KEGG   ENZYME: 2.1.1.346
Entry
EC 2.1.1.346                Enzyme                                 
Name
U6 snRNA m6A methyltransferase;
METTL16 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:adenine in U6 snRNA methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA [RN:R11953]
Reaction(KEGG)
R11953
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine in U6 snRNA [CPD:C21798]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N6-methyladenine in U6 snRNA [CPD:C21799]
Comment
This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions [2].
History
EC 2.1.1.346 created 2018
Orthology
K11393  U6 snRNA m6A methyltransferase
Genes
HSA79066(METTL16)
PTR468142(METTL16)
PPS100985777(METTL16)
GGO101136835(METTL16)
PON100432341(METTL16)
NLE100588460(METTL16)
MCC721312(METTL16)
MCF102126585(METTL16)
CSAB103242135(METTL16)
CATY105584038(METTL16)
PANU101025110(METTL16)
TGE112609893(METTL16)
RRO104682018(METTL16)
RBB108526344(METTL16)
TFN117067927(METTL16)
PTEH111521382(METTL16)
CJC100394235(METTL16)
SBQ101040153(METTL16)
CSYR103260578(METTL16)
MMUR105857981(METTL16)
OGA100951183(METTL16)
MMU67493(Mettl16)
MCAL110304744(Mettl16)
MPAH110331579(Mettl16)
MCOC116078078(Mettl16)
MUN110551483(Mettl16) 110558711
CGE100765063(Mettl16)
PLEU114691415(Mettl16)
NGI103730532(Mettl16)
HGL101709207(Mettl16)
CPOC100734997(Mettl16)
CCAN109685289(Mettl16)
DORD105985682(Mettl16)
DSP122103374(Mettl16)
OCU100354377(METTL16)
OPI101529808(METTL16)
TUP102500444(METTL16)
CFA480655(METTL16)
VVP112933136(METTL16)
VLG121474145(METTL16)
AML100479575(METTL16)
UMR103667151(METTL16)
UAH113269143(METTL16)
UAR123776841(METTL16)
ELK111151376
LLV125087822
MPUF101670495(METTL16)
ORO101368257(METTL16)
EJU114213998(METTL16)
ZCA113939559(METTL16)
MLX118025196(METTL16)
FCA101098176(METTL16)
PYU121017336(METTL16)
PBG122485099(METTL16)
PTG102953476(METTL16)
PPAD109255176(METTL16)
AJU106983218(METTL16)
HHV120244873(METTL16)
BTA509278(METTL16)
BOM102269245(METTL16)
BIU109573961(METTL16)
BBUB102415457(METTL16)
CHX102181233(METTL16)
OAS101118885(METTL16)
ODA120866207(METTL16)
CCAD122447430(METTL16)
SSC100512985(METTL16)
CFR102517540(METTL16)
CBAI105071497(METTL16)
CDK105094394(METTL16)
VPC102524731(METTL16)
BACU103018670(METTL16)
LVE103079111(METTL16)
OOR101277494(METTL16)
DLE111185691(METTL16)
PCAD102980728(METTL16)
PSIU116745499(METTL16)
ECB100060313(METTL16)
EPZ103554989(METTL16)
EAI106822016(METTL16)
MYB102245762(METTL16)
MYD102763524(METTL16)
MMYO118671926(METTL16)
MLF102432877(METTL16)
MNA107535629(METTL16)
PKL118702505(METTL16)
HAI109386913(METTL16)
DRO112308453(METTL16)
SHON119003680(METTL16)
AJM119040680(METTL16)
PDIC114503053(METTL16)
PHAS123817040(METTL16)
MMF118634690(METTL16)
RFQ117013310(METTL16)
PALE102893627(METTL16)
PGIG120621061(METTL16)
PVP105291837(METTL16)
RAY107507706(METTL16)
MJV108391798(METTL16)
TOD119230470(METTL16)
SARA101536921(METTL16)
LAV100667422(METTL16)
TMU101359623
MDO100013253(METTL16)
GAS123244469(METTL16)
SHR100929591(METTL16)
PCW110222082(METTL16)
OAA100078226(METTL16)
GGA431184(METTL16)
PCOC116242295(METTL16)
MGP100544219
CJO107319635(METTL16)
NMEL110399133(METTL16)
APLA101799964(METTL16)
AFUL116502055(METTL16)
TGU100224599(METTL16)
LSR110480767(METTL16)
SCAN103827124(METTL16)
PMOA120506461(METTL16)
OTC121339304(METTL16)
PRUF121351679(METTL16)
GFR102035966(METTL16)
FAB101821499(METTL16)
PHI102104214(METTL16)
PMAJ107213548(METTL16)
CCAE111938740 111942600
CCW104687188(METTL16)
ETL114062564(METTL16)
ZAB102065399(METTL16)
FPG101917549(METTL16)
FCH102058069(METTL16)
CLV102083907(METTL16)
EGZ104126569(METTL16)
NNI104008661(METTL16)
ACUN113480566(METTL16)
TALA104355567(METTL16)
PADL103922188(METTL16)
ACHC115343907(METTL16)
AAM106497249(METTL16)
NPD112956853(METTL16)
ASN102379059(METTL16)
AMJ102560118(METTL16)
CPOO109319186(METTL16)
GGN109304704(METTL16)
PSS102445105(METTL16)
CMY102934705(METTL16)
CPIC101940016(METTL16)
TST117886467(METTL16)
CABI116820862(METTL16)
MRV120400403(METTL16)
ACS100561572(mettl16)
PVT110088992(METTL16)
SUND121935449(METTL16)
PBI103059496(METTL16)
PMUR107303009(METTL16)
TSR106554152(METTL16)
PGUT117664720(METTL16)
VKO123031825(METTL16)
PMUA114582238(METTL16)
ZVI118094428(METTL16)
GJA107121598(METTL16)
XLA108709350 443759(mettl16.L)
XTR100170444(mettl16)
NPR108785099(METTL16)
RTEM120927637(METTL16)
BBUF120994719(METTL16)
BGAR122932496(METTL16)
DRE445217(mettl16)
SRX107743666 107744784
SANH107664944
SGH107585611
CCAR109058035(mettl16) 109067099 109084010
CAUA113115019
IPU108277677(mettl16)
PHYP113532552(mettl16)
SMEO124394684(mettl16)
AMEX103028752(mettl16)
EEE113569750(mettl16)
TRU101062099(mettl16)
TNGGSTEN00033357G001
LCO104935454(mettl16)
NCC104967203(mettl16)
CGOB115017956(mettl16)
ELY117259408(mettl16)
PLEP121943521(mettl16)
SLUC116048313(mettl16)
ECRA117941740(mettl16)
PFLV114552438(mettl16)
GAT120826703(mettl16)
PPUG119218599(mettl16)
MSAM119883414(mettl16)
CUD121516304(mettl16)
MZE101474733(mettl16)
ONL100695707(mettl16)
OAU116315193(mettl16)
OLA101169471(mettl16)
OML112149898(mettl16)
XMA102232539(mettl16)
XCO114133391(mettl16)
XHE116708147(mettl16)
PRET103474551(mettl16)
PFOR103155190(mettl16)
PLAI106957252(mettl16)
PMEI106927285(mettl16)
GAF122833170(mettl16)
CVG107103570(mettl16) 107103989
CTUL119782803(mettl16)
GMU124883746(mettl16)
NFU107380377(mettl16)
KMR108246060(mettl16)
ALIM106515476(mettl16)
NWH119410587(mettl16)
AOCE111573002(mettl16)
CSEM103378477(mettl16)
POV109630391(mettl16)
SSEN122773745(mettl16)
HHIP117772515(mettl16)
LCF108890382(mettl16)
SDU111238017(mettl16)
SLAL111653420(mettl16)
XGL120792465(mettl16)
HCQ109525371 109525404(mettl16)
BPEC110154120(mettl16)
MALB109960183(mettl16)
SASA100195164(mettl16)
OTW112267042
OMY110503873
OGO124005289
ONE115141778(mettl16)
SALP111959225(mettl16)
SNH120018221 120028973(mettl16)
ELS105005717(mettl16)
SFM108921289(mettl16)
PKI111852900(mettl16)
AANG118234918(mettl16)
LOC102697714(mettl16)
PSPA121308682(mettl16)
ARUT117429870 117430782
LCM102357476(METTL16)
CMK103183305(mettl16)
RTP109915373(mettl16)
BFO118426728
BBEL109463429
SCLV120336691 120341264
SPU115918828 588854
APLC110982293
SKO100375111
DMEDmel_CG7544(CG7544)
DER6548994
DSE6609249
DSIDsimw501_GD11099(Dsim_GD11099)
DYADyak_GE13632
DAN6495163
DSR110177681
DPODpse_GA20428
DPE6590543
DMN108158198
DWI6639760
DGR6561347
DMODmoj_GI18716
DAZ108615824
DNV115564616
DHE111602555
DVI6626490
CCAT101450250
BOD106621395
MDE101892334
SCAC106082350
LCQ111680035
AGAAgaP_AGAP011889
ACOZ120955374
AARA120901475
AAG5571925
AALB109410613 109410722
CQUCpipJ_CPIJ012620 CpipJ_CPIJ015643
CPII120420336
CNS116337892
AME552510
ACER107998128
ALAB122712223
BIM100746437
BBIF117209209
BVK117239531
BVAN117165875
BTER100644922
BPYO122565928
CCAL108625270
OBB114879372
MGEN117217881
NMEA116432072
CGIG122398540
SOC105199230
MPHA105836936
AEC105144290
ACEP105619207
PBAR105433112
VEM105558905
HST105183808
DQU106744101
CFO105251370
FEX115242323
LHU105670136
PGC109854953
OBO105283767
PCF106792967
PFUC122520048
VPS122631774
NVI100123669
CSOL105368924
TPRE106655576
MDL103574787 106694290
CGLO123266173
FAS105269043
DAM107036703
AGIF122857209
CCIN107268788
TCA661821
DPA109540451
SOY115884915
ATD109598942
CSET123313863
AGB108912949
LDC111505005
NVL108562140
APLN108742476
PPYR116181369
OTU111425792
BMOR101744195
BMAN114249898
MSEX115445230
DPLKGM_207769
BANY112046226
PMAC106717726
PPOT106108468
PXU106115835
PRAP110995152
ZCE119830802
HAW110372866
TNL113499038
OFU114360958
PXY105387479
API100168380
DNX107171844
AGS114120252
RMD113550631
BTAB109034206
DCI103516521
CLEC106669960
HHAL106691140
NLU111049543
PHUPhum_PHUM438210
FOC113203902
ZNE110837239
CSEC111866269
FCD110852948
DPXDAPPUDRAFT_50570
PVM113811444 113811458
PJA122267067
HAME121872293
PCLA123772872
PTRU123513720
HAZT108680475
EAF111709284
ISCIscW_ISCW007419
DSV119445610
RSAN119376011 119390515
RMP119170013
VDE111252059
VJA111271195
TUT107371698
DPTE113797178
DFR124497197
CSCU111642630
PTEP107440288
SDM118189118
CELCELE_ZK1128.2(mett-10)
CBRCBG_09879(Cbr-mett-10)
BMYBM_BM7633(Bma-mett-10)
LOALOAG_01952
NAINECAME_02035
TSPTsp_01507 Tsp_12275
HROHELRODRAFT_194040
LGILOTGIDRAFT_121844
PCAN112561775
BGT106068367
GAE121389997
HRF124132071
HRJ124254187
CRG105347004
MYI110455566
PMAX117333072
MMER123533929
OBI106869560
OSN115224468
LAK106154003
SMMSmp_129140.1
SHXMS3_0018462
OVIT265_01188
EGLEGR_05066
NVE5507281
EPA110233634
ATEN116304784
ADF107354373
AMIL114966831
PDAM113685660
SPIS111339945
DGT114520431 114538261
XEN124434517
HMG100201906
TADTRIADDRAFT_28751
AQU100631625
ATHAT2G21070(FIO1)
ALY9314600
CRB17888846 17892947
CSAT104702653 104713551 104751764
EUSEUTSA_v10000146mg
BRP103864244
BNA106420602 106420607
BOE106337314
RSZ108849697 108855622
THJ104807791
CPAP110816590
CIT102612205
CICCICLE_v10028267mg
PVY116131100
MINC123228120
TCC18607582
GRA105762922
GHI107932657 107945042
GAB108476494
DZI111308762
EGR104453416
GMX100802073 100819552
GSJ114412695 114421505
PVUPHAVU_002G189600g
VRA106765472 106768963
VAR108319107
VUN114177723
CCAJ109812802
APRC113857587
CAM101510943 101511570
LJALj4g3v0217740.1(Lj4g3v0217740.1)
ADU107481620
AIP107631485
AHF112734636 112792420
LANG109359826
FVE101304449
RCN112172166
PPER18767317
PMUM103334800
PAVI110753721
PDUL117612162
MDM103409315
PXB103932385 103932395
ZJU107427563
MNT21407692
CSV101205279
CMO103490299
BHJ120077072
MCHA111007785 111022944
CMAX111468473
CMOS111455141
CPEP111811582
RCU8265345
JCU105650305
HBR110673417
MESC110607518
POP7470383
PEU105109101
PALZ118040472
JRE109006580
QSU111985288 112036962
QLO115969591
TWL120011892
VVI100247029
VRI117911072
SLY101254840
SPEN107008552
SOT102594731 102601562
CANN107839524
NTA107785301 107785444 107807777
NSY104229034 104234132
NTO104111976
NAU109212298 109226024
INI109160032 109173465
ITR116003834 116028928
SIND105169769
OEU111380735
EGT105957750
SSPL121749702 121752381
HAN110921632
ECAD122585743
LSV111898983
CCAV112525712
DCR108196683
CSIN114257962 114283336
BVG104903954
SOE110786532
CQI110718560 110739526
NNU104593486
MING122085403
TSS122648798 122663704
PSOM113290514
NCOL116260499
OSA4328120
DOSAOs02t0121200-01(Os02g0121200)
OBR102710182
BDI100835129
ATS109766444
TDC119314521 119325488
TAES123131893 123135878 123143395
SBI8068259
ZMA100275693
SITA101782727
SVS117864922
PVIR120654471 120702680
PHAI112877496
PDA103706342
EGU105055058
MUS103973364
DCT110095485
PEQ110037379
AOF109819811
ATR18441638
SMOSELMODRAFT_110877 SELMODRAFT_443646
PPP112285489
CRECHLRE_01g044150v5
MNGMNEG_7697
CSLCOCSUDRAFT_53530
APROF751_5074
OLUOSTLU_4809
OTAOT_ostta12g02050
MISMICPUN_113202(MET10)
MPPMICPUCDRAFT_49964
AGOAGOS_AAR189C
ERCEcym_6027
PPAPAS_chr4_0027
PGUPGUG_02662
YLIYALI0D10329g
SLBAWJ20_2950
BNNFOA43_002320
BBRXBRETT_005110
NCRNCU11362
NTENEUTE1DRAFT144835(NEUTE1DRAFT_144835)
SMPSMAC_09439
PANPODANSg6041
TTTTHITE_2116145
MTMMYCTH_2299692
MGRMGG_09820
TMNUCRPA7_694
SSCKSPSK_07417
FGRFGSG_04198
FPUFPSE_10402
FVRFVEG_10386
FOXFOXG_20534
NHENECHADRAFT_44289
TRETRIREDRAFT_39285
TRRM419DRAFT_106028
MAWMAC_04269
MAJMAA_02785
CMTCCM_03996
PLJVFPFJ_08810
VALVDBG_08418
VDAVDAG_08081
CFJCFIO01_03901
SAPOSAPIO_CDS1502
ELAUCREL1_7286
PFYPFICI_12837
BFUBCIN_12g05310
MBEMBM_00697
PSCOLY89DRAFT_617710
GLZGLAREA_09615
ANIAN6713.2
AFMAFUA_7G05590
ACTACLA_007350
NFINFIA_026840
ANGANI_1_1582064(An07g02250)
AFVAFLA_003222
ALUCAKAW2_11930A
ACHEACHE_60967A
APUUAPUU_70243S
PCSPc12g06780
PDPPDIP_54270
TMFPMAA_091650
TRGTRUGW13939_06975
CIMCIMG_05470
CPWCPC735_066140
UREUREG_06255
PBLPAAG_00036
PBNPADG_07222
ABEARB_00675
TVETRV_05018
PNOSNOG_05851
PTEPTT_11931
BZECOCCADRAFT_9081
BSCCOCSADRAFT_38221
BORCOCMIDRAFT_30632
AALTCC77DRAFT_168121
ZTRMYCGRDRAFT_24632
PFJMYCFIDRAFT_41101
BCOMBAUCODRAFT_70727
TMLGSTUM_00002139001
SPOSPAC27D7.08c
CNECNC04020
CNBCNBC3160
CGICGB_C6130W
TMSTREMEDRAFT_30662
TASAA1Q1_06990
PPLPOSPLDRAFT_28036
TVSTRAVEDRAFT_60998
DSQDICSQDRAFT_108620
PCOPHACADRAFT_258520
SHSSTEHIDRAFT_126591
HIRHETIRDRAFT_478853
PSQPUNSTDRAFT_91935
ADLAURDEDRAFT_176350
FMEFOMMEDRAFT_153997
GTRGLOTRDRAFT_123633
MRRMoror_16301
SCMSCHCODRAFT_258453
CPUTCONPUDRAFT_169696
WSEWALSEDRAFT_60716
WICJ056_000752
MGLMGL_0651
MRTMRET_2521
PGRPGTG_12226
MLRMELLADRAFT_74344
MBRMONBRDRAFT_27301
SREPTSG_06103
DDIDDB_G0275203
DPPDICPUDRAFT_25940 DICPUDRAFT_78256
DFADFA_04208
ACANACA1_142640
BBIGBBBOND_0312970
TPSTHAPSDRAFT_11744
PIFPITG_06794
PSOJPHYSODRAFT_486208
SPARSPRG_09490
 » show all
Reference
1  [PMID:28525753]
  Authors
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK
  Title
The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
  Journal
Cell 169:824-835.e14 (2017)
DOI:10.1016/j.cell.2017.05.003
  Sequence
[hsa:79066]
Reference
2  [PMID:29051200]
  Authors
Warda AS, Kretschmer J, Hackert P, Lenz C, Urlaub H, Hobartner C, Sloan KE, Bohnsack MT
  Title
Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.
  Journal
EMBO Rep 18:2004-2014 (2017)
DOI:10.15252/embr.201744940
  Sequence
[hsa:79066]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.346
IUBMB Enzyme Nomenclature: 2.1.1.346
ExPASy - ENZYME nomenclature database: 2.1.1.346
BRENDA, the Enzyme Database: 2.1.1.346

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