KEGG   ENZYME: 2.1.1.365
Entry
EC 2.1.1.365                Enzyme                                 
Name
MMP 1-O-methyltransferase;
MeT1;
3-O-methylmannose polysaccharide 1-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:3,3'-di-O-methyl-4alpha-mannobiose 1-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3,3'-di-O-methyl-4alpha-mannobiose = S-adenosyl-L-homocysteine + 1,3,3'-tri-O-methyl-4alpha-mannobiose [RN:R12632]
Reaction(KEGG)
R12632
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3,3'-di-O-methyl-4alpha-mannobiose [CPD:C22291]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
1,3,3'-tri-O-methyl-4alpha-mannobiose [CPD:C22292]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Mycolicibacterium hassiacum, participates in the biosynthesis of 3-O-methylmannose polysaccharides (MMP), which are intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism in nontuberculous mycobacteria. The methylation catalysed by this enzyme was shown to block the reducing end of 3,3'-di-O-methyl-alpha-mannobiose, a probable early precursor of the 3-O-methylmannose polysaccharides.
History
EC 2.1.1.365 created 2020
Orthology
K24288  MMP 1-O-methyltransferase
Genes
PHVHU739_020910
SPSHFM037_20045
CJACJA_0304
CEBB0D95_12740
CELLCBR65_15030
CEKD0B88_05540
CEGD0C16_15035
SDESde_3506
TTUTERTU_0412
SAGAM5M_14240
MARQMARGE09_P2655
SPOIIMCC21906_00226
SNANI6N98_17605
ZALAZF00_17310
OSGBST96_06835
MTHDA3224_06815
MICCAUP74_03005
MAGAMag101_10295
MIIBTJ40_15100
MICTFIU95_07060
MHYDGTQ55_10860
MCELLPW13_05475
MICZGL2_42990
HJABST95_02415
HALCEY643_00375
KIMG3T16_10250
AFUSEYZ66_00275
CJAPGWK36_01850
DOLDole_2587
DMLDmul_07990
DALDalk_3107
DATHRM2_16960
DTOTOL2_C16480
DOVDSCO28_27450
DWDDSCW_61250
DALKDSCA_54850
DLIdnl_63680
DEKDSLASN_22160
DBRDeba_1046
PLAPlav_2490
PMOBHG718_03650
RBSRHODOSMS8_01706
MMRMmar10_2009
GAKX907_1358
HYTHXX25_02505
MPAMAP_1663
MAOMAP4_2173
MAVIRC58_10820
MAVURE97_10830
MAVMAV_2758
MITOCO_25850
MIAOCU_25710
MIDMIP_03595
MYOOEM_24290
MCHIAN480_13580
MIROCQ_24410
MMALCKJ54_11650
MMANMMAN_13200
MSAMycsm_06269
MMCMmcs_5096
MKMMkms_5184
MJLMjls_5475
MMIMMAR_2922
MMAEMMARE11_28430
MMMW7S_12490
MLIMULP_02912
MYVG155_29030
MYEAB431_14925
MGOAFA91_04705
MDXBTO20_01875
MSHGMSG_02743
MFJMFLOJ_04380
MSTOMSTO_05760
MSIMMSIM_50040
MSAKMSAS_08410
MKUI2456_14205
MGROFZ046_04900
MXEMYXE_23770
MNVMNVI_42830
MPAGC0J29_16720
MNMMNVM_30710
MGORH0P51_15560
MCOOMCOO_10820
MBAIMB901379_02701
MSEOMSEO_16050
MPSEMPSD_30260
MSHOMSHO_43550
MHEKJMUB5695_02300(trmR)
MGAUMGALJ_44380
MBRDMBRA_37650
MDFK0O62_27975
MMAMK3U93_13125
MHOLK3U96_25715
MSENK3U95_27905
MPAEK0O64_14315
MSMMSMEG_6482
MSGMSMEI_6309
MSBLJ00_32035
MSNLI99_32040
MSHLI98_32045
MVAMvan_5715
MGIMflv_1102
MSPMspyr1_50860
MCBMycch_5060
MNED174_00760
MYNMyAD_00730
MFTXA26_58720
MPHLMPHLCCUG_00126
MVQMYVA_5637
MLLB1R94_12110
MRHMycrhN_2463
MTHN4412656_04481
MHASMHAS_04405
MDUMDUV_45190
MCHTMCHIJ_39800
MDRMDOR_36190
MAUUNCTC10437_05481
MMAGMMAD_52450
MMORMMOR_06920
MAICMAIC_26160
MIJMINS_29570
MALVMALV_37790
MTYMTOK_53020
MPSCMPSYJ_11640
MARZMARA_43540
MGADMGAD_41530
MHEVMHEL_49340
MSARMSAR_41770
MANYMANY_12530
MPOFMPOR_03200
MMATMMAGJ_27540
MBOKMBOE_10040
MFGK6L26_02515
MSEIMSEDJ_07230
MFLVNCTC10271_00130
MJDJDM601_2997
NFANFA_25750
NFRERS450000_01520
NNONONO_c03370
NSLBOX37_22025
NODFOH10_29885
NWLNWFMUON74_03260
NTCKHQ06_07710
NHUH0264_02915
NYALTV02_29830
RHARHA1_ro04659
ROPROP_47570
ROAPd630_LPD01161
RPYY013_20115
RBYCEJ39_06530
RAVAAT18_05405
RHWBFN03_14745
RRZCS378_20905
RHUA3Q40_02416
RHQIM25_09855
RRT4535765_00817
RCRNCTC10994_01898
RKOJWS14_25690
GBRGbro_3869
GPOGPOL_c37200
GORKTR9_3803
GOQACH46_16385
GTABCM27_19950
GOCCXX93_18620
GRUGCWB2_19520
GOMD7316_04854
GAVC5O27_08595
GODGKZ92_18460
GAMGII34_06220
GPDGII33_05595
GJIH1R19_18375
GOILK459_15285
SPINKV203_10860
DTMBJL86_2443
DITC3V38_01840
DIZCT688_12095
DPCA6048_12635
DLUA6035_11720
TOYFO059_16555
SCOSCO2312(SCC53.03)
SALBXNR_4568
SMASAVERM_5860
SGRSGR_5196
SGBWQO_09335
SCBSCAB_65521
SSXSACTE_1809
SVLStrvi_7396
SHYSHJG_3802
SHOSHJGH_3567
SRCM271_34110
SMALSMALA_2253
SSOII1A49_14435
SCTSCAT_1402
SCYSCATT_14050
SFASfla_4517
SBHSBI_07608
SVESVEN_2025
SDVBN159_6082
SALSSLNWT_5528
STRPF750_2172
SFISFUL_1894
SCIB446_12120
SALUDC74_2791
SALLSAZ_15335
SLVSLIV_26160
SGUSGLAU_10595
SVTSVTN_11335
STREGZL_06198
SCWTU94_09980
SLDT261_5776
SLCSL103_07630
SXISXIM_12560
STRMM444_11705
STRCAA958_07730
SAMBSAM23877_2385
SPRISPRI_5189
SCZABE83_26380
SCXAS200_31130
SRWTUE45_02897
STRFASR50_11205
SLEsle_48770(sle_48770)
SRNA4G23_01456
SPAVSpa2297_09665
STRTA8713_08925
SCLFBB341_20485
SGSAVL59_38620
STSIA4E84_11980
SKYD0C37_24650
SALWCP975_10355
SGMGCM10017557_58560
SCADDN051_26845
SLSSLINC_2645
SNRSNOUR_28735
SPLULK06_008460
STRDNI25_27520
SNWBBN63_24775
SAUOBV401_14725
SSIAA7J05_25320
SVUB1H20_08475
SPUNBFF78_29545
SGVB1H19_13405
SLAUSLA_1925
SALFSMD44_02540
SALJSMD11_4780
SLXSLAV_25695
STROSTRMOE7_12400
SFKKY5_2375
SNZDC008_09860
SGEDWG14_05985
SRJSRO_5136
SLKSLUN_11475
SDXC4B68_28325
SGDELQ87_27780
SQZFQU76_08320
SCYAEJ357_13595
SASTCD934_23610
SNQCP978_11090
STIRDDW44_04770
SKACP970_30700
SGZC0216_24535
SVNCP980_23325
SNKCP967_24345
SHAWCEB94_12475
SRKFGW37_09805
SFICEIZ62_23520
SGALCP966_10400
SSPODDQ41_04485
SVRCP971_23745
SPADDVK44_07610
SFYGFH48_28315
SAQUEJC51_15385
SGFHEP81_05440
SCAVCVT27_08300
SSEOD0Z67_08260
SBYH7H31_25945
SRIMCP984_28700
SSUBCP968_23250
SPHVF9278_12150
SCINCP977_10465
SFUGCNQ36_10560
SPACB1H29_25815
STSUB7R87_08250
SCHACP983_30565
SGXH4W23_11995
SCOECP976_13495
SBATG4Z16_24800
SSPBCP982_13550
SNFJYK04_03016
SPLACP981_11685
SBROGQF42_14555
STUIGCM10017668_19540
SATAC5746_12700
SCHFIPT68_11075
SHUNDWB77_05395
SHARHUT13_06980
SCYGS1361_12775
SFEUIM697_10105
SLIAHA039_24570
SDWK7C20_11095
SVDCP969_12730
SCALI6J39_08650
SAUHSU9_009440
SFBCP974_07970
SMOBJ7W19_09465
SPRACP972_10725
SPEUCGZ69_10390
SROIIAG44_28580
SXNIAG42_25030
SGJIAG43_09040
SHKJ2N69_10210
SANUK7396_25385
STRYEQG64_08420
SDDD9753_25000
SACTDMT42_12005
KSKKSE_24080
KABB7C62_08340
KAUB6264_18320
KITCFP65_2117
STRIC7M71_007635
YIALO772_10660
DNIHX89_13595
DAYFV141_12965
LMOIVV02_03785
YIMJ5M86_13660
ALXLVQ62_04945
NCANoca_2796
NDKI601_3491
NOYEXE57_01125
NOIFCL41_07980
NOOFE634_11090
NDPE2C04_08590
NSNEXE58_18275
NBEBack2_02910
NANOG5V58_09605
NMESH9L09_21280
NAROCFH99_11650
NPIG7071_16025
NAQUENKNEFLB_02539
NROK8W59_09575
NOQLN652_04145
PSIMKR76_12290
AERAERYTH_02160
AEZC3E78_12220
AEBC6I20_10180
AEFGEV26_12280
TFUTfu_0569
THAONI17_023665
NDANdas_0387
NALB005_3258
NGVCDO52_08270
STRREKD16_04460
SAIUJ4H86_10560
TCUTcur_3661
ACTWF7P10_32405
AGRAAGRA3207_006070
SROSros_8251
NOABKM31_52765
NOWGBF35_43355
NCXNocox_35705
NGNLCN96_48590
TBITbis_2876
FRAFrancci3_0013
FREFranean1_0009
FRIFraEuI1c_0011
FALFRAAL0022
GOBGobs_3597
BSDBLASA_3349
MMARMODMU_3969
SACGFDZ84_22785
PBROHOP40_20875
SACEGIY23_13420
AMSAMIS_45050
NHYJQS43_17670
CAICaci_2147
AEYCDG81_08880
ABAIIMCC26256_111674
AYMYM304_09090
ATQGH723_15495
IAMHC251_04080
LSKJ5X98_16775
NPYNPRO_24670
MEAPMTHMO_0470
PLONPla110_38590
BROCIPI25_13135
BPITBPIT_31510
JETL3J17_02005
 » show all
Reference
1  [PMID:30606802]
  Authors
Ripoll-Rozada J, Costa M, Manso JA, Maranha A, Miranda V, Sequeira A, Ventura MR, Macedo-Ribeiro S, Pereira PJB, Empadinhas N
  Title
Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides.
  Journal
Proc Natl Acad Sci U S A 116:835-844 (2019)
DOI:10.1073/pnas.1813450116
  Sequence
[mhas:MHAS_04405]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.365
IUBMB Enzyme Nomenclature: 2.1.1.365
ExPASy - ENZYME nomenclature database: 2.1.1.365
BRENDA, the Enzyme Database: 2.1.1.365

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