Entry
Name
2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase;
dsyB (gene name);
methylthiohydroxybutyrate methyltransferase;
MTHB methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(2R)-2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate = S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate [RN:
R12666 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
(2R)-2-hydroxy-4-(methylsulfanyl)butanoate [CPD:
C22315 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
(2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate [CPD:
C22316 ]
Comment
The enzyme, characterized from the marine bacterium Labrenzia aggregata, participates in the biosynthesis of dimethylsulfoniopropanoate (DMSP). A eukaryotic enzyme that shares little sequence similarity with the bacterial enzyme was identified in many marine phytoplankton species.
History
EC 2.1.1.373 created 2020
Orthology
K24666 2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase
Genes
» show all
Taxonomy
Reference
1
Authors
Summers, P.S., Nolte, K.D., Cooper, A.J.L., Borgeas, H., Leustek, T., Rhodes, D. and Hanson, A.D.
Title
Identification and stereospecificity of the first three enzymes of 3-dimethylsulfoniopropionate biosynthesis in a chlorophyte alga.
Journal
Plant Physiol 116:369-378 (1998)
Reference
Authors
Curson AR, Liu J, Bermejo Martinez A, Green RT, Chan Y, Carrion O, Williams BT, Zhang SH, Yang GP, Bulman Page PC, Zhang XH, Todd JD.
Title
Dimethylsulfoniopropionate biosynthesis in marine bacteria and identification of the key gene in this process.
Journal
Sequence
Reference
Authors
Kageyama H, Tanaka Y, Shibata A, Waditee-Sirisattha R, Takabe T.
Title
Dimethylsulfoniopropionate biosynthesis in a diatom Thalassiosira pseudonana: Identification of a gene encoding MTHB-methyltransferase.
Journal
Sequence
Reference
Authors
Curson ARJ, Williams BT, Pinchbeck BJ, Sims LP, Martinez AB, Rivera PPL, Kumaresan D, Mercade E, Spurgin LG, Carrion O, Moxon S, Cattolico RA, Kuzhiumparambil U, Guagliardo P, Clode PL, Raina JB, Todd JD.
Title
DSYB catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.373