) |
ADA: | A5CPEGH6_13100(trmH) |
EST: | DN752_02745 DN752_23160 |
FOK: | KK2020170_17140(trmH) |
CLH: | IX49_00370 IX49_07275 |
COMN: | PBN93_00685 PBN93_07290 |
PHG: | KCTC32516_02128(trmH_2) |
FOP: | FNB79_08265 FNB79_14365 |
SEON: | BWZ22_11280 BWZ22_15880 |
FEK: | C1H87_19905 C1H87_22675 |
KOS: | KORDIASMS9_03995(trmH) |
KAN: | IMCC3317_00810(trmH_1) |
AQA: | D1815_02190 D1815_08635 |
AQD: | D1816_01280 D1816_06855 |
SPON: | HME9304_00053(trmH) |
CIH: | ATE47_01675 ATE47_18805 |
CGLE: | NCTC11432_04377(trmH) |
CTAI: | NCTC12078_03246(trmH) |
CTAK: | 4412677_02418(trmH) |
CHRJ: | CHRYMOREF3P_3797(trmH) |
CJG: | NCTC13459_03044(trmH) |
CANT: | NCTC13489_01328(trmH) |
PTAN: | CRYO30217_01295(trmH_1) |
PROC: | Ptc2401_01020(trmH) |
GEA: | GARCT_03023(trmH_1) GARCT_03439(trmH_2) |
PARG: | PspKH34_37550(trmH) |
SYR: | SynRCC307_0572(spoU) |
SYX: | SynWH7803_1782(spoU) |
SYNW: | SynWH8103_01912(trmH) |
LEP: | Lepto7376_1444 Lepto7376_3891 |
DEIN: | DAAJ005_17120(trmH) |
» show all
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Reference |
|
Authors |
Gefter ML. |
Title |
The in vitro synthesis of 2'-omethylguanosine and 2-methylthio 6N (gamma,gamma, dimethylallyl) adenosine in transfer RNA of Escherichia coli. |
Journal |
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Reference |
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Authors |
Kumagai I, Watanabe K, Oshima T. |
Title |
Thermally induced biosynthesis of 2'-O-methylguanosine in tRNA from an extreme thermophile, Thermus thermophilus HB27. |
Journal |
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Reference |
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Authors |
Hori H, Yamazaki N, Matsumoto T, Watanabe Y, Ueda T, Nishikawa K, Kumagai I, Watanabe K. |
Title |
Substrate recognition of tRNA (Guanosine-2'-)-methyltransferase from Thermus thermophilus HB27. |
Journal |
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Reference |
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Authors |
Pleshe E, Truesdell J, Batey RT |
Title |
Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus. |
Journal |
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Sequence |
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Reference |
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Authors |
Ochi A, Makabe K, Kuwajima K, Hori H |
Title |
Flexible recognition of the tRNA G18 methylation target site by TrmH methyltransferase through first binding and induced fit processes. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.1.1.34 |
ExPASy - ENZYME nomenclature database: | 2.1.1.34 |
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