KEGG   ENZYME: 2.1.1.376
Entry
EC 2.1.1.376                Enzyme                                 
Name
glycine betaine---corrinoid protein Co-methyltransferase;
mtgB (gene name);
glycine betaine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
glycine betaine:[Co(I) glycine betaine-specific corrinoid protein] Co-methyltransferase
Reaction(IUBMB)
glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein] [RN:R12787]
Reaction(KEGG)
R12787
Substrate
glycine betaine [CPD:C00719];
[Co(I) glycine betaine-specific corrinoid protein]
Product
N,N-dimethylglycine [CPD:C01026];
[methyl-Co(III) glycine betaine-specific corrinoid protein]
Comment
The enzyme, which catalyses the transfer of a methyl group from glycine betaine to a glycine betaine-specific corrinoid protein (MtgC), is involved in methanogenesis from glycine betaine in some methanogenic archaea, and in glycine betaine degradation in some bacteria. Unlike similar enzymes involved in methanogenesis from methylated C1 compounds, this enzyme does not contain the unusual amino acid L-pyrrolysine.
History
EC 2.1.1.376 created 2021
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K25220  glycine betaine---corrinoid protein Co-methyltransferase
Genes
LEIM: K3557_00545
ASCA: QEZ52_21285
PPSO: QPJ95_17585
PBIZ: LWC08_01290
BWS: WCP94_000459
DBK: DGMP_29310
DVR: Dvar_49030 Dvar_49770 Dvar_49780 Dvar_49800 Dvar_63100 Dvar_78110
DEK: DSLASN_08550
ALAM: RT761_00980 RT761_01750
CACE: CACET_c34470(mttB)
BIE: RFF05_05425 RFF05_08705
DSY: DSY3156
DHD: Dhaf_4326
DDH: Desde_3695
DOR: Desor_0412
DMI: Desmer_0448
FWA: DCMF_23125 DCMF_26765
AACX: DEACI_1208 DEACI_1210 DEACI_1255 DEACI_1256 DEACI_1266 DEACI_1268 DEACI_1278 DEACI_1681 DEACI_4248
PHOS: ABFY19_13685 ABFY19_13695 ABFY19_13700
TJR: TherJR_2945
AWO: Awo_c07540(mttB10)
AWI: CHL1_003003(mtgB)
BCOC: BLCOC_17010(mtgB_1) BLCOC_22790(mtgB_2) BLCOC_22880(mtgB_3) BLCOC_43120(mtgB_5) BLCOC_43160(mtgB_6)
BLIQ: INP51_05155 INP51_12235 INP51_14665
BLAR: LC508_08010 LC508_08055 LC508_10695 LC508_14925 LC508_22935 LC508_25320 LC508_25335
WHJ: H9Q79_07380 H9Q79_08790 H9Q79_08880 H9Q79_14845
ETM: CE91St48_00670(mttB_1) CE91St48_00770 CE91St48_05970 CE91St48_09680 CE91St48_13000 CE91St48_22250(mttB_3) CE91St48_22260(mttB_4) CE91St48_31720 CE91St48_31730(mttB_5)
EMJ: V1225_13135
AHAD: FRZ06_09125 FRZ06_12560 FRZ06_12565
GFE: Gferi_19940
TEB: T8CH_0245 T8CH_0486 T8CH_1979 T8CH_2735 T8CH_2737
THYR: P4S50_05620 P4S50_14775
NCD: ACONDI_01179 ACONDI_01398 ACONDI_01399 ACONDI_01401 ACONDI_02393 ACONDI_03100
AAR: Acear_1049 Acear_1222
STED: SPTER_06970(mtgB_3)
SSPH: SPSPH_008900(mtgB_1) SPSPH_008990 SPSPH_009000 SPSPH_030030 SPSPH_031240(mtgB_6) SPSPH_031270(mtgB_7) SPSPH_037480(mtgB_8) SPSPH_038090(mtgB_10)
SOVA: SOV_32270 SOV_32280 SOV_46740 SOV_46750 SOV_47250 SOV_48340
SSID: SPSIL_018430(mtgB_1) SPSIL_045080(mtgB_2) SPSIL_045280(mtgB_3) SPSIL_045290(mtgB_4)
SACV: SPACI_034660(mtgB_1) SPACI_039610(mtgB_2) SPACI_043820(mtgB_3) SPACI_045540(mtgB_6)
SCAO: SCACP_29580(mtgB_1)
CALK: HUE98_00750 HUE98_00760 HUE98_08960
METW: AAY43_00640
MELO: J7W08_01665
MPOT: BKM01_01380
MEHF: MmiHf6_10000(mtgB_2)
MEES: MmiEs2_13280(mtgB_1) MmiEs2_13340(mtgB_3)
MEUZ: KRP56_05670
 » show all
Reference
1  [PMID:25313086]
  Authors
Ticak T, Kountz DJ, Girosky KE, Krzycki JA, Ferguson DJ Jr.
  Title
A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.
  Journal
Proc Natl Acad Sci U S A 111:E4668-76 (2014)
DOI:10.1073/pnas.1409642111
  Sequence
[dsy:DSY3156]
Reference
2  [PMID:31787957]
  Authors
Creighbaum AJ, Ticak T, Shinde S, Wang X, Ferguson DJ Jr.
  Title
Examination of the Glycine Betaine-Dependent Methylotrophic Methanogenesis Pathway: Insights Into Anaerobic Quaternary Amine Methylotrophy.
  Journal
Front Microbiol 10:2572 (2019)
DOI:10.3389/fmicb.2019.02572
  Sequence
[ag:TQD25076]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.376
IUBMB Enzyme Nomenclature: 2.1.1.376
ExPASy - ENZYME nomenclature database: 2.1.1.376
BRENDA, the Enzyme Database: 2.1.1.376

  All links  
Gene (7)   
   MGENES (7)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (2)   
   InterPro (2)   
All databases (15)   

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