KEGG   ENZYME: 2.1.1.355Help
Entry
EC 2.1.1.355                Enzyme                                 

Name
[histone H3]-lysine9 N-trimethyltransferase;
KMT1A (gene name);
KMT1B (gene name);
KMT1C (gene name);
KMT1D (gene name);
KMT1E (gene name);
KMT1F (gene name);
MT8 (gene name);
SUV39H1 (gene name);
G9A (gene name);
EHMT1 (gene name);
PRDM2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Comment
This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
History
EC 2.1.1.355 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.355
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11419  [histone H3]-lysine9 N-trimethyltransferase SUV39H
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT
K11421  [histone H3]-lysine9 N-trimethyltransferase SETDB1
K11432  [histone H3]-lysine9 N-trimethyltransferase PRDM2
K18494  [histone H3]-lysine9 N-trimethyltransferase SETDB2
Genes
HSA: 10919(EHMT2) 6839(SUV39H1) 7799(PRDM2) 79723(SUV39H2) 79813(EHMT1) 83852(SETDB2) 9869(SETDB1)
PTR: 107971148(SUV39H1) 452719(SETDB2) 462572(EHMT2) 464891(EHMT1) 466014(SUV39H2) 469125(PRDM2) 469481(SETDB1)
PPS: 100968253(EHMT1) 100972839(SETDB1) 100977497(SUV39H1) 100982469(SUV39H2) 100986951(SETDB2) 100991724(EHMT2) 103782930(PRDM2)
GGO: 101125370(PRDM2) 101126338(SUV39H2) 101139808(EHMT2) 101141713(SETDB2) 101146215(SETDB1) 101146540(SUV39H1) 101151843(EHMT1)
PON: 100172621(SUV39H1) 100431310(SETDB1) 100436926(SUV39H2) 100436958(PRDM2) 100437576(SETDB2) 100449422(EHMT1) 100460372(EHMT2)
NLE: 100581330(SETDB1) 100582767(PRDM2) 100591032(SUV39H2) 100593118 100598636(SUV39H1) 100606578(EHMT2)
MCC: 697378(SUV39H2) 706277(SETDB2) 711040(SUV39H1) 715824(EHMT2) 716141(SETDB1) 716295(PRDM2) 721470(EHMT1)
MCF: 101926557(PRDM2) 102117410(SETDB1) 102124788(SETDB2) 102125769(EHMT1) 102134179(SUV39H1) 102136014(SUV39H2) 102139754(EHMT2)
CSAB: 103214423(SETDB2) 103221737(EHMT2) 103225565(PRDM2) 103231938(SUV39H1) 103237926(SUV39H2) 103239544(EHMT1) 103247223(SETDB1)
RRO: 104660660(SUV39H1) 104662745(SETDB2) 104664471(SUV39H2) 104669606(EHMT1) 104674046(PRDM2) 104678126(EHMT2) 104681064(SETDB1)
RBB: 108517467(SUV39H1) 108519969 108520267(EHMT2) 108530731(SETDB2) 108531071(SUV39H2) 108533259(SETDB1) 108542880(EHMT1)
CJC: 100385110(PRDM2) 100394788(SETDB2) 100398057(EHMT1) 100401369(SUV39H1) 100401513(SUV39H2) 100411734(SETDB1)
SBQ: 101040475(SUV39H2) 101042658(SETDB1) 101043411(SETDB2) 101046305(EHMT2) 101052197(SUV39H1) 101054202(PRDM2) 101054241(EHMT1) 104652487
MMU: 107303348(Gm45935) 110147(Ehmt2) 110593(Prdm2) 20937(Suv39h1) 239122(Setdb2) 64707(Suv39h2) 77683(Ehmt1) 84505(Setdb1)
MCAL: 110284133(Ehmt2) 110287176(Suv39h1) 110289296(Suv39h2) 110291522(Setdb1) 110293588(Prdm2) 110309030(Setdb2) 110312405(Ehmt1)
MPAH: 110313347(Suv39h1) 110317691(Ehmt1) 110320737(Setdb1) 110322886(Prdm2) 110325326(Setdb2) 110333642(Suv39h2) 110335935(Ehmt2)
RNO: 100361710(Setdb2) 302553(Suv39h1) 313678(Prdm2) 361798(Ehmt2) 362078(Ehmt1) 364785(Suv39h2) 689883(Setdb1)
MUN: 110554698(Suv39h2) 110556467(Prdm2) 110560108(Ehmt2) 110560774(Setdb1) 110561991(Suv39h1)
CGE: 100754544(Ehmt1) 100755145(Suv39h2) 100764568(Suv39h1) 100765697(Setdb1) 100769417(Ehmt2) 100773277(Prdm2) 100774155
NGI: 103724422(Ehmt2) 103730089(Setdb1) 103732609(Ehmt1) 103735184(Suv39h2) 103741644(Suv39h1) 103752332(Prdm2)
HGL: 101696702(Setdb2) 101697232(Ehmt2) 101699104(Ehmt1) 101699822(Prdm2) 101701917(Suv39h2) 101706867(Suv39h1) 101715248(Setdb1)
CCAN: 109681205(Setdb1) 109688969(Ehmt1) 109689573(Ehmt2) 109691104(Setdb2) 109691500(Suv39h2) 109701207(Suv39h1) 109702677(Prdm2)
OCU: 100342335(PHF11) 100348361(EHMT1) 100350859 100354725(SUV39H1) 100355131(EHMT2) 100355877(SETDB1) 100358024(SUV39H2) 103352508(PRDM2)
TUP: 102468719(SUV39H1) 102472765 102479735(EHMT2) 102498729(EHMT1) 102499550(PRDM2) 102502264(SETDB1) 102503290(SETDB2)
CFA: 100688431(PRDM2) 474851(EHMT2) 477995(SUV39H2) 483186(SETDB1) 485441(SETDB2) 491224(EHMT1) 491868(SUV39H1)
VVP: 112907242(SUV39H1) 112907769(SETDB1) 112911417(EHMT1) 112913622(EHMT2) 112929764(PRDM2) 112933120(SUV39H2) 112933943(SETDB2)
AML: 100466861(EHMT1) 100468794(EHMT2) 100469547(SUV39H2) 100472595(SUV39H1) 100476962(SETDB2) 100481446(PRDM2) 100482250(SETDB1) 105240378
UMR: 103664189(SUV39H2) 103666633(PRDM2) 103666849 103667532(SETDB1) 103669105(SUV39H1) 103675323(EHMT1) 103677615(SETDB2) 103682289(EHMT2)
UAH: 113241391(SUV39H2) 113243735(EHMT2) 113246155(SETDB1) 113248390 113248430 113251315 113265922(SUV39H1) 113270485(PRDM2)
ORO: 101364966(PRDM2) 101372094(SETDB1) 101374258(SUV39H2) 101375740(EHMT1) 101376988(EHMT2) 101381146(SUV39H1) 101381937(SETDB2)
FCA: 101082169(PRDM2) 101083571(SUV39H1) 101087111(EHMT1) 101091940(EHMT2) 101094118(SETDB1) 101099218(SUV39H2)
PTG: 102950897(SUV39H1) 102954489(EHMT1) 102962904(SETDB2) 102963752(SUV39H2) 102966552 102967892(PRDM2) 102968259(EHMT2) 102970727(SETDB1)
PPAD: 109248069(SUV39H1) 109257028(SETDB1) 109260239(EHMT1) 109260503(EHMT2) 109265964 109273698(SUV39H2) 109274376(PRDM2)
AJU: 106970864(SUV39H1) 106971016(SUV39H2) 106972687 106979835(SETDB1) 106983481(EHMT2) 106988167(PRDM2) 106989056(EHMT1)
BTA: 100138100(SETDB1) 509382(SETDB2) 514062(EHMT2) 523047(SUV39H1) 528606(EHMT1) 536936(SUV39H2) 789222(PRDM2)
BOM: 102264756(SUV39H2) 102271111(EHMT1) 102271191(SUV39H1) 102279999(EHMT2) 102281203(PRDM2) 102287560(SETDB2) 102288279(SETDB1)
BIU: 109555305(SETDB1) 109565691(EHMT1) 109566720(SETDB2) 109567973(SUV39H2) 109570372(PRDM2) 109576929(EHMT2)
BBUB: 102392662(SETDB2) 102395323(EHMT1) 102396138(PRDM2) 102401546(SUV39H1) 102405188(EHMT2) 102408652(SETDB1) 102415169(SUV39H2)
CHX: 102171636(PRDM2) 102174919(SUV39H1) 102176621(SUV39H2) 102178316(EHMT2) 102180982(SETDB1) 102186776(SETDB2) 102189411(EHMT1)
OAS: 101109230(SETDB1) 101110031(SUV39H1) 101115739(EHMT2) 101116064(SETDB2) 101116417(SUV39H2) 101123545(EHMT1) 105601941(PRDM2)
SSC: 100124382(EHMT2) 100157885(SETDB2) 100157920(SETDB1) 100518559(PRDM2) 110258080(EHMT1) 664651(SUV39H2) 767626(SUV39H1)
CFR: 102512057(SETDB1) 102514882(PRDM2) 102514903 102518579(EHMT2) 102521199(SUV39H2)
CDK: 105087443(EHMT2) 105101932 105102102(EHMT1) 105103196(SETDB1) 105103308(SUV39H1) 105104521(SUV39H2) 105107110(PRDM2)
BACU: 102999710(SUV39H2) 103005831(SUV39H1) 103009894(SETDB1) 103017152(SETDB2) 103017744(EHMT1) 103018553(EHMT2) 103020862(PRDM2)
LVE: 103068757(SETDB2) 103072310(EHMT2) 103073919(SUV39H1) 103076461(SETDB1) 103079038(EHMT1) 103083070(PRDM2) 103084616(SUV39H2)
OOR: 101269551(PRDM2) 101270688(SETDB1) 101272833(EHMT1) 101279239(SUV39H2) 101282385(EHMT2) 101289196(SUV39H1)
DLE: 111169525(SUV39H1) 111169744(SETDB1) 111170699(EHMT2) 111175303 111176964(EHMT1) 111178089(SUV39H2) 111187234(PRDM2)
PCAD: 102974835(PRDM2) 102978732(EHMT1) 102988226(SUV39H2) 102988363(SUV39H1) 102990347(SETDB2) 102993056(EHMT2)
ECB: 100054973(PRDM2) 100056120(SETDB2) 100058869(EHMT1) 100059118(EHMT2) 100059254(SETDB1) 100062108(SUV39H1) 100068891(SUV39H2)
EPZ: 103544360 103544897(SUV39H1) 103547642(SETDB1) 103554163(EHMT1) 103556824(SUV39H2) 103563300(EHMT2) 103563428(SETDB2) 103564688(PRDM2)
EAI: 106822324(EHMT2) 106822761(EHMT1) 106827436(SUV39H1) 106828015(PRDM2) 106829693(SETDB2) 106840452(SUV39H2) 106846522(SETDB1)
MYB: 102243180(SUV39H1) 102248401(SETDB2) 102249747(PRDM2) 102257713(SETDB1) 102260054(SUV39H2) 102263672(EHMT2)
MYD: 102756540(EHMT1) 102757145(SUV39H2) 102760935(PRDM2) 102763954(SUV39H1) 102765299(SETDB2) 102773684(SETDB1)
MNA: 107531408(SETDB2) 107531564 107534821(SUV39H2) 107536199(EHMT1) 107538997(EHMT2) 107539129(SETDB1) 107541392(SUV39H1)
HAI: 109372277(SETDB1) 109373117(EHMT2) 109374812(SUV39H1) 109381271(PRDM2) 109382055(EHMT1) 109387125(SETDB2) 109393823(SUV39H2)
DRO: 112299124(PRDM2) 112302258(EHMT2) 112306260(EHMT1) 112313171 112313537(SETDB1) 112320455(SUV39H2) 112322458(SUV39H1)
PALE: 102879374(EHMT2) 102879589(PRDM2) 102891996 102893102(EHMT1) 102894853(SUV39H1) 102898400(SUV39H2)
RAY: 107498490(EHMT2) 107499036(SETDB1) 107504834(SUV39H2) 107510017(SETDB2) 107513143(PRDM2) 107515026(SUV39H1)
MJV: 108397103(SUV39H2) 108397963(PRDM2) 108400840(EHMT2) 108403560(SETDB2) 108408400(SUV39H1) 108409453(SETDB1)
LAV: 100653780(SUV39H1) 100658021(PRDM2) 100659207(EHMT2) 100670438 100673374(SETDB1) 100674328(SUV39H2)
MDO: 100010516(PRDM2) 100014806(SUV39H2) 100018670(SUV39H1) 100023838(EHMT1) 100025360(EHMT2) 100028710(SETDB2) 100618580(SETDB1)
SHR: 100922258(SUV39H1) 100928904(SETDB1) 100931147(EHMT2) 100932927(EHMT1) 100933751(SUV39H2) 100934863 111719909(PRDM2)
PCW: 110198885(PRDM2) 110199440(EHMT2) 110201087(SUV39H1) 110205249(EHMT1) 110213411(SETDB2) 110217388(SUV39H2) 110220597(SETDB1)
OAA: 100078328(EHMT1) 100082943(EHMT2) 100083315(SETDB2) 100084051(SUV39H1) 100085175(SUV39H2) 100091318(SETDB1) 100681503(PRDM2)
GGA: 100859816(SETDB1) 112529925 112529927(SUV39H1) 395847(MLLT11) 417250(EHMT1) 418866(SETDB2) 419478(PRDM2) 426314(SUV39H2)
CJO: 107307203(SUV39H1) 107308162 107319605(SUV39H2) 107321652(EHMT1) 107323354(PRDM2) 107324577(SETDB1)
NMEL: 110387900(SETDB1) 110391539(SUV39H1) 110392282(SUV39H2) 110406734(EHMT1) 110408674(PRDM2)
APLA: 101790074 101794756(SETDB1) 101795723(PRDM2) 101796000(SUV39H2) 101805087(EHMT1)
ACYG: 106037080(EHMT1) 106040216(PRDM2) 106040219 106046190(SUV39H2) 106049268(SETDB1)
LSR: 110469585 110470972(SUV39H2) 110476787(PRDM2) 110476821(SETDB1) 110476956(EHMT1) 110481760(SUV39H1)
GFR: 102031848(SUV39H2) 102034546(SETDB1) 102036198(EHMT1) 106631968(PRDM2)
FAB: 101806838(EHMT1) 101812782(PRDM2) 101812936(PHF11) 101814584 101816158(SUV39H2)
PHI: 102099526(EHMT1) 102101563(SETDB1) 102104074(SETDB2) 102110616(SUV39H1) 102111894(PRDM2) 102114300(SUV39H2)
PMAJ: 107204624(SUV39H2) 107211503 107212039(EHMT1) 107213672(PRDM2) 107214655(SETDB1)
CCAE: 111923103(SUV39H2) 111935294 111936927(EHMT1) 111938730(PRDM2) 111939473(SETDB1)
CCW: 104688230(EHMT1) 104689965 104693258(PRDM2) 104693366 104694491(SUV39H2)
ETL: 114065121(PRDM2) 114067139(EHMT1) 114067551(SUV39H2) 114071955(SETDB1)
FPG: 101912073(SETDB1) 101912815(SUV39H2) 101914490(PRDM2) 101916063(EHMT1) 101917763(SETDB2) 106112052
FCH: 102055212(SETDB1) 102055395 102057247(EHMT1) 102059458(SUV39H2) 102059903 106631029(PRDM2)
CLV: 102085960(EHMT1) 102088543 102092575(PRDM2) 102094505(SETDB1) 102098917(SUV39H2)
EGZ: 104124045(EHMT1) 104129700(SETDB1) 104132393(SUV39H2) 104133098(PRDM2)
NNI: 104009017 104009090 104014430(SETDB1) 104014630(SUV39H2) 104022219(EHMT1)
ACUN: 113486655(EHMT1) 113487883(PRDM2) 113488725(SETDB1) 113489768(SUV39H2)
PADL: 103915032(SUV39H2) 103918059(PRDM2) 103918930(EHMT1) 103919479(SETDB1)
AAM: 106482427(PRDM2) 106482431 106485143(SUV39H2) 106493032(EHMT1) 106495416(SETDB1)
ASN: 102371718(PRDM2) 102374916(EHMT1) 102375358(SUV39H2) 102378805(SUV39H1) 102380189 102382539(SETDB1)
AMJ: 102558468(SUV39H1) 102561958(PRDM2) 102563656(SUV39H2) 102564850(EHMT1) 102575637(SETDB1) 102576351(SETDB2)
CMY: 102932781(SETDB2) 102933671(EHMT1) 102937045(SUV39H2) 102937828(SETDB1) 102937831(SUV39H1) 102942942(PRDM2)
CPIC: 101931963(SETDB1) 101939547(PRDM2) 101942163(EHMT1) 101945875(SUV39H2) 101951503(SUV39H1)
ACS: 100552443(setdb2) 100553897(suv39h1) 100556375(ehmt2) 100565799(setdb1) 100567365(prdm2)
PVT: 110072610 110081193(SUV39H1) 110081479(SETDB1) 110088696(EHMT2)
PBI: 103049261(EHMT2) 103052540(SUV39H1) 103053131(SETDB1) 103053645 103060604(PRDM2) 103067345
PMUR: 107291380(PRDM2) 107292899(SETDB1) 107300048(SUV39H1)
TSR: 106546114(SUV39H1) 106546292(SETDB1) 106553032(PRDM2)
PMUA: 114586177(SETDB1) 114588136(SUV39H1) 114592073(EHMT2) 114602405(PRDM2)
GJA: 107105480(EHMT2) 107106223(PRDM2) 107112843(SUV39H1) 107118801(EHMT1) 107121584(SETDB1)
XLA: 100037174(suv39h2.L) 108696585(prdm2.L) 108698163(ehmt1.L) 108698559(ehmt2.L) 108699889(ehmt1.S) 108700299(suv39h1.S) 108700333(setdb1.S) 108713053(suv39h2.S) 398711(setdb2.S) 431943(suv39h1.L) 432147(setdb1.L) 494709(prdm2.S)
XTR: 100124713(ehmt1) 100124743(setdb2) 100170624(prdm2) 100484992(ehmt2) 100490309(setdb1) 116408207 549262(suv39h2)
NPR: 108783946(PRDM2) 108786543(EHMT2) 108788266(SUV39H1) 108789810(SETDB1) 108794066(SUV39H2)
DRE: 100003615(prdm2a) 100005761(ehmt1a) 326906(suv39h1b) 335153(setdb2) 402830(ehmt1b) 445198(suv39h1a) 553292(setdb1a) 569250(ehmt2) 768131(setdb1b) 797296(prdm2b)
LCO: 104919369(prdm2) 104920221 104920543(setdb1) 104932794(suv39h1)
NCC: 104944919(setdb1) 104951536(prdm2) 104953540(suv39h1) 104955184
ONL: 100693758(suv39h1) 100697429(prdm2) 100710331(setdb1) 102080474
OLA: 101155408(suv39h1) 101156736 101157610(prdm2) 101158302(setdb1) 101163233
XMA: 102218201(suv39h1) 102218386 102225394 102225694(prdm2) 102235762(setdb1)
XCO: 114135463(prdm2) 114141956(setdb1) 114142201(suv39h1) 114144686
PRET: 103464486(prdm2) 103466971(suv39h1) 103467994 103478723(setdb1)
CVG: 107088829(setdb1) 107088877 107089331(prdm2) 107090999(suv39h1)
NFU: 107379696(setdb1) 107385249 107390532(suv39h1) 107390711
KMR: 108231376(prdm2) 108231967(suv39h1) 108236789 108241152(setdb1)
AOCE: 111563741 111586482(setdb1) 111588009 111588288(suv39h1)
CSEM: 103384853(suv39h1) 103384937 103385671(prdm2) 103388279(setdb1)
POV: 109630614 109630999(suv39h1) 109633224 109638572(prdm2)
LCF: 108885905(setdb1) 108891714 108899885 108900517(suv39h1)
SDU: 111219081(suv39h1) 111219130 111223982(prdm2) 111230127(setdb1)
SLAL: 111652197(setdb1) 111658260(prdm2) 111664278 111670678 111670830(suv39h1)
HCQ: 109522778(setdb1) 109526575 109528227(suv39h1) 109529179(prdm2)
BPEC: 110156027(suv39h1) 110158800 110163046(setdb1) 110168576(prdm2)
SFM: 108918498(prdm2) 108923796(setdb1) 108924930 108934780(suv39h1)
PKI: 111847791(suv39h1) 111853328(setdb1) 111857023 111859124
LCM: 102351913 102356699(SETDB1) 102359250(PRDM2) 102360554(SUV39H2) 102363588(SETDB2)
CMK: 103173106 103181338(prdm2)
RTP: 109921345(suv39h2) 109937263(prdm2)
DME: Dmel_CG12196(egg) Dmel_CG2995(G9a) Dmel_CG43664(Su(var)3-9) Dmel_CG43665(eIF2gamma)
DSI: Dsimw501_GD16494(Dsim_GD16494) Dsimw501_GD24920(Dsim_GD24920)
DSR: 110189614
ACEP: 105620791
BMOR: 101742950 692623(Su(var)3-9)
BMAN: 114244119
PMAC: 106721248
PRAP: 110997400
CEL: CELE_R05D3.11(met-2)
CBR: CBG18157(Cbr-met-2)
TSP: Tsp_05330
EGL: EGR_06122
ATH: AT1G17770(SUVH7) AT1G73100(SUVH3) AT2G22740(SUVH6) AT2G24740(SDG21) AT2G33290(SUVH2) AT2G35160(SUVH5) AT4G13460(SUVH9) AT5G04940(SUVH1) AT5G13960(SUVH4)
BRP: 103847241
CAM: 101495955
LJA: Lj1g3v4059050.1(Lj1g3v4059050.1)
ADU: 107494232
AIP: 107604714
JCU: 105631294
MESC: 110613379
SPEN: 107027330
NTA: 107807217
NNU: 104595796
DOSA: Os01t0811300-01(Os01g0811300) Os04t0544100-01(Os04g0544100) Os05t0490700-01(Os05g0490700) Os07t0435900-01(Os07g0435900) Os08t0400000-01(Os08g0400000) Os08t0400200-00(Os08g0400200) Os11t0131600-00(Os11g0131600) Os11t0602200-01(Os11g0602200)
ATS: 109746199(LOC109746199) 109751482(LOC109751482) 109769961(LOC109769961) 109774279(LOC109774279)
ZMA: 100280164 541980(sdg113) 542085 542089(sdg118) 542090 542102
CRE: CHLREDRAFT_6823(SET3)
OLU: OSTLU_25709(SDG3507)
NCR: NCU04402(dim-5)
NTE: NEUTE1DRAFT121214(NEUTE1DRAFT_121214)
MGR: MGG_06852
SSCK: SPSK_07647
NHE: NECHADRAFT_94199(SDG2104)
MAW: MAC_09094
MAJ: MAA_00272
CMT: CCM_00746
BFU: BCIN_11g02360(BcDIM5)
MBE: MBM_05751
ANI: AN1170.2
ANG: ANI_1_1828074(An08g03380)
ABE: ARB_02816
TVE: TRV_01916
PTE: PTT_11395
ZTR: MYCGRDRAFT_107709(SDG2411)
SPO: SPBC428.08c(clr4)
CNE: CNH00720
CNB: CNBL0680
LBC: LACBIDRAFT_296206(SDG16210) LACBIDRAFT_300409(SDG16205)
ABP: AGABI1DRAFT108076(AGABI1DRAFT_108076) AGABI1DRAFT129982(AGABI1DRAFT_129982)
ABV: AGABI2DRAFT180791(AGABI2DRAFT_180791)
 » show all
Taxonomy
Reference
1  [PMID:11094092]
  Authors
O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T
  Title
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase  gene that displays testis-specific expression.
  Journal
Mol Cell Biol 20:9423-33 (2000)
DOI:10.1128/mcb.20.24.9423-9433.2000
  Sequence
[mmu:20937 64707]
Reference
2  [PMID:11867540]
  Authors
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G
  Title
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
  Journal
EMBO J 21:1121-31 (2002)
  Sequence
Reference
3  [PMID:12130538]
  Authors
Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y
  Title
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
  Journal
Genes Dev 16:1779-91 (2002)
DOI:10.1101/gad.989402
  Sequence
[mmu:110147]
Reference
4  [PMID:11959841]
  Authors
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd
  Title
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase  that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
  Journal
Genes Dev 16:919-32 (2002)
DOI:10.1101/gad.973302
  Sequence
[hsa:9869]
Reference
5  [PMID:14633678]
  Authors
Kim KC, Geng L, Huang S
  Title
Inactivation of a histone methyltransferase by mutations in human cancers.
  Journal
Cancer Res 63:7619-23 (2003)
  Sequence
[hsa:7799]
Reference
6  [PMID:20084102]
  Authors
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M
  Title
Structural biology of human H3K9 methyltransferases.
  Journal
PLoS One 5:e8570 (2010)
DOI:10.1371/journal.pone.0008570
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.355
IUBMB Enzyme Nomenclature: 2.1.1.355
ExPASy - ENZYME nomenclature database: 2.1.1.355
BRENDA, the Enzyme Database: 2.1.1.355

DBGET integrated database retrieval system