KEGG   ENZYME: 2.1.1.358Help
Entry
EC 2.1.1.358                Enzyme                                 

Name
[histone H3]-dimethyl-L-lysine36 N-methyltransferase;
KMT3A (gene name);
SETD2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-N6,N6-dimethyl-L-lysine36 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
Reaction(KEGG)
(other) R04867
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-N6,N6-dimethyl-L-lysine36
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine36
Comment
The enzyme, found in metazoa, methylates a dimethylated L-lysine36 residue of histone H3 (H3K36), which has been methylated previously by EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase. The homologous enzyme from yeast catalyses all three methylations (see EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase).
History
EC 2.1.1.358 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.358
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11423  [histone H3]-dimethyl-L-lysine36 N-methyltransferase
Genes
HSA: 29072(SETD2)
PTR: 460331(SETD2)
PPS: 100993006(SETD2)
GGO: 101132140(SETD2)
PON: 100433116(SETD2)
NLE: 100584442(SETD2)
MCC: 711825(SETD2)
MCF: 102121581(SETD2)
CSAB: 103227561(SETD2)
RRO: 104671311(SETD2)
RBB: 108517641(SETD2)
CJC: 100411953(SETD2)
SBQ: 101034613(SETD2)
MMU: 235626(Setd2)
MCAL: 110301050(Setd2)
MPAH: 110328077(Setd2)
RNO: 316013(Setd2)
MUN: 110554986(Setd2)
CGE: 100765637(Setd2)
NGI: 103732034(Setd2)
HGL: 101719404(Setd2)
CCAN: 109689470(Setd2)
TUP: 102477917(SETD2)
CFA: 476643(SETD2)
VVP: 112912390(SETD2)
AML: 100466135(SETD2)
UMR: 103675118(SETD2)
UAH: 113256807(SETD2)
ORO: 101365495(SETD2)
ELK: 111144347
FCA: 101085029(SETD2)
PTG: 102955436(SETD2)
PPAD: 109247730(SETD2)
AJU: 106969033(SETD2)
BTA: 539860(SETD2)
BOM: 102266643(SETD2)
BIU: 109575988(SETD2)
BBUB: 102393639(SETD2)
CHX: 102183113(SETD2)
OAS: 101114649(SETD2)
SSC: 100623101(SETD2)
CFR: 102512396(SETD2)
CDK: 105103636(SETD2)
BACU: 102997833(SETD2)
LVE: 103086894(SETD2)
OOR: 101280364(SETD2)
DLE: 111174450(SETD2)
PCAD: 112064944(SETD2)
ECB: 100064888(SETD2)
EPZ: 103551032(SETD2)
EAI: 106823246(SETD2)
MYB: 102260404(SETD2)
MYD: 102758485(SETD2)
MNA: 107529409(SETD2)
HAI: 109376628(SETD2)
DRO: 112309866(SETD2)
PALE: 102884085(SETD2)
RAY: 107509112(SETD2)
MJV: 108400455(SETD2)
LAV: 100655356(SETD2)
TMU: 101343139
MDO: 100024848(SETD2)
SHR: 100931646(SETD2)
PCW: 110217008(SETD2)
OAA: 114816148(SETD2)
GGA: 420404(SETD2)
MGP: 100539457(SETD2)
CJO: 107308808(SETD2)
NMEL: 110393293(SETD2)
ACYG: 106046805(SETD2)
TGU: 100224614(SETD2)
LSR: 110476945(SETD2)
SCAN: 103813035(SETD2)
GFR: 102039322(SETD2)
FAB: 101814785(SETD2)
PHI: 102106397(SETD2)
PMAJ: 107215411(SETD2)
CCAE: 111925482(SETD2)
CCW: 104686490(SETD2)
ETL: 114070402(SETD2)
FPG: 101913975(SETD2)
FCH: 102053248(SETD2)
CLV: 102098192(SETD2)
EGZ: 104123260(SETD2)
NNI: 104019238(SETD2)
ACUN: 113476423(SETD2)
PADL: 103916778(SETD2)
ASN: 102378063(SETD2)
AMJ: 102567964(SETD2)
PSS: 102460966(SETD2)
CMY: 102947543(SETD2)
CPIC: 101953039(SETD2)
ACS: 100559621(setd2)
PVT: 110069987(SETD2)
PMUR: 107286005(SETD2)
TSR: 106542655(SETD2)
PMUA: 114607160(SETD2)
GJA: 107120098(SETD2)
XLA: 108718681(setd2.L) 108719797(setd2.S)
XTR: 100492810(setd2)
DRE: 794199(setd2)
LCM: 102359121(SETD2)
SPU: 578079
DME: Dmel_CG1716(Set2)
DSI: Dsimw501_GD17127(Dsim_GD17127)
DPE: 6601763
DMN: 108156147
AAG: 5567362
AME: 100578450
TCA: 662406
BMY: Bm1_35965
ATH: AT2G44150(ASHH3) AT3G59960(ASHH4)
CRB: 17888828
BRP: 103866771
BOE: 106339348
RSZ: 108832868
THJ: 104804421
VRA: 106762940
VAR: 108346086
VUN: 114182699
CCAJ: 109816703
LJA: Lj0g3v0135089.1(Lj0g3v0135089.1) Lj2g3v0523280.1(Lj2g3v0523280.1)
VVI: 100252753
SLY: 101250245
SPEN: 107011725
SOT: 102585737
DOSA: Os09t0307800-01(Os09g0307800)
OBR: 102707707
SBI: 8064682
ZMA: 100194312 100282875 542662(sdg110a)
OLU: OSTLU_18587(SDG3502)
 » show all
Taxonomy
Reference
1  [PMID:15798214]
  Authors
Kizer KO, Phatnani HP, Shibata Y, Hall H, Greenleaf AL, Strahl BD
  Title
A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
  Journal
Mol Cell Biol 25:3305-16 (2005)
DOI:10.1128/MCB.25.8.3305-3316.2005
Reference
2  [PMID:19332550]
  Authors
Yuan W, Xie J, Long C, Erdjument-Bromage H, Ding X, Zheng Y, Tempst P, Chen S, Zhu B, Reinberg D
  Title
Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.
  Journal
J Biol Chem 284:15701-7 (2009)
DOI:10.1074/jbc.M808431200
  Sequence
[hsa:29072]
Reference
3  [PMID:22266761]
  Authors
Wagner EJ, Carpenter PB
  Title
Understanding the language of Lys36 methylation at histone H3.
  Journal
Nat Rev Mol Cell Biol 13:115-26 (2012)
DOI:10.1038/nrm3274
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.358
IUBMB Enzyme Nomenclature: 2.1.1.358
ExPASy - ENZYME nomenclature database: 2.1.1.358
BRENDA, the Enzyme Database: 2.1.1.358

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