methoxylated aromatic compound---corrinoid protein Co-methyltransferase;
mtoB (gene name);
mtvB (gene name);
vdmB (gene name)
Transferring one-carbon groups;
methoxylated aromatic compound:cobamide Co-methyltransferase
a methoxylated aromatic compound + a [Co(I) methoxylated-aromatic-compound-specific corrinoid protein] = a [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + a phenol
methoxylated aromatic compound;
[Co(I) methoxylated-aromatic-compound-specific corrinoid protein]
[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein];
This entry stands for a family of enzymes that have been characterized from acetogenic bacteria and archaeal species. Different members of this family have different substrate specificity. In the methanogenic archaeon Methermicoccus shengliensis the enzyme participates in methanogenesis from methoxylated aromatic compounds, while in acetogenic bacteria and in non-methanogenic archaea it participates in methoxydotrophic growth. Most of the enzymes have a wide specificity and were shown to act on a large number of methoxylated aromatic compounds, carrying a methoxy group at positions 2, 3 or 4 of the aromatic ring. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state; during methylation the cobalt is oxidized to the Co(III) state.
EC 18.104.22.1682 created 2022
ec01120 Microbial metabolism in diverse environments
K25916 methoxylated aromatic compound---corrinoid protein Co-methyltransferase
MTHO: MOTHE_c03170 MOTHE_c13020
MTHZ: MOTHA_c04110 MOTHA_c13880 » show all
Kaufmann F, Wohlfarth G, Diekert G.
O-demethylase from Acetobacterium dehalogenans--substrate specificity and function of the participating proteins.
Engelmann T, Kaufmann F, Diekert G.
Isolation and characterization of a veratrol:corrinoid protein methyl transferase from Acetobacterium dehalogenans.
Naidu D, Ragsdale SW.
Characterization of a three-component vanillate O-demethylase from Moorella thermoacetica.
Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW
The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).
Kurth JM, Nobu MK, Tamaki H, de Jonge N, Berger S, Jetten MSM, Yamamoto K, Mayumi D, Sakata S, Bai L, Cheng L, Nielsen JL, Kamagata Y, Wagner T, Welte CU.
Methanogenic archaea use a bacteria-like methyltransferase system to demethoxylate aromatic compounds.
Welte CU, de Graaf R, Dalcin Martins P, Jansen RS, Jetten MSM, Kurth JM.
A novel methoxydotrophic metabolism discovered in the hyperthermophilic archaeon Archaeoglobus fulgidus.
ExPASy - ENZYME nomenclature database: 22.214.171.1242