KEGG   ENZYME: 2.1.1.348Help
Entry
EC 2.1.1.348                Enzyme                                 

Name
mRNA m6A methyltransferase;
METTL3 (gene name);
METTL14 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:adenine in mRNA methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N6-methyladenine in mRNA [RN:R12011]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine in mRNA [CPD:C21844]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N6-methyladenine in mRNA [CPD:C21845]
Comment
This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.
History
EC 2.1.1.348 created 2018
Orthology
K05925  mRNA m6A methyltransferase
Genes
HSA: 56339(METTL3) 57721(METTL14)
PTR: 452765(METTL3) 461454(METTL14)
PPS: 100989441(METTL14) 100990968(METTL3)
GGO: 101127472(METTL3) 101150193(METTL14)
PON: 100173728(METTL14) 100440500(METTL3)
NLE: 100580019(METTL3) 100607837(METTL14)
MCC: 704667(METTL14) 706852(METTL3)
MCF: 101867229(METTL3)
CSAB: 103231389(METTL3) 103236171(METTL14)
RRO: 104656255(METTL3) 104663582(METTL14)
RBB: 108516152(METTL3) 108528877(METTL14)
CJC: 100407273(METTL14) 100408434(METTL3)
SBQ: 101039159(METTL14) 101048921(METTL3)
MMU: 210529(Mettl14) 56335(Mettl3)
RNO: 295428(Mettl14) 361035(Mettl3)
MUN: 110557725(Mettl3) 110561950 110561956
CGE: 100774068(Mettl14) 100774316(Mettl3)
NGI: 103733818(Mettl3) 103744300(Mettl14)
HGL: 101700628(Mettl3) 101708897(Mettl14)
CCAN: 109688822(Mettl14) 109690937(Mettl3)
OCU: 100340084(METTL14) 100353801(METTL3)
TUP: 102499898(METTL14) 102503047(METTL3)
CFA: 475404(METTL3) 487920(METTL14)
AML: 100464193(METTL3) 100484603(METTL14)
UMR: 103661775(METTL14) 103681541(METTL3)
ORO: 101368245(METTL14) 101373645(METTL3)
FCA: 101094504(METTL14) 101099304(METTL3)
PTG: 102963962(METTL14) 102972213(METTL3)
AJU: 106971425(METTL3) 106984321(METTL14)
BTA: 531382(METTL14) 540339(METTL3)
BOM: 102279941(METTL3) 102287913(METTL14)
BIU: 109560228(METTL14) 109564845(METTL3)
PHD: 102326039(METTL14) 102343710(METTL3)
CHX: 100861319(METTL3) 102170592(METTL14)
OAS: 101108050(METTL3) 101110842(METTL14) 114113917
SSC: 100513294(METTL3) 100525761(METTL14)
CFR: 102511663(METTL3) 102521576(METTL14)
CDK: 105093641(METTL14) 105097615(METTL3)
BACU: 102998073(METTL3) 103002890(METTL14)
LVE: 103077878(METTL3) 103078027(METTL14)
OOR: 101283418(METTL3) 101289935(METTL14)
DLE: 111181830(METTL3) 111186108(METTL14)
ECB: 100059413(METTL3) 100072440(METTL14)
EPZ: 103556623(METTL3) 103560425(METTL14)
EAI: 106833262(METTL3) 106842023(METTL14)
MYB: 102248922(METTL14) 102257958(METTL3)
MYD: 102752704(METTL3) 102769311(METTL14)
MNA: 107526983(METTL3) 107527849(METTL14)
HAI: 109373254(METTL14) 109374267(METTL3)
RSS: 109435592(METTL3) 109454129(METTL14)
PALE: 102884097(METTL3) 102891868(METTL14)
LAV: 100666170(METTL14) 100670664(METTL3)
TMU: 101345064 101351297
MDO: 100012069(METTL14) 100023433(METTL3)
SHR: 100917530(METTL14) 100917802(METTL3)
PCW: 110220332(METTL3) 110222982(METTL14)
OAA: 100081630(METTL14)
GGA: 107050363 422684(METTL14)
MGP: 100540744(METTL14) 104916039
CJO: 107307025(METTL3) 107313539(METTL14)
APLA: 101797227(METTL14) 113841882
ACYG: 106038636(METTL14)
TGU: 100226836(METTL14)
LSR: 110481642(METTL3) 110484376(METTL14)
SCAN: 103821400(METTL14) 108964165(METTL3)
GFR: 102043164(METTL14)
FAB: 101812238(METTL14)
PHI: 102100035(METTL3) 102101748(METTL14)
PMAJ: 107202947(METTL14)
CCAE: 111922569(METTL3) 111929078(METTL14)
CCW: 104693665(METTL14)
ETL: 114059016(METTL14)
FPG: 101915595(METTL14)
FCH: 102056930(METTL14)
CLV: 102092744(METTL14)
EGZ: 104121944(METTL14)
NNI: 104019152(METTL14)
ACUN: 113479761(METTL14)
AAM: 106492125(METTL14) 106498855(METTL3)
ASN: 102379144(METTL3) 102382866(METTL14)
AMJ: 102561217(METTL14) 102564955(METTL3)
PSS: 102445384(METTL3) 102459435(METTL14)
CMY: 102932846(METTL3) 102938080(METTL14)
CPIC: 101942180(METTL3) 101949029(METTL14)
ACS: 100557846(mettl3) 100567789(mettl14)
PVT: 110072809(METTL14) 110087634(METTL3)
PBI: 103057213(METTL14) 103063883(METTL3)
PMUR: 107286571(METTL3) 107294082(METTL14) 107295391
GJA: 107105870(METTL14) 107118160(METTL3)
XLA: 414467(mettl14.L) 414662(mettl3.L)
XTR: 493301(mettl14) 549173(mettl3)
NPR: 108792215(METTL14) 108792373(METTL3)
DRE: 100004398(mettl3) 404603(mettl14)
SRX: 107750474 107750776 107753969 107754186
SANH: 107659734 107664282 107702295(mettl14)
SGH: 107560293 107591585 107591586 107595277
CCAR: 109052741 109079142 109096172 109100071
IPU: 108260941(mettl14) 108267670(mettl3)
PHYP: 113539785(mettl3) 113544255(mettl14)
AMEX: 103027470(mettl14) 103037149(mettl3)
EEE: 113586470(mettl14) 113590997(mettl3)
TRU: 101075454(mettl3) 101077070(mettl14)
TNG: GSTEN00009248G001 GSTEN00024364G001
LCO: 104927608(mettl3) 104930832(mettl14)
NCC: 104943831 104943836 104964486(mettl3)
MZE: 101471954(mettl14) 101474156(mettl3)
OLA: 101169238(mettl3) 101170004(mettl14)
XMA: 102221352(mettl14) 102235065(mettl3)
PRET: 103467343(mettl14) 103476007(mettl3) 103480536
NFU: 107375218(mettl14) 107377303(mettl3)
KMR: 108230574(mettl14) 108247769(mettl3)
CSEM: 103383809(mettl14) 103388127(mettl3)
LCF: 108896635(mettl14) 108902339(mettl3)
SDU: 111231459(mettl14) 111235619(mettl3)
HCQ: 109516651(mettl3) 109519915(mettl14)
BPEC: 110165386(mettl14) 110172009(mettl3)
MALB: 109961417(mettl14) 109966479(mettl3)
SASA: 106577778(mettl3) 106594353(mettl14)
OTW: 112236308(mettl3)
SALP: 111953381 112070048(mettl3)
ELS: 105028165(mettl3) 105028566(mettl14)
SFM: 108924424(mettl14) 108930616(mettl3)
PKI: 111837446(mettl14) 111856469(mettl3)
LCM: 102363787(METTL14) 102366801(METTL3)
CMK: 103177374(mettl14)
BFO: BRAFLDRAFT_217213 BRAFLDRAFT_58874
CIN: 100176137 100176240
SPU: 579598 589354
APLC: 110973730 110973834
SKO: 100376676 102807369
DME: Dmel_CG5933(Mettl3) Dmel_CG7818(Mettl14)
DPO: Dpse_GA19241 Dpse_GA20607
DAN: Dana_GF14632 Dana_GF17033
DER: 6543418 6555004
DPE: 113566243 6588749
DSE: Dsec_GM16880 Dsec_GM26549
DSI: Dsimw501_GD21054(Dsim_GD21054) Dsimw501_GD23521(Dsim_GD23521)
DWI: 6641646 6651528
DYA: Dyak_GE18751 Dyak_GE23438
DGR: Dgri_GH11588 Dgri_GH18483
DMO: Dmoj_GI17157 Dmoj_GI24144
DAZ: 108608658 108611673 108612151
DNV: 108649911 108660009
DHE: 111596222 111602733
DVI: Dvir_GJ17661 Dvir_GJ24659
MDE: 101898583 101899377
AGA: AgaP_AGAP002895 AgaP_AGAP008111
AAG: 5573075 5575912
CQU: CpipJ_CPIJ014114 CpipJ_CPIJ016981
AME: 409900 551911
BIM: 100743733 105681627
BTER: 100643430 105665938
SOC: 105193495 105195961
MPHA: 105835104 105839876
AEC: 105148021 105148785
ACEP: 105619920 105623451
PBAR: 105426770 105427889
HST: 105190187 105192295
DQU: 106747677 106748554
CFO: 105249913 105253073
LHU: 105670176 105675085
PGC: 109855379 109856661
OBO: 105280773 105284146
PCF: 106786253 106792463
NVI: 100117110 100122395
MDL: 103571070 103580719
TCA: 656280 663857
DPA: 109542187 109546131
NVL: 108560379 108560527
BMOR: 101738928 101745362
DPL: KGM_201008 KGM_213490A KGM_213490B KGM_213491B
PMAC: 106707321 106707636 106718366 106718659
PRAP: 110993902 110995972
HAW: 110373243 110382051
TNL: 113494182 113497665 113507541
PXY: 105382983 105384679 105395098
API: 100159080 100163326 100169342
DNX: 107170768 107173584
AGS: 114120906 114123910 114128995
CLEC: 106665130 106674105
PHU: Phum_PHUM423190 Phum_PHUM529280
ZNE: 110829164 110831070
FCD: 110843651 110848223
DPX: DAPPUDRAFT_114050 DAPPUDRAFT_114053 DAPPUDRAFT_130106 DAPPUDRAFT_192406 DAPPUDRAFT_305196 DAPPUDRAFT_66395 DAPPUDRAFT_70850 DAPPUDRAFT_70851
ISC: IscW_ISCW004856 IscW_ISCW009375
TUT: 107360421 107369304
DPTE: 113792246 113794402
HRO: HELRODRAFT_121421 HELRODRAFT_153237 HELRODRAFT_164465 HELRODRAFT_68987 HELRODRAFT_79167
LGI: LOTGIDRAFT_134083
PCAN: 112564988 112576566
CRG: 105326041 105329074
MYI: 110443235 110451229
OBI: 106879257 106879794
LAK: 106161038 106169103
SMM: Smp_146300 Smp_172190.1
SHX: MS3_05251 MS3_05841
OVI: T265_06150 T265_11801
EGL: EGR_08094 EGR_08908 EGR_09506
EPA: 110231743 110235523
ADF: 107340361 107352743
PDAM: 113664980 113675223
SPIS: 111328332 111340244
HMG: 100197023 100197970
AQU: 100635916 100641238
ATH: AT4G10760(MTA)
ALY: ARALYDRAFT_911384
CRB: 17882338
CSAT: 104707363 104720582 104737069
EUS: EUTSA_v10028481mg
BRP: 103833930
BNA: 106391767 106439910 111212589 111213587
BOE: 106319315
THJ: 104806452
CPAP: 110811296 110816112
CIT: 102614335
CIC: CICLE_v10019070mg
TCC: 18605995
GRA: 105765337
GHI: 107947151 107947165
GAB: 108479123
DZI: 111290769
EGR: 104441622
GMX: 100782695 100788519
PVU: PHAVU_010G102500g
VRA: 106774348
VAR: 108321597
CCAJ: 109796915
MTR: MTR_2g099870 MTR_8g104280
CAM: 101513814
LJA: Lj0g3v0251359.1(Lj0g3v0251359.1)
ADU: 107472736
AIP: 107621980
LANG: 109330921 109360911
FVE: 101294526
PPER: 18777165
PMUM: 103337850
PAVI: 110758914 110774093
MDM: 103409630 103437411 103452571
PXB: 103949298 103950148
ZJU: 107430083
CSV: 101210377
CMO: 103490711
MCHA: 111014877
CMAX: 111465197 111498696
CMOS: 111431216 111453835
CPEP: 111800888 111810602
RCU: 8288826
JCU: 105645610
HBR: 110669519
MESC: 110609534
POP: 7477828
JRE: 108993781
QSU: 112033194
VVI: 100256414
SLY: 101256793
SPEN: 107028842
SOT: 102597470
CANN: 107839021 107842841 107871488
NTA: 107760789 107764634 107788400 107790746
NSY: 104210563
NTO: 104095181
NAU: 109220278
INI: 109194080
SIND: 105167810 105179105
OEU: 111372136 111375721
HAN: 110926324
LSV: 111918792
CCAV: 112525682 112527942
DCR: 108209424
BVG: 104892598
SOE: 110796381
CQI: 110722755 110732287
NNU: 104594082
PSOM: 113297700 113301518
OSA: 4330284
DOSA: Os02t0672600-01(Os02g0672600)
OBR: 102715647
BDI: 100840009
ATS: 109748756(LOC109748756)
SBI: 8073912
ZMA: 100281493
SITA: 101781789
PDA: 103707720 103719473
EGU: 105043457 105054093
MUS: 103970310 103993223
DCT: 110094702
PEQ: 110019823
AOF: 109839565
ATR: 18441600
SMO: SELMODRAFT_123364 SELMODRAFT_130187
PPP: 112282262 112283558 112289060
CRE: CHLREDRAFT_128290 CHLREDRAFT_146896 CHLREDRAFT_174824
VCN: VOLCADRAFT_116042 VOLCADRAFT_59216
MNG: MNEG_3732 MNEG_4535 MNEG_9590
OTA: OT_ostta11g01180
BPG: Bathy10g03150 Bathy13g02200 Bathy13g02600
MIS: MICPUN_76124
MPP: MICPUCDRAFT_51320
CSL: COCSUDRAFT_13342 COCSUDRAFT_19144 COCSUDRAFT_20697
CVR: CHLNCDRAFT_50385
APRO: F751_4347
CME: CYME_CMH026C
GSL: Gasu_34680 Gasu_54970
SCE: YGL192W(IME4)
AGO: AGOS_AFR173W
KLA: KLLA0_F09097g
KMX: KLMA_20298(IME4)
LTH: KLTH0E06468g
VPO: Kpol_246p4
ZRO: ZYRO0G19294g
CGR: CAGL0A03300g
NCS: NCAS_0B05490(NCAS0B05490)
NDI: NDAI_0B02700(NDAI0B02700)
TPF: TPHA_0H00330(TPHA0H00330)
TBL: TBLA_0F00390(TBLA0F00390)
TDL: TDEL_0B04590(TDEL0B04590)
KAF: KAFR_0C02930(KAFR0C02930)
PPA: PAS_chr2-1_0364
DHA: DEHA2B04598g
PIC: PICST_57562(IME4)
PGU: PGUG_03704
SPAA: SPAPADRAFT_71109
LEL: LELG_00925
CAL: CAALFM_C201650WA(CaO19.1476)
CTP: CTRG_01256
COT: CORT_0A09720
CDU: CD36_16510
CTEN: CANTEDRAFT_128415
YLI: YALI0B03498g
CLU: CLUG_03093
CLUS: A9F13_12g01133
SLB: AWJ20_4711(IME4)
CNE: CNE03860
CNB: CNBE3850
CGI: CGB_E5150C
TMS: TREMEDRAFT_45948 TREMEDRAFT_74548
PPL: POSPLDRAFT_106379 POSPLDRAFT_25577
TVS: TRAVEDRAFT_163442 TRAVEDRAFT_21767
DSQ: DICSQDRAFT_103275 DICSQDRAFT_58163
PCO: PHACADRAFT_82400 PHACADRAFT_88183
SHS: STEHIDRAFT_123102 STEHIDRAFT_77013
HIR: HETIRDRAFT_181243 HETIRDRAFT_419396
PSQ: PUNSTDRAFT_142376 PUNSTDRAFT_145711
ADL: AURDEDRAFT_96559 AURDEDRAFT_98965
FME: FOMMEDRAFT_18690 FOMMEDRAFT_90465
GTR: GLOTRDRAFT_41260 GLOTRDRAFT_71184
LBC: LACBIDRAFT_243879 LACBIDRAFT_319029
MPR: MPER_08097 MPER_15234
MRR: Moror_17635 Moror_769
CCI: CC1G_11190 CC1G_14583
SCM: SCHCODRAFT_114339 SCHCODRAFT_46077
ABP: AGABI1DRAFT131540(AGABI1DRAFT_131540) AGABI1DRAFT73723(AGABI1DRAFT_73723)
ABV: AGABI2DRAFT121782(AGABI2DRAFT_121782) AGABI2DRAFT67638(AGABI2DRAFT_67638)
CPUT: CONPUDRAFT_63441
SLA: SERLADRAFT_335862 SERLADRAFT_434451
WSE: WALSEDRAFT_60123 WALSEDRAFT_61194
WIC: J056_001511 J056_002978
UMA: UMAG_02405 UMAG_02989
PFP: PFL1_01537 PFL1_05073
MGL: MGL_2977
PGR: PGTG_00232 PGTG_07393
MLR: MELLADRAFT_41874
SRE: PTSG_03395 PTSG_04805
ACAN: ACA1_074420 ACA1_366350
PFA: PF3D7_0729500 PF3D7_1235500
PFD: PFDG_00015
PFH: PFHG_02087 PFHG_05435
PYO: PY17X_0215000(PY01472) PY17X_1452600(PY00961)
PCB: PCHAS_021200(PC000795.04.0) PCHAS_145240(PC000027.01.0)
PBE: PBANKA_021360 PBANKA_145010
PKN: PKH_021420 PKH_145410
PVX: PVX_081775 PVX_100725
PCY: PCYB_146120
BMIC: BMR1_02g01255 BmR1_04g05440
TGO: TGME49_217350
TET: TTHERM_00136470 TTHERM_00558100 TTHERM_00704040 TTHERM_00962190
PTM: GSPATT00000069001 GSPATT00003428001 GSPATT00015836001 GSPATT00017263001 GSPATT00018667001 GSPATT00019450001 GSPATT00027481001 GSPATT00027862001 GSPATT00032234001 GSPATT00034109001 GSPATT00034815001 GSPATT00037207001 GSPATT00039029001
SMIN: v1.2.005563.t1(symbB.v1.2.005563.t1) v1.2.013056.t1(symbB.v1.2.013056.t1) v1.2.027718.t1(symbB.v1.2.027718.t1)
NGD: NGA_2019900
SPAR: SPRG_03347 SPRG_10355
EHX: EMIHUDRAFT_211665 EMIHUDRAFT_232802 EMIHUDRAFT_449178
NGR: NAEGRDRAFT_30463 NAEGRDRAFT_72415
TVA: TVAG_002370
 » show all
Taxonomy
Reference
1  [PMID:24316715]
  Authors
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C
  Title
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
  Journal
Nat Chem Biol 10:93-5 (2014)
DOI:10.1038/nchembio.1432
  Sequence
[hsa:56339 57721]
Reference
2  [PMID:28121234]
  Authors
Wang X, Huang J, Zou T, Yin P
  Title
Human m(6)A writers: Two subunits, 2 roles.
  Journal
RNA Biol 14:300-304 (2017)
DOI:10.1080/15476286.2017.1282025
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.348
IUBMB Enzyme Nomenclature: 2.1.1.348
ExPASy - ENZYME nomenclature database: 2.1.1.348
BRENDA, the Enzyme Database: 2.1.1.348

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1766)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (698)   
   KEGG MGENES (1067)   
Protein sequence (34)   
   UniProt (13)   
   SWISS-PROT (13)   
   RefSeq(pep) (8)   
DNA sequence (8)   
   RefSeq(nuc) (8)   
Protein domain (1)   
   InterPro (1)   
All databases (1816)   

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