KEGG   ENZYME: 2.1.1.362
Entry
EC 2.1.1.362                Enzyme                                 
Name
[histone H4]-N-methyl-L-lysine20 N-methyltransferase;
KMT5B (gene name);
KMT5C (gene name);
SUV420H1 (gene name);
SUV420H2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H4]-N6-methyl-L-lysine20 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20
Reaction(KEGG)
(other) R04866
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H4]-N6-methyl-L-lysine20
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H4]-N6,N6-dimethyl-L-lysine20
Comment
This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.
History
EC 2.1.1.362 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.362
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11429  [histone H4]-N-methyl-L-lysine20 N-methyltransferase
Genes
HSA51111(KMT5B) 84787(KMT5C)
PTR451378(KMT5B) 735868(KMT5C)
PPS100984020(KMT5C) 100995372(KMT5B)
GGO101139439(KMT5C) 101151252(KMT5B)
PON100450271(KMT5B) 100450936(KMT5C)
NLE100583977(KMT5B) 100599527(KMT5C)
MCC699963(KMT5C) 710481(KMT5B)
MCF102117388(KMT5B) 102129054(KMT5C)
CSAB103215291(KMT5B) 103235303(KMT5C)
CATY105577329(SUV420H1) 105582752(SUV420H2)
PANU101000900(KMT5B) 101018573(KMT5C) 116268663
TGE112606406(KMT5B) 112612678(KMT5C)
RRO104664716(KMT5B) 104674764(KMT5C)
RBB108518702(KMT5B) 108542541(KMT5C)
TFN117081487(KMT5B) 117091737(KMT5C)
PTEH111521169(KMT5C) 111522408(KMT5B)
CJC100393036(KMT5C) 100400804(KMT5B)
SBQ101047990(SUV420H2) 101053072(SUV420H1)
CSYR103271344(KMT5C)
MMUR105863301 105867495(KMT5B) 105877204(KMT5C)
OGA100966648(KMT5C)
MMU225888(Kmt5b) 232811(Kmt5c)
MCAL110285500(Kmt5b) 110298763(Kmt5c)
MPAH110334213(Kmt5b) 110336454(Kmt5c)
RNO308345(Kmt5c) 361688(Kmt5b)
MCOC116101555(Kmt5c) 116103298(Kmt5b)
MUN110547082(Kmt5b) 110561067(Kmt5c)
CGE100761878(Kmt5b) 100772952(Kmt5c)
PLEU114687711(Kmt5c) 114694607(Kmt5b)
NGI103744517(Kmt5b) 103744814(Kmt5c)
HGL101707567(Kmt5c) 101719039(Kmt5b)
CPOC100713625(Kmt5c) 100727663(Kmt5b)
CCAN109692079(Kmt5b) 109696272(Kmt5c)
DORD105989210(Suv420h1) 105999513(Suv420h2)
DSP122104871(Kmt5b) 122110645(Kmt5c)
NCAR124958337 124966912
OCU100340037(KMT5B)
OPI101530071(KMT5B) 101531050(KMT5C)
TUP102474475 102497986(KMT5B) 102499452(KMT5C)
CFA483690(KMT5B) 484295(KMT5C)
VVP112909339(KMT5C) 112924166(KMT5B)
VLG121485831(KMT5C) 121501552(KMT5B)
AML100468595(KMT5B) 100478438(KMT5C)
UMR103679527 103680304(KMT5C)
UAH113244004(KMT5B) 113247443(KMT5C)
UAR123778528(KMT5B) 123786942(KMT5C)
ELK111139579 111149436
LLV125078124 125089130
MPUF101671221(SUV420H2) 101680981(SUV420H1)
ORO101374708(SUV420H2) 101375610(SUV420H1)
EJU114202071(KMT5C) 114220184(KMT5B)
ZCA113913906(KMT5B) 113935831(KMT5C)
MLX117997814(KMT5C) 118016151(KMT5B)
FCA101091322(KMT5C) 101094702(KMT5B)
PYU121023446(KMT5C) 121023792(KMT5B)
PBG122484079(KMT5B) 122493730(KMT5C)
PTG102953097(KMT5C) 102963329(KMT5B)
PPAD109246874(KMT5B) 109259888(KMT5C)
AJU106971172(KMT5B) 106980935(KMT5C)
HHV120233920(KMT5B) 120239642(KMT5C)
BTA519777(KMT5C) 767828(KMT5B)
BOM102268312(KMT5B) 102288327(KMT5C)
BIU109572897(KMT5C)
BBUB102390793(KMT5C) 102405866(KMT5B)
CHX102185214(KMT5C) 102185720(KMT5B)
OAS101111001 101121289(KMT5C) 101121812(KMT5B)
ODA120871894(KMT5C) 120874128(KMT5B)
CCAD122421123(KMT5C) 122430562(KMT5B)
SSC100521358(KMT5B) 110261054(KMT5C)
CFR102520054(KMT5B) 116666001(KMT5C)
CBAI105070355(SUV420H1) 105074363(SUV420H2)
CDK105098743(KMT5C) 105104405(KMT5B)
VPC102526722(KMT5B) 102544997(KMT5C)
BACU102997321(KMT5C) 103007228(KMT5B)
LVE103090973(KMT5C) 103091082(KMT5B)
OOR101269348(SUV420H2) 101270232(SUV420H1)
DLE111181001(KMT5C) 111183648(KMT5B)
PCAD102982740(KMT5C) 102994432(KMT5B)
PSIU116743805(KMT5C) 116757549(KMT5B)
ECB100053438(KMT5B) 100055743(KMT5C)
EPZ103551272(KMT5B) 103562880(KMT5C)
EAI106840934(KMT5C) 106844276(KMT5B)
MYB102257692(KMT5B)
MYD102762755(KMT5B)
MMYO118655158(KMT5C) 118665198(KMT5B)
MLF102423838(KMT5B)
MNA107537430(KMT5B) 107541336(KMT5C)
PKL118706936(KMT5B) 118718049(KMT5C)
HAI109373782(KMT5C) 109389302(KMT5B)
DRO112313746(KMT5C) 112317051(KMT5B)
SHON118981365(KMT5C) 118998385(KMT5B)
AJM119041826(KMT5B) 119059966(KMT5C)
PDIC114499232(KMT5B) 114511636(KMT5C)
PHAS123813333(KMT5C) 123829288(KMT5B)
MMF118628825(KMT5B) 118639430(KMT5C)
RFQ117030117(KMT5B) 117035542(KMT5C)
PALE102887326(KMT5B) 102887846(KMT5C)
PGIG120584736(KMT5B) 120598318(KMT5C)
PVP105304911(KMT5C) 105306566(KMT5B)
RAY107503474(KMT5B) 107515406(KMT5C)
MJV108388709(KMT5C) 108405830(KMT5B)
TOD119249888(KMT5B) 119250478(KMT5C)
SARA101553901(SUV420H1) 101559080(SUV420H2)
LAV100671600(KMT5B) 100671832(KMT5C)
TMU101357481 101362054
DNM101441925(KMT5C)
MDO100010281(KMT5B)
GAS123252988(KMT5B) 123254396(KMT5C)
SHR100917457(KMT5B)
PCW110195350(KMT5B) 110219937(KMT5C)
OAA100088070(KMT5B) 114814778(KMT5C)
GGA101748081(KMT5C) 425119(KMT5B)
PCOC116238984(KMT5B) 116239624(KMT5C)
MGP100547012(KMT5B) 116217397
CJO107307235(KMT5C) 107314523(KMT5B)
NMEL110391343(KMT5C) 110401096(KMT5B)
APLA101803754(KMT5B)
ACYG106038840(SUV420H1)
AFUL116489780(KMT5B)
TGU100222904(KMT5B)
LSR110484490(KMT5B)
SCAN103824088(KMT5B)
PMOA120511379(KMT5B)
OTC121344840(KMT5B)
PRUF121360949(KMT5B)
GFR102041210(KMT5B)
FAB101805731(KMT5B)
PHI102102011(KMT5B) 102106962(KMT5C)
PMAJ107205911(KMT5B)
CCAE111930710(KMT5B)
CCW104692390(KMT5B)
ETL114064814(KMT5B)
ZAB102071604(KMT5B)
FPG101921673(KMT5B)
FCH102046441(KMT5B)
CLV102091143(KMT5B)
EGZ104132445(SUV420H1)
NNI104017300(SUV420H1)
ACUN113481137(KMT5B)
TALA104357837(KMT5B)
PADL103919876(SUV420H1)
ACHC115351814(KMT5B)
AAM106494851 106494860(KMT5B)
AROW112962693(KMT5B)
NPD112948832(KMT5B)
DNE112987944(KMT5B)
ASN102378990(KMT5C) 102379587(KMT5B)
AMJ102559156(KMT5C) 102568601(KMT5B)
CPOO109318193(KMT5B)
GGN109299233(KMT5B)
PSS102456135(KMT5B)
CMY102946000(KMT5B) 119564929(KMT5C)
CPIC101932218 101950551(KMT5B)
TST117877341(KMT5B) 117888425
CABI116837275(KMT5B) 116840038(KMT5C)
MRV120404891(KMT5B)
ACS100553817(kmt5b) 100562840(suv420h2)
PVT110074171(KMT5B) 110078503(KMT5C)
SUND121928073(KMT5B) 121934852(KMT5C)
PBI103053694(KMT5B) 103066601(KMT5C)
PMUR107282452(KMT5C) 107295878(KMT5B) 107296922
TSR106547726 106553569(SUV420H1)
PGUT117665172(KMT5B) 117669086(KMT5C)
VKO123021166(KMT5B) 123032305(KMT5C)
PMUA114599913(KMT5B) 114608036(KMT5C)
ZVI118088653(KMT5B) 118094429(KMT5C)
GJA107118429(KMT5C) 107119069(KMT5B)
STOW125425986(KMT5B) 125444823(KMT5C)
XLA108697809(kmt5c.S) 444204(kmt5b.S) 495826(kmt5b.L) 779432(kmt5c.L)
XTR100038141(kmt5b) 100145748(kmt5c)
NPR108784118(KMT5B) 108795144
RTEM120915318 120917547(KMT5B)
BBUF120981232(KMT5B) 121001291(KMT5C)
BGAR122920197(KMT5B) 122928660(KMT5C)
DRE569041(kmt5c) 572849(kmt5b)
SRX107726382 107729507 107732880 107738677
SANH107658443 107672243 107674147 107694947
SGH107563992 107583067 107583742 107596936
CCAR109059335 109059339 109060235 109060291
CAUA113046445 113047040 113070223 113118399
PPRM120487671
MAMB125254463(kmt5b)
IPU108264420(kmt5b) 108271342 108280634(kmt5c) 124626874
PHYP113534430(kmt5b) 113536364
SMEO124391472 124395577(kmt5b) 124397332(kmt5c)
TFD113652428(kmt5b) 113663272
AMEX103025343 103035158(kmt5b)
EEE113573589 113575774
TRU101069597 101076428(kmt5b)
TNGGSTEN00005213G001 GSTEN00027784G001
LCO104937792(kmt5b)
NCC104958752(suv420h1)
CGOB115012065 115026499
ELY117254537(kmt5b)
PLEP121964343(kmt5b)
SLUC116067275(kmt5b)
ECRA117936389(kmt5b)
PFLV114554902(kmt5b)
GAT120809098(kmt5b)
PPUG119194941(kmt5b)
MSAM119889981(kmt5b) 119893874(kmt5c) 119899939 119912002 119912004 119912054 119912055
CUD121507226(kmt5b) 121525183
MZE101471827(kmt5b) 101477849
ONL100691614 100700783(kmt5b)
OAU116328928(kmt5c) 116334293(kmt5b)
OLA101156070(kmt5b) 101165555
OML112160800(kmt5b)
XMA102220708(kmt5b) 102236356
XCO114143669(kmt5b) 114159982
XHE116719207(kmt5b)
PRET103460097(kmt5b) 103468964
PFOR103153448(kmt5b)
PLAI106949316(kmt5b)
PMEI106904685(kmt5b)
GAF122823807(kmt5b)
CVG107085059(kmt5b) 107096940
CTUL119773604(kmt5b)
GMU124866992(kmt5b)
NFU107378497 107381531(kmt5b)
KMR108237783(kmt5c) 108250521(kmt5b)
ALIM106532050(suv420h1)
NWH119424991(kmt5b)
AOCE111578621(kmt5b)
CSEM103379016(kmt5b)
POV109634192 109645819(kmt5b)
SSEN122772416(kmt5b)
HHIP117779341(kmt5b)
LCF108894245(kmt5b)
SDU111217719 111224033(kmt5b)
SLAL111656626(kmt5b) 111660544
XGL120784195(kmt5c) 120803744(kmt5b)
HCQ109514373(kmt5b) 109527740
BPEC110168042(kmt5b)
MALB109951248(kmt5b) 109963137
SASA106560809 106573759 106587945 106601577 106601580
OTW112218551(kmt5b) 112252375 112255835
OMY110486659 110495327(kmt5b) 110520608 110526840 110526843 110538619
OGO124000754 124015425 124018489 124036872(kmt5b)
ONE115109400 115110747 115110921 115115615 115134271
SALP111952187 111962386 111968141 111982123
SNH120034096 120040364 120053924 120066257(kmt5b)
ELS105023468 105029585(kmt5b)
SFM108934513(kmt5b) 108941728(kmt5c) 108942441
PKI111841219 111859433
AANG118215224(kmt5b) 118228085
LOC102687526(kmt5b)
PSPA121294829 121305894(kmt5c) 121330193
ARUT117432399 117435056
LCM102357247(KMT5C) 102357304(KMT5B)
CMK103174937(kmt5b) 103189530
RTP109912567(kmt5b) 109932362
BFO118413910
BBEL109482963
CIN100186975
SCLV120342400
SPU583266
APLC110975028
SKO100372808
DMEDmel_CG13363(Hmt4-20)
DER6555511
DSE6615887
DSIDsimw501_GD16466(Dsim_GD16466)
DYADyak_GE16574
DSR110178198
DPODpse_GA22871
DPE6600100
DMN108164669
DWI6644812
DGR6569283
DAZ108618025
DNV108655611
DHE111596240
CCAT101453125
BOD106621763
MDE101897840
SCAC106085721
LCQ111679605
AGAAgaP_AGAP000042
ACOZ120956120
AAG110677788 5569935
AALB109427501 115256334
CQUCpipJ_CPIJ018501
CPII120422523
AME411906
ACER108002910
ALAB122717225
BIM100742553
BBIF117212202
BVK117236757
BVAN117155624
BTER100644080
BPYO122577827
CCAL108624513
OBB114881313
MGEN117229524
NMEA116430221
CGIG122397843
SOC105195127
MPHA105830481
AEC105144221
ACEP105627042
PBAR105427527
VEM105568890
HST105183369
DQU106749629
CFO105255356
FEX115246007
LHU105672756
PGC109853314
OBO105280691
PCF106793217
PFUC122523891
VPS122629202
NVI100122935 100678131 103316358 107981420 107981583 116415916 116415922 116416736
CSOL105362524
TPRE106650619 106657718
CGLO123262315
FAS105263324
DAM107045329
AGIF122848923
CCIN107272637
TCA663776
DPA109533054
SOY115878747
ATD109597721
CSET123309746
AGB108911996
LDC111506674
NVL108569827
APLN108741460
PPYR116169470
OTU111417657
BMOR101735557
BMAN114248506
MSEX115445850
DPLKGM_211967
BANY112053522
PMAC106708893
PPOT106100398
PXU106123472
PRAP110992850
ZCE119833224
HAW110372275
TNL113508300
SLIU111358317
OFU114365076
PXY105397967
API100168226 103307719 103308720 103308751 115033073
DNX107167420 107169873 107169876 107170026 107170623
AGS114121201 114130887
RMD113549136
BTAB109030108
CLEC106669134
HHAL106691237
NLU111058049
PHUPhum_PHUM503290
FOC113204709
ZNE110835364
CSEC111870522
FCD110843123 110850670
DPXDAPPUDRAFT_329141
DMK116919653 123470429
PVM113818296 113827471
PJA122260818 122263832
PCHN125045839
HAME121865412
PCLA123762683
PTRU123507187
HAZT108673820
EAF111714029
LSM121121046
ISCIscW_ISCW002573
DSV119450535
RSAN119383577
RMP119170614
VDE111253391
VJA111268338
TUT107371540
DPTE113794752
DFR124491223
CSCU111636078
PTEP107455782
SDM118193236
CELCELE_C32D5.5(set-4)
CBRCBG_02629(Cbr-set-4)
LOALOAG_03384
NAINECAME_12013
HROHELRODRAFT_162504
LGILOTGIDRAFT_116803
PCAN112560425
BGT106072944
GAE121380962
HRF124135482
HRJ124286750
CRG105319029
MYI110457084
PMAX117335663
MMER123536245
OBI106875752
OSN115211617
LAK106158801 106168595
SMMSmp_062530
SHXMS3_0012812
OVIT265_07853
EGLEGR_03818
NVE5514661
EPA110245633
ATEN116291058
ADF107353716
AMIL114956880
PDAM113667740
SPIS111325445
DGT114533764
HMG100207998
TADTRIADDRAFT_29474
QSU112005838
YLIYALI0E21802g
SLBAWJ20_2557
NCRNCU08551
NTENEUTE1DRAFT82859(NEUTE1DRAFT_82859)
SMPSMAC_08815
PANPODANSg4666
TTTTHITE_42348
MTMMYCTH_73315
CTHRCTHT_0021730
MGRMGG_07393
PPEIPpBr36_02272
TMNUCRPA7_4749
SSCKSPSK_07036
FGRFGSG_06529
FPUFPSE_01728
FVRFVEG_05617
FOXFOXG_02431
NHENECHADRAFT_12117(SDG2118)
TRETRIREDRAFT_51287
TRRM419DRAFT_116228
MAWMAC_03332
MAJMAA_07113
CMTCCM_08113
PLJVFPFJ_05859
VALVDBG_02527
VDAVDAG_09723
CFJCFIO01_05267
CHIGCH63R_03496
SAPOSAPIO_CDS1739
ELAUCREL1_6230
PFYPFICI_03652
SSLSS1G_08939
BFUBCIN_16g03730
MBEMBM_09131
PSCOLY89DRAFT_612664
GLZGLAREA_07838
ANIAN6147.2
AFMAFUA_2G08510
ACTACLA_080330
NFINFIA_084130
AORAO090011000851
ANGANI_1_476104(An12g03880)
AFVAFLA_008242
ALUCAKAW2_60797A(SET9)
ACHEACHE_50381A(SET9)
APUUAPUU_51081S(SET9)
PCSPc13g04130
PDPPDIP_84710
TMFPMAA_070880
TRGTRUGW13939_06230
CIMCIMG_00843
CPWCPC735_054670
UREUREG_00803
PBLPAAG_07512
PBNPADG_11894
ABEARB_04917
TVETRV_05893
AJEHCAG_07358
BGHBDBG_08098
PNOSNOG_13760
PTEPTT_18535
BZECOCCADRAFT_27851
BSCCOCSADRAFT_37170
BORCOCMIDRAFT_106770
AALTCC77DRAFT_17486
ZTRMYCGRDRAFT_85175
PFJMYCFIDRAFT_152998
FFUCLAFUR5_06045
BCOMBAUCODRAFT_393590
NPAUCRNP2_2977
TMLGSTUM_00001870001
CNECNC03710
CNBCNBC3500
CNGCNAG_02749
CGICGB_C5580C
TMSTREMEDRAFT_58833
TASAA1Q1_07214
PPLPOSPLDRAFT_94935
TVSTRAVEDRAFT_17441
DSQDICSQDRAFT_38056
PCOPHACADRAFT_258533
SHSSTEHIDRAFT_35628
HIRHETIRDRAFT_246877
PSQPUNSTDRAFT_29950
ADLAURDEDRAFT_19077
FMEFOMMEDRAFT_69036
GTRGLOTRDRAFT_13276
LBCLACBIDRAFT_326385
MPRMPER_04819
MRRMoror_6353
MOREE1B28_000565
CCICC1G_11834
SCMSCHCODRAFT_235958
ABPAGABI1DRAFT119579(AGABI1DRAFT_119579)
ABVAGABI2DRAFT185465(AGABI2DRAFT_185465)
WSEWALSEDRAFT_70560
WICJ056_002541
UMAUMAG_00543
PFPPFL1_06099
MGLMGL_1066
MRTMRET_3089
MSYMMSY001_0796
PGRPGTG_18068
MLRMELLADRAFT_63110
SREPTSG_09637
 » show all
Reference
1  [PMID:15145825]
  Authors
Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T
  Title
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.
  Journal
Genes Dev 18:1251-62 (2004)
DOI:10.1101/gad.300704
  Sequence
Reference
2  [PMID:23345616]
  Authors
Jorgensen S, Schotta G, Sorensen CS
  Title
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic  integrity.
  Journal
Nucleic Acids Res 41:2797-806 (2013)
DOI:10.1093/nar/gkt012
Reference
3  [PMID:24396869]
  Authors
Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J
  Title
Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
  Journal
FEBS Lett 587:3859-68 (2013)
DOI:10.1016/j.febslet.2013.10.020
  Sequence
[hsa:51111 84787]
Reference
4  [PMID:24049080]
  Authors
Southall SM, Cronin NB, Wilson JR
  Title
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.
  Journal
Nucleic Acids Res 42:661-71 (2014)
DOI:10.1093/nar/gkt776
  Sequence
Reference
5  [PMID:27105552]
  Authors
Weirich S, Kudithipudi S, Jeltsch A
  Title
Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and  methylation of novel substrates.
  Journal
J Mol Biol 428:2344-2358 (2016)
DOI:10.1016/j.jmb.2016.04.015
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.362
IUBMB Enzyme Nomenclature: 2.1.1.362
ExPASy - ENZYME nomenclature database: 2.1.1.362
BRENDA, the Enzyme Database: 2.1.1.362

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