KEGG   ENZYME: 2.1.1.348
Entry
EC 2.1.1.348                Enzyme                                 
Name
mRNA m6A methyltransferase;
METTL3 (gene name);
METTL14 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:adenine in mRNA methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N6-methyladenine in mRNA [RN:R12011]
Reaction(KEGG)
R12011
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine in mRNA [CPD:C21844]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N6-methyladenine in mRNA [CPD:C21845]
Comment
This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.
History
EC 2.1.1.348 created 2018
Orthology
K05925  mRNA m6A methyltransferase catalytic subunit
Genes
HSA56339(METTL3)
PTR452765(METTL3)
PPS100990968(METTL3)
GGO101127472(METTL3)
PON100440500(METTL3)
NLE100580019(METTL3)
MCC706852(METTL3)
MCF101867229(METTL3)
CSAB103231389(METTL3)
CATY105593901(METTL3)
PANU101026443(METTL3)
TGE112629458(METTL3)
RRO104656255(METTL3)
RBB108516152(METTL3)
TFN117070047(METTL3)
PTEH111554803(METTL3)
CJC100408434(METTL3)
SBQ101048921(METTL3)
CSYR103264677(METTL3)
MMUR105864667(METTL3)
OGA100959724(METTL3)
MMU56335(Mettl3)
MCAL110309342(Mettl3)
MPAH110325286(Mettl3)
RNO361035(Mettl3)
MCOC116084237(Mettl3)
MUN110557725(Mettl3)
CGE100774316(Mettl3)
PLEU114682274(Mettl3)
NGI103733818(Mettl3)
HGL101700628(Mettl3)
CPOC100712853(Mettl3)
CCAN109690937(Mettl3)
DORD105995808(Mettl3)
DSP122107861(Mettl3)
NCAR124977675
OCU100353801(METTL3)
OPI101535102(METTL3)
TUP102503047(METTL3)
CFA475404(METTL3)
VVP112914863(METTL3)
VLG121481131(METTL3)
AML100464193(METTL3)
UMR103681541(METTL3)
UAH113248480(METTL3)
UAR123783884(METTL3)
ELK111153137 111153313
LLV125103856
MPUF101690372(METTL3)
ORO101373645(METTL3)
EJU114202127(METTL3)
ZCA113910485(METTL3)
MLX118003447(METTL3)
FCA101099304(METTL3)
PYU121031440(METTL3)
PBG122467717(METTL3)
PTG102972213(METTL3)
PPAD109255743(METTL3)
AJU106971425(METTL3)
HHV120240498(METTL3)
BTA540339(METTL3)
BOM102279941(METTL3)
BIU109564845(METTL3)
BBUB102403037(METTL3)
CHX100861319(METTL3)
OAS101108050(METTL3)
ODA120853374(METTL3)
CCAD122443280(METTL3)
SSC100513294(METTL3)
CFR102511663(METTL3)
CBAI105064645(METTL3)
CDK105097615(METTL3)
VPC102531686(METTL3)
BACU102998073(METTL3)
LVE103077878(METTL3)
OOR101283418(METTL3)
DLE111181830(METTL3)
PCAD102992275(METTL3)
PSIU116748978(METTL3)
ECB100059413(METTL3)
EPZ103556623(METTL3)
EAI106833262(METTL3)
MYB102257958(METTL3)
MYD102752704(METTL3)
MMYO118679511(METTL3)
MLF102431558(METTL3)
MNA107526983(METTL3)
PKL118724712(METTL3)
HAI109374267(METTL3)
DRO112311275(METTL3)
SHON118982662(METTL3)
AJM119040151 119054260(METTL3)
PDIC114490279(METTL3)
PHAS123808263(METTL3)
MMF118642319(METTL3)
RFQ117022934(METTL3)
PALE102884097(METTL3)
PGIG120608087(METTL3)
PVP105307311(METTL3)
RAY107521144(METTL3)
MJV108392562(METTL3)
TOD119238892(METTL3)
SARA101554037(METTL3)
LAV100670664(METTL3)
TMU101351297
DNM101416609(METTL3)
MDO100023433(METTL3)
GAS123238001(METTL3)
SHR100917802(METTL3)
PCW110220332(METTL3)
OAA103165659(METTL3)
GGA107050363
PCOC116239395(METTL3)
MGP104916039
CJO107307025(METTL3)
NMEL110391442(METTL3)
PHI102100035(METTL3)
CCAE111922569(METTL3)
AAM106498855(METTL3)
AROW112961330(METTL3)
NPD112955612(METTL3)
DNE112991773(METTL3)
ASN102379144(METTL3)
AMJ102564955(METTL3)
PSS102445384(METTL3)
CMY102932846(METTL3)
CPIC101942180(METTL3)
TST117886229(METTL3)
CABI116828063(METTL3)
MRV120380546(METTL3)
ACS100557846(mettl3)
PVT110087634(METTL3)
SUND121933359(METTL3)
PBI103063883(METTL3)
PMUR107286571(METTL3) 107295391
PGUT117671232(METTL3)
VKO123018934(METTL3)
PMUA114581421(METTL3)
ZVI118094797(METTL3)
GJA107118160(METTL3)
STOW125443949(METTL3)
XLA414662(mettl3.L)
XTR549173(mettl3)
NPR108792373(METTL3)
RTEM120940159(METTL3)
BBUF120988990(METTL3)
BGAR122933220(METTL3)
DRE100004398(mettl3)
SRX107750776 107753969
SANH107659734 107664282
SGH107560293 107595277
CCAR109096172 109100071
CAUA113052177 113076162 113105868
PPRM120469320(mettl3)
MAMB125265579(mettl3)
IPU108267670(mettl3)
PHYP113539785(mettl3)
SMEO124386767(mettl3)
TFD113654727(mettl3)
AMEX103037149(mettl3)
EEE113590997(mettl3)
TRU101075454(mettl3)
TNGGSTEN00024364G001
LCO104927608(mettl3)
NCC104964486(mettl3)
CGOB115023783(mettl3)
ELY117246187(mettl3)
PLEP121962505(mettl3)
SLUC116043306(mettl3)
ECRA117962191(mettl3)
PFLV114545481(mettl3)
GAT120822104(mettl3)
PPUG119222539(mettl3)
MSAM119896743 119912345(mettl3)
CUD121504201(mettl3)
MZE101474156(mettl3)
ONL100699671(mettl3)
OAU116327726(mettl3)
OLA101169238(mettl3)
OML112155877(mettl3)
XMA102235065(mettl3)
XCO114157282(mettl3)
XHE116732443(mettl3)
PRET103476007(mettl3) 103480536
PFOR103137573(mettl3)
PLAI106954577(mettl3)
PMEI106924009(mettl3)
GAF122820088(mettl3)
CVG107095594(mettl3)
CTUL119773426(mettl3)
GMU124881401(mettl3)
NFU107377303(mettl3)
KMR108247769(mettl3)
ALIM106533329(mettl3)
NWH119416559(mettl3)
AOCE111587471
CSEM103388127(mettl3)
POV109634817(mettl3)
SSEN122766248(mettl3)
HHIP117779387(mettl3)
LCF108902339(mettl3)
SDU111235619(mettl3)
SLAL111647204(mettl3)
XGL120797159(mettl3)
HCQ109516651(mettl3)
BPEC110172009(mettl3)
MALB109966479(mettl3)
SASA106577778(mettl3)
OTW112236308(mettl3)
OMY110531644
OGO124008356
ONE115137988(mettl3)
SALP111953381 112070048(mettl3)
SNH120030549(mettl3)
ELS105028165(mettl3)
SFM108930616 114911834
PKI111856469(mettl3)
AANG118231267(mettl3)
PSPA121307338(mettl3)
ARUT117398967(mettl3)
LCM102366801(METTL3)
BFO118417847
BBEL109473577
CIN100176137
SCLV120340890
SPU589354
APLC110973730
SKO102807369
DMEDmel_CG5933(Mettl3)
DER6555004
DSE6607666
DSIDsimw501_GD21054(Dsim_GD21054)
DYADyak_GE23438
DAN6499822
DSR110191308
DPODpse_GA19241
DPE113566243
DMN108154881
DWI6651528
DGR6563419
DMODmoj_GI24144
DAZ108608658
DNV108660009
DHE111602733
DVI6631190
CCAT101448363
BOD106616450
MDE101898583
SCAC106091810
LCQ111684902
AGAAgaP_AGAP002895
ACOZ120951301
AARA120896465
AAG5575912
AALB109423296
CQUCpipJ_CPIJ014114
CPII120423499
CNS116339116
AME551911
ACER108004331
ALAB122719502
BIM105681627
BBIF117209288
BVK117237330
BVAN117156011
BTER105665938
BPYO122569257
OBB114871782
MGEN117229085
NMEA116432249
CGIG122399929
SOC105193495
MPHA105839876
AEC105148021
ACEP105623451
PBAR105427889
VEM105565913
HST105190187
DQU106747677
CFO105249913
FEX115242609
LHU105675085
PGC109855379
OBO105280773
PCF106792463
PFUC122514555
VPS122629804
NVI100122395
CSOL105362090
TPRE106659296
MDL103580719
CGLO123258684
FAS105265102
DAM107045944
AGIF122852708
CCIN107267332
TCA656280
DPA109546131
SOY115882514
ATD109595553
CSET123312355
AGB108903896
LDC111503758
NVL108560527
APLN108738764
PPYR116159665 116173594
OTU111419411
BMOR101745362
BMAN114245052
MSEX115451127
DPLKGM_213490B
BANY112052401
PMAC106718659
PPOT106108728
PXU106127912
PRAP110995972
ZCE119837075
HAW110382051
TNL113494182 113507541
SLIU111351012
OFU114353266
PXY105384679
API100159080
DNX107170768
AGS114123910
RMD113556624 113560382
BTAB109042245
CLEC106674105
HHAL106677983
NLU111059382
PHUPhum_PHUM423190
FOC113202186
ZNE110829164
CSEC111872107
FCD110848223
DPXDAPPUDRAFT_192406 DAPPUDRAFT_305196 DAPPUDRAFT_66395
DMK116931030
PVM113807389
PJA122243284
PCHN125042425
HAME121864072
PCLA123750747
PTRU123500161
HAZT108682997
EAF111710437
LSM121117502
ISCIscW_ISCW004856
DSV119434499 119434554
RSAN119396896
RMP119174979
VDE111247420
VJA111263195
TUT107360421
DPTE113792246
DFR124499247
CSCU111623820
PTEP107455937
SDM118184251
HROHELRODRAFT_121421 HELRODRAFT_68987 HELRODRAFT_79167
LGILOTGIDRAFT_134083
PCAN112576566
BGT106060772
GAE121388404
HRF124133956
HRJ124283470
CRG105329074
MYI110443235
PMAX117337680
MMER123549775
OBI106879794
OSN115222362
LAK106169103
SMMSmp_146300
SHXMS3_0018810
OVIT265_11801
EGLEGR_08094 EGR_08908
NVE5518041
EPA110235523
ATEN116297498
ADF107352743
AMIL114976158
PDAM113675223
SPIS111340244
DGT114532757
XEN124435799
HMG100197970
AQU100641238
ATHAT4G10760(MTA)
ALY9308605
CRB17882338
CSAT104707363 104720582 104737069
EUSEUTSA_v10028481mg
BRP103833930
BNA106391767 106439910 111212589
BOE106319315
RSZ108828508
THJ104806452
CPAP110811296
CIT102614335
CICCICLE_v10019070mg
PVY116120890 116126453
MINC123204628
TCC18605995
GRA105765337
GHI107947151 107947165
GAB108479123
DZI111290769
EGR104441622
GMX100782695 100788519
GSJ114390412 114418405
PVUPHAVU_010G102500g
VRA106774348
VAR108321597
VUN114167117 114181972
CCAJ109796915
APRC113848974
MTRMTR_2g099870 MTR_8g104280
CAM101513814
LJALj0g3v0251359.1(Lj0g3v0251359.1)
ADU107472736
AIP107621980
AHF112726331 112732648
LANG109330921 109360911
FVE101294526
RCN112175860
PPER18777165
PMUM103337850
PAVI110758914 110774093
PDUL117628055
MDM103437411 103452571
PXB103949298
ZJU107430083
MNT21385301
CSV101210377
CMO103490711
BHJ120069008
MCHA111014877
CMAX111465197 111498696
CMOS111431216 111453835
CPEP111800888 111810602
RCU8288826
JCU105645610
HBR110669519
MESC110609534
POP7477828
PEU105127270
PALZ118033942
JRE108993781
QSU112033194
QLO115975222
TWL120016470
VVI100256414
VRI117907648
SLY101256793
SPEN107028842
SOT102597470
CANN107839021 107842841
NTA107788400 107790746
NSY104210563
NTO104095181
NAU109220278
INI109194080
ITR115999207
SIND105167810 105179105
OEU111375721
EGT105975681
SSPL121796126 121799870
HAN110926324
ECAD122611053
LSV111918792
CCAV112527942
DCR108209424
CSIN114279743
BVG104892598
SOE110796381
CQI110722755 110732287
NNU104594082
MING122084152
TSS122642711
PSOM113297700 113301518
NCOL116260838
OSA4330284
DOSAOs02t0672600-01(Os02g0672600)
OBR102715647
BDI100840009
ATS109748756
TDC119317406 119322786
TAES123127974 123137653 123145073
SBI8073912
ZMA100281493
SITA101781789
SVS117866514
PVIR120656777 120712316
PHAI112899429
PDA103707720 103719473
EGU105043457 105054093
MUS103970310 103993223
DCT110094702
PEQ110019823
AOF109839565
ATR18441600
SMOSELMODRAFT_123364 SELMODRAFT_130187
PPP112289060
CRECHLRE_06g288100v5 CHLRE_06g295600v5
VCNVOLCADRAFT_116042 VOLCADRAFT_59216
MNGMNEG_9590
CSLCOCSUDRAFT_13342 COCSUDRAFT_19144
CVRCHLNCDRAFT_50385
APROF751_4347
OLUOSTLU_43977
OTAOT_ostta11g01180
BPGBathy13g02200 Bathy13g02600
MISMICPUN_76124
MPPMICPUCDRAFT_51320
CMECYME_CME116C
GSLGasu_34680
SCEYGL192W(IME4)
SEUBDI49_1787
SPAOSPAR_G00640
AGOAGOS_AFR173W
KLAKLLA0_F09097g
KMXKLMA_20298(IME4)
LTHKLTH0E06468g
VPOKpol_246p4
ZROZYRO0G19294g
CGRCAGL0A03300g
NCSNCAS_0B05490(NCAS0B05490)
NDINDAI_0B02700(NDAI0B02700)
TPFTPHA_0H00330(TPHA0H00330)
TBLTBLA_0F00390(TBLA0F00390)
TDLTDEL_0B04590(TDEL0B04590)
TGBHG536_0D02570
KAFKAFR_0C02930(KAFR0C02930)
KNGKNAG_0G01340(KNAG0G01340)
ZMKHG535_0G01790
PPAPAS_chr2-1_0364
DHADEHA2B04598g
PICPICST_57562(IME4)
PGUPGUG_03704
SPAASPAPADRAFT_71109
LELLELG_00925
CALCAALFM_C201650WA(CaO19.1476)
CTPCTRG_01256
COTCORT_0A09720
CDUCD36_16510
CTENCANTEDRAFT_128415
YLIYALI0B03498g
CLUCLUG_03093
CLUSA9F13_12g01133
CAURCJI97_000151
PKZC5L36_0B06040
BNNFOA43_003348
BBRXBRETT_004194
CNECNE03860
CNBCNBE3850
CNGCNAG_02150
CGICGB_E5150C
TMSTREMEDRAFT_74548
PPLPOSPLDRAFT_25577
TVSTRAVEDRAFT_163442
DSQDICSQDRAFT_103275
PCOPHACADRAFT_88183
SHSSTEHIDRAFT_77013
HIRHETIRDRAFT_181243
PSQPUNSTDRAFT_142376
ADLAURDEDRAFT_96559
FMEFOMMEDRAFT_90465
GTRGLOTRDRAFT_71184
LBCLACBIDRAFT_243879
MPRMPER_15234
MRRMoror_17635
MOREE1B28_004554
CCICC1G_14583
SCMSCHCODRAFT_46077
ABPAGABI1DRAFT73723(AGABI1DRAFT_73723)
ABVAGABI2DRAFT67638(AGABI2DRAFT_67638)
SLASERLADRAFT_335862
WSEWALSEDRAFT_60123
WICJ056_001511
UMAUMAG_02989
PFPPFL1_05073
MGLMGL_2977
MRTMRET_3582
MSYMMSY001_0445
PGRPGTG_00232
MLRMELLADRAFT_41874
SREPTSG_03395
ACANACA1_366350
PFAPF3D7_0729500
PFHPFHG_05435
PREIPRSY57_0726300
PGABPGSY75_0729500
PYOPY17X_0215000
PCBPCHAS_021200(PC000795.04.0)
PBEPBANKA_0213600
PVVPVVCY_0201330
PKNPKNH_0214400
PVXPVX_081775
BBOBBOV_III001900(17.m07187)
BMICBmR1_04g05440
BBIGBBBOND_0303370
TGOTGME49_217350
TETTTHERM_00704040 TTHERM_00962190
PTMGSPATT00000069001 GSPATT00003428001 GSPATT00015836001 GSPATT00017263001 GSPATT00019450001 GSPATT00027862001 GSPATT00039029001
SPARSPRG_03347
EHXEMIHUDRAFT_211665 EMIHUDRAFT_232802
NGRNAEGRDRAFT_72415
TVATVAG_002370 TVAG_062450 TVAG_136190 TVAG_389630
 » show all
Reference
1  [PMID:24316715]
  Authors
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C
  Title
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
  Journal
Nat Chem Biol 10:93-5 (2014)
DOI:10.1038/nchembio.1432
  Sequence
[hsa:56339 57721]
Reference
2  [PMID:28121234]
  Authors
Wang X, Huang J, Zou T, Yin P
  Title
Human m(6)A writers: Two subunits, 2 roles.
  Journal
RNA Biol 14:300-304 (2017)
DOI:10.1080/15476286.2017.1282025
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.348
IUBMB Enzyme Nomenclature: 2.1.1.348
ExPASy - ENZYME nomenclature database: 2.1.1.348
BRENDA, the Enzyme Database: 2.1.1.348

DBGET integrated database retrieval system