KEGG   ENZYME: 2.1.1.350Help
Entry
EC 2.1.1.350                Enzyme                                 

Name
menaquinone C8-methyltransferase;
mqnK (gene name);
menK (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:menaquinone C8-methyltransferase
Reaction(IUBMB)
(1) 2 S-adenosyl-L-methionine + a menaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + an 8-methylmenaquinone + oxidized flavodoxin [RN:R12238];
(2) 2 S-adenosyl-L-methionine + a 2-demethylmenaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + oxidized flavodoxin [RN:R12239]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
menaquinone [CPD:C00828];
reduced flavodoxin [CPD:C02745];
2-demethylmenaquinone [CPD:C05818]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
L-methionine [CPD:C00073];
5'-deoxyadenosine [CPD:C05198];
8-methylmenaquinone [CPD:C22027];
oxidized flavodoxin [CPD:C02869];
2-demethyl-8-methylmenaquinone [CPD:C22028]
Comment
The enzyme, found in a wide range of bacteria and archaea, is a radical SAM (AdoMet) enzyme that utilizes two molecules of S-adenosyl-L-methionine, one as the methyl group donor, and one for the creation of a 5'-deoxyadenosine radical that drives the reaction forward.
History
EC 2.1.1.350 created 2018
Orthology
K23078  menaquinone C8-methyltransferase
Genes
SON: SO_4520
SFR: Sfri_0076
SAZ: Sama_3604
SBL: Sbal_0219
SBM: Shew185_4118
SBN: Sbal195_4239
SBP: Sbal223_0221
SBT: Sbal678_4272
SBS: Sbal117_0320
SBB: Sbal175_4025
SLO: Shew_0073
SSE: Ssed_4414
SPL: Spea_4126
SHL: Shal_0116
SWD: Swoo_4806
SWP: swp_5018
SPSW: Sps_05512
FBL: Fbal_3716
WSU: WS0113
CJE: Cj0363c
CJU: C8J_0339
CJI: CJSA_0336
CJM: CJM1_0341
CJS: CJS3_0353
CJEJ: N564_00346
CJEU: N565_00396
CJEN: N755_00396
CJEI: N135_00407
CJER: H730_02375
CJV: MTVDSCj20_0334(hemN1)
CJY: QZ67_00365(hemN_1)
CJQ: UC78_0350(hemN_1)
CJR: CJE0412
CFT: CFF04554_1668(hemN3)
CFV: CFVI03293_1690(hemN3)
CFX: CFV97608_1793(hemN3)
CFZ: CSG_18010
CAMP: CFT03427_1618(hemN3)
CCV: CCV52592_1538(hemN1)
CCO: CCC13826_1654(hemN1)
CCOC: CCON33237_0218(hemN1)
CLR: UPTC16701_1531(hemN3)
CLM: UPTC16712_1565(hemN3)
CLQ: UPTC4110_1538(hemN3)
CLN: UPTC3659_1773(hemN3)
CLL: CONCH_1507(hemN3)
CCQ: N149_0360
CCF: YSQ_08070
CCY: YSS_01590
CCOI: YSU_07070
CCOF: VC76_01910(hemN_1)
CCOO: ATE51_03488(hemN_3)
CAJ: CIG1485E_1563(hemN3)
CIS: CINS_1496(hemN3)
CVO: CVOL_1544(hemN3)
CPEL: CPEL_1663(hemN3)
CAMR: CAQ16704_1568(hemN3)
CSM: CSUB8521_1773(hemN3)
CSF: CSUB8523_1875(hemN3)
CGRA: CGRAC_0306(hemN1)
CURE: CUREO_1484(hemN3)
CHYO: CHH_1647(hemN3)
CHV: CHELV3228_1122(hemN1)
CSPF: CSF_1445(hemN3)
CPIN: CPIN18020_0428(hemN1)
CLX: CLAN_1392(hemN3)
CAVI: CAV_0263(hemN1)
CAMZ: CVIC12175_1403(hemN3)
CAMY: CSUIS_1438(hemN3)
AHS: AHALO_2059(hemN3)
AMAR: AMRN_2162(hemN3)
SDL: Sdel_0275
SMUL: SMUL_0352
SHAL: SHALO_0317
SULJ: SJPD1_0315
SAT: SYN_01802
CBN: CbC4_2070
CSQ: CSCA_0406
EYY: EGYY_01090(HemN)
GPA: GPA_12440
ATM: ANT_30420
TTN: TTX_0250(hemN)
ASC: ASAC_0728
ACIA: SE86_03530
 » show all
Taxonomy
Reference
1  [PMID:28164386]
  Authors
Hein S, Klimmek O, Polly M, Kern M, Simon J
  Title
A class C radical S-adenosylmethionine methyltransferase synthesizes 8-methylmenaquinone.
  Journal
Mol Microbiol 104:449-462 (2017)
DOI:10.1111/mmi.13638
  Sequence
[wsu:WS0113] [son:SO_4520] [aeq:AEQU_0025]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.350
IUBMB Enzyme Nomenclature: 2.1.1.350
ExPASy - ENZYME nomenclature database: 2.1.1.350
BRENDA, the Enzyme Database: 2.1.1.350

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