KEGG ENZYME: 2.1.1.365

ENZYME: 2.1.1.365

Entry

EC 2.1.1.365                Enzyme

Name

MMP 1-O-methyltransferase;
MeT1;
3-O-methylmannose polysaccharide 1-O-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:3,3'-di-O-methyl-4alpha-mannobiose 1-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 3,3'-di-O-methyl-4alpha-mannobiose = S-adenosyl-L-homocysteine + 1,3,3'-tri-O-methyl-4alpha-mannobiose [RN:R12632]

Reaction(KEGG)

R12632

Substrate

S-adenosyl-L-methionine [CPD:C00019];
3,3'-di-O-methyl-4alpha-mannobiose [CPD:C22291]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
1,3,3'-tri-O-methyl-4alpha-mannobiose [CPD:C22292]

Comment

Requires Mg2+. The enzyme, characterized from the bacterium Mycolicibacterium hassiacum, participates in the biosynthesis of 3-O-methylmannose polysaccharides (MMP), which are intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism in nontuberculous mycobacteria. The methylation catalysed by this enzyme was shown to block the reducing end of 3,3'-di-O-methyl-alpha-mannobiose, a probable early precursor of the 3-O-methylmannose polysaccharides.

History

EC 2.1.1.365 created 2020

Orthology

K24288

MMP 1-O-methyltransferase

Genes

CJA:

CJA_0304

CEB:	B0D95_12740

CELL:

CBR65_15030

CEK:	D0B88_05540

CEG:	D0C16_15035

SDE:

Sde_3506

TTU:	TERTU_0412

SAGA:

M5M_14240

MARQ:

MARGE09_P2655

SPOI:

IMCC21906_00226

SNAN:

I6N98_17605

STAW:

NCG89_08465

ZAL:	AZF00_17310

OSG:	BST96_06835

MTHD:

A3224_06815

MICC:

AUP74_03005

MAGA:

Mag101_10295

MII:	BTJ40_15100

MICT:

FIU95_07060

MHYD:

GTQ55_10860

MCEL:

LPW13_05475

MICZ:

GL2_42990

MVB:	MJO52_14275

MPAF:

R5R33_02420

MBRG:

PVT68_00270

MICL:

GNX18_03410

MICY:

HUW35_17625

HJA:	BST95_02415

HALC:

EY643_00375

KIM:	G3T16_10250

AFUS:

EYZ66_00275

PAQM:

E0F26_02980

PLA:

Plav_2490

PMOB:

HG718_03650

PECT:

BN1012_Phect388

RBS:	RHODOSMS8_01706

MMR:	Mmar10_2009

GAK:

X907_1358

HYT:	HXX25_02505

DOL:

Dole_2587

DAL:

Dalk_3107

DAT:	HRM2_16960

DTO:	TOL2_C16480

DOV:	DSCO28_27450

DWD:	DSCW_61250

DALK:

DSCA_54850

DML:	Dmul_07990

DLI:

dnl_63680

DEK:	DSLASN_22160

DBR:

Deba_1046

MPA:

MAP_1663

MAO:

MAP4_2173

MAVI:

RC58_10820

MAVU:

RE97_10830

MAV:

MAV_2758

MIT:

OCO_25850

MIA:

OCU_25710

MID:

MIP_03595

MYO:

OEM_24290

MCHI:

AN480_13580

MIR:

OCQ_24410

MMAL:

CKJ54_11650

MMAN:

MMAN_13200

MSER:

MTY59_41600

MSA:	Mycsm_06269

MMI:

MMAR_2922

MMAE:

MMARE11_28430

MLI:	MULP_02912

MPSE:

MPSD_30260

MSHO:

MSHO_43550

MMC:

Mmcs_5096

MKM:

Mkms_5184

MJL:

Mjls_5475

MMM:

W7S_12490

MYV:	G155_29030

MYE:	AB431_14925

MDX:	BTO20_01875

MSHG:

MSG_02743

MFJ:	MFLOJ_04380

MSTO:

MSTO_05760

MSIM:

MSIM_50040

MSAK:

MSAS_08410

MKU:	I2456_14205

MLW:	MJO58_14675

MXE:	MYXE_23770

MNV:	MNVI_42830

MPAG:

C0J29_16720

MNM:	MNVM_30710

MGOR:

H0P51_15560

MCOO:

MCOO_10820

MBAI:

MB901379_02701

MSEO:

MSEO_16050

MHEK:

JMUB5695_02300(trmR)

MGAU:

MGALJ_44380

MBRD:

MBRA_37650

MMAM:

K3U93_13125

MPAA:

MKK62_13100

MKY:	IWGMT90018_28680

MADI:

A7U43_04460

MWU:	PT015_06505

MYW:	BVC93_24205

MSM:	MSMEG_6482

MSG:	MSMEI_6309

MSB:	LJ00_32035

MSN:	LI99_32040

MSH:	LI98_32045

MVA:

Mvan_5715

MGI:

Mflv_1102

MSP:	Mspyr1_50860

MCB:	Mycch_5060

MNE:	D174_00760

MYN:	MyAD_00730

MFT:	XA26_58720

MPHL:

MPHLCCUG_00126

MVQ:

MYVA_5637

MLL:	B1R94_12110

MRH:	MycrhN_2463

MTHN:

4412656_04481

MHAS:

MHAS_04405

MDU:	MDUV_45190

MCHT:

MCHIJ_39800

MDR:	MDOR_36190

MAUU:

NCTC10437_05481

MMAG:

MMAD_52450

MMOR:

MMOR_06920

MAIC:

MAIC_26160

MIJ:	MINS_29570

MALV:

MALV_37790

MTY:	MTOK_53020

MPSC:

MPSYJ_11640

MARZ:

MARA_43540

MGAD:

MGAD_41530

MHEV:

MHEL_49340

MSAR:

MSAR_41770

MANY:

MANY_12530

MPOF:

MPOR_03200

MMAT:

MMAGJ_27540

MBOK:

MBOE_10040

MFG:	K6L26_02515

MSEI:

MSEDJ_07230

MFLV:

NCTC10271_00130

MCEE:

MCEL_33470

MMON:

EWR22_27475

MGO:	AFA91_04705

MHOL:

K3U96_25715

MSEN:

K3U95_27905

MPAE:

K0O64_14315

MRF:	MJO55_26320

MDF:	K0O62_27975

MCRO:

MI149_15115

MGRO:

FZ046_04900

MAUS:

JN090_28605

MFRE:

EXE63_16330

MJD:	JDM601_2997

NFA:

NFA_25750

NFR:	ERS450000_01520

NNO:	NONO_c03370

NSL:	BOX37_22025

NSR:	NS506_00430

NOD:	FOH10_29885

NWL:	NWFMUON74_03260

NTC:	KHQ06_07710

NHU:	H0264_02915

NYA:	LTV02_29830

RHA:	RHA1_ro04659

ROP:

ROP_47570

ROA:	Pd630_LPD01161

RPY:	Y013_20115

RBY:	CEJ39_06530

RAV:	AAT18_05405

RHW:	BFN03_14745

RRZ:	CS378_20905

RHU:	A3Q40_02416

RHQ:	IM25_09855

RRT:	4535765_00817

RCR:	NCTC10994_01898

RKO:	JWS14_25690

ROZ:	CBI38_04860

RPSK:

JWS13_18700

RGOR:

NMQ04_03555

RHOU:

KZJ41_05940

RHOW:

A4U64_19145

RHOJ:

JVH1_12955

WHR:	OG579_07850

GBR:

Gbro_3869

GPO:	GPOL_c37200

GOR:

KTR9_3803

GOQ:	ACH46_16385

GTA:	BCM27_19950

GOC:	CXX93_18620

GRU:	GCWB2_19520

GOM:	D7316_04854

GAV:	C5O27_08595

GOD:	GKZ92_18460

GOS:	QAD21_18870

GOJ:	GR168_18235

GAM:	GII34_06220

GPD:	GII33_05595

GJI:	H1R19_18375

GOI:	LK459_15285

GHN:	MVF96_18870

GAMI:

IHQ52_22445

GMG:	NWF22_03865

GSI:	P5P27_02085

SPIN:

KV203_10860

DTM:	BJL86_2443

DIT:	C3V38_01840

DIZ:	CT688_12095

DPC:	A6048_12635

DLU:	A6035_11720

DKN:	NHB83_12085

DCD:	VYL96_11945

TOY:	FO059_16555

SCO:	SCO2312(SCC53.03)

SALB:

XNR_4568

SMA:	SAVERM_5860

SGR:

SGR_5196

SGB:

WQO_09335

SFI:

SFUL_1894

SANL:

KZO11_09145

SGRF:

SGFS_081410

SCYE:

R2B67_26940

SCB:	SCAB_65521

SSX:	SACTE_1809

SVL:	Strvi_7396

SHY:

SHJG_3802

SHO:	SHJGH_3567

SRC:	M271_34110

SMAL:

SMALA_2253

SSOI:

I1A49_14435

SFA:

Sfla_4517

SBH:

SBI_07608

SVE:

SVEN_2025

SDV:	BN159_6082

SALS:

SLNWT_5528

STRP:

F750_2172

SCI:	B446_12120

SLV:	SLIV_26160

SGU:	SGLAU_10595

SVT:	SVTN_11335

STRE:

GZL_06198

SCW:	TU94_09980

SLD:

T261_5776

SLC:	SL103_07630

SXI:	SXIM_12560

STRM:

M444_11705

STRC:

AA958_07730

SAMB:

SAM23877_2385

SPRI:

SPRI_5189

SCZ:	ABE83_26380

SCX:	AS200_31130

SRW:	TUE45_02897

STRF:

ASR50_11205

SLE:	sle_48770(sle_48770)

SRN:	A4G23_01456

SPAV:

Spa2297_09665

STRT:

A8713_08925

SCLF:

BB341_20485

SGS:	AVL59_38620

STSI:

A4E84_11980

SKY:	D0C37_24650

SALW:

CP975_10355

SGM:	GCM10017557_58560

SCAD:

DN051_26845

SPHW:

NFX46_32335

SLS:	SLINC_2645

SNR:	SNOUR_28735

SALU:

DC74_2791

SALL:

SAZ_15335

SPLU:

LK06_008460

STRD:

NI25_27520

SNW:	BBN63_24775

SAUO:

BV401_14725

SSIA:

A7J05_25320

SVU:	B1H20_08475

SPUN:

BFF78_29545

SGV:	B1H19_13405

SLAU:

SLA_1925

SALF:

SMD44_02540

SALJ:

SMD11_4780

SLX:	SLAV_25695

STRO:

STRMOE7_12400

SFK:

KY5_2375

SNZ:	DC008_09860

SGE:	DWG14_05985

SRJ:

SRO_5136

SLK:	SLUN_11475

SDX:	C4B68_28325

SGD:	ELQ87_27780

SQZ:	FQU76_08320

SCYA:

EJ357_13595

SAST:

CD934_23610

SNQ:	CP978_11090

STIR:

DDW44_04770

SKA:	CP970_30700

SGZ:	C0216_24535

SVN:	CP980_23325

SNK:	CP967_24345

SHAW:

CEB94_12475

SRK:	FGW37_09805

SFIC:

EIZ62_23520

SGAL:

CP966_10400

SSPO:

DDQ41_04485

SVR:	CP971_23745

SPAD:

DVK44_07610

SFY:	GFH48_28315

SAQU:

EJC51_15385

SGF:	HEP81_05440

SCAV:

CVT27_08300

SSEO:

D0Z67_08260

SBY:	H7H31_25945

SRIM:

CP984_28700

SSUB:

CP968_23250

SPHV:

F9278_12150

SCIN:

CP977_10465

SFUG:

CNQ36_10560

SPAC:

B1H29_25815

STSU:

B7R87_08250

SCHA:

CP983_30565

SGX:	H4W23_11995

SCOE:

CP976_13495

SBAT:

G4Z16_24800

SSPB:

CP982_13550

SNF:	JYK04_03016

SPLA:

CP981_11685

SBRO:

GQF42_14555

STUI:

GCM10017668_19540

SATA:

C5746_12700

SCHF:

IPT68_11075

SHUN:

DWB77_05395

SHAR:

HUT13_06980

SCYG:

S1361_12775

SFEU:

IM697_10105

SLIA:

HA039_24570

SDW:	K7C20_11095

SVD:	CP969_12730

SCAL:

I6J39_08650

SAUH:

SU9_009440

SFB:	CP974_07970

SMOB:

J7W19_09465

SPRA:

CP972_10725

SPEU:

CGZ69_10390

SROI:

IAG44_28580

SXN:	IAG42_25030

SGJ:	IAG43_09040

SHK:	J2N69_10210

SANU:

K7396_25385

STRY:

EQG64_08420

SDD:	D9753_25000

SACT:

DMT42_12005

SMAO:

CAG99_21295

SGOB:

test1122_04895

SINE:

KI385_14630

SLF:	JEQ17_32485

SDEC:

L3078_13685

SAOV:

G3H79_26385

SDUR:

M4V62_29330

SYAN:

NRK68_10580

SRUG:

F0345_07215

STAA:

LDH80_27635

SNIG:

HEK616_11790

SVIO:

HWN34_23080

SCAE:

IHE65_31945

STUB:

MMF93_10010

SSPN:

LXH13_12475

SCIR:

STRCI_002544

SXT:	KPP03845_102536

SLON:

LGI35_15545

SDRZ:

NEH16_22550

STUD:

STRTU_005034

STEE:

F3L20_25105

SGK:	PET44_10330

SANT:

QR300_30425

SYUN:

MOV08_28820

SARG:

HKX69_24385

SJN:	RI060_30115

SCYN:

N8I84_12860

SOV:	QZH56_25905

SFIY:

F0344_26825

SHAU:

K9S39_31470

SKG:	KJK29_27160

SCOA:

QU709_31025

SLAI:

P8A22_27635

SROC:

RGF97_24200

SFP:	QUY26_28465

SCHG:

NRO40_07995

STTN:

BSL84_10280

SINN:

ABB07_26785

STRZ:

OYE22_25230

SCAY:

PYS65_25630

KBU:	Q4V64_14635

SARM:

DVA86_22125

SPRF:

K4G22_22965

SLUO:

PS467_13210

STPB:

QR97_02400

SRPA:

HEP86_12900

SMIB:

SMIR_27260

SCAJ:

O1G22_29485

STRW:

QHG49_24530

STRL:

HEP84_17665

STSD:

HEP87_18030

SRPZ:

HEP85_12850

SCT:

SCAT_1402

SCY:	SCATT_14050

KSK:

KSE_24080

KAB:	B7C62_08340

KAU:	B6264_18320

KIT:	CFP65_2117

KIS:	HUT16_10165

KCH:	O1G21_26770

STRI:

C7M71_007635

YIA:	LO772_10660

STRH:

GXP74_08905

ABRY:

NYE86_08040

AGLA:

OIE69_27625

DNI:	HX89_13595

DAY:	FV141_12965

DERM:

H7F30_04395

LMOI:

VV02_03785

YIM:	J5M86_13660

ALX:	LVQ62_04945

BEI:	GCM100_34160

NCA:

Noca_2796

NDK:

I601_3491

NOY:	EXE57_01125

NOI:	FCL41_07980

NOO:	FE634_11090

NDP:	E2C04_08590

NSN:	EXE58_18275

NBE:	Back2_02910

NANO:

G5V58_09605

NMES:

H9L09_21280

NARO:

CFH99_11650

NPI:	G7071_16025

NAQU:

ENKNEFLB_02539

NRO:	K8W59_09575

NOQ:	LN652_04145

NCQ:	K6T13_08415

NPC:	KUV85_04180

NPS:	KRR39_07200

NMAR:

HPC71_09250

NFC:	KG111_10110

NRN:	SHK17_12220

NBI:	SHK19_12710

PSIM:

KR76_12290

AER:	AERYTH_02160

AEZ:	C3E78_12220

AEB:	C6I20_10180

AEF:	GEV26_12280

ASEZ:

H9L21_13710

ADB:	NP095_13645

AWN:	NQV15_12890

NBT:	KLP28_00580

TFU:

Tfu_0569

THAO:

NI17_023665

TALX:

FOF52_20755

NDA:

Ndas_0387

NAL:

B005_3258

NGV:	CDO52_08270

NEX:	NE857_08195

NAKE:

KGD83_23870

NCG:	KGD84_25510

STRR:

EKD16_04460

SNAH:

OUQ99_25330

SAIU:

J4H86_10560

TCU:

Tcur_3661

ACTW:

F7P10_32405

AGRA:

AGRA3207_006070

AMAZ:

LUW76_38110

ACIR:

OG979_07950

SPIQ:

OHA34_31820

ACTQ:

OG417_14980

SRO:

Sros_8251

NOA:	BKM31_52765

NOW:	GBF35_43355

NCX:	Nocox_35705

NGN:	LCN96_48590

NFS:	OIE67_00420

TBI:

Tbis_2876

MHAI:

OHB01_03460

FRA:	Francci3_0013

FAL:

FRAAL0022

FRE:	Franean1_0009

FRI:	FraEuI1c_0011

GOB:

Gobs_3597

BSD:	BLASA_3349

BLAP:

MVA48_01025

BBRG:

U6N30_18505

MMAR:

MODMU_3969

MOM:	KUM42_03350

SACG:

FDZ84_22785

SACE:

GIY23_13420

AMS:	AMIS_45050

ASIC:

Q0Z83_054810

ACTE:

ACTI_60770

NHY:	JQS43_17670

CAI:

Caci_2147

AEY:	CDG81_08880

ABAI:

IMCC26256_111674

PARN:

NBH00_09275

AYM:	YM304_09090

ATQ:	GH723_15495

IAM:	HC251_04080

IMA:	PO878_03800

DHI:	LH044_14845

THEY:

JW907_01075

TSQ:	D3A95_11800

ACAM:

HRE53_08730

» show all

Reference

1 [PMID:30606802]

Authors

Ripoll-Rozada J, Costa M, Manso JA, Maranha A, Miranda V, Sequeira A, Ventura MR, Macedo-Ribeiro S, Pereira PJB, Empadinhas N

Title

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides.

Journal

Proc Natl Acad Sci U S A 116:835-844 (2019)
DOI:10.1073/pnas.1813450116

Sequence

[mhas:MHAS_04405]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.365

IUBMB Enzyme Nomenclature:

2.1.1.365

ExPASy - ENZYME nomenclature database:

2.1.1.365

BRENDA, the Enzyme Database:

2.1.1.365

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (6059)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (508)   
   KEGG MGENES (5550)   
Protein sequence (3)   
   UniProt (2)   
   SWISS-PROT (1)   
Protein domain (1)   
   InterPro (1)   
All databases (6068)   

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