KEGG   ENZYME: 2.1.1.351Help
Entry
EC 2.1.1.351                Enzyme                                 

Name
nocamycin O-methyltransferase;
ncmP (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:nocamycin E O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + nocamycin E = S-adenosyl-L-homocysteine + nocamycin I [RN:R12263]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
nocamycin E [CPD:C22046]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
nocamycin I [CPD:C22047]
Comment
The enzyme, isolated from the bacterium Saccharothrix syringae, is involved in the biosynthesis of nocamycin I and nocamycin II.
History
EC 2.1.1.351 created 2018
Orthology
K23153  nocamycin O-methyltransferase
Reference
1  [PMID:28818448]
  Authors
Mo X, Gui C, Wang Q
  Title
Elucidation of a carboxylate O-methyltransferase NcmP in nocamycin biosynthetic pathway.
  Journal
Bioorg Med Chem Lett 27:4431-4435 (2017)
DOI:10.1016/j.bmcl.2017.08.010
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.351
IUBMB Enzyme Nomenclature: 2.1.1.351
ExPASy - ENZYME nomenclature database: 2.1.1.351
BRENDA, the Enzyme Database: 2.1.1.351

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