KEGG   ENZYME: 2.1.1.344Help
Entry
EC 2.1.1.344                Enzyme                                 

Name
ornithine lipid N-methyltransferase;
olsG (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:ornithine lipid N-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + an ornithine lipid = 3 S-adenosyl-L-homocysteine + an N,N,N-trimethylornithine lipid (overall reaction) [RN:R11797];
(1a) S-adenosyl-L-methionine + an ornithine lipid = S-adenosyl-L-homocysteine + an N-methylornithine lipid [RN:R11798];
(1b) S-adenosyl-L-methionine + an N-methylornithine lipid = S-adenosyl-L-homocysteine + an N,N-dimethylornithine lipid [RN:R11799];
(1c) S-adenosyl-L-methionine + an N,N-dimethylornithine lipid = S-adenosyl-L-homocysteine + an N,N,N-trimethylornithine lipid [RN:R11800]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
ornithine lipid [CPD:C21672];
N-methylornithine lipid [CPD:C21673];
N,N-dimethylornithine lipid [CPD:C21674]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N,N,N-trimethylornithine lipid [CPD:C21675];
N-methylornithine lipid [CPD:C21673];
N,N-dimethylornithine lipid [CPD:C21674]
Comment
The enzyme, characterized from the bacterium Singulisphaera acidiphila, catalyses three successive methylations of the terminal delta-nitrogen in ornithine lipids.
History
EC 2.1.1.344 created 2017
Orthology
K22309  ornithine lipid N-methyltransferase
Genes
PLH: VT85_18490
GES: VT84_27445(ermA1)
IPA: Isop_2139
SACI: Sinac_1600
PBOR: BSF38_01809(rsmA_1)
Taxonomy
Reference
1  [PMID:25925947]
  Authors
Escobedo-Hinojosa WI, Vences-Guzman MA, Schubotz F, Sandoval-Calderon M, Summons RE, Lopez-Lara IM, Geiger O, Sohlenkamp C
  Title
OlsG (Sinac_1600) Is an Ornithine Lipid N-Methyltransferase from the Planctomycete Singulisphaera acidiphila.
  Journal
J Biol Chem 290:15102-11 (2015)
DOI:10.1074/jbc.M115.639575
  Sequence
[saci:Sinac_1600]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.344
IUBMB Enzyme Nomenclature: 2.1.1.344
ExPASy - ENZYME nomenclature database: 2.1.1.344
BRENDA, the Enzyme Database: 2.1.1.344

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