KEGG   ENZYME: 2.1.1.345Help
Entry
EC 2.1.1.345                Enzyme                                 

Name
psilocybin synthase;
PsiM
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:4-hydroxytryptamine-4-phosphate N,N-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = 2 S-adenosyl-L-homocysteine + psilocybin (overall reaction) [RN:R11934];
(1a) S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine 4-phosphate [RN:R11935];
(1b) S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine 4-phosphate = S-adenosyl-L-homocysteine + psilocybin [RN:R11936]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4-hydroxytryptamine 4-phosphate [CPD:C21778];
4-hydroxy-N-methyltryptamine 4-phosphate [CPD:C21779]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
psilocybin [CPD:C07576];
4-hydroxy-N-methyltryptamine 4-phosphate [CPD:C21779]
Comment
Isolated from the fungus Psilocybe cubensis. The product, psilocybin, is a psychoactive compound.
History
EC 2.1.1.345 created 2017
Pathway
ec00901  Indole alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22436  psilocybin synthase
Reference
1  [PMID:28763571]
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.345
IUBMB Enzyme Nomenclature: 2.1.1.345
ExPASy - ENZYME nomenclature database: 2.1.1.345
BRENDA, the Enzyme Database: 2.1.1.345

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