KEGG   ENZYME: 2.1.1.352Help
Entry
EC 2.1.1.352                Enzyme                                 

Name
3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine [RN:R11692]
Reaction(KEGG)
R11692;
(other) R12262
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-O-acetyl-4'-O-demethylpapaveroxine [CPD:C21590]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-O-acetylpapaveroxine [CPD:C21591]
Comment
This activity is part of the noscapine biosynthesis pathway, as characterized in the plant Papaver somniferum (opium poppy). It is catalysed by heterodimeric complexes of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes.
History
EC 2.1.1.352 created 2018
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K23157  3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase subunit OMT2
Genes
PSOM: 113322802
Taxonomy
Reference
1  [PMID:27378283]
  Authors
Li Y, Smolke CD
  Title
Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
  Journal
Nat Commun 7:12137 (2016)
DOI:10.1038/ncomms12137
Reference
2  [PMID:29723437]
  Authors
Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ
  Title
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
  Journal
Plant J 95:252-267 (2018)
DOI:10.1111/tpj.13947
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.352
IUBMB Enzyme Nomenclature: 2.1.1.352
ExPASy - ENZYME nomenclature database: 2.1.1.352
BRENDA, the Enzyme Database: 2.1.1.352

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