KEGG   ENZYME: 2.1.1.380
Entry
EC 2.1.1.380                Enzyme                                 
Name
3-amino-4-hydroxybenzoate 4-O-methyltransferase;
creN (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:3-amino-4-hydroxybenzoate 4-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-amino-2,4-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-amino-2-hydroxy-4-methoxybenzoate [RN:R12928]
Reaction(KEGG)
R12928
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-amino-2,4-dihydroxybenzoate [CPD:C22455]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-amino-2-hydroxy-4-methoxybenzoate [CPD:C22425]
Comment
The enzyme, characterized from the bacterium Streptomyces cremeus, is involved in cremeomycin biosynthesis.
History
EC 2.1.1.380 created 2021
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K25594  3-amino-4-hydroxybenzoate 4-O-methyltransferase
Reference
1  [PMID:26278892]
  Authors
Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP.
  Title
The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation.
  Journal
Chembiochem 16:2172-5 (2015)
DOI:10.1002/cbic.201500407
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.380
IUBMB Enzyme Nomenclature: 2.1.1.380
ExPASy - ENZYME nomenclature database: 2.1.1.380
BRENDA, the Enzyme Database: 2.1.1.380

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