KEGG   ENZYME: 2.1.1.359Help
Entry
EC 2.1.1.359                Enzyme                                 

Name
[histone H3]-lysine36 N-trimethyltransferase;
SET2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-trimethyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36
Comment
The enzyme, characterized from yeast, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. In mammals this activity is catalysed by two different enzymes, EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase and EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase.
History
EC 2.1.1.359 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.359
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K23700  [histone H3]-lysine36 N-trimethyltransferase
Genes
QSU: 112010221 112037919
SLY: 101265474
SPEN: 107030284
SCE: YJL168C(SET2)
AGO: AGOS_AEL128C
ERC: Ecym_8108
KLA: KLLA0_A06600g
KMX: KLMA_10383(SET2)
LTH: KLTH0F04510g
VPO: Kpol_2001p35
NCS: NCAS_0I02880(NCAS0I02880)
NDI: NDAI_0B00260(NDAI0B00260)
TPF: TPHA_0A02720(TPHA0A02720)
TBL: TBLA_0J01040(TBLA0J01040)
TDL: TDEL_0G02090(TDEL0G02090)
KAF: KAFR_0F01770(KAFR0F01770)
CAL: CAALFM_C210250CA(SET2)
SLB: AWJ20_4803(SET2)
NCR: NCU00269(set-2)
NTE: NEUTE1DRAFT122301(NEUTE1DRAFT_122301)
MGR: MGG_01661
SSCK: SPSK_04901
NHE: NECHADRAFT_106311(SDG2102)
MAW: MAC_05010
MAJ: MAA_03512
CMT: CCM_07296
BFU: BCIN_10g05250(Bcset2)
MBE: MBM_00950
ANI: AN8825.2
ANG: ANI_1_490154(An17g01825)
ABE: ARB_07003
TVE: TRV_02085
PTE: PTT_20031
ZTR: MYCGRDRAFT_20674(SDG2404)
NPA: UCRNP2_87
SPO: SPAC29B12.02c(set2)
CNE: CNG03810
CNB: CNBG0940
LBC: LACBIDRAFT_318928(SDG16202)
ABP: AGABI1DRAFT123473(AGABI1DRAFT_123473)
ABV: AGABI2DRAFT76781(AGABI2DRAFT_76781)
MGL: MGL_3860
MRT: MRET_0662
SPAR: SPRG_02673
 » show all
Taxonomy
Reference
1  [PMID:11839797]
  Authors
Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, Mollah S, Cook RG, Shabanowitz J, Hunt DF, Allis CD
  Title
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.
  Journal
Mol Cell Biol 22:1298-306 (2002)
  Sequence
[sce:YJL168C]
Reference
2  [PMID:12917322]
  Authors
Landry J, Sutton A, Hesman T, Min J, Xu RM, Johnston M, Sternglanz R
  Title
Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.
  Journal
Mol Cell Biol 23:5972-8 (2003)
  Sequence
[sce:YJL168C]
Reference
3  [PMID:16087749]
  Authors
Morris SA, Shibata Y, Noma K, Tsukamoto Y, Warren E, Temple B, Grewal SI, Strahl BD
  Title
Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe.
  Journal
Eukaryot Cell 4:1446-54 (2005)
DOI:10.1128/EC.4.8.1446-1454.2005
  Sequence
Reference
4  [PMID:20048053]
  Authors
Lin LJ, Minard LV, Johnston GC, Singer RA, Schultz MC
  Title
Asf1 can promote trimethylation of H3 K36 by Set2.
  Journal
Mol Cell Biol 30:1116-29 (2010)
  Sequence
[sce:YJL168C]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.359
IUBMB Enzyme Nomenclature: 2.1.1.359
ExPASy - ENZYME nomenclature database: 2.1.1.359
BRENDA, the Enzyme Database: 2.1.1.359

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